Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma

Environmental Health Perspectives

Volumn 114, Issue 11, 2006, Pages 1736-1743

  Delfino, Ralph J ^a   Staimer, Norbert ^a   Gillen, Dan ^b   Tjoa, Thomas ^a   Sioutas, Constantinos ^c   Fung, Kochy ^d   George, Steven C ^e   Kleinman, Michael T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Ringgold Standard Institution Informatics   (United States)

^c AtmAA Inc ^*  (United States)

^d AtmAA Inc   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Asthma; Epidemiology; Exhaled nitric oxide; Longitudinal data analysis; Nitrogen dioxide; Ozone; Panel study; Particulate air pollution

Indexed keywords

ANTIINFLAMMATORY AGENT; BIOLOGICAL MARKER; CORTICOSTEROID; LEUKOTRIENE RECEPTOR BLOCKING AGENT; NITRIC OXIDE; NITROGEN DIOXIDE; ORGANIC CARBON; OZONE;

ADOLESCENT; AIR POLLUTANT; AIR POLLUTION; AIRBORNE PARTICLE; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONFIDENCE INTERVAL; DATA ANALYSIS; ENVIRONMENTAL TEMPERATURE; EXHAUST GAS; EXPIRED AIR; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; PANEL STUDY; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; UNITED STATES;

ADOLESCENT; ADRENAL CORTEX HORMONES; AIR POLLUTANTS; AIR POLLUTION; ANTI-INFLAMMATORY AGENTS; ASTHMA; CALIFORNIA; CARBON; CHILD; EXHALATION; FEMALE; HUMANS; LEUKOTRIENE ANTAGONISTS; MALE; NITRIC OXIDE; NITROGEN DIOXIDE; PARTICULATE MATTER;

EID: 33750845844     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.9141     Document Type: Article

References (49)

