-
1
-
-
84946065192
-
PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes
-
Ali HR, Glont SE, Blows FM, Provenzano E, Dawson SJ, Liu B, Hiller L, Dunn J, Poole CJ, Bowden S, Earl HM, Pharoah PD, Caldas C (2015) PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes. Ann Oncol 26(7):1488–1493. doi:10.1093/annonc/mdv192
-
(2015)
Ann Oncol
, vol.26
, Issue.7
, pp. 1488-1493
-
-
Ali, H.R.1
Glont, S.E.2
Blows, F.M.3
Provenzano, E.4
Dawson, S.J.5
Liu, B.6
Hiller, L.7
Dunn, J.8
Poole, C.J.9
Bowden, S.10
Earl, H.M.11
Pharoah, P.D.12
Caldas, C.13
-
2
-
-
84925221855
-
PD-1 blockade with nivolumab in relapsed or refractory Hodgkin’s lymphoma
-
Ansell SM, Lesokhin AM, Borrello I, Halwani A, Scott EC, Gutierrez M, Schuster SJ, Millenson MM, Cattry D, Freeman GJ, Rodig SJ, Chapuy B, Ligon AH, Zhu L, Grosso JF, Kim SY, Timmerman JM, Shipp MA, Armand P (2015) PD-1 blockade with nivolumab in relapsed or refractory Hodgkin’s lymphoma. N Engl J Med 372(4):311–319. doi:10.1056/NEJMoa1411087
-
(2015)
N Engl J Med
, vol.372
, Issue.4
, pp. 311-319
-
-
Ansell, S.M.1
Lesokhin, A.M.2
Borrello, I.3
Halwani, A.4
Scott, E.C.5
Gutierrez, M.6
Schuster, S.J.7
Millenson, M.M.8
Cattry, D.9
Freeman, G.J.10
Rodig, S.J.11
Chapuy, B.12
Ligon, A.H.13
Zhu, L.14
Grosso, J.F.15
Kim, S.Y.16
Timmerman, J.M.17
Shipp, M.A.18
Armand, P.19
-
3
-
-
84923072443
-
Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer
-
Azuma K, Ota K, Kawahara A, Hattori S, Iwama E, Harada T, Matsumoto K, Takayama K, Takamori S, Kage M, Hoshino T, Nakanishi Y, Okamoto I (2014) Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer. Ann Oncol 25(10):1935–1940. doi:10.1093/annonc/mdu242
-
(2014)
Ann Oncol
, vol.25
, Issue.10
, pp. 1935-1940
-
-
Azuma, K.1
Ota, K.2
Kawahara, A.3
Hattori, S.4
Iwama, E.5
Harada, T.6
Matsumoto, K.7
Takayama, K.8
Takamori, S.9
Kage, M.10
Hoshino, T.11
Nakanishi, Y.12
Okamoto, I.13
-
4
-
-
79551649114
-
Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists
-
Badve S, Dabbs DJ, Schnitt SJ, Baehner FL, Decker T, Eusebi V, Fox SB, Ichihara S, Jacquemier J, Lakhani SR, Palacios J, Rakha EA, Richardson AL, Schmitt FC, Tan PH, Tse GM, Weigelt B, Ellis IO, Reis-Filho JS (2011) Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists. Mod Pathol 24(2):157–167. doi:10.1038/modpathol.2010.200
-
(2011)
Mod Pathol
, vol.24
, Issue.2
, pp. 157-167
-
-
Badve, S.1
Dabbs, D.J.2
Schnitt, S.J.3
Baehner, F.L.4
Decker, T.5
Eusebi, V.6
Fox, S.B.7
Ichihara, S.8
Jacquemier, J.9
Lakhani, S.R.10
Palacios, J.11
Rakha, E.A.12
Richardson, A.L.13
Schmitt, F.C.14
Tan, P.H.15
Tse, G.M.16
Weigelt, B.17
Ellis, I.O.18
Reis-Filho, J.S.19
-
5
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, Pitot HC, Hamid O, Bhatia S, Martins R, Eaton K, Chen S, Salay TM, Alaparthy S, Grosso JF, Korman AJ, Parker SM, Agrawal S, Goldberg SM, Pardoll DM, Gupta A, Wigginton JM (2012) Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 366(26):2455–2465. doi:10.1056/NEJMoa1200694
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
Hwu, W.J.4
Topalian, S.L.5
Hwu, P.6
Drake, C.G.7
Camacho, L.H.8
Kauh, J.9
Odunsi, K.10
Pitot, H.C.11
Hamid, O.12
Bhatia, S.13
Martins, R.14
Eaton, K.15
Chen, S.16
Salay, T.M.17
Alaparthy, S.18
Grosso, J.F.19
Korman, A.J.20
Parker, S.M.21
Agrawal, S.22
Goldberg, S.M.23
Pardoll, D.M.24
Gupta, A.25
Wigginton, J.M.26
more..
