Production of virus-like particles for vaccination

Methods in Molecular Biology

Volumn 1350, Issue , 2016, Pages 299-315

  Thompson, Christine M ^a   Aucoin, Marc G ^a   Kamen, Amine A ^a  

^a NONE

Author keywords

Baculovirus; Insect cells; Viral vector; Virus like particle; VLP

Indexed keywords

VIRUS LIKE PARTICLE VACCINE; VIRUS VECTOR;

BACULOVIRIDAE; DRUG DELIVERY SYSTEM; EXPRESSION VECTOR; INSECT CELL; NONHUMAN; VACCINATION; VIRUS LIKE AGENT; ANIMAL; BIOREACTOR; BIOSYNTHESIS; CELL CULTURE TECHNIQUE; ELECTRON MICROSCOPY; GENETIC ENGINEERING; GENETICS; IMMUNOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROCEDURES; SF9 CELL LINE; SPODOPTERA; STAINING; VIROLOGY;

ANIMALS; BACULOVIRIDAE; BIOREACTORS; CULTURE TECHNIQUES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENETIC ENGINEERING; MICROSCOPY, ELECTRON; SF9 CELLS; SPODOPTERA; STAINING AND LABELING; VACCINATION; VACCINES, VIRUS-LIKE PARTICLE;

EID: 84976215538     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-3043-2_14     Document Type: Chapter

References (43)

