-
1
-
-
84901424065
-
Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity
-
PID: 24781408
-
Huh JY, Park YJ, Ham M, Kim JB (2014) Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. Mol Cells 37:365–371
-
(2014)
Mol Cells
, vol.37
, pp. 365-371
-
-
Huh, J.Y.1
Park, Y.J.2
Ham, M.3
Kim, J.B.4
-
2
-
-
84893663418
-
Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance
-
COI: 1:CAS:528:DC%2BC3sXptFKrtLg%3D, PID: 23707515
-
Lee BC, Lee J (2014) Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta 1842:446–462
-
(2014)
Biochim Biophys Acta
, vol.1842
, pp. 446-462
-
-
Lee, B.C.1
Lee, J.2
-
3
-
-
79953046341
-
Inflammatory mechanisms in obesity
-
COI: 1:CAS:528:DC%2BC3MXltlKnsL8%3D, PID: 21219177
-
Gregor MF, Hotamisligil GS (2011) Inflammatory mechanisms in obesity. Annu Rev Immunol 29:415–445
-
(2011)
Annu Rev Immunol
, vol.29
, pp. 415-445
-
-
Gregor, M.F.1
Hotamisligil, G.S.2
-
4
-
-
79151484704
-
Adipokines in inflammation and metabolic disease
-
COI: 1:CAS:528:DC%2BC3MXotlSgsg%3D%3D, PID: 21252989
-
Ouchi N, Parker JL, Lugus JJ, Walsh K (2011) Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11:85–97
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 85-97
-
-
Ouchi, N.1
Parker, J.L.2
Lugus, J.J.3
Walsh, K.4
-
5
-
-
84878785347
-
Immunological goings-on in visceral adipose tissue
-
COI: 1:CAS:528:DC%2BC3sXptV2msL0%3D, PID: 23747244
-
Mathis D (2013) Immunological goings-on in visceral adipose tissue. Cell Metab 17:851–859
-
(2013)
Cell Metab
, vol.17
, pp. 851-859
-
-
Mathis, D.1
-
6
-
-
33845886915
-
Abdominal obesity and metabolic syndrome
-
COI: 1:CAS:528:DC%2BD28XhtlShtrzF, PID: 17167477
-
Despres JP, Lemieux I (2006) Abdominal obesity and metabolic syndrome. Nature 444:881–887
-
(2006)
Nature
, vol.444
, pp. 881-887
-
-
Despres, J.P.1
Lemieux, I.2
-
7
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
COI: 1:CAS:528:DC%2BD3sXhtVSmtLvO, PID: 14679176
-
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–1808
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante, A.W.6
-
8
-
-
84863279872
-
Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases
-
PID: 22240242
-
Xu JM, Shi GP (2012) Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases. Endocr Rev 33:71–108
-
(2012)
Endocr Rev
, vol.33
, pp. 71-108
-
-
Xu, J.M.1
Shi, G.P.2
-
9
-
-
79953211885
-
Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice
-
COI: 1:CAS:528:DC%2BC3MXisFKku78%3D, PID: 21148461
-
Altintas MM, Azad A, Nayer B et al (2011) Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice. J Lipid Res 52:480–488
-
(2011)
J Lipid Res
, vol.52
, pp. 480-488
-
-
Altintas, M.M.1
Azad, A.2
Nayer, B.3
-
10
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
COI: 1:CAS:528:DC%2BD2sXmvV2quw%3D%3D, PID: 17200717
-
Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117:175–184
-
(2007)
J Clin Invest
, vol.117
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
11
-
-
77954249680
-
+ adipose tissue macrophages are associated with insulin resistance in human obesity
-
COI: 1:CAS:528:DC%2BC3cXpsVOlsrY%3D, PID: 20357360
-
+ adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes 59:1648–1656
-
(2010)
Diabetes
, vol.59
, pp. 1648-1656
-
-
Wentworth, J.M.1
Naselli, G.2
Brown, W.A.3
-
12
-
-
58149347227
-
Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
-
COI: 1:CAS:528:DC%2BD1MXhsleisbY%3D, PID: 18829989
-
Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR (2008) Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 57:3239–3246
-
(2008)
Diabetes
, vol.57
, pp. 3239-3246
-
-
Lumeng, C.N.1
DelProposto, J.B.2
Westcott, D.J.3
Saltiel, A.R.4
-
13
-
-
84874781588
-
The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance
-
COI: 1:CAS:528:DC%2BC3sXksVKjsLw%3D, PID: 23364297
-
Chmelar J, Chung KJ, Chavakis T (2013) The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance. Thromb Haemost 109:399–406
-
(2013)
Thromb Haemost
, vol.109
, pp. 399-406
-
-
Chmelar, J.1
Chung, K.J.2
Chavakis, T.3
-
14
-
-
84907991703
-
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages
-
COI: 1:CAS:528:DC%2BC2cXhsFyrtbbO, PID: 25242226
-
Kratz M, Coats BR, Hisert KB et al (2014) Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. Cell Metab 20:614–625
-
(2014)
Cell Metab
, vol.20
, pp. 614-625
-
-
Kratz, M.1
Coats, B.R.2
Hisert, K.B.3
-
15
-
-
84901944300
-
Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice
-
COI: 1:CAS:528:DC%2BC2cXivFahs7o%3D, PID: 24668788
-
Xu N, Zhang L, Dong J et al (2014) Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice. Mol Nutr Food Res 58:1258–1268
-
(2014)
Mol Nutr Food Res
, vol.58
, pp. 1258-1268
-
-
Xu, N.1
Zhang, L.2
Dong, J.3
-
16
-
-
84880763686
-
Luteolin inhibits inflammatory responses via p38/MK2/TTP-mediated mRNA stability
-
COI: 1:CAS:528:DC%2BC3sXhtFyisbzO, PID: 23839113
-
Wu W, Li D, Zong Y et al (2013) Luteolin inhibits inflammatory responses via p38/MK2/TTP-mediated mRNA stability. Molecules 18:8083–8094
-
(2013)
Molecules
, vol.18
, pp. 8083-8094
-
-
Wu, W.1
Li, D.2
Zong, Y.3
-
17
-
-
71749121785
-
Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation
-
COI: 1:CAS:528:DC%2BD1MXhsVWls73F, PID: 19854181
-
Ando C, Takahashi N, Hirai S et al (2009) Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation. FEBS Lett 583:3649–3654
-
(2009)
FEBS Lett
, vol.583
, pp. 3649-3654
-
-
Ando, C.1
Takahashi, N.2
Hirai, S.3
-
18
-
-
36148988399
-
Luteolin suppresses inflammation-associated gene expression by blocking NF-kB and AP-1 activation pathway in mouse alveolar macrophages
-
COI: 1:CAS:528:DC%2BD2sXhtlGhsb7F, PID: 17977562
-
Chen CY, Peng WH, Tsai KD, Hsu SL (2007) Luteolin suppresses inflammation-associated gene expression by blocking NF-kB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci 81:1602–1614
-
(2007)
Life Sci
, vol.81
, pp. 1602-1614
-
-
Chen, C.Y.1
Peng, W.H.2
Tsai, K.D.3
Hsu, S.L.4
-
19
-
-
84899446511
-
AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease
-
COI: 1:CAS:528:DC%2BC2cXktl2qt7Y%3D, PID: 24638063
-
Steinberg GR, Schertzer JD (2014) AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease. Immunol Cell Biol 92:340–345
-
(2014)
Immunol Cell Biol
, vol.92
, pp. 340-345
-
-
Steinberg, G.R.1
Schertzer, J.D.2
-
20
-
-
79959956336
-
AMP-activated protein kinase inhibits NF-kB signaling and inflammation: impact on healthspan and lifespan
-
COI: 1:CAS:528:DC%2BC3MXnt1Kru7o%3D
-
Salminen A, Hyttinen JM, Kaarniranta K (2011) AMP-activated protein kinase inhibits NF-kB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) 89:667–676
-
(2011)
J Mol Med (Berl)
, vol.89
, pp. 667-676
-
-
Salminen, A.1
Hyttinen, J.M.2
Kaarniranta, K.3
-
21
-
-
58849115949
-
Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
-
COI: 1:CAS:528:DC%2BD1cXhsVCktr3M, PID: 19050283
-
