Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Volumn 14, Issue 4, 2013, Pages 252-260

  Narayanan, Ramesh K ^a   Mangelsdorf, Marie ^a   Panwar, Ajay ^a   Butler, Tim J ^a   Noakes, Peter G ^a   Wallace, Robyn H ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Amyotrophic lateral sclerosis; RNA processing; TDP 43

Indexed keywords

PROTEIN ANTIBODY; RNA; TAR DNA BINDING PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICROARRAY ANALYSIS; MOUSE; NERVE ENDING; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA ISOLATION; RNA PROCESSING;

ANIMALS; BRAIN; DNA-BINDING PROTEINS; MICE; MICE, INBRED C57BL; PRESYNAPTIC TERMINALS; PROTEIN BINDING; RIBONUCLEOPROTEINS; RNA;

EID: 84877854066     PISSN: 21678421     EISSN: 21679223     Source Type: Journal    
DOI: 10.3109/21678421.2012.734520     Document Type: Article

References (43)

1. Arai T, Hasegawa 1. M, A kiyama H, I keda K, N onaka T, Mori H.et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun. 2006; 351 : 602-11 (Pubitemid 44708852)
2. Neumann M, S ampathu DM, K wong LK, T ruax AC, Micsenyi MC, Chou T.T.et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006; 314 : 130-3 (Pubitemid 44547757)
3. O u SH, W u F, H arrich D, G arcia-Martinez LF, G aynor RB. Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodefi ciency virus type 1 TAR DNA sequence motifs. J Virol. 1995; 69 : 3584-96
4. Sreedharan J, B lair IP, T ripathi VB, H u X, V ance C, Rogelj B.et al. TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science. 2008; 319 : 1668-72 (Pubitemid 351432505)
5. Kabashi E, V aldmanis PN, D ion P, S piegelman D, McConkey BJ, Vande Velde C.et al. TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Nat Genet. 2008; 40 : 572-4 (Pubitemid 351601218)
6. Mackenzie I R, R ademakers R, N eumann M. T DP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol. 2010; 9 : 995-1007
7. Ayala Y M, Z ago P, D 'Ambrogio A, X u Y F, P etrucelli L, Buratti E.et al. Structural determinants of the cellular localization and shuttling of TDP-43. J Cell Sci. 2008; 121 : 3778-85
8. Elvira G, W asiak S, B landford V, T ong XK, S errano A, Fan X.et al. Characterization of an RNA granule from developing brain. Mol Cell Proteomics. 2006; 5 : 635-51
9. Buratti E, B aralle FE. T he multiple roles of TDP-43 in premRNA processing and gene expression regulation. RNA Biology. 2010; 7 : 420-9
10. Garcia-Blanco M A, B araniak AP, L asda EL. Alternative splicing in disease and therapy. Nat Biotechnol. 2004; 22 : 535-46 (Pubitemid 38585905)
11. Chang Y, K ong Q, S han X, T ian G, I lieva H, C leveland D.W.et al. Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. PLoS One. 2008; 3 :E2849
12. Kwiatkowski TJ Jr, B osco D A, L eclerc AL, T amrazian E, Vanderburg CR, Russ C.et al. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science. 2009; 323 : 1205-8
13. Zhao Z H, C hen W Z, W u Z Y, W ang N, Z hao G X, C hen W.J.et al. A novel mutation in the senataxin gene identifi ed in a Chinese patient with sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2009; 10 : 118-22
14. Chari A, P aknia E, F ischer U. T he role of RNP biogenesis in spinal muscular atrophy. Curr Opin Cell Biol. 2009; 21 : 387-93
15. Greenway MJ, A ndersen PM, R uss C, E nnis S, C ashman S, Donaghy C.et al. ANG mutations segregate with familial and ' sporadic ' amyotrophic lateral sclerosis. Nat Genet. 2006; 38 : 411-3
16. S impson CL, L emmens R, M iskiewicz K, B room WJ, H ansen VK, van Vught P.W.et al. Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Hum Mol Genet. 2009 ; 18 : 472-81
17. Wegorzewska I, B ell S, C airns NJ, M iller TM, B aloh RH. TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A. 2009; 106 : 18809-14
18. Feiguin F, G odena VK, R omano G, D 'Ambrogio A, K lima R, Baralle FE. Depletion of TDP-43 affects Drosophila motor neurons terminal synapsis and locomotive behaviour. FEBS Lett. 2009; 583 : 1586-92
19. Kabashi E, L in L, T radewell M L, D ion P A, B ercier V, Bourgouin P.et al. Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor defi cits in vivo. Hum Mol Genet. 2010; 19 : 671-83
20. Sephton CF, C enik C, K ucukural A, D ammer EB, C enik B, Han Y.et al. Identifi cation of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes. J Biol Chem. 2011; 286 : 1204-15
