Associations of oxidative stress and inflammatory biomarkers with chemically-characterized air pollutant exposures in an elderly cohort

Environmental Research

Volumn 150, Issue , 2016, Pages 306-319

  Zhang, Xian ^a   Staimer, Norbert ^a   Gillen, Daniel L ^b   Tjoa, Tomas ^a   Schauer, James J ^c   Shafer, Martin M ^c   Hasheminassab, Sina ^d   Pakbin, Payam ^d   Vaziri, Nosratola D ^a   Sioutas, Constantinos ^d   Delfino, Ralph J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b 5226 Donald Bren Hall   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d University of Southern California   (United States)

Author keywords

Air pollution; Biomarkers; Inflammation; Oxidative stress; Particulate matter components

Indexed keywords

BIOLOGICAL MARKER; CHROMIUM; COPPER; DITHIOTHREITOL; FOSSIL FUEL; INTERLEUKIN 6; IRON; MALONALDEHYDE; MANGANESE; NICKEL; NITRIC OXIDE; NITROGEN OXIDE; ORGANIC CARBON; OXIDIZED LOW DENSITY LIPOPROTEIN; POLYCYCLIC AROMATIC HYDROCARBON; REACTIVE OXYGEN METABOLITE; TRANSITION ELEMENT; VANADIUM; AIR POLLUTANT; PARTICULATE MATTER;

AGING POPULATION; ATMOSPHERIC POLLUTION; BIOMARKER; CARDIOVASCULAR DISEASE; CHEMICAL COMPOSITION; COHORT ANALYSIS; IMMUNE RESPONSE; MORBIDITY; NITROGEN OXIDES; OXIDATION; PARTICLE SIZE; PARTICULATE MATTER; POLLUTION EXPOSURE; TRAFFIC EMISSION;

AGED; AIR POLLUTANT; AIR POLLUTION; ARTICLE; CARDIOVASCULAR DISEASE; COMBUSTION; FEMALE; FOLLOW UP; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; METEOROLOGY; OXIDATIVE STRESS; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; BLOOD; CALIFORNIA; CHEMICALLY INDUCED; COHORT ANALYSIS; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; INFLAMMATION; METABOLISM; TOXICITY; VERY ELDERLY;

CALIFORNIA; LOS ANGELES [CALIFORNIA]; UNITED STATES;

AGED; AGED, 80 AND OVER; AIR POLLUTANTS; BIOMARKERS; COHORT STUDIES; ENVIRONMENTAL EXPOSURE; FEMALE; FOSSIL FUELS; HUMANS; INFLAMMATION; LOS ANGELES; MALE; OXIDATIVE STRESS; PARTICLE SIZE; PARTICULATE MATTER;

EID: 84976354220     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2016.06.019     Document Type: Article

References (68)

