Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms

Antioxidants and Redox Signaling

Volumn 24, Issue 18, 2016, Pages 1058-1071

  Brennan, Melanie S ^a,b   Patel, Hiral ^a   Allaire, Norm ^a   Thai, Alice ^a   Cullen, Patrick ^a   Ryan, Sarah ^a   Lukashev, Matvey ^a   Bista, Pradeep ^a   Huang, Ron ^a   Rhodes, Kenneth J ^a   Scannevin, Robert H ^a  

^a BIOGEN   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR 6; FUMARIC ACID DIMETHYL ESTER; GLUTAMATE CYSTEINE LIGASE; GROWTH DIFFERENTIATION FACTOR 15; HEME OXYGENASE 1; NEUROPILIN; RETINOL BINDING PROTEIN 4; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; NFE2L2 PROTEIN, MOUSE; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENE ONTOLOGY; GENETIC TRANSCRIPTION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE DRUG DOSE; TISSUE SPECIFICITY; ANIMAL; ANTIBODY SPECIFICITY; BRAIN; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; KNOCKOUT MOUSE; METABOLISM; ORAL DRUG ADMINISTRATION; PRECLINICAL STUDY; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; DIMETHYL FUMARATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; ORGAN SPECIFICITY; TISSUE DISTRIBUTION; TRANSCRIPTOME;

EID: 84975883336     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2015.6622     Document Type: Article

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