Adipocytes contribute to the growth and progression of multiple myeloma: Unraveling obesity related differences in adipocyte signaling

Cancer Letters

Volumn 380, Issue 1, 2016, Pages 114-121

  Bullwinkle, Erica M ^a   Parker, Melissa D ^a   Bonan, Nicole F ^a   Falkenberg, Lauren G ^a   Davison, Steven P ^b   DeCicco Skinner, Kathleen L ^a  

^a AMERICAN UNIVERSITY   (United States)

^b DAVinci Plastic Surgery   (United States)

Author keywords

Adhesion; Adipocyte; Adipose derived stem cells; Angiogenesis; Multiple myeloma; Obesity

Indexed keywords

CYTOCHROME C; FATTY ACID SYNTHASE; GELATINASE A; INTERLEUKIN 6; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STAT3 PROTEIN; CONDITIONED MEDIUM; FASN PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; MMP2 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

ADIPOCYTE; ADIPOSE DERIVED STEM CELL; ADULT; AGED; ARTICLE; BODY MASS; CELL ADHESION; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; COCULTURE; CONDITIONED MEDIUM; CONTROLLED STUDY; ELECTIVE SURGERY; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIPOSUCTION; MALE; MIDDLE AGED; MULTIPLE MYELOMA; MULTIPLE MYELOMA CELL LINE; NCI H929 CELL LINE; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RPMI 8226 CELL LINE; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION; ANGIOGENESIS; COMPLICATION; DISEASE COURSE; METABOLISM; PARACRINE SIGNALING; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

ADIPOCYTES; CELL ADHESION; CELL LINE, TUMOR; CELL PROLIFERATION; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYTOCHROMES C; DISEASE PROGRESSION; FATTY ACID SYNTHASE, TYPE I; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN-6; LEPTIN; MATRIX METALLOPROTEINASE 2; MULTIPLE MYELOMA; NEOVASCULARIZATION, PHYSIOLOGIC; OBESITY; PARACRINE COMMUNICATION; PHOSPHORYLATION; PPAR GAMMA; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR MICROENVIRONMENT;

EID: 84976439502     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2016.06.010     Document Type: Article

References (54)