-
6
-
-
84927621560
-
Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer
-
Burstein MD, Tsimelzon A, Poage GM, Covington KR, Contreras A, Fuqua SA, Savage MI, Osborne CK, Hilsenbeck SG, Chang JC, Mills GB, Lau CC, Brown PH (2015) Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer. Clin Cancer Res 21(7):1688–1698. doi:10.1158/1078-0432.CCR-14-0432
-
(2015)
Clin Cancer Res
, vol.21
, Issue.7
, pp. 1688-1698
-
-
Burstein, M.D.1
Tsimelzon, A.2
Poage, G.M.3
Covington, K.R.4
Contreras, A.5
Fuqua, S.A.6
Savage, M.I.7
Osborne, C.K.8
Hilsenbeck, S.G.9
Chang, J.C.10
Mills, G.B.11
Lau, C.C.12
Brown, P.H.13
-
7
-
-
34447646310
-
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
-
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ (2007) Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 27(1):111–122. doi:10.1016/j.immuni.2007.05.016
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 111-122
-
-
Butte, M.J.1
Keir, M.E.2
Phamduy, T.B.3
Sharpe, A.H.4
Freeman, G.J.5
-
8
-
-
84907270779
-
Comprehensive molecular characterization of gastric adenocarcinoma
-
Cancer Genome Atlas Research Network (2014) Comprehensive molecular characterization of gastric adenocarcinoma. Nature 513(7517):202–209. doi:10.1038/nature13480
-
(2014)
Nature
, vol.513
, Issue.7517
, pp. 202-209
-
-
Cancer Genome Atlas Research Network1
-
9
-
-
34547661993
-
Triple-negative breast cancer: clinical features and patterns of recurrence
-
Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, Lickley LA, Rawlinson E, Sun P, Narod SA (2007) Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 13(15 Pt 1):4429–4434. doi:10.1158/1078-0432.CCR-06-3045
-
(2007)
Clin Cancer Res
, vol.13
, Issue.15
, pp. 4429-4434
-
-
Dent, R.1
Trudeau, M.2
Pritchard, K.I.3
Hanna, W.M.4
Kahn, H.K.5
Sawka, C.A.6
Lickley, L.A.7
Rawlinson, E.8
Sun, P.9
Narod, S.A.10
-
10
-
-
0032736029
-
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
-
Dong H, Zhu G, Tamada K, Chen L (1999) B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 5(12):1365–1369. doi:10.1038/70932
-
(1999)
Nat Med
, vol.5
, Issue.12
, pp. 1365-1369
-
-
Dong, H.1
Zhu, G.2
Tamada, K.3
Chen, L.4
-
11
-
-
0036852241
-
Cancer immunoediting: from immunosurveillance to tumor escape
-
Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD (2002) Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 3(11):991–998. doi:10.1038/ni1102-991
-
(2002)
Nat Immunol
, vol.3
, Issue.11
, pp. 991-998
-
-
Dunn, G.P.1
Bruce, A.T.2
Ikeda, H.3
Old, L.J.4
Schreiber, R.D.5
-
12
-
-
84879901369
-
Comparison of basal-like triple-negative breast cancer defined by morphology, immunohistochemistry and transcriptional profiles
-