1. Anderson, G.B., Bell, M.L., Peng, R.D., Methods to calculate the heat index as an exposure metric in environmental health research. Environ. Health Perspect. 121:10 (2013), 1111–1119, 10.1289/ehp.1206273.
2. ATS/ERS, ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am. J. Respir. Crit. Care Med. 171:8 (2005), 912–930 DOI: 171/8/912 [pii] 10.1164/rccm.200406-710ST.
3. Ayres, J.G., Borm, P., Cassee, F.R., Castranova, V., Donaldson, K., Ghio, A., Harrison, R.M., Hider, R., Kelly, F., Kooter, I.M., Marano, F., Maynard, R.L., Mudway, I., Nel, A., Sioutas, C., Smith, S., Baeza-Squiban, A., Cho, A., Duggan, S., Froines, J., Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential - A workshop report and consensus statement. Inhal. Toxicol. 20:1 (2008), 75–99, 10.1080/08958370701665517.
4. Behndig, A.F., Mudway, I.S., Brown, J.L., Stenfors, N., Helleday, R., Duggan, S.T., Wilson, S.J., Boman, C., Cassee, F.R., Frew, A.J., Kelly, F.J., Sandstrom, T., Blomberg, A., Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans. Eur. Respir. J. 27:2 (2006), 359–365 DOI: 27/2/359 [pii] 10.1183/09031936.06.00136904.
5. Bender, R., Lange, S., Adjusting for multiple testing - when and how?. J. Clin. Epidemiol. 54:4 (2001), 343–349, 10.1016/S0895-4356(00)00314-0.
6. Borm, P.J.A., Kelly, F., Kunzli, N., Schins, R.P.F., Donaldson, K., Oxidant generation by particulate matter: from biologically effective dose to a promising, novel metric. Occup. Environ. Med. 64:2 (2007), 73–74, 10.1136/oem.2006.029090.
7. Bosson, J., Barath, S., Pourazar, J., Behindig, A.F., Sandstrom, T., Blomberg, A., Adelroth, E., Diesel exhaust exposure enhances the ozone-induced airway inflammation in healthy humans. Eur. Respir. J. 31:6 (2008), 1234–1240, 10.1183/09031936.00078407.
8. Brindicci, C., Ito, K., Resta, O., Pride, N.B., Barnes, P.J., Kharitonov, S.A., Exhaled nitric oxide from lung periphery is increased in COPD. Eur. Respir. J. 26:1 (2005), 52–59, 10.1183/09031936.05.00125304.
9. Brook, R.D., Rajagopalan, S., Pope, C.A. 3rd, Brook, J.R., Bhatnagar, A., Diez-Roux, A.V., Holguin, F., Hong, Y., Luepker, R.V., Mittleman, M.A., Peters, A., Siscovick, D., Smith, S.C. Jr., Whitsel, L., Kaufman, J.D., American Heart Association Council on Epidemiology and Prevention, Council on Kidney in Cardiovascular Disease, Council on Nutrition, Physical Activity and Metabolism, Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 121:21 (2010), 2331–2378, 10.1161/CIR.0b013e3181dbece1.
10. Chen, R., Zhao, Z., Sun, Q., Lin, Z., Zhao, A., Wang, C., Xia, Y., Xu, X., Kan, H., Size-fractionated particulate air pollution and circulating biomarkers of inflammation, coagulation, and vasoconstriction in a panel of young adults. Epidemiology 26:3 (2015), 328–336, 10.1097/EDE.0000000000000273.
11. Cho, A.K., Sioutas, C., Miguel, A.H., Kumagai, Y., Schmitz, D.A., Singh, M., Eiguren-Fernandez, A., Froines, J.R., Redox activity of airborne particulate matter at different sites in the Los Angeles Basin. Environ. Res. 99:1 (2005), 40–47, 10.1016/j.envres.2005.01.003.
12. Cook, R.D., Detection of influential observation in linear-regression. Technometrics 19:1 (1977), 15–18, 10.2307/1268249.
13. Cook, R.D., Weisberg, S., Residuals and Influence in Regression, 1982, Chapman & Hall, New York, NY.
14. Daher, N., Hasheminassab, S., Shafer, M.M., Schauer, J.J., Sioutas, C., Seasonal and spatial variability in chemical composition and mass closure of ambient ultrafine particles in the megacity of Los Angeles. Environ. Sci.-Proc. Imp. 15:1 (2013), 283–295, 10.1039/c2em30615h.
15. Delfino, R.J., Sioutas, C., Malik, S., Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. Environ. Health Perspect. 113:8 (2005), 934–946, 10.1289/ehp.7938.