1. [1] Vincent Rajkumar, S., Multiple myeloma: 2014 update on diagnosis, risk-stratification, and management. Am. J. Hematol 89 (2014), 999–1009.
2. [2] Rajkumar, S.V., Kumar, S., Multiple myeloma: diagnosis and treatment. Mayo Clin. Proc 91 (2016), 101–119.
3. [3] Larsson, S.C., Wolk, A., Body mass index and risk of multiple myeloma: a meta-analysis. Int. J. Cancer 121 (2007), 2512–2516.
4. [4] Lichtman, M.A., Obesity and the risk for a hematological malignancy: leukemia, lymphoma, or myeloma. Oncologist 15 (2010), 1083–1101.
5. [5] Teras, L.R., Kitahara, C.M., Birmann, B.M., Hartge, P.A., Wang, S.S., Robien, K., et al. Body size and multiple myeloma mortality: a pooled analysis of 20 prospective studies. Br. J. Haematol 166 (2014), 667–676.
6. [6] Wallin, A., Larsson, S.C., Body mass index and risk of multiple myeloma: a meta-analysis of prospective studies. Eur. J. Cancer 47 (2011), 1606–1615.
7. [7] Rollig, C., Knop, S., Bornhauser, M., Multiple myeloma. Lancet 385 (2015), 2197–2208.
8. [8] Palumbo, A., Anderson, K., Multiple myeloma. N. Engl. J. Med 364 (2011), 1046–1060.
9. [9] Shain, K.H., Dalton, W.S., Tao, J., The tumor microenvironment shapes hallmarks of mature B-cell malignancies. Oncogene 34 (2015), 4673–4682.
10. [10] Gimble, J.M., Robinson, C.E., Wu, X., Kelly, K.A., The function of adipocytes in the bone marrow stroma: an update. Bone 19 (1996), 421–428.
11. [11] Nieman, K.M., Romero, I.L., Van Houten, B., Lengyel, E., Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim. Biophys. Acta 2013 (1831), 1533–1541.
12. [12] Booth, A., Magnuson, A., Fouts, J., Foster, M., Adipose tissue, obesity and adipokines: role in cancer promotion. Horm. Mol. Biol. Clin. Investig 21 (2015), 57–74.
13. [13] Prieto-Hontoria, P.L., Perez-Matute, P., Fernandez-Galilea, M., Bustos, M., Martinez, J.A., Moreno-Aliaga, M.J., Role of obesity-associated dysfunctional adipose tissue in cancer: a molecular nutrition approach. Biochim. Biophys. Acta 1807 (2011), 664–678.
14. [14] Colotta, F., Allavena, P., Sica, A., Garlanda, C., Mantovani, A., Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30 (2009), 1073–1081.
15. [15] Kidane, D., Chae, W.J., Czochor, J., Eckert, K.A., Glazer, P.M., Bothwell, A.L., et al. Interplay between DNA repair and inflammation, and the link to cancer. Crit. Rev. Biochem. Mol. Biol 49 (2014), 116–139.
16. [16] DeCicco-Skinner, K.L., Henry, G.H., Cataisson, C., Tabib, T., Gwilliam, J.C., Watson, N.J., et al. Endothelial cell tube formation assay for the in vitro study of angiogenesis. J. Vis. Exp, 2014, e51312.
17. [17] Pfaffl, M.W., A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res, 29, 2001, e45.
18. [18] Katz, B.Z., Adhesion molecules–the lifelines of multiple myeloma cells. Semin. Cancer Biol 20 (2010), 186–195.
19. [19] Cao, Y., Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases. Nat. Rev. Drug Discov 9 (2010), 107–115.
20. [20] Hefetz-Sela, S., Scherer, P.E., Adipocytes: impact on tumor growth and potential sites for therapeutic intervention. Pharmacol. Ther 138 (2013), 197–210.
21. [21] Vacca, A., Ribatti, D., Roccaro, A.M., Frigeri, A., Dammacco, F., Bone marrow angiogenesis in patients with active multiple myeloma. Semin. Oncol 28 (2001), 543–550.
22. [22] Basen-Engquist, K., Chang, M., Obesity and cancer risk: recent review and evidence. Curr. Oncol. Rep 13 (2011), 71–76.
23. [23] Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384 (2014), 766–781.
24. [24] Whitlock, G., Lewington, S., Sherliker, P., Clarke, R., Emberson, J., Halsey, J., et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 373 (2009), 1083–1096.
25. [25] Rozman, C., Feliu, E., Berga, L., Reverter, J.C., Climent, C., Ferran, M.J., Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study. Exp. Hematol 17 (1989), 34–37.
26. [26] Rajala, M.W., Scherer, P.E., Minireview: the adipocyte–at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144 (2003), 3765–3773.
27. [27] Caers, J., Deleu, S., Belaid, Z., De Raeve, H., Van Valckenborgh, E., De Bruyne, E., et al. Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells. Leukemia 21 (2007), 1580–1584.
28. [28] Klok, M.D., Jakobsdottir, S., Drent, M.L., The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes. Rev 8 (2007), 21–34.
29. [29] De Ugarte, D.A., Morizono, K., Elbarbary, A., Alfonso, Z., Zuk, P.A., Zhu, M., et al. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs 174 (2003), 101–109.
30. [30] Strioga, M., Viswanathan, S., Darinskas, A., Slaby, O., Michalek, J., Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells. Stem Cells Dev 21 (2012), 2724–2752.
31. [31] Jin, H.J., Bae, Y.K., Kim, M., Kwon, S.J., Jeon, H.B., Choi, S.J., et al. Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy. Int. J. Mol. Sci 14 (2013), 17986–18001.
