Magnetic targeted drug delivery carriers encapsulated with pH-sensitive polymer: synthesis, characterization and in vitro doxorubicin release studies

Journal of Biomaterials Science, Polymer Edition

Volumn 27, Issue 13, 2016, Pages 1303-1316

  Wu, Juan ^a   Shen, Yueqing ^a   Jiang, Wei ^a   Shen, Yewen ^a  

^a NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

doxorubicin; drug release; Fe3O4 nanoparticles; pH sensitive; poly(acrylic acid)

Indexed keywords

ACRYLICS; CARBOXYLIC ACIDS; CONTROLLED DRUG DELIVERY; DISEASES; DRUG PRODUCTS; IRON OXIDES; MAGNETITE; MEDICAL APPLICATIONS; NANOMAGNETICS; NANOPARTICLES; ONCOLOGY; PH SENSORS; TUMORS;

DOXORUBICIN; DRUG RELEASE; FE3O4 NANOPARTICLES; PH SENSITIVE; POLY(ACRYLIC ACID );

TARGETED DRUG DELIVERY;

DOXORUBICIN; DRUG CARRIER; MAGNETIC NANOPARTICLE; POLYACRYLIC ACID; POLYMER; ACRYLIC ACID RESIN; ANTINEOPLASTIC AGENT; CARBOPOL 940; EXCIPIENT; MAGNETITE NANOPARTICLE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; MCF 7 CELL LINE; MTT ASSAY; PARTICLE SIZE; PH; PRIORITY JOURNAL; STATIC ELECTRICITY; SYNTHESIS; UMBILICAL VEIN ENDOTHELIAL CELL; CELL SURVIVAL; CHEMISTRY; MCF-7 CELL LINE; SURFACE PROPERTY;

ACRYLIC RESINS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; DRUG LIBERATION; EXCIPIENTS; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNETITE NANOPARTICLES; MCF-7 CELLS; PARTICLE SIZE; STATIC ELECTRICITY; SURFACE PROPERTIES;

EID: 84975452033     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1080/09205063.2016.1195159     Document Type: Article

References (33)