16. Delfino, R.J., Staimer, N., Gillen, D., Tjoa, T., Sioutas, C., Fung, K., George, S.C., Kleinman, M.T., Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma. Environ. Health Perspect. 114:11 (2006), 1736–1743.
17. Delfino, R.J., Staimer, N., Tjoa, T., Polidori, A., Arhami, M., Gillen, D.L., Kleinman, M.T., Vaziri, N.D., Longhurst, J., Zaldivar, F., Sioutas, C., Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery disease. Environ. Health Perspect. 116:7 (2008), 898–906, 10.1289/ehp.11189.
18. Delfino, R.J., Staimer, N., Tjoa, T., Gillen, D.L., Polidori, A., Arhami, M., Kleinman, M.T., Vaziri, N.D., Longhurst, J., Sioutas, C., Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms. Environ. Health Perspect. 117:8 (2009), 1232–1238, 10.1289/ehp.0800194.
19. Delfino, R.J., Staimer, N., Tjoa, T., Arhami, M., Polidori, A., Gillen, D.L., George, S.C., Shafer, M.M., Schauer, J.J., Sioutas, C., Associations of primary and secondary organic aerosols with airway and systemic inflammation in an elderly panel cohort. Epidemiology 21:6 (2010), 892–902, 10.1097/EDE.0b013e3181f20e6c.
20. Delfino, R.J., Staimer, N., Tjoa, T., Arhami, M., Polidori, A., Gillen, D.L., Kleinman, M.T., Schauer, J.J., Sioutas, C., Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles. Environ. Health Perspect. 118:6 (2010), 756–762, 10.1289/ehp.0901407.
21. Delfino, R.J., Tjoa, T., Gillen, D.L., Staimer, N., Polidori, A., Arhami, M., Jamner, L., Sioutas, C., Longhurst, J., Traffic-related air pollution and blood pressure in elderly subjects with coronary artery disease. Epidemiology 21:3 (2010), 396–404, 10.1097/EDE.0b013e3181d5e19b.
22. Delfino, R.J., Staimer, N., Tjoa, T., Gillen, D.L., Schauer, J.J., Shafer, M.M., Airway inflammation and oxidative potential of air pollutant particles in a pediatric asthma panel. J. Expo. Sci. Environ. Epidemiol. 23:5 (2013), 466–473, 10.1038/jes.2013.25.
23. Dierckx, N., Horvath, G., van Gils, C., Vertommen, J., van de Vliet, J., De Leeuw, I., Manuel-y-Keenoy, B., Oxidative stress status in patients with diabetes mellitus: relationship to diet. Eur. J. Clin. Nutr. 57:8 (2003), 999–1008, 10.1038/sj.ejcn.1601635.
24. Elder, A., Oberdorster, G., Translocation and effects of ultrafine particles outside of the lung. Clin. Occup. Environ. Med. 5:4 (2006), 785–796 DOI: S1526-0046(06)00044-6 [pii] 10.1016/j.coem.2006.07.003.
25. Fang, S.C., Mehta, A.J., Alexeeff, S.E., Gryparis, A., Coull, B., Vokonas, P., Christiani, D.C., Schwartz, J., Residential black carbon exposure and circulating markers of systemic inflammation in elderly males: the normative aging study. Environ. Health Perspect. 120:5 (2012), 674–680, 10.1289/ehp.1103982.
26. Fox, J., Long, J.S., 1990. Modern Methods of Data-Analysis. pp. 257–291.
27. Franck, U., Odeh, S., Wiedensohler, A., Wehner, B., Herbarth, O., The effect of particle size on cardiovascular disorders - The smaller the worse. Sci. Total Environ. 409:20 (2011), 4217–4221, 10.1016/j.scitotenv.2011.05.049.
28. Franklin, B.A., Brook, R., Pope, C. Arden 3rd, Air pollution and cardiovascular disease. Curr. Probl. Cardiol. 40:5 (2015), 207–238, 10.1016/j.cpcardiol.2015.01.003.
29. Ghio, A.J., Carraway, M.S., Madden, M.C., Composition of air pollution particles and oxidative stress cells, tissues, living system. J. Toxicol. Environ. Heal B 15:1 (2012), 1–21, 10.1080/10937404.2012.632359.
30. Goff, D.C., Lloyd-Jones, D.M., Bennett, G., Coady, S., D'Agostino, R.B., Gibbons, R., Greenland, P., Lackland, D.T., Levy, D., O'Donnell, C.J., Robinson, J.G., Schwartz, J.S., Shero, S.T., Smith, S.C., Sorlie, P., Stone, N.J., Wilson, P.W.F., 2013 ACC/AHA guideline on the assessment of cardiovascular risk a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. J. Am. Coll. Cardiol. 63:25 (2014), 2935–2959, 10.1016/j.jacc.2013.11.005.