Gazinska P, Grigoriadis A, Brown JP, Millis RR, Mera A, Gillett CE, Holmberg LH, Tutt AN, Pinder SE (2013) Comparison of basal-like triple-negative breast cancer defined by morphology, immunohistochemistry and transcriptional profiles. Mod Pathol 26(7):955–966. doi:10.1038/modpathol.2012.244
-
(2013)
Mod Pathol
, vol.26
, Issue.7
, pp. 955-966
-
-
Gazinska, P.1
Grigoriadis, A.2
Brown, J.P.3
Millis, R.R.4
Mera, A.5
Gillett, C.E.6
Holmberg, L.H.7
Tutt, A.N.8
Pinder, S.E.9
-
13
-
-
34247381115
-
Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
-
Haffty BG, Yang Q, Reiss M, Kearney T, Higgins SA, Weidhaas J, Harris L, Hait W, Toppmeyer D (2006) Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. J Clin Oncol 24(36):5652–5657. doi:10.1200/JCO.2006.06.5664
-
(2006)
J Clin Oncol
, vol.24
, Issue.36
, pp. 5652-5657
-
-
Haffty, B.G.1
Yang, Q.2
Reiss, M.3
Kearney, T.4
Higgins, S.A.5
Weidhaas, J.6
Harris, L.7
Hait, W.8
Toppmeyer, D.9
-
14
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, Sosman JA, McDermott DF, Powderly JD, Gettinger SN, Kohrt HE, Horn L, Lawrence DP, Rost S, Leabman M, Xiao Y, Mokatrin A, Koeppen H, Hegde PS, Mellman I, Chen DS, Hodi FS (2014) Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 515(7528):563–567. doi:10.1038/nature14011
-
(2014)
Nature
, vol.515
, Issue.7528
, pp. 563-567
-
-
Herbst, R.S.1
Soria, J.C.2
Kowanetz, M.3
Fine, G.D.4
Hamid, O.5
Gordon, M.S.6
Sosman, J.A.7
McDermott, D.F.8
Powderly, J.D.9
Gettinger, S.N.10
Kohrt, H.E.11
Horn, L.12
Lawrence, D.P.13
Rost, S.14
Leabman, M.15
Xiao, Y.16
Mokatrin, A.17
Koeppen, H.18
Hegde, P.S.19
Mellman, I.20
Chen, D.S.21
Hodi, F.S.22
more..
-
15
-
-
84931094433
-
Is the future of personalized therapy in triple-negative breast cancer based on molecular subtype?
-
Le Du F, Eckhardt BL, Lim B, Litton JK, Moulder S, Meric-Bernstam F, Gonzalez-Angulo AM, Ueno NT (2015) Is the future of personalized therapy in triple-negative breast cancer based on molecular subtype? Oncotarget 6(15):12890–12908. doi:10.18632/oncotarget.3849
-
(2015)
Oncotarget
, vol.6
, Issue.15
, pp. 12890-12908
-
-
Le Du, F.1
Eckhardt, B.L.2
Lim, B.3
Litton, J.K.4
Moulder, S.5
Meric-Bernstam, F.6
Gonzalez-Angulo, A.M.7
Ueno, N.T.8
-
16
-
-
79960015997
-
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
-
Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA (2011) Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 121(7):2750–2767. doi:10.1172/JCI45014
-
(2011)
J Clin Invest
, vol.121
, Issue.7
, pp. 2750-2767
-
-
Lehmann, B.D.1
Bauer, J.A.2
Chen, X.3
Sanders, M.E.4
Chakravarthy, A.B.5
Shyr, Y.6
Pietenpol, J.A.7
-
17
-
-
84902582266
-
PD-L1 expression in triple-negative breast cancer
-
Mittendorf EA, Philips AV, Meric-Bernstam F, Qiao N, Wu Y, Harrington S, Su X, Wang Y, Gonzalez-Angulo AM, Akcakanat A, Chawla A, Curran M, Hwu P, Sharma P, Litton JK, Molldrem JJ, Alatrash G (2014) PD-L1 expression in triple-negative breast cancer. Cancer Immunol Res 2(4):361–370. doi:10.1158/2326-6066.CIR-13-0127
