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Volumn 5, Issue 6, 2016, Pages

Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma

Author keywords

Anti gd2 mAb therapy; histone deacytelase inhibitor; immunotherapy; myeloid derived suppressor cell; neuroblastoma

Indexed keywords

ABEXINOSTAT; ANTI GD2 MONOCLONAL ANTIBODY; BELINOSTAT; ENTINOSTAT; GIVINOSTAT; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 6; MONOCLONAL ANTIBODY; TUBACIN; UNCLASSIFIED DRUG; VORINOSTAT;

EID: 84976293012     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2016.1164919     Document Type: Article
Times cited : (53)

References (58)
  • 2
    • 61449106633 scopus 로고    scopus 로고
    • Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study
    • 19171716
    • K.K.Matthay, C.P.Reynolds, R.C.Seeger, H.Shimada, E.S.Adkins, D.Haas-Kogan, R.B.Gerbing, W.B.London, J.G.Villablanca. Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study. J Clin Oncol 2009; 27:1007-13; PMID:19171716; 10.1200/JCO.2007.13.8925
    • (2009) J Clin Oncol , vol.27 , pp. 1007-1013
    • Matthay, K.K.1    Reynolds, C.P.2    Seeger, R.C.3    Shimada, H.4    Adkins, E.S.5    Haas-Kogan, D.6    Gerbing, R.B.7    London, W.B.8    Villablanca, J.G.9
  • 5
    • 84906234428 scopus 로고    scopus 로고
    • Key role for myeloid cells: Phase II results of anti-G antibody 3F8 plus granulocyte-macrophage colony-stimulating factor for chemoresistant osteomedullary neuroblastoma
    • N.K.Cheung, I.Y.Cheung, K.Kramer, S.Modak, D.Kuk, N.Pandit-Taskar, E.Chamberlain, I.Ostrovnaya, B.H.Kushner. Key role for myeloid cells: Phase II results of anti-G antibody 3F8 plus granulocyte-macrophage colony-stimulating factor for chemoresistant osteomedullary neuroblastoma. Int J Cancer 2014; 135(9):2199-205; PMID:24644014; 10.1002/ijc.28851
    • (2014) Int J Cancer , vol.135 , Issue.9 , pp. 2199-2205
    • Cheung, N.K.1    Cheung, I.Y.2    Kramer, K.3    Modak, S.4    Kuk, D.5    Pandit-Taskar, N.6    Chamberlain, E.7    Ostrovnaya, I.8    Kushner, B.H.9
  • 6
    • 84861923685 scopus 로고    scopus 로고
    • Immunocombination therapy for high-risk neuroblastoma
    • 22394368
    • M.Kroesen, D.Lindau, P.Hoogerbrugge, G.J.Adema. Immunocombination therapy for high-risk neuroblastoma. Immunotherapy 2012; 4:163-74; PMID:22394368; 10.2217/imt.11.169
    • (2012) Immunotherapy , vol.4 , pp. 163-174
    • Kroesen, M.1    Lindau, D.2    Hoogerbrugge, P.3    Adema, G.J.4
  • 7
    • 84855471990 scopus 로고    scopus 로고
    • HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications
    • 22124371
    • O.Khan, N.B.La Thangue. HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications. Immunol Cell Biol 2012; 90:85-94; PMID:22124371; 10.1038/icb.2011.100
    • (2012) Immunol Cell Biol , vol.90 , pp. 85-94
    • Khan, O.1    La Thangue, N.B.2
  • 9
    • 79955148265 scopus 로고    scopus 로고
    • Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization
    • 21743813
    • N.Nalabothula, F.Carrier. Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization. Epigenomics 2011; 3:145-55; PMID:21743813; 10.2217/epi.11.12
    • (2011) Epigenomics , vol.3 , pp. 145-155
    • Nalabothula, N.1    Carrier, F.2
  • 10
    • 47349097996 scopus 로고    scopus 로고
    • Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells
    • 18549473
    • A.Muhlethaler-Mottet, R.Meier, M.Flahaut, K.B.Bourloud, K.Nardou, J.M.Joseph, N.Gross. Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells. Mol Cancer 2008; 7:55; PMID:18549473; 10.1186/1476-4598-7-55