1. Vicente T, Roldão A, Peixoto C et al (2011) Large-scale production and purifi cation of VLP-based vaccines. J Invertebr Pathol 107: S42–S48
2. Roldão A, Mellado M, Castilho L et al (2010) Virus-like particles in vaccine development. Expert Rev Vaccines 9:1149–1176
3. Mena J, Kamen A (2011) Insect cell technology as a versatile and robust vaccine manufacturing platform. Expert Rev Vaccines 10:1063–1081
4. Zheng Y, Greenfi eld P, Reid S (1999) Optimized production of recombinant bluetongue core-like particles produced by the baculovirus expression system. Biotechnol Bioeng 65:600–604
5. Maranga L, Cruz P, Aunins J et al (2002) Production of core and virus-like particles with baculovirus infected cells. Adv Biochem Eng Biotechnol 74:183–206
6. Palomares L, Ramírez O (2009) Challenges for the production of virus-like particles in insect cells: the case of rotavirus-like particles. Biochem Eng J 45:158–167
7. Roldão A, Vieira H, Charpilienne A et al (2007) Modeling rotavirus-like particles production in a baculovirus expression vector system: infection kinetics, baculovirus DNA replication, mRNA synthesis and protein production. J Biotechnol 128:875–894
8. Palomares L, Lopez S, Ramirez O (2002) Strategies for manipulating the relative concentration of recombinant rotavirus structural proteins during simultaneous production by insect cells. Biotechnol Bioeng 78:635–644
9. Jiang B, Barniak V, Smith R et al (1998) Synthesis of rotavirus-like particles in insect cells: comparative and quantitative analysis. Biotechnol Bioeng 60:369–374
10. Park J, Kim H, Hwang H et al (2004) Large- scale production of rotavirus VLP as vaccine candidate using Baculovirus Expression Vector System (BEVS). J Microbiol Biotechnol 14: 35–40
11. Shelly D, Cleave V (2009) Parvovirus B19 VLP vaccine manufacturing. Genet Eng Biotechnol News 29:1–4
12. Tsao E, Mason M, Cacciuttolo M et al (1996) Production of parvovirus B19 vaccine in insect cells co-infected with double baculoviruses. Biotechnol Bioeng 49:130–138
13. Maranga L, Brazao T, Carrondo M (2003) Virus-like particle production at low multiplicities of infection with the baculovirus insect cell system. Biotechnol Bioeng 84:245–253
14. Maranga L, Cunha A, Clemente J et al (2004) Scale-up of virus-like particles production: effects of sparging, agitation and bioreactor scale on cell growth, infection kinetics and productivity. J Biotechnol 107:55–64
15. Maranga L, Rueda P, Antonis A et al (2002) Large scale production and downstream processing of a recombinant porcine parvovirus vaccine. Appl Microbiol Biotechnol 59:45–50
16. Cruz P, Maranga L, Carrondo M (2002) Integrated process optimization: lessons from retrovirus and virus-like particle production. J Biotechnol 99:199–214
17. Pillay S, Meyers A (2009) Optimization of chimeric HIV-1 virus-like-particle production in a baculovirus-insect cell expression system. Biotechnol Prog 25:1153–1160
18. Cruz P, Cunha A, Peixoto C et al (1998) Optimization of the production of virus-like particles in insect cells. Biotechnol Bioeng 60:408–418
19. Hu Y, Bentley W (2009) Enhancing yield of infectious bursal disease virus structural proteins in baculovirus expression systems: focus on media, protease inhibitors, and dissolved oxygen. Biotechnol Prog 15:1065–1071
20. Hu Y, Bentley W (2000) A kinetic and statistical- thermodynamic model for baculovirus infection and virus-like particle assembly in suspended insect cells. Chem Eng Sci 55: 3991–4008
21. Haynes J (2009) Infl uenza virus-like particle vaccines. Expert Rev Vaccines 8:435–445
22. Krammer F, Schinko T, Palmberger D et al (2010) Trichoplusia ni cells (High Five) are highly effi cient for the production of infl uenza A virus-like particles: a comparison of two insect cell lines as production platforms for infl uenza vaccines. Mol Biotechnol 45: 226–234
23. Sun Y, Carrion R Jr, Ye L et al (2009) Protection against lethal challenge by Ebola virus-like particles produced in insect cells. Virology 383:12–21
24. Sokolenko S, George S, Wagner A et al (2012) Co-expression vs. co-infection using baculovirus expression vectors in insect cell culture: benefi ts and drawbacks. Biotechnol Adv 30: 766–781
25. Haynes J, Dokken L, Wiley J et al (2009) Infl uenza-pseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian infl uenza challenge. Vaccine 27:530–541
26. Pushko P, Tumpey T, Bu F et al (2005) Infl uenza virus-like particles comprised of the HA, NA, and M1 proteins of H9N2 infl uenza virus induce protective immune responses in BALB/c mice. Vaccine 23:5751–5759
27. Ghosh S, Parvez K, Banerjee K et al (2000) Baculovirus as mammalian cell expression vector for gene therapy: an emerging strategy. Mol Ther 6:5–11
28. Urabe M, Ding C, Kotin R (2002) Insect cells as a factory to produce adeno-associated virus type 2 vectors. Hum Gene Ther 13:1935–1943
29. Meghrous J, Aucoin M, Jacob D et al (2005) Production of recombinant adeno-associated viral vectors using a baculovirus/insect cell suspension culture system: from shake fl asks to a 20-L bioreactor. Biotechnol Prog 21:154–160
30. Aucoin MG, Perrier M, Kamen AA (2006) Production of adeno-associated viral vectors in insect cells using triple infection: optimization of baculovirus concentration ratios. Biotechnol Bioeng 95:1081–1092
31. Aucoin MG, Perrier M, Kamen AA (2007) Improving AAV vector yield in insect cells by modulating the temperature after infection. Biotechnol Bioeng 97:1501–1509
32. Kamen AA, Bédard C, Tom R et al (1996) On-line monitoring of respiration in recombinant- baculovirus-infected and uninfected insect cell bioreactor cultures. Biotechnol Bioeng 50:36–48
33. Latham T, Galarza JM (2001) Formation of wild-type and chimeric infl uenza virus-like particles following simultaneous expression of only four structural proteins. Society 75: 6154–6165
34. Peixoto CC, Sousa MFQ, Silva AC et al (2007) Downstream processing of triple layered rotavirus like particles. J Biotechnol 127:452–461
35. Aucoin MG, Mena JA, Kamen AA (2010) Bioprocessing of baculovirus vectors: a review. Curr Gene Ther 10:174–186
36. Pushko P, Pearce MB, Ahmad A et al (2011) Infl uenza virus-like particle can accommodate multiple subtypes of hemagglutinin and protect from multiple infl uenza types and subtypes. Vaccine 29:5911–5918
37. Chahal PS, Aucoin MG, Kamen AA (2007) Primary recovery and chromatographic purifi cation of adeno-associated virus type 2 produced by baculovirus/insect cell system. J Virol Methods 139:61–70
38. Aucoin MG, Perrier M, Kamen AA (2008) Critical assessment of current adeno-associated viral vector production and quantifi cation methods. Biotechnol Adv 26:73–88
39. Mena JA, Aucoin MG, Montes J et al (2010) Improving adeno-associated vectorar G et al (2008) Universal antibodies and their applications to the quantitative determination of vi yield in high density insect cell cultures. J Gene Med 12:157–167
40. Ishizu K, Watanabe H, Han S et al (2001) Roles of disulfi de linkage and calcium ion- mediated interactions in assembly and disassembly of virus-like particles composed of simian virus 40 VP1 capsid protein roles of disulfi de linkage and calcium ion-mediated interactions in assembly and disassembly of virus-like particles composed of simian virus 40 VP1 capsid protein. J Virol 75:61–72
41. Chun S, Li C, Van Domselartually all subtypes of the infl uenza a viral hemagglutinins. Vaccine 26:6068–6076
42. Alain R, Nadon F, Séguin C et al (1987) Rapid virus subunit visualization by direct sedimentation of samples on electron microscope grids. J Virol Methods 16:209–216
43. Goldsmith CS, Miller SE (2009) Modern uses of electron microscopy for detection of viruses. Clin Microbial Rev 22:552–563