Chemical Reactivity and Respiratory Toxicity of the α-Diketone Flavoring Agents

Toxicologic Pathology

Volumn 44, Issue 5, 2016, Pages 763-783

  Morgan, Daniel L ^a   Jokinen, Micheal P ^b   Johnson, Crystal L ^c   Price, Herman C ^d   Gwinn, William M ^a   Bousquet, Ronald W ^d   Flake, Gordon P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b INTEGRATED LABORATORY SYSTEMS   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

^d ALION SCIENCE AND TECHNOLOGY   (United States)

Author keywords

2,3 butanedione (diacetyl); 2,3 hexanedione (acetyl butyryl); 2,3 pentanedione (acetyl propionyl); fibrosis; flavoring agents; obliterative bronchiolitis; pulmonary function

Indexed keywords

1,2 DICARBONYL DERIVATIVE; 2,3 BUTANEDIONE; 2,3 HEXANEDIONE; ACETYLACETONE; HEXANE; UNCLASSIFIED DRUG; 2,3-HEXANEDIONE; 2,3-PENTANEDIONE; ALKANONE; FLAVORING AGENT;

ANIMAL EXPERIMENT; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; FIBROSING ALVEOLITIS; HISTOPATHOLOGY; LUNG FUNCTION; LUNG PARENCHYMA; LUNG TOXICITY; LUNG WEIGHT; MALE; NONHUMAN; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RAT; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; EXPOSURE; LUNG; PATHOLOGY;

ANIMALS; DIACETYL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVORING AGENTS; HEXANONES; INHALATION EXPOSURE; LUNG; MALE; PENTANONES; RATS;

EID: 84975497006     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623316638962     Document Type: Article

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