    • (2008) Mol Cancer , vol.7 , pp. 55
    • Muhlethaler-Mottet, A.1    Meier, R.2    Flahaut, M.3    Bourloud, K.B.4    Nardou, K.5    Joseph, J.M.6    Gross, N.7
  • 11
    • 39449138853 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells
    • 18059320
    • F.Condorelli, I.Gnemmi, A.Vallario, A.A.Genazzani, P.L.Canonico. Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. Br J Pharmacol 2008; 153:657-68; PMID:18059320; 10.1038/sj.bjp.0707608
    • (2008) Br J Pharmacol , vol.153 , pp. 657-668
    • Condorelli, F.1    Gnemmi, I.2    Vallario, A.3    Genazzani, A.A.4    Canonico, P.L.5
  • 13
    • 34447509697 scopus 로고    scopus 로고
    • Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma
    • 17594194
    • M.Duvic, J.Vu. Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma. Expert Opin Investig Drugs 2007; 16:1111-20; PMID:17594194; 10.1517/13543784.16.7.1111
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 1111-1120
    • Duvic, M.1    Vu, J.2
  • 15
    • 0022388606 scopus 로고
    • Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas
    • 4047115
    • R.C.Seeger, G.M.Brodeur, H.Sather, A.Dalton, S.E.Siegel, K.Y.Wong, D.Hammond. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 1985; 313:1111-6; PMID:4047115; 10.1056/NEJM198510313131802
    • (1985) N Engl J Med , vol.313 , pp. 1111-1116
    • Seeger, R.C.1    Brodeur, G.M.2    Sather, H.3    Dalton, A.4    Siegel, S.E.5    Wong, K.Y.6    Hammond, D.7
  • 17
    • 0030999641 scopus 로고    scopus 로고
    • Targeted expression of MYCN causes neuroblastoma in transgenic mice
    • 9214616
    • W.A.Weiss, K.Aldape, G.Mohapatra, B.G.Feuerstein, J.M.Bishop. Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J 1997; 16:2985-95; PMID:9214616; 10.1093/emboj/16.11.2985
    • (1997) EMBO J , vol.16 , pp. 2985-2995
    • Weiss, W.A.1    Aldape, K.2    Mohapatra, G.3    Feuerstein, B.G.4    Bishop, J.M.5
  • 19
  • 20
    • 84877118822 scopus 로고    scopus 로고
    • Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma
    • 23349014
    • L.M.Carlson, A.Rasmuson, H.Idborg, L.Segerstrom, P.J.Jakobsson, B.Sveinbjornsson, P.Kogner. Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma. Carcinogenesis 2013; 34:1081-8; PMID:23349014; 10.1093/carcin/bgt009
    • (2013) Carcinogenesis , vol.34 , pp. 1081-1088
    • Carlson, L.M.1    Rasmuson, A.2    Idborg, H.3    Segerstrom, L.4    Jakobsson, P.J.5    Sveinbjornsson, B.6    Kogner, P.7
  • 26
  • 27
    • 42449114964 scopus 로고    scopus 로고
    • Disruption of GM2/GD2 synthase gene resulted in overt expression of 9-O-acetyl GD3 irrespective of Tis21
    • 18194438
    • K.Furukawa, W.Aixinjueluo, T.Kasama, Y.Ohkawa, M.Yoshihara, Y.Ohmi, O.Tajima, A.Suzumura, D.Kittaka. Disruption of GM2/GD2 synthase gene resulted in overt expression of 9-O-acetyl GD3 irrespective of Tis21. J Neurochem 2008; 105:1057-66; PMID:18194438; 10.1111/j.1471-4159.2008.05232.x
    • (2008) J Neurochem , vol.105 , pp. 1057-1066
    • Furukawa, K.1    Aixinjueluo, W.2    Kasama, T.3    Ohkawa, Y.4    Yoshihara, M.5    Ohmi, Y.6    Tajima, O.7    Suzumura, A.8    Kittaka, D.9
  • 28
    • 79851502666 scopus 로고    scopus 로고
    • Histone acetylation-mediated glycosyltransferase gene regulation in mouse brain during development
    • 21214566
    • Y.Suzuki, M.Yanagisawa, T.Ariga, R.K.Yu. Histone acetylation-mediated glycosyltransferase gene regulation in mouse brain during development. J Neurochem 2011; 116:874-80; PMID:21214566; 10.1111/j.1471-4159.2010.07042.x
