Enhancing yield of infectious bursal disease virus structural proteins in baculovirus expression systems: Focus on media, protease inhibitors, and dissolved oxygen

Biotechnology Progress

Volumn 15, Issue 6, 1999, Pages 1065-1071

  Hu, Yu Chen ^a,b   Bentley, William E ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; BACULOVIRUS EXPRESSION SYSTEM; BENZYLSULFONYL FLUORIDE; BIOREACTOR; CELL GROWTH; CULTURE MEDIUM; DISSOLVED OXYGEN; EDETIC ACID; ENZYME INHIBITOR; LEUPEPTIN; PEPSTATIN; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; PROTEINASE; REOVIRUS; VIRUS PROTEIN;

ANIMAL CELL CULTURE; BIODEGRADATION; BIOREACTORS; DISEASES; ENZYME INHIBITION; OXYGEN; VIRUSES;

INFECTIOUS BURSAL DISEASE VIRUS (IBDV);

BIOTECHNOLOGY;

ANIMALS; BACULOVIRIDAE; CELL CULTURE TECHNIQUES; CELL DIVISION; CELL LINE; CULTURE MEDIA, SERUM-FREE; INFECTIOUS BURSAL DISEASE VIRUS; POULTRY; RECOMBINANT PROTEINS; SPODOPTERA; TRANSFECTION; VIRAL STRUCTURAL PROTEINS;

ANIMALIA; INFECTIOUS BURSAL DISEASE VIRUS; INSECTA; REOVIRUS SP.; UNIDENTIFIED BACULOVIRUS;

EID: 0033231460     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp990094k     Document Type: Article

References (35)

