The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

Nature Medicine

Volumn 22, Issue 8, 2016, Pages 869-878

  Wang, Wenzhang ^a   Wang, Luwen ^a   Lu, Junjie ^b   Siedlak, Sandra L ^a   Fujioka, Hisashi ^c   Liang, Jingjing ^a   Jiang, Sirui ^a   Ma, Xiaopin ^a   Jiang, Zhen ^a   Da Rocha, Edroaldo Lummertz ^a   Sheng, Max ^a   Choi, Heewon ^a   Lerou, Paul H ^e   Li, Hu ^d   Wang, Xinglong ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d MAYO CLINIC   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TAR DNA BINDING PROTEIN; DNA BINDING PROTEIN; MT-ND3 PROTEIN, HUMAN; MT-ND6 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TDP-43 PROTEIN, HUMAN; TDP-43 PROTEIN, MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; CELL LOSS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; FRONTOTEMPORAL DEMENTIA; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MITOCHONDRION; MOUSE; MUTANT; MUTATION; NERVE CELL; NEURONAL TOXICITY; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; WILD TYPE; ADULT; AGED; ANIMAL; GENETICS; METABOLISM; MIDDLE AGED; TRANSGENIC MOUSE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DNA-BINDING PROTEINS; ELECTRON TRANSPORT COMPLEX I; FEMALE; FRONTOTEMPORAL DEMENTIA; HUMANS; MALE; MICE; MICE, TRANSGENIC; MIDDLE AGED; MITOCHONDRIA; MUTATION; NADH DEHYDROGENASE; NEURONS; PHENOTYPE; RNA, MESSENGER;

EID: 84976333438     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4130     Document Type: Article

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