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Volumn 36, Issue 4, 2017, Pages 525-533

Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; CARBOHYDRATE; CITRIC ACID; GLYCOGEN; HEXOKINASE; HEXOKINASE 2; KI 67 ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; PYRUVATE DEHYDROGENASE; RNA DIRECTED DNA POLYMERASE; TESTOSTERONE; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL 1; PTEN PROTEIN, HUMAN; PTEN PROTEIN, MOUSE;

EID: 84976867074     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2016.223     Document Type: Article
Times cited : (42)

References (52)
  • 1
    • 84969908932 scopus 로고    scopus 로고
    • American Cancer Society
    • American Cancer Society (2015). Cancer Facts and Figures 2015. Available at http://www.cancer.org/acs/groups/content/@editorial/documents/document/ acspc-044552.pdf.
    • (2015) Cancer Facts and Figures 2015
  • 2
    • 84900373381 scopus 로고    scopus 로고
    • Targeting the androgen receptor pathway in castration-resistant prostate cancer: Progresses and prospects
    • Ferraldeschi R, Welti J, Luo J, Attard G, de Bono JS. Targeting the androgen receptor pathway in castration-resistant prostate cancer: progresses and prospects. Oncogene 2014; 34: 1745-1757.
    • (2014) Oncogene , vol.34 , pp. 1745-1757
    • Ferraldeschi, R.1    Welti, J.2    Luo, J.3    Attard, G.4    De Bono, J.S.5
  • 3
    • 84948717393 scopus 로고    scopus 로고
    • Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
    • Watson PA, Arora VK, Sawyers CL. Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer. Nat Rev Cancer 2015; 15: 701-711.
    • (2015) Nat Rev Cancer , vol.15 , pp. 701-711
    • Watson, P.A.1    Arora, V.K.2    Sawyers, C.L.3
  • 7
    • 84879671701 scopus 로고    scopus 로고
    • A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer
    • Lunardi A, Ala U, Epping MT, Salmena L, Clohessy JG, Webster KA et al. A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. Nat Genet 2013; 45: 747-755.
    • (2013) Nat Genet , vol.45 , pp. 747-755
    • Lunardi, A.1    Ala, U.2    Epping, M.T.3    Salmena, L.4    Clohessy, J.G.5    Webster, K.A.6
  • 8
    • 0033215472 scopus 로고    scopus 로고
    • Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgendependent tumors through a two-step process
    • Craft N, Chhor C, Tran C, Belldegrun A, DeKernion J, Witte ON et al. Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgendependent tumors through a two-step process. Cancer Res 1999; 59: 5030-5036.
    • (1999) Cancer Res , vol.59 , pp. 5030-5036
    • Craft, N.1    Chhor, C.2    Tran, C.3    Belldegrun, A.4    DeKernion, J.5    Witte, O.N.6
  • 9
    • 84880560009 scopus 로고    scopus 로고
    • A preclinical xenograft model identifies castration-tolerant cancer-repopulating cells in localized prostate tumors
    • Toivanen R, Frydenberg M, Murphy D, Pedersen J, Ryan A, Pook D et al. A preclinical xenograft model identifies castration-tolerant cancer-repopulating cells in localized prostate tumors. Sci Transl Med 2013; 5: 187ra171.
    • (2013) Sci Transl Med , vol.5 , pp. 187ra171
    • Toivanen, R.1    Frydenberg, M.2    Murphy, D.3    Pedersen, J.4    Ryan, A.5    Pook, D.6
  • 10
    • 84873738494 scopus 로고    scopus 로고
    • Adaptation or selection-mechanisms of castration-resistant prostate cancer
    • Zong Y, Goldstein AS. Adaptation or selection-mechanisms of castration-resistant prostate cancer. Nat Rev Urol 2013; 10: 90-98.
    • (2013) Nat Rev Urol , vol.10 , pp. 90-98
    • Zong, Y.1    Goldstein, A.S.2
  • 11
    • 33745512125 scopus 로고    scopus 로고
    • The clinical relevance of the metabolism of prostate cancer; Zinc and tumor suppression: Connecting the dots
    • Costello LC, Franklin RB. The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots. Mol Cancer 2006; 5: 17.
