C57BL/6J congenic Prp-TDP43A315T mice develop progressive neurodegeneration in the myenteric plexus of the colon without exhibiting key features of ALS

Brain Research

Volumn 1584, Issue , 2014, Pages 59-72

  Hatzipetros, Theo ^a   Bogdanik, Laurent P ^b   Tassinari, Valerie R ^a   Kidd, Joshua D ^a   Moreno, Andy J ^a   Davis, Crystal ^b   Osborne, Melissa ^b   Austin, Andrew ^b   Vieira, Fernando G ^a   Lutz, Cathleen ^b   Perrin, Steve ^a  

^a ALS Therapy Development Institute   (United States)

^b JACKSON LABORATORY   (United States)

Author keywords

ALS; Myenteric plexus; Neurodegeneration; Prion; Proteinopathy; RNA binding; TDP 43; Transgenic animal models

Indexed keywords

TAR DNA BINDING PROTEIN; UBIQUITIN; DNA BINDING PROTEIN; GLIAL FIBRILLARY ASTROCYTIC PROTEIN, MOUSE; NERVE PROTEIN; PROTEIN TDP-43;

AGE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; C57BL 6 MOUSE; CAUSE OF DEATH; COLON; CONGENIC STRAIN; CONTROLLED STUDY; CYTOPLASM; DIGESTIVE SYSTEM FUNCTION DISORDER; DISEASE COURSE; FEMALE; GENE; GENE CONTROL; GENE OVEREXPRESSION; GENETIC STRAIN; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE INNERVATION; INTESTINE MOTILITY; LONGEVITY; MALE; MOUSE; MOUSE MODEL; MUSCLE STRENGTH; MUTANT MOUSE STRAIN; MYENTERIC PLEXUS; NERVE DEGENERATION; NEUROMUSCULAR DISEASE; NONHUMAN; PHENOTYPE; PROMOTER REGION; SEX DIFFERENCE; SPINAL CORD; SURVIVAL RATE; TDP43 GENE; TRANSGENE; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; CELL INCLUSION; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; GENETICS; INNERVATION; METABOLISM; MOTONEURON; PATHOLOGY;

ANIMALIA; MUS;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; COLON; DNA-BINDING PROTEINS; FEMALE; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; HUMANS; INCLUSION BODIES; MALE; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR NEURONS; MYENTERIC PLEXUS; NERVE TISSUE PROTEINS; SEX FACTORS; SPINAL CORD; UBIQUITIN;

EID: 84907687330     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.10.013     Document Type: Article

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