Microglia-derived proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta induce Purkinje neuronal apoptosis via their receptors in hypoxic neonatal rat brain

Brain Structure and Function

Volumn 219, Issue 1, 2014, Pages 151-170

  Kaur, Charanjit ^a   Sivakumar, Viswanathan ^a   Zou, Zhirong ^b   Ling, Eng Ang ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Activated microglia; Hypoxia; Hypoxia inducible factor 1 ; Nitric oxide; Proinflammatory cytokines; Purkinje neurons; TNF IL 1 receptors

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LECTIN; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; APOPTOSIS; ARTICLE; BRAIN HYPOXIA; CELLULAR DISTRIBUTION; CEREBELLUM; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOCOMPETENT CELL; IMMUNOFLUORESCENCE; MICROGLIA; NEWBORN; NICK END LABELING; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PURKINJE CELL; RAT; SERODIAGNOSIS;

RATTUS;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ANTIBODIES; ANTIGENS, CD11B; APOPTOSIS; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOXIA, BRAIN; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IN SITU NICK-END LABELING; INTERLEUKIN-1BETA; LECTINS; MICROGLIA; NITRIC OXIDE; PURKINJE CELLS; RATS; RATS, WISTAR; RECEPTORS, CYTOKINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84892373577     PISSN: 18632653     EISSN: 18632661     Source Type: Journal    
DOI: 10.1007/s00429-012-0491-5     Document Type: Article

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