Histamine Receptor 2 is Required to Suppress Innate Immune Responses to Bacterial Ligands in Patients with Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Volumn 22, Issue 7, 2016, Pages 1575-1586

  Smolinska, Sylwia ^a,b   Groeger, David ^c,d   Perez, Noelia Rodriguez ^c   Schiavi, Elisa ^c   Ferstl, Ruth ^c   Frei, Remo ^c,e   Konieczna, Patrycja ^c   Akdis, Cezmi A ^c   Jutel, Marek ^a,b   O'Mahony, Liam ^c  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b ALL MED Medical Research Institute   (Poland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d ALIMENTARY HEALTH LTD   (Ireland)

^e CK CARE Christine Kühne Center for Allergy Research and Education   (Switzerland)

Author keywords

histamine; IBD; TLR

Indexed keywords

CD14 ANTIGEN; CD161 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR6; FAMOTIDINE; GAMMA INTERFERON; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H4 RECEPTOR; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 5; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR GATA 3; CYTOKINE; FLAGELLIN; HISTAMINE H2 RECEPTOR ANTAGONIST; LIGAND; LIPOPOLYSACCHARIDE; LIPOPROTEIN; N-PALMITOYL-S-(2,3-BIS(PALMITOYLOXY)PROPYL)CYSTEINYL-SERYL-LYSYL-LYSYL-LYSYL-LYSINE; TOLL LIKE RECEPTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE RELEASE; CYTOKINE RESPONSE; FEMALE; FLOW CYTOMETRY; GASTROINTESTINAL MUCOSA; GENE EXPRESSION; HISTAMINE METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MALE; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TH17 CELL; ULCERATIVE COLITIS; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT LOSS; CASE CONTROL STUDY; CELL CULTURE; DISEASE MODEL; DOWN REGULATION; DRUG EFFECTS; GENETICS; IMMUNOLOGY; INTESTINE MUCOSA; LYMPHOCYTE COUNT; METABOLISM; MIDDLE AGED; SCID MOUSE; SECRETION (PROCESS); SEVERITY OF ILLNESS INDEX; TH1 CELL; YOUNG ADULT;

ADULT; ANIMALS; CASE-CONTROL STUDIES; CELLS, CULTURED; COLITIS, ULCERATIVE; CROHN DISEASE; CYTOKINES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FAMOTIDINE; FEMALE; FLAGELLIN; GENE EXPRESSION; HISTAMINE; HISTAMINE H2 ANTAGONISTS; HUMANS; IMMUNITY, INNATE; INTESTINAL MUCOSA; LIGANDS; LIPOPOLYSACCHARIDES; LIPOPROTEINS; LYMPHOCYTE COUNT; MALE; MICE; MICE, SCID; MIDDLE AGED; MONOCYTES; RECEPTORS, HISTAMINE H1; RECEPTORS, HISTAMINE H2; RECEPTORS, HISTAMINE H4; SEVERITY OF ILLNESS INDEX; TH1 CELLS; TH17 CELLS; TOLL-LIKE RECEPTORS; WEIGHT LOSS; YOUNG ADULT;

EID: 84976320110     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0000000000000825     Document Type: Article

References (36)

1. Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007;448:427-434
2. Schaubeck M, Clavel T, Calasan J, et al. Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence. Gut. 2016;65:225-237
3. McCarthy J, O'Mahony L, O'Callaghan L, et al. Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance. Gut. 2003;52:975-980
4. Iwasaki A, Medzhitov R. Control of adaptive immunity by the innate immune system. Nat Immunol. 2015;16:343-353
5. Frosali S, Pagliari D, Gambassi G, et al. How the Intricate interaction among Toll-like receptors, microbiota, and intestinal immunity can influence gastrointestinal pathology. J Immunol Res. 2015;2015:489821
6. Frei R, Lauener RP, Crameri R, et al. Microbiota and dietary interactions: an update to the hygiene hypothesis? Allergy. 2012;67:451-461
7. Konieczna P, Groeger D, Ziegler M, et al. Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells. Gut. 2012;61:354-366
8. Ferstl R, Akdis CA, O'Mahony L. Histamine regulation of innate and adaptive immunity. Front Biosci (Landmark Ed). 2012;17:40-53
9. O'Mahony L, Akdis M, Akdis CA. Regulation of the immune response and inflammation by histamine and histamine receptors. J Allergy Clin Immunol. 2011;128:1153-1162
10. Frei R, Ferstl R, Konieczna P, et al. Histamine receptor 2 modifies dendritic cell responses to microbial ligands. J Allergy Clin Immunol. 2013; 132:194-204
11. Gschwandtner M, Bunk H, Kother B, et al. Histamine down-regulates IL-27 production in antigen-presenting cells. J Leukoc Biol. 2012;92: 21-29
12. Teuscher C, Poynter ME, Offner H, et al. Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells. Am J Pathol. 2004;164: 883-892
13. Ferstl R, Frei R, Schiavi E, et al. Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes. J Allergy Clin Immunol. 2014;134:744-746
14. Meiler F, Zumkehr J, Klunker S, et al. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med. 2008;205: 2887-2898
15. Jutel M, Watanabe T, Klunker S, et al. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature. 2001;413:420-425
16. Raithel M, Matek M, Baenkler HW, et al. Mucosal histamine content and histamine secretion in Crohn's disease, ulcerative colitis and allergic enteropathy. Int Arch Allergy Immunol. 1995;108:127-133
17. Winterkamp S, Weidenhiller M, Otte P, et al. Urinary excretion of N-methylhistamine as a marker of disease activity in inflammatory bowel disease. Am J Gastroenterol. 2002;97:3071-3077
18. Hagel AF, de Rossi T, Konturek PC, et al. Plasma histamine and tumour necrosis factor-alpha levels in Crohn's disease and ulcerative colitis at various stages of disease. J Physiol Pharmacol. 2015;66:549-556
19. Kjellev S, Lundsgaard D, Poulsen SS, et al. Reconstitution of Scid mice with CD4+CD25-T cells leads to rapid colitis: an improved model for pharmacologic testing. Int Immunopharmacol. 2006;6:1341-1354
20. Takahashi HK, Iwagaki H, Mori S, et al. Histamine inhibits lipopolysaccharide-induced interleukin (IL)-18 production in human monocytes. Clin Immunol. 2004;112:30-34
21. Morichika T, Takahashi HK, Iwagaki H, et al. Histamine inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production in an intercellular adhesion molecule-1-and B7.1-dependent manner. J Pharmacol Exp Ther. 2003;304:624-633
22. Zhang J, Takahashi HK, Liu K, et al. Histamine inhibits adhesion molecule expression in human monocytes, induced by advanced glycation end products, during the mixed lymphocyte reaction. Br J Pharmacol. 2010; 160:1378-1386
23. Cowden JM, Yu F, Banie H, et al. The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis. Ann Rheum Dis. 2014;73:600-608
24. Schirmer B, Rezniczek T, Seifert R, et al. Proinflammatory role of the histamine H4 receptor in dextrane sodium sulfate-induced acute colitis. Biochem Pharmacol. 2015;98:102-109
25. Capelo R, Lehmann C, Ahmad K, et al. Cellular analysis of the histamine H4 receptor in human myeloid cells. Biochem Pharmacol. 2016;103:74-84
26. Veen W, Stanic B, Yaman G, et al. IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses. J Allergy Clin Immunol. 2013;131:1204-1212
27. Ring S, Pushkarevskaya A, Schild H, et al. Regulatory T cell-derived adenosine induces dendritic cell migration through the Epac-Rap1 pathway. J Immunol. 2015;194:3735-3744
28. Akdis M, Burgler S, Crameri R, et al. Interleukins, from 1 to 37, and interferon-g: receptors, functions, and roles in diseases. J Allergy Clin Immunol. 2011;127:701-721
29. Petersen J, Raithel M, Schwelberger HG. Histamine N-methyltransferase and diamine oxidase gene polymorphisms in patients with inflammatory and neoplastic intestinal diseases. Inflamm Res. 2002;51:S91-S92
30. Schulze HA, Hasler R, Mah N, et al. From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD. Genes Immun. 2008;9:240-248
31. Juillerat P, Schneeweiss S, Cook EF, et al. Drugs that inhibit gastric acid secretion may alter the course of inflammatory bowel disease. Aliment Pharmacol Ther. 2012;36:239-247
32. Chen K, Xiang Y, Yao X, et al. The active contribution of Toll-like receptors to allergic airway inflammation. Int Immunopharmacol. 2011;11:1391-1398
33. Reece P, Thanendran A, Crawford L, et al. Maternal allergy modulates cord blood hematopoietic progenitor Toll-like receptor expression and function. J Allergy Clin Immunol. 2011;127:447-453
34. Wood LG, Simpson JL, Wark PA, et al. Characterization of innate immune signalling receptors in virus-induced acute asthma. Clin Exp Allergy. 2011;41:640-648
35. Smolinska S, Jutel M, Crameri R, et al. Histamine and gut mucosal immune regulation. Allergy. 2014;69:273-281
36. Gao C, Major A, Rendon D, et al. Histamine H2 receptor-mediated suppression of intestinal inflammation by probiotic Lactobacillus reuteri. MBio. 2015;6:e01358-e01415