-
(2014)
Cancer Immunol Res
, vol.2
, Issue.4
, pp. 361-370
-
-
Mittendorf, E.A.1
Philips, A.V.2
Meric-Bernstam, F.3
Qiao, N.4
Wu, Y.5
Harrington, S.6
Su, X.7
Wang, Y.8
Gonzalez-Angulo, A.M.9
Akcakanat, A.10
Chawla, A.11
Curran, M.12
Hwu, P.13
Sharma, P.14
Litton, J.K.15
Molldrem, J.J.16
Alatrash, G.17
-
18
-
-
84886443514
-
CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients
-
Ott PA, Hodi FS, Robert C (2013) CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients. Clin Cancer Res 19(19):5300–5309. doi:10.1158/1078-0432.CCR-13-0143
-
(2013)
Clin Cancer Res
, vol.19
, Issue.19
, pp. 5300-5309
-
-
Ott, P.A.1
Hodi, F.S.2
Robert, C.3
-
19
-
-
84874376997
-
Molecular characterization of basal-like and non-basal-like triple-negative breast cancer
-
Prat A, Adamo B, Cheang MC, Anders CK, Carey LA, Perou CM (2013) Molecular characterization of basal-like and non-basal-like triple-negative breast cancer. Oncologist 18(2):123–133. doi:10.1634/theoncologist.2012-0397
-
(2013)
Oncologist
, vol.18
, Issue.2
, pp. 123-133
-
-
Prat, A.1
Adamo, B.2
Cheang, M.C.3
Anders, C.K.4
Carey, L.A.5
Perou, C.M.6
-
20
-
-
84946015377
-
High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer
-
Qin T, Zeng YD, Qin G, Xu F, Lu JB, Fang WF, Xue C, Zhan JH, Zhang XK, Zheng QF, Peng RJ, Yuan ZY, Zhang L, Wang SS (2015) High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer. Oncotarget 6(32):33972–33981. doi:10.18632/oncotarget.5583
-
(2015)
Oncotarget
, vol.6
, Issue.32
, pp. 33972-33981
-
-
Qin, T.1
Zeng, Y.D.2
Qin, G.3
Xu, F.4
Lu, J.B.5
Fang, W.F.6
Xue, C.7
Zhan, J.H.8
Zhang, X.K.9
Zheng, Q.F.10
Peng, R.J.11
Yuan, Z.Y.12
Zhang, L.13
Wang, S.S.14
-
21
-
-
84925002847
-
Prognostic and predictive value of PDL1 expression in breast cancer
-
Sabatier R, Finetti P, Mamessier E, Adelaide J, Chaffanet M, Ali HR, Viens P, Caldas C, Birnbaum D, Bertucci F (2015) Prognostic and predictive value of PDL1 expression in breast cancer. Oncotarget 6(7):5449–5464. doi:10.18632/oncotarget.3216
-
(2015)
Oncotarget
, vol.6
, Issue.7
, pp. 5449-5464
-
-
Sabatier, R.1
Finetti, P.2
Mamessier, E.3
Adelaide, J.4
Chaffanet, M.5
Ali, H.R.6
Viens, P.7
Caldas, C.8
Birnbaum, D.9
Bertucci, F.10
-
22
-
-
84901044976
-
In situ tumor PD-L1 mRNA expression is associated with increased TILs and better outcome in breast carcinomas
-
Schalper KA, Velcheti V, Carvajal D, Wimberly H, Brown J, Pusztai L, Rimm DL (2014) In situ tumor PD-L1 mRNA expression is associated with increased TILs and better outcome in breast carcinomas. Clin Cancer Res 20(10):2773–2782. doi:10.1158/1078-0432.CCR-13-2702
-
(2014)
Clin Cancer Res
, vol.20
, Issue.10
, pp. 2773-2782