31. Gong, J.C., Zhu, T., Kipen, H., Wang, G.F., Hu, M., Ohman-Strickland, P., Lu, S.E., Zhang, L., Wang, Y.D., Zhu, P., Rich, D.Q., Diehl, S.R., Huang, W., Zhang, J.F., Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress. J. Expo. Sci. Environ. Epidemiol. 23:3 (2013), 322–327, 10.1038/jes.2012.127.
32. Hasheminassab, S., Daher, N., Ostro, B.D., Sioutas, C., Long-term source apportionment of ambient fine particulate matter (PM2.5) in the Los Angeles Basin: a focus on emissions reduction from vehicular sources. Environ. Pollut. 193 (2014), 54–64, 10.1016/j.envpol.2014.06.012.
33. Hasheminassab, S., Daher, N., Shafer, M.M., Schauer, J.J., Delfino, R.J., Sioutas, C., Chemical characterization and source apportionment of indoor and outdoor fine particulatematter (PM2.5) in retirement communities of the Los Angeles Basin. Sci. Total Environ. 490 (2014), 528–537, 10.1016/j.scitotenv.2014.05.044.
34. Holvoet, P., Harris, T.B., Tracy, R.P., Verhamme, P., Newman, A.B., Rubin, S.M., Simonsick, E.M., Colbert, L.H., Kritchevsky, S.B., Association of high coronary heart disease risk status with circulating oxidized LDL in the well-functioning elderly: findings from the health, aging, and body composition study. Arter. Thromb. Vasc. Biol. 23:8 (2003), 1444–1448 DOI: 10.1161/01.ATV.0000080379.05071.22 01.ATV.0000080379.05071.22 (pii).
35. Huang, W., Wang, G., Lu, S.E., Kipen, H., Wang, Y., Hu, M., Lin, W., Rich, D., Ohman-Strickland, P., Diehl, S.R., Zhu, P., Tong, J., Gong, J., Zhu, T., Zhang, J., Inflammatory and oxidative stress responses of healthy young adults to changes in air quality during the Beijing Olympics. Am. J. Crit. Care 186:11 (2012), 1150–1159, 10.1164/rccm.201205-0850OC.
36. Landreman, A.P., Shafer, M.M., Hemming, J.C., Hannigan, M.P., Schauer, J.J., A macrophage-based method for the assessment of the reactive oxygen species (ROS) activity of atmospheric particulate matter (PM) and application to routine (daily-24 h) aerosol monitoring studies. Aerosol Sci. Technol. 42:11 (2008), 946–957, 10.1080/02786820802363819.
37. Lanzinger, S., Schneider, A., Breitner, S., Stafoggia, M., Erzen, I., Dostal, M., Pastorkova, A., Bastian, S., Cyrys, J., Zscheppang, A., Kolodnitska, T., Peters, A., Grp, U.S., Associations between ultrafine and fine particles and mortality in five central European cities - results from the UFIREG study. Environ. Int. 88 (2016), 44–52, 10.1016/j.envint.2015.12.006.
38. Larstad, M., Ljungkvist, G., Olin, A.C., Toren, K., Determination of malondialdehyde in breath condensate by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. B 766:1 (2002), 107–114, 10.1016/S0378-4347(01)00437-6.
39. Laumbach, R.J., Kipen, H.M., Acute effects of motor vehicle traffic-related air pollution exposures on measures of oxidative stress in human airways. Ann. NY Acad. Sci. 1203 (2010), 107–112, 10.1111/j.1749–6632.2010.05604.x.
40. Lee, J.S., Shin, J.H., Hwang, J.H., Baek, J.E., Choi, B.S., Malondialdehyde and 3-nitrotyrosine in exhaled breath condensate in retired elderly coal miners with chronic obstructive pulmonary disease. Saf. Health Work. 5:2 (2014), 91–96, 10.1016/j.shaw.2014.03.001 S2093-7911(14)00019-5 (pii).
41. Li, N., Kim, S., Wang, M., Froines, J., Sioutas, C., Nel, A., Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhal. Toxicol. 14:5 (2002), 459–486, 10.1080/089583701753678571.
