TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells

Pharmacological Research

Volumn 111, Issue , 2016, Pages 226-236

  Yang, Zhiying ^a,b   Xiong, Fengxiao ^a   Wang, Yu ^a   Gong, Wenyan ^a   Huang, Junying ^a   Chen, Cheng ^a   Liu, Peiqing ^a,b   Huang, Heqing ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b National and Local United Engineering Lab of Drug Screening and Evaluation   (China)

Author keywords

AP 1; Fibronectin; Renal fibrosis; S1P2; TGR5

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; FIBRONECTIN; G PROTEIN COUPLED RECEPTOR; GLUCOSE; INT 777; INTERCELLULAR ADHESION MOLECULE 1; PROTEIN C FOS; PROTEIN C JUN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; TGR5 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; 6ALPHA-ETHYL-23(S)-METHYLCHOLIC ACID; CHOLIC ACID DERIVATIVE; GPBAR1 PROTEIN, MOUSE; GPBAR1 PROTEIN, RAT; ICAM1 PROTEIN, RAT; LYSOPHOSPHOLIPID; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE-1-PHOSPHATE RECEPTOR-2, RAT; TGFB1 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; INTERNALIZATION; KIDNEY FIBROSIS; MESANGIUM CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; FIBROSIS; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; CHOLIC ACIDS; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; FIBRONECTINS; FIBROSIS; GLUCOSE; INTERCELLULAR ADHESION MOLECULE-1; LYSOPHOSPHOLIPIDS; MESANGIAL CELLS; MICE, INBRED C57BL; PHOSPHORYLATION; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LYSOSPHINGOLIPID; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPHINGOSINE; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84976407076     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2016.05.035     Document Type: Article

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