32. [32] Li, C.Y., Wu, X.Y., Tong, J.B., Yang, X.X., Zhao, J.L., Zheng, Q.F., et al. Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. Stem Cell Res. Ther, 6, 2015, 55.
33. [33] Lotfy, A., Salama, M., Zahran, F., Jones, E., Badawy, A., Sobh, M., Characterization of mesenchymal stem cells derived from rat bone marrow and adipose tissue: a comparative study. Int. J. Stem Cells 7 (2014), 135–142.
34. [34] Ock, S.A., Baregundi Subbarao, R., Lee, Y.M., Lee, J.H., Jeon, R.H., Lee, S.L., et al. Comparison of immunomodulation properties of porcine mesenchymal stromal/stem cells derived from the bone marrow, adipose tissue, and dermal skin tissue. Stem Cells Int, 2016, 2016, 9581350.
35. [35] Peng, L., Jia, Z., Yin, X., Zhang, X., Liu, Y., Chen, P., et al. Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue. Stem Cells Dev 17 (2008), 761–773.
36. [36] Chen, D., Liu, S., Ma, H., Liang, X., Ma, H., Yan, X., et al. Paracrine factors from adipose-mesenchymal stem cells enhance metastatic capacity through Wnt signaling pathway in a colon cancer cell co-culture model. Cancer Cell Int, 15, 2015, 42.
37. [37] Strong, A.L., Ohlstein, J.F., Biagas, B.A., Rhodes, L.V., Pei, D.T., Tucker, H.A., et al. Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers. Breast Cancer Res, 17, 2015, 112.
38. [38] Strong, A.L., Strong, T.A., Rhodes, L.V., Semon, J.A., Zhang, X., Shi, Z., et al. Obesity associated alterations in the biology of adipose stem cells mediate enhanced tumorigenesis by estrogen dependent pathways. Breast Cancer Res, 15, 2013, R102.
39. [39] Trevellin, E., Scarpa, M., Carraro, A., Lunardi, F., Kotsafti, A., Porzionato, A., et al. Esophageal adenocarcinoma and obesity: peritumoral adipose tissue plays a role in lymph node invasion. Oncotarget 6 (2015), 11203–11215.
40. [40] Zhang, Y., Nowicka, A., Solley, T.N., Wei, C., Parikh, A., Court, L., et al. Stromal cells derived from visceral and obese adipose tissue promote growth of ovarian cancers. PLoS ONE, 10, 2015 e0136361.
41. [41] Freese, K.E., Kokai, L., Edwards, R.P., Philips, B.J., Sheikh, M.A., Kelley, J., et al. Adipose-derived stems cells and their role in human cancer development, growth, progression, and metastasis: a systematic review. Cancer Res 75 (2015), 1161–1168.
42. [42] Ribeiro, R., Monteiro, C., Cunha, V., Oliveira, M.J., Freitas, M., Fraga, A., et al. Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro. J. Exp. Clin. Cancer Res, 31, 2012, 32.
43. [43] Frazier, T.P., Gimble, J.M., Devay, J.W., Tucker, H.A., Chiu, E.S., Rowan, B.G., Body mass index affects proliferation and osteogenic differentiation of human subcutaneous adipose tissue-derived stem cells. BMC Cell Biol, 14, 2013, 34.
44. [44] Goh, B.C., Thirumala, S., Kilroy, G., Devireddy, R.V., Gimble, J.M., Cryopreservation characteristics of adipose-derived stem cells: maintenance of differentiation potential and viability. J. Tissue Eng. Regen. Med 1 (2007), 322–324.
45. [45] Kawano, Y., Moschetta, M., Manier, S., Glavey, S., Gorgun, G.T., Roccaro, A.M., et al. Targeting the bone marrow microenvironment in multiple myeloma. Immunol. Rev 263 (2015), 160–172.
46. [46] Olechnowicz, S.W., Edwards, C.M., Contributions of the host microenvironment to cancer-induced bone disease. Cancer Res 74 (2014), 1625–1631.
47. [47] Noborio-Hatano, K., Kikuchi, J., Takatoku, M., Shimizu, R., Wada, T., Ueda, M., et al. Bortezomib overcomes cell-adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma. Oncogene 28 (2009), 231–242.
48. [48] Shain, K.H., Yarde, D.N., Meads, M.B., Huang, M., Jove, R., Hazlehurst, L.A., et al. Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation. Cancer Res 69 (2009), 1009–1015.
49. [49] Giuliani, N., Storti, P., Bolzoni, M., Palma, B.D., Bonomini, S., Angiogenesis and multiple myeloma. Cancer Microenviron 4 (2011), 325–337.
50. [50] Vacca, A., Ribatti, D., Bone marrow angiogenesis in multiple myeloma. Leukemia 20 (2006), 193–199.
51. [51] Moschetta, M., Mishima, Y., Kawano, Y., Manier, S., Paiva, B., Palomera, L., et al. Targeting vasculogenesis to prevent progression in multiple myeloma. Leukemia 30 (2016), 1103–1115.
52. [52] Rajkumar, S.V., Leong, T., Roche, P.C., Fonseca, R., Dispenzieri, A., Lacy, M.Q., et al. Prognostic value of bone marrow angiogenesis in multiple myeloma. Clin. Cancer Res 6 (2000), 3111–3116.
53. [53] Kessenbrock, K., Plaks, V., Werb, Z., Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141 (2010), 52–67.
54. [54] Rehrer, C.W., Karimpour-Fard, A., Hernandez, T.L., Law, C.K., Stob, N.R., Hunter, L.E., et al. Regional differences in subcutaneous adipose tissue gene expression. Obesity (Silver Spring) 20 (2012), 2168–2173.