    • (2006) Mol Cancer , vol.5 , pp. 17
    • Costello, L.C.1    Franklin, R.B.2
  • 13
    • 84918573255 scopus 로고    scopus 로고
    • AKT1 and MYC induce distinctive metabolic fingerprints in human prostate cancer
    • Priolo C, Pyne S, Rose J, Regan ER, Zadra G, Photopoulos C et al. AKT1 and MYC induce distinctive metabolic fingerprints in human prostate cancer. Cancer Res 2014; 74: 7198-7204.
    • (2014) Cancer Res , vol.74 , pp. 7198-7204
    • Priolo, C.1    Pyne, S.2    Rose, J.3    Regan, E.R.4    Zadra, G.5    Photopoulos, C.6
  • 14
    • 84891706485 scopus 로고    scopus 로고
    • Molecular imaging of prostate cancer with PET
    • Jadvar H. Molecular imaging of prostate cancer with PET. J Nucl Med 2013; 54: 1685-1688.
    • (2013) J Nucl Med , vol.54 , pp. 1685-1688
    • Jadvar, H.1
  • 15
    • 84881557242 scopus 로고    scopus 로고
    • Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
    • Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W et al. Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell 2013; 24: 213-228.
    • (2013) Cancer Cell , vol.24 , pp. 213-228
    • Patra, K.C.1    Wang, Q.2    Bhaskar, P.T.3    Miller, L.4    Wang, Z.5    Wheaton, W.6
  • 16
    • 84922503253 scopus 로고    scopus 로고
    • Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth
    • Wang L, Xiong H, Wu F, Zhang Y, Wang J, Zhao L et al. Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth. Cell Reports 2014; 8: 1461-1474.
    • (2014) Cell Reports , vol.8 , pp. 1461-1474
    • Wang, L.1    Xiong, H.2    Wu, F.3    Zhang, Y.4    Wang, J.5    Zhao, L.6
  • 17
    • 0024237766 scopus 로고
    • Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP
    • Arora KK, Pedersen PL. Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP. J Biol Chem 1988; 263: 17422-17428.
    • (1988) J Biol Chem , vol.263 , pp. 17422-17428
    • Arora, K.K.1    Pedersen, P.L.2
  • 18
    • 9744221185 scopus 로고    scopus 로고
    • Hexokinasemitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
    • Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K et al. Hexokinasemitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 2004; 16: 819-830.
    • (2004) Mol Cell , vol.16 , pp. 819-830
    • Majewski, N.1    Nogueira, V.2    Bhaskar, P.3    Coy, P.E.4    Skeen, J.E.5    Gottlob, K.6
  • 19
    • 84921887492 scopus 로고    scopus 로고
    • Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy
    • Roberts DJ, Miyamoto S. Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy. Cell Death Differ 2015; 22: 364.
    • (2015) Cell Death Differ , vol.22 , pp. 364
    • Roberts, D.J.1    Miyamoto, S.2
  • 20
    • 84946195510 scopus 로고    scopus 로고
    • The molecular taxonomy of primary prostate cancer
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network, The molecular taxonomy of primary prostate cancer. Cell 2015; 163: 1011-1025.
    • (2015) Cell , vol.163 , pp. 1011-1025
  • 21
    • 84868446982 scopus 로고    scopus 로고
    • Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancer
    • Chaux A, Peskoe SB, Gonzalez-Roibon N, Schultz L, Albadine R, Hicks J et al. Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancer. Mod Pathol 2012; 25: 1543-1549.
    • (2012) Mod Pathol , vol.25 , pp. 1543-1549
    • Chaux, A.1    Peskoe, S.B.2    Gonzalez-Roibon, N.3    Schultz, L.4    Albadine, R.5    Hicks, J.6
  • 22
    • 53849146755 scopus 로고    scopus 로고
    • Is PTEN loss associated with clinical outcome measures in human prostate cancer?