42. Li, N., Sioutas, C., Cho, A., Schmitz, D., Misra, C., Sempf, J., Wang, M.Y., Oberley, T., Froines, J., Nel, A., Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ. Health Perspect. 111:4 (2003), 455–460, 10.1289/ehp.6000.
43. Li, W.G., Kong, A.N., Molecular mechanisms of Nrf2-mediated antioxidant response. Mol. Carcinog. 48:2 (2009), 91–104, 10.1002/mc.20465.
44. Lippmann, M., 1977. Regional deposition of particles in the human respiratory trend. In: Lee, D.H.K., Falk, H.L., et al., Handbook of physiology, reaction to environmental agents. American Physiological Society, Bethesda, MD.
45. Ljungman, P.L., Wilker, E.H., Rice, M.B., Schwartz, J., Gold, D.R., Koutrakis, P., Vita, J.A., Mitchell, G.F., Vasan, R.S., Benjamin, E.J., Mittleman, M.A., Hamburg, N.M., Short-term exposure to air pollution and digital vascular function. Am. J. Epidemiol. 180:5 (2014), 482–489, 10.1093/aje/kwu161.
46. Mar, T.F., Jansen, K., Shepherd, K., Lumley, T., Larson, T.V., Koenig, J.Q., Exhaled nitric oxide in children with asthma and short-term PM2.5 exposure in Seattle. Environ. Health Perspect. 113:12 (2005), 1791–1794.
47. Nordenhall, C., Pourazar, J., Blomberg, A., Levin, J.O., Sandstrom, T., Adelroth, E., Airway inflammation following exposure to diesel exhaust: a study of time kinetics using induced sputum. Eur. Respir. J. 15:6 (2000), 1046–1051.
48. Ogawa & Company, U., Inc. 2006. NO, NO2, NOx and SO2 Sampling Protocol Using the Ogawa Sampler.
49. Pant, P., Harrison, R.M., Estimation of the contribution of road traffic emissions to particulate matter concentrations from field measurements: a review. Atmos. Environ. 77 (2013), 78–97, 10.1016/j.atmosenv.2013.04.028.
50. Polidori, A., Arhami, M., Sioutas, C., Delfino, R.J., Allen, R., Indoor/outdoor relationships, trends, and carbonaceous content of fine particulate matter in retirement homes of the Los Angeles basin. J. Air Waste Manag. 57:3 (2007), 366–379.
51. Provost, E.B., Louwies, T., Cox, B., Op't Roodt, J., Solmi, F., Dons, E., Panis, L. Int, Boever, P. De, Nawrot, T.S., Short-term fluctuations in personal black carbon exposure are associated with rapid changes in carotid arterial stiffening. Environ. Int. 88 (2016), 228–234, 10.1016/j.envint.2015.12.023.
52. Rogge, W.F., Mazurek, M.A., Hildemann, L.M., Cass, G.R., Simoneit, B.R.T., Quantification of urban organic aerosols at a molecular-level - identification, abundance and seasonal-variation. Atmos. Environ. A-Gen. Topics 27:8 (1993), 1309–1330, 10.1016/0960–1686(93)90257-Y.
53. Romieu, I., Barraza-Villarreal, A., Escamilla-Nunez, C., Almstrand, A.C., Diaz-Sanchez, D., Sly, P.D., Olin, A.C., Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma. J. Allergy Clin. Immun. 121:4 (2008), 903–909, 10.1016/j.jaci.2007.12.004.
54. Ruckerl, R., Hampel, R., Breitner, S., Cyrys, J., Kraus, U., Carter, J., Dailey, L., Devlin, R.B., Diaz-Sanchez, D., Koenig, W., Phipps, R., Silbajoris, R., Soentgen, J., Soukup, J., Peters, A., Schneider, A., Associations between ambient air pollution and blood markers of inflammation and coagulation/fibrinolysis in susceptible populations. Environ. Int. 70 (2014), 32–49, 10.1016/j.envint.2014.05.013.
55. Rückerl, R., Ibald-Mulli, A., Koenig, W., Schneider, A., Woelke, G., Cyrys, J., Heinrich, J., Marder, V., Frampton, M., Wichmann, H.E., Peters, A., Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am. J. Respir. Crit. Care Med. 173:4 (2006), 432–441 DOI: 200507-1123OC [pii] 10.1164/rccm.200507-1123OC.
56. Rückerl, R., Greven, S., Ljungman, P., Aalto, P., Antoniades, C., Bellander, T., Berglind, N., Chrysohoou, C., Forastiere, F., Jacquemin, B., von Klot, S., Koenig, W., Kuchenhoff, H., Lanki, T., Pekkanen, J., Perucci, C.A., Schneider, A., Sunyer, J., Peters, A., Air pollution and inflammation (interleukin-6,C-reactive protein, fibrinogen) in myocardial infarction survivors. Environ. Health Perspect. 115:7 (2007), 1072–1080, 10.1289/ehp.10021.