1. T.López, E.Ortiz-Islas, P.Guevara,. Release of copper complexes from a nanostructured sol-gel titania for cancer treatment. J. Mater. Sci. 2015;50:2410–2421.10.1007/s10853-014-8796-9
2. S.Nie, Y.Xing, G.J.Kim,. Nanotechnology applications in cancer. Annu. Rev. Biomed. Eng. 2007;9:257–288.10.1146/annurev.bioeng.9.060906.152025
3. S.Sahu, R.K.Dutta. Novel hybrid nanostructured materials of magnetite nanoparticles and pectin. J. Magn. Magn. Mater. 2011;323:980–987.10.1016/j.jmmm.2010.11.085
4. C.Xu, S.Sun. Monodisperse magnetic nanoparticles for biomedical applications. Polym. Int. 2007;56:821–826.10.1002/(ISSN)1097-0126
5. N.Ahmed, H.Fessi, A.Elaissari. Theranostic applications of nanoparticles in cancer. Drug Discovery Today. 2012;17:928–934.10.1016/j.drudis.2012.03.010
6. N.Ahmed, M.Michelin-Jamois, H.Fessi,. Modified double emulsion process as a new route to prepare submicron biodegradable magnetic/polycaprolactone particles for in vivo theranostics. Soft Matter. 2012;8:2554–2564.10.1039/c2sm06872a
7. H.W.Sun, L.Y.Zhang, X.J.Zhu,. Magnetic poly(pegma–maa) nanoparticles: photochemical preparation and potential application in drug delivery. J. Biomater. Sci. Polym. Ed. 2009;20:1675–1686.10.1163/156856208X386264
8. D.Dorniani, A.U.Kura, M.Hussein,. Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications. J. Mater. Sci. 2014;49:8487–8497.10.1007/s10853-014-8559-7
9. R.M.Ferguson, K.R.Minard, K.M.Krishnan. Optimization of nanoparticle core size for magnetic particle imaging. J. Magn. Magn. Mater. 2009;321:1548–1551.10.1016/j.jmmm.2009.02.083
10. N.Ahmed, C.Jaafar-Maalej, M.M.Eissa,. New oil-in-water magnetic emulsion as contrast agent for in vivo magnetic resonance imaging (MRI). J. Biomed. Nanotechnol. 2013;9:1579–1585.10.1166/jbn.2013.1644
11. C.Sun, K.Du, C.Fang,. PEG-mediated synthesis of highly dispersive multifunctional superparamagnetic nanoparticles: their physicochemical properties and function in vivo. ACS Nano. 2010;4:2402–2410.10.1021/nn100190v
12. Y.Bae, N.Nishiyama, S.Fukushima,. Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. Bioconjugate Chem. 2005;16:122–130.10.1021/bc0498166
13. 4-OA-g-P(OA-co-NIPAAm) magnetomicelles. J. Biomater. Sci. Polym. Ed. 2008;19:1249–1259.10.1163/156856208785540109
14. J.Zhou, H.Fa, W.Yin,. Synthesis of superparamagnetic iron oxide nanoparticles coated with a DDNP-carboxyl derivative for in vitro magnetic resonance imaging of Alzheimer’s disease. Mater. Sci. Eng. C. 2014;37:348–355.10.1016/j.msec.2014.01.005
15. 4 nanoparticles. Appl. Surf. Sci. 2014;303:425–432.10.1016/j.apsusc.2014.03.018
16. 4 magnetic microspheres formed by self-assembly of nanocrystals and their applications. Mater. Res. Bull. 2013;48:895–900.10.1016/j.materresbull.2012.11.078
17. X.W.Ding, Y.Liu, J.H.Li,. Hydrazone-bearing PMMA-functionalized magnetic nanocubes as pH-responsive drug carriers for remotely targeted cancer therapy in vitro and in vivo. ACS Appl. Mater. Interfaces. 2014;6:7395–7407.10.1021/am500818m
18. A.K.Gupta, M.Gupta. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials. 2005;26:3995–4021.10.1016/j.biomaterials.2004.10.012
19. H.Zhao, Z.Li, B.Yang,. Synthesis of dual-functional targeting probes for cancer theranostics based on iron oxide nanoparticles coated by centipede-like polymer connected with pH-responsive anticancer drug. J. Biomater. Sci. Polym. Ed. 2015;26:1178–1189.10.1080/09205063.2015.1080900
20. A.Escudero, M.E.Calvo, S.Rivera-Fernández,. Microwave-assisted synthesis of biocompatible europium-doped calcium hydroxyapatite and fluoroapatite luminescent nanospindles functionalized with poly(acrylic acid). Langmuir. 2013;29:1985–1994.10.1021/la304534f
21. O.Moscoso-Londoño, J.S.Gonzalez, D.Muraca,. Structural and magnetic behavior of ferrogels obtained by freezing thawing of polyvinylalcool/poly(acrylic acid) (PAA)-coated iron oxide nanoparticles. Eur. Polym. J. 2013;49:279–289.10.1016/j.eurpolymj.2012.11.007
22. A.Hajdú, M.Szekeres, I.Y.Tóth,. Enhanced stability of polyacrylate-coated magnetite nanoparticles in biorelevant media. Colloids Surf. B. 2012;94:242–249.10.1016/j.colsurfb.2012.01.042
23. L.E.Gerweck, K.Seetharaman. Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res. 1996;56:1194–1198.
24. Z.Tian, A.Y.Zhang, L.Ye,. Preparation and evaluation of a linoleic-acid-modified amphiphilic polypeptide copolymer as a carrier for controlled drug release. Biomed. Mater. 2008;3:4855–4863.
25. J.Wu, Y.Wang, W.Jiang,. Synthesis and characterization of recyclable clusters of magnetic nanoparticles as doxorubicin carriers for cancer therapy. Appl. Surf. Sci. 2014;321:43–49.
26. S.J.Guo, D.Li, L.X.Zhang,. Monodisperse mesoporous superparamagnetic single-crystal magnetite nanoparticles for drug delivery. Biomaterials. 2009;30:1881–1889.10.1016/j.biomaterials.2008.12.042
27. K.Petcharoen, A.Sirivat. Synthesis and characterization of magnetite nanoparticles via the chemical co-precipitation method. Mater. Sci. Eng. B. 2012;177:421–427.10.1016/j.mseb.2012.01.003
28. 4 (M = Fe, Co, Mn) nanoparticles. J. Am. Chem. Soc. 2004;126:273–279.10.1021/ja0380852
29. B.Gaihre, M.Khil, D.Lee,. Gelatin-coated magnetic iron oxide nanoparticles as carrier system: drug loading and in vitro drug release study. Int. J. Pharm. 2009;365:180–189.10.1016/j.ijpharm.2008.08.020
30. F.M.Kievit, F.Y.Wang, C.Fang,. Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro. J. Controlled Release. 2011;152:76–83.10.1016/j.jconrel.2011.01.024
31. T.Fan, M.Li, X.Wu,. Preparation of thermoresponsive and pH-sensitivity polymer magnetic hydrogel nanospheres as anticancer drug carriers. Colloids Surf. B. 2011;88:593–600.10.1016/j.colsurfb.2011.07.048
32. J.Varshosaz, H.Sadeghi-aliabadi, S.Ghasemi,. Use of magnetic folate-dextran-retinoic acid micelles for dual targeting of doxorubicin in breast cancer. Biomed. Res. Int. 2013;1:680712.
33. H.S.Yoo, T.G.Park. Folate-receptor-targeted delivery of doxorubicin nano-aggregates stabilized by doxorubicin-PEG-folate conjugate. J. Controlled Release. 2004;100:247–256.10.1016/j.jconrel.2004.08.017