1. Azad, A. A.; Barrett, S. A.; Fahey, K. J. The characterization and molecular cloning of the double-stranded RNA genome of an Australian strain of infectious bursal disease virus. Virology 1985, 143, 35-44.
2. Bentley, W. E.; Wang, M.-Y.; Vakharia, V. N. Development of an efficient bioprocess for poultry vaccines using high-density insect cell culture. Ann. N.Y. Acad. Sci. 1994, 745, 336-359.
3. Bentley, W. E.; Kebede, B.; Franey, T.; Wang, M.-Y. Segregated characterization of recombinant epoxide hydrolase synthesis via the baculovirus/insect cell expression system. Chem. Eng. Sci. 1994, 49, 4133-4141.
4. De Gooijer, C. D.; Koken, R. H. M.; van Lier, F. L. J.; Kool, M.; Vlak, J. M.; Tramper, J. A structured dynamic model for the baculovirus infection process in insect-cell reactior configurations. Biotechnol. Bioeng. 1992, 40, 537-548.
5. Malinowski, J. J.; Daugulis, A. J. Bioreactor design for insect cell cultivation: a review. In Insect cell culture engineering; Goosen, M. F. A., Daugulis, A. J., Faulker, P., Eds.; Marcel Dekker: New York, 1993; pp 51-67.
6. Gottesman, S.; Maurizi, M. R. Regulation by proteolysis: energy-dependent proteases and their targets. Microbiol. Rev. 1992, 56, 592-621.
7. Hu, Y.-C.; Bentley, W. E. A statistics and thermodynamics-based model for the baculovirus infection and the virus-like particle assembly. Submitted to Chem. Eng. Sci.
8. Hu, Y.-C.; Bentley, W. E.; Edwards, G. H.; Vakharia, V. N. Chimeric infectious bursal disease virus-like particles expressed in insect cells and purified by immobilized metal affinity chromatography. Biotechnol. Bioeng. 1999, 63, 721-729.
9. Jiang, B.; Barniak, V.; Smith, R. P.; Sharma, R.; Corsaro, B.; Hu, B.; Madore, H. P. Synthesis of rotavirus-like particles in insect cells: Comparative and quantitative analysis. Biotechnol. Bioeng. 1998, 60, 369-374.
10. Kamen, A. A.; Tom, R. L.; Caron, A. W.; Chavarie, C.; Massie, B.; Archambault, J. Culture of insect cells in a helical ribbon impeller bioreactor. Biotechnol. Bioeng. 1991, 38, 619-628.
11. Li, T.-C.; Yamakawa, Y.; Suzuki, K.; Tatsumi, M.; Razak, M. A. A.; Uchida, T.; Takeda, N.; Miyamura, T. Expression and self-assembly of empty virus-like particles of hepatitis E virus. J. Virol. 1997, 71, 7207-7213.
12. Licari, P.; Bailey, J. E. Modeling the population dynamics of baculovirus infected insect cells: optimizing infection strategies for enhanced recombinant protein yields. Biotechnol. Bioeng. 1992, 30, 432-441.
13. Lindsay, D. A.; Betenbaugh, M. J. Quantification of cell culture factors affecting recombinant protein yields in baculovirus-infected insect cells. Biotechnol. Bioeng. 1992, 39, 614-618.
14. Maiorella, B.; Inlow, D.; Shauger, A.; Harano, D. Large-scale insect cell-culture for recombinant for recombinant protein production. Bio / Technology 1988, 6, 1406-1410.
15. Murhammer, D. W.; Goochee, C. F. Scale-up of insect cell cultures: protective effects of pluronic F-68. Bio / Technology 1988, 6, 1411-1418.
16. Naggie, S.; Bentley, W. E. Appearance of protease activities coincides with p10 and polyhedrin-driven protein production in the baculovirus expression system: effects on yield. Biotechnol. Prog. 1998, 14, 227-232.
17. Naggie, S.; Hu, Y.-C.; Pulliam-Holoman, T. R.; Bentley, W. E. Substrate (gelatin) gel electrophoretic method for analysis of protease activity in insect (Sf-9) cells. Biotechnol. Tech. 1997, 11, 297-300.
18. O'Reilly, D.; Miller, L.; Luckow, V. Baculovirus expression vectors; W. H. Freeman and Co.: New York, 1992; pp 124-138.
19. Pyle, L. E.; Barton, P.; Fujiwara, Y.; Mitchell A.; Fidge, N. Secretion of biologically active human proapolipoprotein A-1 in a baculovirus-insect cell system: protection from degradation by protease inhibitors. J. Lipid Res. 1995, 36, 2355-2361.
20. Ruggli, N.; Moser, C.; Mitchell, D.; Hofmann, M.; Tratschin. Baculovirus expression and affinity purification of protein E2 of classical swine fever virus strain Alfort/187. Virus Genes 1995, 10, 115-126.
21. Slack, J. M.; Kuzio, J.; Faulkner, P. Characterization of v-cath, a cathepsin L-like proteinase expressed by the baculovirus Autographa californica multiple nuclear polyhedrosis virus. J. Gen. Virol. 1995, 76, 1091-1098.
22. Taticek, R. A.; Shuler, M. L. Effect of elevated oxygen and glutamine levels on foreign protein production at high cell densities using the insect cell-baculovirus expression system. Biotechnol. Bioeng. 1997, 54, 142-152.
23. Tsao, E.; Mason, M.; Cacciuttolo, M.; Bowen, S.; Wassweman, G. Production of parvovirus B19 vaccine in insect cells co-infected with double baculovirus. Biotechnol. Bioeng. 1996, 49, 130-138.
24. Urakawa, T.; Ferguson, M.; Minor, P.; Cooper, J. Synthesis of immunogenic, but noninfectious poliovirus particles in insect cells by a baculovirus expression vector. J. Gen. Virol. 1989, 70, 1453-1463.
25. Vakharia, V. N. Development of recombinant vaccines against infectious bursal disease. Biotechnol. Annu. Rev. 1997, 3, 151-168.
26. Vakharia, V. N.; Snyder, D. B.; He, J.; Edwards, G. H.; Savage, P. K.; Mengel-Whereat, S. A. Infectious bursal disease virus structural proteins expressed in a baculovirus recombinant confer protection in chickens. J. Gen. Virol. 1993, 74, 1201-1206.
27. Vakharia, V. N.; Snyder, D. B.; Lütticken, D.; Mengel-Whereat, S. A.; Savage, P. K.; Edwards, G. H.; Goodwin, M. A. Active and passive protection against variant and classic infectious bursal disease virus strains induced by baculovirus-expressed structural proteins. Vaccine 1994, 12, 452-456.
28. Wang, M.-Y.; Bentley, W. E.; Vakharia, V. N. Purification of a recombinant protein produced in a baculovirus expression system by immobilized metal affinity chromatography. Biotechnol. Bioeng. 1994, 43, 349-356.
29. Wang, M.-Y.; Kwong, S.; Bentley, W. E. Effects of oxygen/ glucose/glutamine feeding on insect cell baculovirus protein expression: a study on epoxide hydrolase production. Biotechnol. Prog. 1993, 9, 355-361.
30. Wang, M.-Y.; Pulliam, T. R.; Valle, M.; Vakharia, V. N.; Bentley, W. E. Kinetic analysis of alkaline protease activity, recombinant protein production and metabolites for infected insect (Sf-9) cells under different DO levels. J. Biotechnol. 1996, 46, 243-254.
31. Wang, M.-Y.; Wester, K.; Bentley, W. E. Glutamine determination in insect cell culture media. Biotechnol. Tech. 1993, 7, 841-846.
32. Wang, M.-Y.; Vakharia; V. N.; Bentley, W. E. Expression of epoxide hydrolase in insect cells: a focus on the infected cell. Biotechnol. Bioeng. 1993, 42, 240-246.
33. Wu, J.; King, G.; Daugulis A. J.; Faulkner, P.; Bone, D. H.; Goosen, M. F. A. Engineering aspects of insect cell suspension culture. Appl. Microbiol. Biotechnol. 1989, 32, 249-255.
34. Yang J. D.; Gecik, P.; Collins, A.; Czarnecki, S.; Hsu, H. H.; Lasdun, A.; Sundaram, R.; Muthukumar, G.; Silberklang, M. Rational scale-up of a baculovirus-insect cell batch process based on medium nutritional depth. Biotechnol. Bioeng. 1996, 52, 696-706.
35. Zhang, J.; Kalogerakis, N.; Behie, L. A.; Iatrou, K. A two-stage bioreactor system for the production of recombinant proteins using a genetically engineered baculovirus/insect cell system. Biotechnol. Bioeng. 1993, 42, 357-366.