Lithium distinctly modulates the secretion of pro-and anti-inflammatory interleukins in co-cultures of neurons and glial cells at therapeutic and sub-therapeutic concentrations

Current Alzheimer Research

Volumn 13, Issue 8, 2016, Pages 848-852

  De Paula, Vanessa J ^a   Kerr, Daniel S ^a   Scola, Gustavo ^b   Gattaz, Wagner F ^a   Forlenza, Orestes V ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Co culture; Cortical neurons; Hippocampal neurons; Lithium; Neuroprotection pro and anti inflammatory interleukins

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LITHIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; CENTRAL NERVOUS SYSTEM AGENTS; INTERLEUKIN DERIVATIVE; LITHIUM DERIVATIVE;

ANIMAL CELL; ARTICLE; BRAIN CELL CULTURE; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; EMBRYO; FEMALE; GLIA CELL; GLIAL CELL CULTURE; HIPPOCAMPAL NEURONAL CULTURE; LONG TERM CARE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN CORTEX; CELL CULTURE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; GLIA; HIPPOCAMPUS; IMMUNOLOGY; NERVE CELL; PRECLINICAL STUDY; SECRETION (PROCESS); WISTAR RAT;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM AGENTS; CEREBRAL CORTEX; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HIPPOCAMPUS; INTERLEUKINS; LITHIUM COMPOUNDS; NEUROGLIA; NEURONS; RATS, WISTAR;

EID: 84975701775     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205013666160219112612     Document Type: Article

References (27)

1. Deverman BE, Patterson PH. Cytokines and CNS Development. Neuron 64 (1): 61-78 (2009).
2. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136 (7): 2348-57 (1986).
3. Forlenza O V, De-Paula VJR, Diniz BSO. Neuroprotective effects of lithium: implications for the treatment of Alzheimer’s disease and related neurodegenerative disorders. ACS Chem Neurosci 5(6): 443-50 (2014).
4. Beurel E, Michalek SM, Jope RS. Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3). Trends Immunol 31 (1): 24-31 (2010).
5. Rapaport MH, Manji HK. The effects of lithium on ex vivo cytokine production. Biol Psychiatry 50 (3): 217-24 (2001).
6. Szuster-Ciesielska A, Tustanowska-Stachura A, Słotwińska M, Marmurowska-Michałowska H, Kandefer-Szerszeń M. In vitro immunoregulatory effects of antidepressants in healthy volunteers. Pol J Pharmacol 55 (3): 353-362 (2003).
7. Bhalla US, Iyengar R. Emergent properties of networks of biological signaling pathways. Science 283 381-387 (1999).
8. Bourne HR, Nicoll R. Molecular machines integrate coincident synaptic signals. Cell 72: 65-75 (1993).
9. Quiroz JA, Machado-Vieira R, Zarate CA, Manji HK. Novel insights into lithium’s mechanism of action: neurotrophic and neuroprotective effects. Neuropsychobiology 62 (1): 50-60 (2010).
10. Li H, Li Q, Du X, Sun Y, Wang X, Kroemer G, et al. Lithiummediated long-term neuroprotection in neonatal rat hypoxiaischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem/progenitor cells. J Cereb Blood Flow Metab 31 (10): 2106-15 (2011).
11. Garay PA, McAllister AK. Novel roles for immune molecules in neural development: implications for neurodevelopmental disorders. Front Synaptic Neurosci 2: 136 (2010).
12. Srinivasan D, Yen J-H, Joseph DJ, Friedman W. Cell type-specific interleukin-1beta signaling in the CNS. J Neurosci 24 (29): 6482-6488 (2004).
13. Farrar WL, Hill JM, Harel-Bellan A, Vinocour M. The immune logical brain. Immunol Rev 100: 361-378 (1987).
14. Vitkovic L, Konsman JP, Bockaert J, Dantzer R, Homburger V, Jacque C. Cytokine signals propagate through the brain. Mol Psychiatry 5(6): 604-615 (2000).
15. Morale MC, Gallo F, Tirolo C, Testa N, Caniglia S, Marletta N, et al. Neuroendocrine-immune (NEI) circuitry from neuron-glial interactions to function: Focus on gender and HPA-HPG interactions on early programming of the NEI system. Immunol Cell Biol 79 (4): 400-417 (2001).
16. Yirmiya R, Goshen I. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun 25 (2): 181-213 (2011).
17. Basu S, Larsson A, Vessby J, Vessby B, Berne C. Type 1 diabetes is associated with increased cyclooxygenase-and cytokinemediated inflammation. Diabetes Care 28 (6): 1371-1375 (2005).
18. Sorce S, Myburgh R, Krause K-H. The chemokine receptor CCR5 in the central nervous system. Prog Neurobiol 93 (2): 297-311 (2011).
19. Veenstra M, Ransohoff RM. Chemokine receptor CXCR2: physiology regulator and neuroinflammation controller? J Neuroimmunol 246 (1-2): 1-9 (2012).
20. Shi M, Majumdar D, Gao Y, Brewer BM, Goodwin CR, McLean JA, et al. Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts. Lab Chip 13 (15): 3008-3021 (2013).
21. McAfoose J, Baune BT. Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev 33 (3): 355-366 (2009).
22. Kaur C, Sivakumar V, Zou Z, Ling E-A. Microglia-derived proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta induce Purkinje neuronal apoptosis via their receptors in hypoxic neonatal rat brain. Brain Struct Funct 219(1): 151-170 (2014).
23. Perez-Asensio FJ, Perpina U, Planas AM, Pozas E. Interleukin-10 regulates progenitor differentiation and modulates neurogenesis in adult brain. J Cell Sci 126 (Pt 18): 4208-19 (2013).
24. Goshen I, Kreisel T, Ounallah-Saad H, Renbaum P, Zalzstein Y, Ben-Hur T, et al. A dual role for interleukin-1 in hippocampaldependent memory processes. Psychoneuroendocrinology 32 (8-10): 1106-1115 (2007).
25. Monje ML, Toda H, Palmer TD. Inflammatory blockade restores adult hippocampal neurogenesis. Science 302 (5651): 1760-1765 (2003).
26. Kiyota T, Okuyama S, Swan RJ, Jacobsen MT, Gendelman HE, Ikezu T. CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer’s disease-like pathogenesis in APP+PS1 bigenic mice. FASEB J 24 (8): 3093-3102 (2010).
27. Stellwagen D, Malenka RC. Synaptic scaling mediated by glial TNF-alpha. Nature 440 (7087): 1054-1059 (2006).