    • McCall P, Witton CJ, Grimsley S, Nielsen KV, Edwards J. Is PTEN loss associated with clinical outcome measures in human prostate cancer? Br J Cancer 2008; 99: 1296-1301.
    • (2008) Br J Cancer , vol.99 , pp. 1296-1301
    • McCall, P.1    Witton, C.J.2    Grimsley, S.3    Nielsen, K.V.4    Edwards, J.5
  • 23
    • 80054111295 scopus 로고    scopus 로고
    • PTEN protein loss by immunostaining: Analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients
    • Lotan TL, Gurel B, Sutcliffe S, Esopi D, Liu W, Xu J et al. PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients. Clin Cancer Res 2011; 17: 6563-6573.
    • (2011) Clin Cancer Res , vol.17 , pp. 6563-6573
    • Lotan, T.L.1    Gurel, B.2    Sutcliffe, S.3    Esopi, D.4    Liu, W.5    Xu, J.6
  • 24
    • 67650917081 scopus 로고    scopus 로고
    • PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer
    • Sircar K, Yoshimoto M, Monzon FA, Koumakpayi IH, Katz RL, Khanna et al. PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer. J Pathol 2009; 218: 505-513.
    • (2009) J Pathol , vol.218 , pp. 505-513
    • Sircar, K.1    Yoshimoto, M.2    Monzon, F.A.3    Koumakpayi, I.H.4    Katz, R.L.5    Khanna6
  • 25
    • 33748038440 scopus 로고    scopus 로고
    • Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice
    • Gao H, Ouyang X, Banach-Petrosky WA, Shen MM, Abate-Shen C. Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice. Cancer Res 2006; 66: 7929-7933.
    • (2006) Cancer Res , vol.66 , pp. 7929-7933
    • Gao, H.1    Ouyang, X.2    Banach-Petrosky, W.A.3    Shen, M.M.4    Abate-Shen, C.5
  • 26
    • 34447121369 scopus 로고    scopus 로고
    • Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development
    • Jiao J, Wang S, Qiao R, Vivanco I, Watson PA, Sawyers CL et al. Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development. Cancer Res 2007; 67: 6083-6091.
    • (2007) Cancer Res , vol.67 , pp. 6083-6091
    • Jiao, J.1    Wang, S.2    Qiao, R.3    Vivanco, I.4    Watson, P.A.5    Sawyers, C.L.6
  • 27
    • 79958764107 scopus 로고    scopus 로고
    • Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth
    • Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S et al. Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. Cancer Cell 2011; 19: 792-804.
    • (2011) Cancer Cell , vol.19 , pp. 792-804
    • Mulholland, D.J.1    Tran, L.M.2    Li, Y.3    Cai, H.4    Morim, A.5    Wang, S.6
  • 28
    • 84926330368 scopus 로고    scopus 로고
    • Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer
    • Hong MK, Macintyre G, Wedge DC, Van Loo P, Patel K, Lunke S et al. Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer. Nat Commun2015; 6: 6605.
    • (2015) Nat Commun , vol.6 , pp. 6605
    • Hong, M.K.1    Macintyre, G.2    Wedge, D.C.3    Van Loo, P.4    Patel, K.5    Lunke, S.6
  • 30
    • 84934281252 scopus 로고    scopus 로고
    • P53 in survival, death and metabolic health: A lifeguard with a licence to kill
    • Kruiswijk F, Labuschagne CF, Vousden KH. p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nat Rev Mol Cell Biol 2015; 16: 393-405.
    • (2015) Nat Rev Mol Cell Biol , vol.16 , pp. 393-405
    • Kruiswijk, F.1    Labuschagne, C.F.2    Vousden, K.H.3
  • 32
    • 80052461278 scopus 로고    scopus 로고
    • Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition
    • Martin P, Liu YN, Pierce R, Abou-Kheir W, Casey O, Seng V et al. Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition. Am J Pathol 2011; 179: 422-435.
    • (2011) Am J Pathol , vol.179 , pp. 422-435
    • Martin, P.1    Liu, Y.N.2    Pierce, R.3    Abou-Kheir, W.4    Casey, O.5    Seng, V.6
  • 33
    • 79960071366 scopus 로고    scopus 로고
    • The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    • Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L et al. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J 2011; 30: 2719-2733.