Sag D, Carling D, Stout RD, Suttles J (2008) Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol 181:8633–8641
-
(2008)
J Immunol
, vol.181
, pp. 8633-8641
-
-
Sag, D.1
Carling, D.2
Stout, R.D.3
Suttles, J.4
-
22
-
-
84055190798
-
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
-
COI: 1:CAS:528:DC%2BC3MXhs1ShsLnO, PID: 22080866
-
Galic S, Fullerton MD, Schertzer JD et al (2011) Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest 121:4903–4915
-
(2011)
J Clin Invest
, vol.121
, pp. 4903-4915
-
-
Galic, S.1
Fullerton, M.D.2
Schertzer, J.D.3
-
23
-
-
79953220498
-
Reduction of lipid accumulation in HepG2 cells by luteolin is associated with activation of AMPK and mitigation of oxidative stress
-
COI: 1:CAS:528:DC%2BC3MXksVKgsrw%3D, PID: 20925133
-
Liu JF, Ma Y, Wang Y, Du ZY, Shen JK, Peng HL (2011) Reduction of lipid accumulation in HepG2 cells by luteolin is associated with activation of AMPK and mitigation of oxidative stress. Phytother Res 25:588–596
-
(2011)
Phytother Res
, vol.25
, pp. 588-596
-
-
Liu, J.F.1
Ma, Y.2
Wang, Y.3
Du, Z.Y.4
Shen, J.K.5
Peng, H.L.6
-
24
-
-
84906936385
-
Quercetin, luteolin, and epigallocatechin gallate promote glucose disposal in adipocytes with regulation of AMP-activated kinase and/or sirtuin 1 activity
-
COI: 1:CAS:528:DC%2BC2cXhvVeku73L, PID: 25057854
-
Xiao N, Mei F, Sun Y, Pan G, Liu B, Liu K (2014) Quercetin, luteolin, and epigallocatechin gallate promote glucose disposal in adipocytes with regulation of AMP-activated kinase and/or sirtuin 1 activity. Planta Med 80:993–1000
-
(2014)
Planta Med
, vol.80
, pp. 993-1000
-
-
Xiao, N.1
Mei, F.2
Sun, Y.3
Pan, G.4
Liu, B.5
Liu, K.6
-
25
-
-
84894815681
-
Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1
-
COI: 1:CAS:528:DC%2BC2cXjt12msbw%3D, PID: 24465016
-
Dong J, Zhang X, Zhang L et al (2014) Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1. J Lipid Res 55:363–374
-
(2014)
J Lipid Res
, vol.55
, pp. 363-374
-
-
Dong, J.1
Zhang, X.2
Zhang, L.3
-
26
-
-
84892934880
-
Momordica charantia (bitter melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues
-
PID: 24358329
-
Bao B, Chen YG, Zhang L et al (2013) Momordica charantia (bitter melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues. PLoS One 8:e84075
-
(2013)
PLoS One
, vol.8
-
-
Bao, B.1
Chen, Y.G.2
Zhang, L.3
-
27
-
-
84896864312
-
Implication of the Tpl2 kinase in inflammatory changes and insulin resistance induced by the interaction between adipocytes and macrophages
-
PID: 24424060
-
Ceppo F, Berthou F, Jager J, Dumas K, Cormont M, Tanti JF (2014) Implication of the Tpl2 kinase in inflammatory changes and insulin resistance induced by the interaction between adipocytes and macrophages. Endocrinology 155:951–964
-
(2014)
Endocrinology
, vol.155
, pp. 951-964
-
-
Ceppo, F.1
Berthou, F.2
Jager, J.3
Dumas, K.4
Cormont, M.5
Tanti, J.F.6
-
28
-
-
84903531205
-
CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice
-
COI: 1:CAS:528:DC%2BC2cXmsV2murs%3D, PID: 24744121
-
Kim D, Kim J, Yoon JH et al (2014) CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice. Diabetologia 57:1456–1465
-
(2014)
Diabetologia
, vol.57
, pp. 1456-1465
-
-
Kim, D.1
Kim, J.2
Yoon, J.H.3
-
29
-
-
62749165351
-
Distribution and biological activities of the flavonoid luteolin
-
COI: 1:CAS:528:DC%2BD1MXks1Srt7Y%3D, PID: 19149659
-
Lopez-Lazaro M (2009) Distribution and biological activities of the flavonoid luteolin. Mini Rev Med Chem 9:31–59