    • (2011) J Neurochem , vol.116 , pp. 874-880
    • Suzuki, Y.1    Yanagisawa, M.2    Ariga, T.3    Yu, R.K.4
  • 31
    • 84858785703 scopus 로고    scopus 로고
    • Coordinated regulation of myeloid cells by tumours
    • 22437938
    • D.I.Gabrilovich, S.Ostrand-Rosenberg, V.Bronte. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol 2012; 12:253-68; PMID:22437938; 10.1038/nri3175
    • (2012) Nat Rev Immunol , vol.12 , pp. 253-268
    • Gabrilovich, D.I.1    Ostrand-Rosenberg, S.2    Bronte, V.3
  • 32
    • 38649108461 scopus 로고    scopus 로고
    • High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trial
    • 18086798
    • D.Canioni, G.Salles, N.Mounier, N.Brousse, M.Keuppens, F.Morchhauser, T.Lamy, A.Sonet, M.C.Rousselet, C.Foussard et al. High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trial. J Clin Oncol 2008; 26:440-6; PMID:18086798; 10.1200/JCO.2007.12.8298
    • (2008) J Clin Oncol , vol.26 , pp. 440-446
    • Canioni, D.1    Salles, G.2    Mounier, N.3    Brousse, N.4    Keuppens, M.5    Morchhauser, F.6    Lamy, T.7    Sonet, A.8    Rousselet, M.C.9    Foussard, C.10
  • 33
    • 84889974550 scopus 로고    scopus 로고
    • Trastuzumab mediates antibody-dependent cell-mediated cytotoxicity and phagocytosis to the same extent in both adjuvant and metastatic HER2/neu breast cancer patients
    • 24330813
    • B.Petricevic, J.Laengle, J.Singer, M.Sachet, J.Fazekas, G.Steger, R.Bartsch, E.Jensen-Jarolim, M.Bergmann. Trastuzumab mediates antibody-dependent cell-mediated cytotoxicity and phagocytosis to the same extent in both adjuvant and metastatic HER2/neu breast cancer patients. J Transl Med 2013; 11:307; PMID:24330813; 10.1186/1479-5876-11-307
    • (2013) J Transl Med , vol.11 , pp. 307
    • Petricevic, B.1    Laengle, J.2    Singer, J.3    Sachet, M.4    Fazekas, J.5    Steger, G.6    Bartsch, R.7    Jensen-Jarolim, E.8    Bergmann, M.9
  • 34
    • 84891626935 scopus 로고    scopus 로고
    • Myeloid cells as effector cells for monoclonal antibody therapy of cancer
    • 23811299
    • R.Braster, T.O'Toole, M.van Egmond. Myeloid cells as effector cells for monoclonal antibody therapy of cancer. Methods 2014; 65:28-37; PMID:23811299; 10.1016/j.ymeth.2013.06.020
    • (2014) Methods , vol.65 , pp. 28-37
    • Braster, R.1    O'Toole, T.2    van Egmond, M.3
  • 35
    • 77956205298 scopus 로고    scopus 로고
    • CD49d is a new marker for distinct myeloid-derived suppressor cell subpopulations in mice
    • 20525890
    • L.A.Haile, J.Gamrekelashvili, M.P.Manns, F.Korangy, T.F.Greten. CD49d is a new marker for distinct myeloid-derived suppressor cell subpopulations in mice. J Immunol 2010; 185:203-10; PMID:20525890; 10.4049/jimmunol.0903573
    • (2010) J Immunol , vol.185 , pp. 203-210
    • Haile, L.A.1    Gamrekelashvili, J.2    Manns, M.P.3    Korangy, F.4    Greten, T.F.5
  • 36
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumor-bearing mice
    • 18832739
    • J.I.Youn, S.Nagaraj, M.Collazo, D.I.Gabrilovich. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol 2008; 181:5791-802; PMID:18832739; 10.4049/jimmunol.181.8.5791
    • (2008) J Immunol , vol.181 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 37
    • 78049427830 scopus 로고    scopus 로고
    • Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape
    • 20697078
