Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 26, 2016, Pages 7065-7070

  Galvagnion, Céline ^a   Brown, James W P ^a   Ouberai, Myriam M ^a   Flagmeier, Patrick ^a   Vendruscolo, Michele ^a   Buell, Alexander K ^a   Sparr, Emma ^b   Dobson, Christopher M ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b LUND UNIVERSITY   (Sweden)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Lipid induced aggregation; Parkinson's disease; Phase diagram; synuclein

Indexed keywords

1 PALMITOYL 2 OLEOYL SN GLYCERO 3 PHOSPHO LEVO SERINE; 1,2 DIOLEOYL SN GLYCERO 3 PHOSPHO LEVO SERINE; 1,2 DIOLEYL SN GLYCERO 3 PHOSPHOETHANOLAMINE; ALPHA SYNUCLEIN; DIMYRISTOYLPHOSPHATIDYLCHOLINE; LIPID; UNCLASSIFIED DRUG; LIPID BILAYER;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; LEWY BODY; MEMBRANE MODEL; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LIPID INTERACTION; CELL MEMBRANE; CHEMISTRY; HUMAN; KINETICS; LIPID BILAYER; METABOLISM; PROTEINOSIS;

ALPHA-SYNUCLEIN; CELL MEMBRANE; HUMANS; KINETICS; LIPID BILAYERS; PARKINSON DISEASE; PROTEIN AGGREGATION, PATHOLOGICAL;

EID: 84976602130     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1601899113     Document Type: Article

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