21. Polymenidou M, L agier-Tourenne C, H utt K R, H uelga S C, Moran J, Liang T.Y.et al. Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci. 2011; 14 : 459-68
22. Tollervey JR, C urk T, R ogelj B, B riese M, C ereda M, Kayikci M.et al. Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nature Neuroscience. 2011; 14 : 452-8
23. Xiao S, S anelli T, D ib S, S heps D, F indlater J, B ilbao J.et al. RNA targets of TDP-43 identifi ed by UV-CLIP are deregulated in ALS. Molecular and Cellular Neurosciences. 2011; 47 : 167-80
24. Colombrita C, O nesto E, M egiorni F, P izzuti A, B aralle FE, Buratti E.et al. TDP-43 and FUS RNA-binding Proteins Bind Distinct Sets of Cytoplasmic Messenger RNAs and Differently Regulate Their Post-transcriptional Fate in Motoneuron-like Cells. The Journal of Biological Chemistry. 2012; 287 : 15635-47
25. Keene J D, K omisarow J M, F riedersdorf M B. R IP-chip:The isolation and identifi cation of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts. Nat Protoc. 2006; 1 : 302-7
26. Bailey TL, E lkan C. F itting a mixture model by expectation maximization to discover motifs in biopolymers. Proc Int Conf Intell Syst Mol Biol. 1994; 2 : 28-36
27. Al-Shahrour F, M inguez P, T ár raga J, M edina I, A lloza E, Montaner D.et al. FatiGO -: A functional profi ling tool for genomic data. Integration of functional annotation, regulatory motifs and interaction data with microarray experiments. Nucleic Acids Research. 2007; 35 : 91-6
28. Moss J, V aughan M. M olecules in the ARF orbit. T he Journal of Biological Chemistry. 1998; 273 : 21431-4 (Pubitemid 28405306)
29. Taylor AM, Berchtold N C, Perreau V M, Tu C H, Li Jeon N, Cotman CW. Axonal mRNA in uninjured and regenerating cortical mammalian axons. The Journal of Neuroscience:The offi cial journal of the Society for Neuroscience. 2009 ; 29 : 4697-707
30. Sasaki S, T akeda T, S hibata N, K obayashi M. A lterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis. Neuroscience Letters. 2010; 478 : 72-6
31. Fallini C, B assell GJ, R ossoll W. T he ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth. Human Molecular Genetics. 2012
32. Ikemoto A, H irano A. C omparative immunohistochemical study on synaptophysin expression in the anterior horn of post-poliomyelitis and sporadic amyotrophic lateral sclerosis. Acta Neuropathol. 1996; 92 : 473-8 (Pubitemid 26356538)
33. Ikemoto A, K awanami T, L lena JF, H irano A. I mmunocytochemical studies on synaptophysin in the anterior horn of lower motor neuron disease. J Neuropathol Exp Neurol. 1994; 53 : 196-201 (Pubitemid 24081892)
34. I kemoto A, N akamura S, A kiguchi I, H irano A. D ifferential expression between synaptic vesicle proteins and presynaptic plasma membrane proteins in the anterior horn of amyotrophic lateral sclerosis. Acta Neuropathol. 2002; 103 : 179-87 (Pubitemid 36067497)
35. Ince PG, S lade J, C hinnery RM, M cKenzie J, R oyston C, Roberts G.W.et al. Quantitative study of synaptophysin immunoreactivity of cerebral cortex and spinal cord in motor neuron disease. J Neuropathol Exp Neurol. 1995; 54 : 673-9
36. Matsumoto S, G oto S, K usaka H, I to H, I mai T. S ynaptic pathology of spinal anterior horn cells in amyotrophic lateral sclerosis: An immunohistochemical study. J Neurol Sci. 1994; 125 : 180-5 (Pubitemid 24275315)
37. Sasaki S, M aruyama S. D ecreased synaptophysin immunoreactivity of the anterior horns in motor neuron disease. Acta Neuropathol. 1994; 87 : 125-8 (Pubitemid 24030519)
38. Wang IF, W u LS, C hang HY, S hen CK. T DP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor. J Neurochem. 2008; 105 : 797-806
39. Sotelo-Silveira JR, C alliari A, K un A, K oenig E, S otelo JR. RNA traffi cking in axons. Traffi c. 2006; 7 : 508-15
40. Baumer D, A nsorge O, A lmeida M, T albot K. T he role of RNA processing in the pathogenesis of motor neuron degeneration. Expert Rev Mol Med. 2010; 12 :E21
41. Dachs E, H ereu M, P iedrafi ta L, C asanovas A, C aldero J, Esquerda JE. Defective neuromuscular junction organization and postnatal myogenesis in mice with severe spinal muscular atrophy. J Neuropathol Exp Neurol. 2011; 70 : 444-61
42. Kong L, W ang X, C hoe DW, P olley M, B urnett B G, Bosch-Marce M.et al. Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice. J Neurosci. 2009; 29 : 842-51
43. Yan D, W u Z, C hisholm A D, J in Y. T he DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell. 2009; 138 : 1005-18