-
-
Schalper, K.A.1
Velcheti, V.2
Carvajal, D.3
Wimberly, H.4
Brown, J.5
Pusztai, L.6
Rimm, D.L.7
-
23
-
-
84895779425
-
PD-L1 expression is increased in a subset of basal type breast cancer cells
-
Soliman H, Khalil F, Antonia S (2014) PD-L1 expression is increased in a subset of basal type breast cancer cells. PLoS ONE 9(2):e88557. doi:10.1371/journal.pone.0088557
-
(2014)
PLoS ONE
, vol.9
, Issue.2
-
-
Soliman, H.1
Khalil, F.2
Antonia, S.3
-
24
-
-
84859128199
-
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
-
Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, Chen S, Klein AP, Pardoll DM, Topalian SL, Chen L (2012) Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 4(127):127–137. doi:10.1126/scitranslmed.3003689
-
(2012)
Sci Transl Med
, vol.4
, Issue.127
, pp. 127-137
-
-
Taube, J.M.1
Anders, R.A.2
Young, G.D.3
Xu, H.4
Sharma, R.5
McMiller, T.L.6
Chen, S.7
Klein, A.P.8
Pardoll, D.M.9
Topalian, S.L.10
Chen, L.11
-
25
-
-
33846852187
-
Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy
-
Thompson RH, Dong H, Kwon ED (2007) Implications of B7-H1 expression in clear cell carcinoma of the kidney for prognostication and therapy. Clin Cancer Res 13(2 Pt 2):709s–715s. doi:10.1158/1078-0432.CCR-06-1868
-
(2007)
Clin Cancer Res
, vol.13
, Issue.2
, pp. 709-715
-
-
Thompson, R.H.1
Dong, H.2
Kwon, E.D.3
-
26
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, Leming PD, Spigel DR, Antonia SJ, Horn L, Drake CG, Pardoll DM, Chen L, Sharfman WH, Anders RA, Taube JM, McMiller TL, Xu H, Korman AJ, Jure-Kunkel M, Agrawal S, McDonald D, Kollia GD, Gupta A, Wigginton JM, Sznol M (2012) Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366(26):2443–2454. doi:10.1056/NEJMoa1200690
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
Powderly, J.D.7
Carvajal, R.D.8
Sosman, J.A.9
Atkins, M.B.10
Leming, P.D.11
Spigel, D.R.12
Antonia, S.J.13
Horn, L.14
Drake, C.G.15
Pardoll, D.M.16
Chen, L.17
Sharfman, W.H.18
Anders, R.A.19
Taube, J.M.20
McMiller, T.L.21
Xu, H.22
Korman, A.J.23
Jure-Kunkel, M.24
Agrawal, S.25
McDonald, D.26
Kollia, G.D.27
Gupta, A.28
Wigginton, J.M.29
Sznol, M.30
more..
-
27
-
-
84940000855
-
Hypermethylation of BRCA1 gene: implication for prognostic biomarker and therapeutic target in sporadic primary triple-negative breast cancer
-
Zhu X, Shan L, Wang F, Wang J, Shen G, Liu X, Wang B, Yuan Y, Ying J, Yang H (2015) Hypermethylation of BRCA1 gene: implication for prognostic biomarker and therapeutic target in sporadic primary triple-negative breast cancer. Breast Cancer Res Treat 150(3):479–486. doi:10.1007/s10549-015-3338-y
-
(2015)
Breast Cancer Res Treat
, vol.150
, Issue.3
, pp. 479-486
-
-
Zhu, X.1
Shan, L.2
Wang, F.3
Wang, J.4
Shen, G.5
Liu, X.6
Wang, B.7
Yuan, Y.8
Ying, J.9
Yang, H.10
|