    • R.L.Ferris, E.M.Jaffee, S.Ferrone. Tumor antigen-targeted, monoclonal antibody-based immunotherapy: clinical response, cellular immunity, and immunoescape. J Clin Oncol 2010; 28:4390-9; PMID:20697078; 10.1200/JCO.2009.27.6360
    • (2010) J Clin Oncol , vol.28 , pp. 4390-4399
    • Ferris, R.L.1    Jaffee, E.M.2    Ferrone, S.3
  • 39
    • 78651428141 scopus 로고    scopus 로고
    • Long-term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy
    • 21244693
    • T.Simon, B.Hero, A.Faldum, R.Handgretinger, M.Schrappe, T.Klingebiel, F.Berthold. Long-term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy. BMC Cancer 2011; 11:21; PMID:21244693; 10.1186/1471-2407-11-21
    • (2011) BMC Cancer , vol.11 , pp. 21
    • Simon, T.1    Hero, B.2    Faldum, A.3    Handgretinger, R.4    Schrappe, M.5    Klingebiel, T.6    Berthold, F.7
  • 40
  • 41
    • 36749069011 scopus 로고    scopus 로고
    • Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis
    • 18003922
    • T.Liu, A.E.Tee, A.Porro, S.A.Smith, T.Dwarte, P.Y.Liu, N.Iraci, E.Sekyere, M.Haber, M.D.Norris et al. Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis. Proc Natl Acad Sci U S A 2007; 104:18682-7; PMID:18003922; 10.1073/pnas.0705524104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18682-18687
    • Liu, T.1    Tee, A.E.2    Porro, A.3    Smith, S.A.4    Dwarte, T.5    Liu, P.Y.6    Iraci, N.7    Sekyere, E.8    Haber, M.9    Norris, M.D.10
  • 43
    • 84872559040 scopus 로고    scopus 로고
    • The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells
    • 23216602
    • D.Lindau, P.Gielen, M.Kroesen, P.Wesseling, G.J.Adema. The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells. Immunology 2013; 138:105-15; PMID:23216602; 10.1111/imm.12036
    • (2013) Immunology , vol.138 , pp. 105-115
    • Lindau, D.1    Gielen, P.2    Kroesen, M.3    Wesseling, P.4    Adema, G.J.5
  • 45
    • 77955277730 scopus 로고    scopus 로고
    • Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs
    • 20478744
    • T.Akimova, G.Ge, T.Golovina, T.Mikheeva, L.Wang, J.L.Riley, W.W.Hancock. Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs. Clin Immunol 2010; 136:348-63; PMID:20478744; 10.1016/j.clim.2010.04.018
    • (2010) Clin Immunol , vol.136 , pp. 348-363
    • Akimova, T.1    Ge, G.2    Golovina, T.3    Mikheeva, T.4    Wang, L.5    Riley, J.L.6    Hancock, W.W.7
  • 46
    • 84878621268 scopus 로고    scopus 로고
    • HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy
    • 23295947
    • B.W.Bridle, L.Chen, C.G.Lemay, J.S.Diallo, J.Pol, A.Nguyen, A.Capretta, R.He, J.L.Bramson, J.C.Bell et al. HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy. Mol Ther 2013; 21:887-94; PMID:23295947; 10.1038/mt.2012.265
    • (2013) Mol Ther , vol.21 , pp. 887-894
    • Bridle, B.W.1    Chen, L.2    Lemay, C.G.3    Diallo, J.S.4    Pol, J.5    Nguyen, A.6    Capretta, A.7    He, R.8    Bramson, J.L.9    Bell, J.C.10
  • 47
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    • 18809714
    • P.Cheng, C.A.Corzo, N.Luetteke, B.Yu, S.Nagaraj, M.M.Bui, M.Ortiz, W.Nacken, C.Sorg, T.Vogl et al. Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 2008; 205:2235-49; PMID:18809714; 10.1084/jem.20080132
    • (2008) J Exp Med , vol.205 , pp. 2235-2249
    • Cheng, P.1    Corzo, C.A.2    Luetteke, N.3    Yu, B.4    Nagaraj, S.5    Bui, M.M.6    Ortiz, M.7    Nacken, W.8    Sorg, C.9    Vogl, T.10
  • 48
    • 43249130187 scopus 로고    scopus 로고
    • Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity
    • 18272812