1. Adamkiewicz G, Ebelt S, Syring M, Slater J, Speizer FE, Schwartz J, et al. 2004. Association between air pollution exposure and exhaled nitric oxide in an elderly population. Thorax 59:204-209.
2. American Thoracic Society (ATS) and European Respiratory Society (ERS). 2005. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 171:912-930.
3. Buchvald F, Baraldi E, Carraro S, Gaston B, De Jongste J, Pijnenburg MW, et al. 2005. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol 115:1130-1136.
4. 2.5 mass monitor (Thermo Anderson pDR-1200) designed for continuous personal exposure measurements. Atmos Environ 38:3329-3340.
5. Delfino RJ. 2002. Epidemiological evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research. Environ Health Perspect 110(suppl 4):573-589.
6. Delfino RJ, Gong H Jr, Linn WS, Hu Y, Pellizzari ED. 2003. Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants. Environ Health Perspect 111:647-656.
7. 1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter. Environ Health Perspect 112:932-941.
8. Delfino RJ, Zeiger RS, Seltzer JM, Street DH. 1998. Symptoms in pediatric asthmatics and air pollution: differences in effects by symptom severity, anti-inflammatory medication use, and particulate averaging time. Environ Health Perspect 106:751-761.
9. Delfino RJ, Zeiger RS, Seltzer JM, Street DH, McLaren C. 2002. Association of asthma symptoms with peak particulate air pollution and effect modification by anti-inflammatory medication use. Environ Health Perspect 110:A607-A617.
10. Diggle P, Heagerty P, Liang KY, Zeger S. 2002. Analysis of Longitudinal Data. 2nd ed. New York:Oxford University Press.
11. Ebelt ST, Wilson WE, Brauer M. 2005. Exposure to ambient and nonambient components of particulate matter: a comparison of health effects. Epidemiology 16:396-405.
12. Fabbri LM, Caramori G, Beghé, Papi A. 1998. Physiologic consequences of long-term inflammation. Am J Repir Crit Care Med 157:S195-S198.
13. Fine PM, Chakrabarti B, Krudysz M, Schauer JJ, Sioutas C. 2004. Diurnal variations of individual organic compound constituents of ultrafine and accumulation mode particulate matter in the Los Angeles basin. Environ Sci Technol 38:1296-1304.
14. Fischer PH, Steerenberg PA, Snelder JD, van Loveren H, van Amsterdam JG. 2002. Association between exhaled nitric oxide, ambient air pollution and respiratory health in school children. Int Arch Occup Environ Health 75:348-353.
15. Fung K, Chow JC, Watson JG. 2002. Evaluation of OC/EC speciation by thermal manganese dioxide oxidation and the IMPROVE Method. J Air Waste Manage Assoc 52:1333-1341.
16. Gent JF, Triche EW, Holford TR, Belanger K, Bracken MB, Beckett WS, et al. 2003. Association of low-level ozone and fine particles with respiratory symptoms in children with asthma. JAMA 290:1859-1867.
17. Gong H Jr, Linn WS, Terrell SL, Anderson KR, Clark KW. 2001. Anti-inflammatory and lung function effects of montelukast (Singular) in asthmatic volunteers exposed to sulfur dioxide. Chest 19:402-408.
18. Hamid Q, Tulić MK, Liu MC, Moqbel R. 2003. Inflammatory cells in asthma: mechanisms and implications for therapy. J Allergy Clin Immunol 111(suppl 1):S5-S12.
19. Hankinson JL, Odencrantz JR, Fedan KB. 1999. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 159:179-187.
20. Jansen KL, Larson TV, Koenig JQ, Mar TF, Fields C, Stewart J, et al. 2005. Associations between health effects and particulate matter and black carbon in subjects with respiratory disease. Environ Health Perspect 113:1741-1746.
21. Jöbsis Q, Raatgeep HC, Hop WC, de Jongste JC. 2001. Controlled low flow off line sampling of exhaled nitric oxide in children. Thorax 56:285-289.
22. Jones SL, Kittelson J, Cowan JO, Flannery EM, Hancox RJ, McLachlan CR, et al. 2001. The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Am J Respir Crit Care Med 164:738-743.
23. Kim JJ, Smorodinsky S, Lipsett M, Singer BC, Hodgson AT, Ostro B. 2004. Traffic-related air pollution near busy roads: the East Bay Children's Respiratory Health Study. Am J Respir Crit Care Med 170:520-526.
24. Koenig JQ, Jansen K, Mar TF, Lumley T, Kaufman J, Trenga CA, et al. 2003. Measurement of offline exhaled nitric oxide in a study of community exposure to air pollution. Environ Health Perspect 111:1625-1629.
25. Koenig JQ, Mar TF, Allen RW, Jansen K, Lumley T, Sullivan JH, et al. 2005. Pulmonary effects of indoor- and outdoor-generated particles in children with asthma. Environ Health Perspect 113:499-503.
26. Kroesbergen A, Jobsis Q, Bel EH, Hop WC, de Jongste JC. 1999. Flow-dependency of exhaled nitric oxide in children with asthma and cystic fibrosis. Eur Respir J 14:871-875.
27. Lewis TC, Robins TG, Dvonch JT, Keeler GJ, Yip FY, Mentz GB, et al. 2005. Air pollution-associated changes in lung function among asthmatic children in Detroit. Environ Health Perspect 113:1068-1075.
28. Li N, Hao M, Phalen RF, Hinds WC, Nel AE. 2003. Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. Clin Immunol 109:250-265.
29. Linn WS, Avila M, Gong H Jr. 2004. Exhaled nitric oxide: sources of error in offline measurement. Arch Environ Health 59:385-391.
30. Lipworth BJ. 1999. Leukotriene-receptor antagonists. Lancet 353:57-62.
31. 2.5 exposure in Seattle. Environ Health Perspect 113:1791-1794.
32. Mortimer KM, Tager IB, Dockery DW, Neas LM, Redline S. 2000. The effect of ozone on inner-city children with asthma: identification of susceptible subgroups. Am J Respir Crit Care Med 162:1838-1845.
33. National Institute for Occupational Safety and Health. 1994. Nitric oxide and nitrogen dioxide: Method 6014. In: NIOSH Manual of Analytical Methods (NMAM), 4th ed (Eller PM, Cassinelli ME, eds) Cincinnati, OH:National Institute for Occupational Safety and Health, DHHS Publication No. 94-113.
34. Persinger RL, Poynter ME, Ckless K, Janssen-Heininger YM. 2002. Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung. Mol Cell Biochem 234-235:71-80.
35. Rabinovitch N, Liu AH, Zhang L, Rodes CE, Foarde K, Dutton SJ, et al. 2005. Importance of the personal endotoxin cloud in school-age children with asthma. J Allergy Clin Immunol 116:1053-1057.
36. Rabinovitch N, Matthew Strand M, Gelfand EW. 2006. Particulate levels are associated with early asthma worsening in children with persistent disease. Am J Resp Crit Care Med 173:1098-1105.
37. Roorda-Knape MC, Janssen NA, de Hartog J, Van Vliet PH, Harssema H, Brunekreef B. 1999. Traffic related air pollution in city districts near motorways. Sci Total Environ 235:339-341.
38. Rundell KW, Spiering BA, Baumann JM, Evans TM. 2005. Bronchoconstriction provoked by exercise in a high-particulate-matter environment is attenuated by montelukast. Inhal Toxicol 17:99-105.
39. Schauer JJ, Kleeman MJ, Cass GR, Simoneit BRT. 2002. Measurement of emissions from air pollution sources. 5. C1-C32 organic compounds from gasoline-powered motor vehicles. Environ Sci Technol 36:1169-1180.
40. Schwartz J. 2000. The distributed lag between air pollution and daily death. Epidemiology 11:320-326.
41. Sheppard L, Slaughter JC, Schildcrout J, Liu LJ, Lumley T. 2005. Exposure and measurement contributions to estimates of acute air pollution effects. J Expo Anal Environ Epidemiol 15:366-376.
42. Sioutas C, Delfino RJ, Singh M. 2005. Exposure assessment for atmospheric ultrafine particles (UFP) and implications in epidemiological research. Environ Health Perspect 113:947-955.
43. 2. Anal Bioanal Chem 383:955-962.
44. Steerenberg PA, Bischoff EW, de Klerk A, Verlaan AP, Jongbloets LM, van Loveren H, et al. 2003. Acute effect of air pollution on respiratory complaints, exhaled NO and biomarkers in nasal lavages of allergic children during the pollen season. Int Arch Allergy Immunol 131:127-137.
45. Steerenberg PA, Nierkens S, Fischer PH, van Loveren H, Opperhuizen A, Vos JG, et al. 2001. Traffic-related air pollution affects peak expiratory flow, exhaled nitric oxide, and inflammatory nasal markers. Arch Environ Health 56:167-174.
46. Van Amsterdam JG, Verlaan BP, Van Loveren H, Elzakker BG, Vos SG, Opperhuizen A, et al. 1999. Air pollution is associated with increased level of exhaled nitric oxide in nonsmoking healthy subjects. Arch Environ Health 54:331-335.
47. Verbeke G, Molenberghs G. 2001. Linear Mixed Models for Longitudinal Data. New York:Springer.
48. Zeidler MR, Kleerup EC, Tashkin DP. 2004. Exhaled nitric oxide in the assessment of asthma. Curr Opin Pulm Med 10:31-36.
49. Zeiger RS, Szefler SJ, Phillips BR, Schatz M, Martinez FD, Chinchilli VM, et al. 2006. Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma. J Allergy Clin Immunol 117:45-52.