57. Saffari, A., Hasheminassab, S., Wang, D.B., Shafer, M.M., Schauer, J.J., Sioutas, C., Impact of primary and secondary organic sources on the oxidative potential of quasi-ultrafine particles (PM0.25) at three contrasting locations in the Los Angeles Basin. Atmos. Environ. 120 (2015), 286–296, 10.1016/j.atmosenv.2015.09.022.
58. Sarnat, J.A., Golan, R., Greenwald, R., Raysoni, A.U., Kewada, P., Winquist, A., Sarnat, S.E., Flanders, W.D., Mirabelli, M.C., Zora, J.E., Bergin, M.H., Yip, F., Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters. Environ. Res. 133 (2014), 66–76, 10.1016/j.envres.2014.05.004.
59. Schauer, J.J., Mader, B.T., Deminter, J.T., Heidemann, G., Bae, M.S., Seinfeld, J.H., Flagan, R.C., Cary, R.A., Smith, D., Huebert, B.J., Bertram, T., Howell, S., Kline, J.T., Quinn, P., Bates, T., Turpin, B., Lim, H.J., Yu, J.Z., Yang, H., Keywood, M.D., ACE-Asia intercomparison of a thermal-optical method for the determination of particle-phase organic and elemental carbon. Environ. Sci. Technol. 37:5 (2003), 993–1001, 10.1021/es020622f.
60. Shirmohammadi, F., Hasheminassab, S., Saffari, A., Schauer, J.J., Delfino, R.J., Sioutas, C., Fine and ultrafine particulate organic carbon in the Los Angeles basin: trends in sources and composition. Sci. Total Environ. 541 (2016), 1083–1096, 10.1016/j.scitotenv.2015.09.133.
61. Sioutas, C., Delfino, R.J., Singh, M., Exposure assessment for atmospheric ultrafine particles (UFPs) and implications in epidemiologic research. Environ. Health Perspect. 113:8 (2005), 947–955.
62. Stone, E.A., Snyder, D.C., Sheesley, R.J., Sullivan, A.P., Weber, R.J., Schauer, J.J., Source apportionment of fine organic aerosol in Mexico City during the MILAGRO experiment 2006. Atmos. Chem. Phys. 8:5 (2008), 1249–1259.
63. Valavanidis, A., Loridas, S., Vlahogianni, T., Fiotakis, K., Influence of ozone on traffic-related particulate matter on the generation of hydroxyl radicals through a heterogeneous synergistic effect. J. Hazard Mater. 162:2–3 (2009), 886–892, 10.1016/j.jhazmat.2008.05.124.
64. Wallenborn, J.G., McGee, J.K., Schladweiler, M.C., Ledbetter, A.D., Kodavanti, U.P., Systemic translocation of particulate matter-associated metals following a single intratracheal instillation in rats. Toxicol. Sci. 98:1 (2007), 231–239, 10.1093/toxsci/kfm088.
65. Weichenthal, S., Selected physiological effects of ultrafine particles in acute cardiovascular morbidity. Environ. Res. 115 (2012), 26–36, 10.1016/j.envres.2012.03.001.
66. Wittkopp, S., Staimer, N., Tjoa, T., Stinchcombe, T., Daher, N., Schauer, J.J., Shafer, M.M., Sioutas, C., Gillen, D.L., Delfino, R.J., Nrf2-related gene expression and exposure to traffic-related air pollution in elderly subjects with cardiovascular disease: an exploratory panel study. J. Expo. Sci. Environ. Epidemiol., 2015, 10.1038/jes.2014.84.
67. Wu, S., Yang, D., Wei, H., Wang, B., Huang, J., Li, H., Shima, M., Deng, F., Guo, X., Association of chemical constituents and pollution sources of ambient fine particulate air pollution and biomarkers of oxidative stress associated with atherosclerosis: a panel study among young adults in Beijing, China. Chemosphere 135 (2015), 347–353 DOI: 10.1016/j.chemosphere.2015.04.096 S0045-6535(15)00454-3 (pii).
68. Yamawaki, H., Iwai, N., Mechanisms underlying nano-sized air-pollution-mediated progression of atherosclerosis: carbon black causes cytotoxic injury/inflammation and inhibits cell growth in vascular endothelial cells. Circ. J. 70:1 (2006), 129–140.