    • (2011) EMBO J , vol.30 , pp. 2719-2733
    • Massie, C.E.1    Lynch, A.2    Ramos-Montoya, A.3    Boren, J.4    Stark, R.5    Fazli, L.6
  • 34
    • 84868633053 scopus 로고    scopus 로고
    • Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
    • Sun Y, Campisi J, Higano C, Beer TM, Porter P, Coleman I et al. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med 2012; 18: 1359-1368.
    • (2012) Nat Med , vol.18 , pp. 1359-1368
    • Sun, Y.1    Campisi, J.2    Higano, C.3    Beer, T.M.4    Porter, P.5    Coleman, I.6
  • 36
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    • Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 2011; 19: 575-586.
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1    Chapinski, C.2    Wongvipat, J.3    Hieronymus, H.4    Chen, Y.5    Chandarlapaty, S.6
  • 37
    • 80053943314 scopus 로고    scopus 로고
    • Self-renewing Pten-/- TP53-/- protospheres produce metastatic adenocarcinoma cell lines with multipotent progenitor activity
    • Abou-Kheir W, Hynes PG, Martin P, Yin JJ, Liu YN, Seng V et al. Self-renewing Pten-/- TP53-/- protospheres produce metastatic adenocarcinoma cell lines with multipotent progenitor activity. PLoS One 2011; 6: e26112.
    • (2011) PLoS One , vol.6 , pp. e26112
    • Abou-Kheir, W.1    Hynes, P.G.2    Martin, P.3    Yin, J.J.4    Liu, Y.N.5    Seng, V.6
  • 38
    • 84875497134 scopus 로고    scopus 로고
    • Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-offlight mass spectrometry
    • Kami K, Fujimori T, Sato H, Sato M, Yamamoto H, Ohashi Y et al. Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-offlight mass spectrometry. Metabolomics 2013; 9: 444-453.
    • (2013) Metabolomics , vol.9 , pp. 444-453
    • Kami, K.1    Fujimori, T.2    Sato, H.3    Sato, M.4    Yamamoto, H.5    Ohashi, Y.6
  • 40
    • 79952937101 scopus 로고    scopus 로고
    • H HRMAS NMR derived bio-markers related to tumor grade, tumor cell fraction, and cell proliferation in prostate tissue samples
    • Stenman K, Stattin P, Stenlund H, Riklund K, Grobner G, Bergh A. H HRMAS NMR derived bio-markers related to tumor grade, tumor cell fraction, and cell proliferation in prostate tissue samples. Biomark Insights 2011; 6: 39-47.
    • (2011) Biomark Insights , vol.6 , pp. 39-47
    • Stenman, K.1    Stattin, P.2    Stenlund, H.3    Riklund, K.4    Grobner, G.5    Bergh, A.6
  • 41
    • 0242353960 scopus 로고    scopus 로고
    • Proton HR-MAS spectroscopy and quantitative pathologic analysis of MRI/3DMRSI- targeted postsurgical prostate tissues
    • Swanson MG, Vigneron DB, Tabatabai ZL, Males RG, Schmitt L, Carroll PR et al. Proton HR-MAS spectroscopy and quantitative pathologic analysis of MRI/3DMRSI- targeted postsurgical prostate tissues. Magn Reson Med 2003; 50: 944-954.
    • (2003) Magn Reson Med , vol.50 , pp. 944-954
    • Swanson, M.G.1    Vigneron, D.B.2    Tabatabai, Z.L.3    Males, R.G.4    Schmitt, L.5    Carroll, P.R.6
  • 42
    • 0034983918 scopus 로고    scopus 로고
    • Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
    • Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 2001; 15: 1406-1418.
    • (2001) Genes Dev , vol.15 , pp. 1406-1418
    • Gottlob, K.1    Majewski, N.2    Kennedy, S.3    Kandel, E.4    Robey, R.B.5    Hay, N.6
  • 43
    • 63649100705 scopus 로고    scopus 로고
    • Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its antiapoptotic activity
    • Arzoine L, Zilberberg N, Ben-Romano R, Shoshan-Barmatz V. Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its antiapoptotic activity. J Biol Chem 2009; 284: 3946-3955.