-
(2009)
Mini Rev Med Chem
, vol.9
, pp. 31-59
-
-
Lopez-Lazaro, M.1
-
30
-
-
33646759971
-
Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells
-
COI: 1:CAS:528:DC%2BD28Xlt1Wntb8%3D, PID: 16702314
-
Harris GK, Qian Y, Leonard SS, Sbarra DC, Shi X (2006) Luteolin and chrysin differentially inhibit cyclooxygenase-2 expression and scavenge reactive oxygen species but similarly inhibit prostaglandin-E2 formation in RAW 264.7 cells. J Nutr 136:1517–1521
-
(2006)
J Nutr
, vol.136
, pp. 1517-1521
-
-
Harris, G.K.1
Qian, Y.2
Leonard, S.S.3
Sbarra, D.C.4
Shi, X.5
-
31
-
-
79959275233
-
Protective effects of luteolin on diabetic nephropathy in STZ-induced diabetic rats
-
PID: 21584231
-
Wang GG, Lu XH, Li W, Zhao X, Zhang C (2011) Protective effects of luteolin on diabetic nephropathy in STZ-induced diabetic rats. Evid Based Complement Alternat Med 2011:323171
-
(2011)
Evid Based Complement Alternat Med
, vol.2011
, pp. 323171
-
-
Wang, G.G.1
Lu, X.H.2
Li, W.3
Zhao, X.4
Zhang, C.5
-
32
-
-
84863780150
-
Luteolin ameliorates cardiac failure in type I diabetic cardiomyopathy
-
PID: 22626874
-
Wang G, Li W, Lu X, Bao P, Zhao X (2012) Luteolin ameliorates cardiac failure in type I diabetic cardiomyopathy. J Diabetes Complications 26:259–265
-
(2012)
J Diabetes Complications
, vol.26
, pp. 259-265
-
-
Wang, G.1
Li, W.2
Lu, X.3
Bao, P.4
Zhao, X.5
-
33
-
-
79151478555
-
Type 2 diabetes as an inflammatory disease
-
COI: 1:CAS:528:DC%2BC3MXlsFehtQ%3D%3D, PID: 21233852
-
Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98–107
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 98-107
-
-
Donath, M.Y.1
Shoelson, S.E.2
-
34
-
-
84951823798
-
Leptin deficiency shifts mast cells toward anti-inflammatory actions and protects mice from obesity and diabetes by polarizing M2 macrophages
-
COI: 1:CAS:528:DC%2BC2MXhs1OrsbnP, PID: 26481668
-
Zhou Y, Yu X, Chen H et al (2015) Leptin deficiency shifts mast cells toward anti-inflammatory actions and protects mice from obesity and diabetes by polarizing M2 macrophages. Cell Metab 22:1045–1058
-
(2015)
Cell Metab
, vol.22
, pp. 1045-1058
-
-
Zhou, Y.1
Yu, X.2
Chen, H.3
-
35
-
-
38449102676
-
Macrophage activation and polarization
-
COI: 1:CAS:528:DC%2BD1cXhs1ChsbY%3D, PID: 17981560
-
Martinez FO, Sica A, Mantovani A, Locati M (2008) Macrophage activation and polarization. Front Biosci 13:453–461
-
(2008)
Front Biosci
, vol.13
, pp. 453-461
-
-
Martinez, F.O.1
Sica, A.2
Mantovani, A.3
Locati, M.4
-
36
-
-
84858016069
-
Unique proteomic signatures distinguish macrophages and dendritic cells
-
COI: 1:CAS:528:DC%2BC38XksFGlsLY%3D, PID: 22428014
-
Becker L, Liu NC, Averill MM et al (2012) Unique proteomic signatures distinguish macrophages and dendritic cells. PLoS One 7:e33297
-
(2012)
PLoS One
, vol.7
-
-
Becker, L.1
Liu, N.C.2
Averill, M.M.3
-
37
-
-
84941602304
-
AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
-
PID: 26013497
-
Herms A, Bosch M, Reddy BJ et al (2015) AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation. Nat Commun 6:7176
-
(2015)
Nat Commun
, vol.6
, pp. 7176
-
-
Herms, A.1
Bosch, M.2
Reddy, B.J.3
-
38
-
-
67349276169
-
+ metabolism and SIRT1 activity
-
COI: 1:CAS:528:DC%2BD1MXivVKltLc%3D, PID: 19262508
-
+ metabolism and SIRT1 activity. Nature 458:1056–1060
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
|