    • K.Movahedi, M.Guilliams, J.Van den Bossche, R.Van den Bergh, C.Gysemans, A.Beschin, P.De Baetselier, J.A.Van Ginderachter. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 2008; 111:4233-44; PMID:18272812; 10.1182/blood-2007-07-099226
    • (2008) Blood , vol.111 , pp. 4233-4244
    • Movahedi, K.1    Guilliams, M.2    Van den Bossche, J.3    Van den Bergh, R.4    Gysemans, C.5    Beschin, A.6    De Baetselier, P.7    Van Ginderachter, J.A.8
  • 49
    • 33645053518 scopus 로고    scopus 로고
    • Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy
    • 16520392
    • Y.Hamaguchi, Y.Xiu, K.Komura, F.Nimmerjahn, T.F.Tedder. Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. J Exp Med 2006; 203:743-53; PMID:16520392; 10.1084/jem.20052283
    • (2006) J Exp Med , vol.203 , pp. 743-753
    • Hamaguchi, Y.1    Xiu, Y.2    Komura, K.3    Nimmerjahn, F.4    Tedder, T.F.5
  • 53
    • 39649122877 scopus 로고    scopus 로고
    • Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30
    • 17909075
    • E.Oflazoglu, I.J.Stone, K.A.Gordon, I.S.Grewal, N.van Rooijen, C.L.Law, H.P.Gerber. Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30. Blood 2007; 110:4370-2; PMID:17909075; 10.1182/blood-2007-06-097014
    • (2007) Blood , vol.110 , pp. 4370-4372
    • Oflazoglu, E.1    Stone, I.J.2    Gordon, K.A.3    Grewal, I.S.4    van Rooijen, N.5    Law, C.L.6    Gerber, H.P.7
  • 55
    • 72249084921 scopus 로고    scopus 로고
    • Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824
    • 19861533
    • D.D.Vo, R.M.Prins, J.L.Begley, T.R.Donahue, L.F.Morris, K.W.Bruhn, P.de la Rocha, M.Y.Yang, S.Mok, H.J.Garban et al. Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824. Cancer Res 2009; 69:8693-9; PMID:19861533; 10.1158/0008-5472.CAN-09-1456
    • (2009) Cancer Res , vol.69 , pp. 8693-8699
    • Vo, D.D.1    Prins, R.M.2    Begley, J.L.3    Donahue, T.R.4    Morris, L.F.5    Bruhn, K.W.6    de la Rocha, P.7    Yang, M.Y.8    Mok, S.9    Garban, H.J.10
  • 56
    • 79952760874 scopus 로고    scopus 로고
    • Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies
    • 21368108
    • A.J.Christiansen, A.West, K.M.Banks, N.M.Haynes, M.W.Teng, M.J.Smyth, R.W.Johnstone. Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies. Proc Natl Acad Sci U S A 2011; 108:4141-6; PMID:21368108; 10.1073/pnas.1011037108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4141-4146
    • Christiansen, A.J.1    West, A.2    Banks, K.M.3    Haynes, N.M.4    Teng, M.W.5    Smyth, M.J.6    Johnstone, R.W.7
  • 57
    • 10744229506 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors
    • 14667227
    • D.K.Kim, J.Y.Lee, J.S.Kim, J.H.Ryu, J.Y.Choi, J.W.Lee, G.J.Im, T.K.Kim, J.W.Seo, H.J.Park et al. Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors. J Med Chem 2003; 46:5745-51; PMID:14667227; 10.1021/jm030377q
    • (2003) J Med Chem , vol.46 , pp. 5745-5751
    • Kim, D.K.1    Lee, J.Y.2    Kim, J.S.3    Ryu, J.H.4    Choi, J.Y.5    Lee, J.W.6    Im, G.J.7    Kim, T.K.8    Seo, J.W.9    Park, H.J.10
  • 58
    • 49449113465 scopus 로고    scopus 로고
    • Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6
    • 18642892
    • A.P.Kozikowski, S.Tapadar, D.N.Luchini, K.H.Kim, D.D.Billadeau. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem 2008; 51:4370-3; PMID:18642892; 10.1021/jm8002894
    • (2008) J Med Chem , vol.51 , pp. 4370-4373
    • Kozikowski, A.P.1    Tapadar, S.2    Luchini, D.N.3    Kim, K.H.4    Billadeau, D.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.