    • (2009) J Biol Chem , vol.284 , pp. 3946-3955
    • Arzoine, L.1    Zilberberg, N.2    Ben-Romano, R.3    Shoshan-Barmatz, V.4
  • 44
  • 45
    • 10844235652 scopus 로고    scopus 로고
    • Androgen-independent prostate cancer is a heterogeneous group of diseases: Lessons from a rapid autopsy program
    • Shah RB, Mehra R, Chinnaiyan AM, Shen R, Ghosh D, Zhou M et al. Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program. Cancer Res 2004; 64: 9209-9216.
    • (2004) Cancer Res , vol.64 , pp. 9209-9216
    • Shah, R.B.1    Mehra, R.2    Chinnaiyan, A.M.3    Shen, R.4    Ghosh, D.5    Zhou, M.6
  • 46
    • 84863456083 scopus 로고    scopus 로고
    • Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production
    • Wu R, Wyatt E, Chawla K, Tran M, Ghanefar M, Laakso M et al. Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production. EMBO Mol Med 2012; 4: 633-646.
    • (2012) EMBO Mol Med , vol.4 , pp. 633-646
    • Wu, R.1    Wyatt, E.2    Chawla, K.3    Tran, M.4    Ghanefar, M.5    Laakso, M.6
  • 47
    • 33746927077 scopus 로고    scopus 로고
    • Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
    • Robey RB, Hay N. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 2006; 25: 4683-4696.
    • (2006) Oncogene , vol.25 , pp. 4683-4696
    • Robey, R.B.1    Hay, N.2
  • 48
    • 0347986675 scopus 로고    scopus 로고
    • Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases
    • Majewski N, Nogueira V, Robey RB, Hay N. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol Cell Biol 2004; 24: 730-740.
    • (2004) Mol Cell Biol , vol.24 , pp. 730-740
    • Majewski, N.1    Nogueira, V.2    Robey, R.B.3    Hay, N.4
  • 49
    • 0036510541 scopus 로고    scopus 로고
    • Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
    • Pastorino JG, Shulga N, Hoek JB. Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J Biol Chem 2002; 277: 7610-7618.
    • (2002) J Biol Chem , vol.277 , pp. 7610-7618
    • Pastorino, J.G.1    Shulga, N.2    Hoek, J.B.3
  • 50
    • 46649106720 scopus 로고    scopus 로고
    • Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels
    • Chiara F, Castellaro D, Marin O, Petronilli V, Brusilow WS, Juhaszova M et al. Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS One 2008; 3: e1852.
    • (2008) PLoS One , vol.3 , pp. e1852
    • Chiara, F.1    Castellaro, D.2    Marin, O.3    Petronilli, V.4    Brusilow, W.S.5    Juhaszova, M.6
  • 51
    • 84872454871 scopus 로고    scopus 로고
    • Effects of androgen deprivation therapy and bisphosphonate treatment on bone in patients with metastatic castration-resistant prostate cancer: Results from the University of Washington Rapid Autopsy Series
    • Morrissey C, Roudier MP, Dowell A, True LD, Ketchanji M, Welty C et al. Effects of androgen deprivation therapy and bisphosphonate treatment on bone in patients with metastatic castration-resistant prostate cancer: results from the University of Washington Rapid Autopsy Series. J Bone Miner Res 2013; 28: 333-340.
    • (2013) J Bone Miner Res , vol.28 , pp. 333-340
    • Morrissey, C.1    Roudier, M.P.2    Dowell, A.3    True, L.D.4    Ketchanji, M.5    Welty, C.6
  • 52
    • 68849083050 scopus 로고    scopus 로고
    • Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems
    • Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem 2009; 81: 6-6667.
    • (2009) Anal Chem , vol.81 , pp. 6-6667
    • Evans, A.M.1    DeHaven, C.D.2    Barrett, T.3    Mitchell, M.4    Milgram, E.5


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