A novel MIR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy

Cell Death and Disease

Volumn 6, Issue 10, 2015, Pages

  d'Avenia, M ^a,b   Citro, R ^c   Marco, M De ^a   Veronese, A ^d   Rosati, A ^a   Visone, R ^d   Leptidis, S ^e   Philippen, L ^e   Vitale, G ^c   Cavallo, A ^c   Silverio, A ^c   Prota, C ^c   Gravina, P ^f   De Cola, Antonella ^d   Carletti, E ^d   Coppola, G ^c   Gallo, S ^c   Provenza, G ^g   Bossone, E ^c   Piscione, F ^c   Hahne, M ^h   Windt, Lj De ^e,i   Turco, M C ^a   Laurenzi, V De ^a,d,j   more..

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c UNIVERSITY HOSPITAL SAN GIOVANNI DI DIO E RUGGI D ARAGONA   (Italy)

^d UNIVERSITY OF CHIETI   (Italy)

^e MAASTRICHT UNIVERSITY   (Netherlands)

^f UNIVERSITY OF ROME TOR VERGATA   (Italy)

^g Division of Cardiology San Francesco d'Assisi   (Italy)

^h INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

ⁱ MAASTRICHT UNIVERSITY   (Netherlands)

^j Dipartimento di Scienze Mediche   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ARGONAUTE 2 PROTEIN; BCL2 ASSOCIATED ATHANOGENE 3 PROTEIN; CHAPERONE; MESSENGER RNA; MICRORNA; MICRORNA 371A 5P; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEOTIDE; PROTEIN; RNA BINDING PROTEIN; RNA INDUCED SILENCING COMPLEX; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BAG3 PROTEIN, HUMAN; EPINEPHRINE; MIRN371 MICRORNA, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

3' UNTRANSLATED REGION; ADRENALIN RELEASE; ADULT; AGED; ARTICLE; CARDIAC MUSCLE CELL; CARDIAC PATIENT; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; MAJOR CLINICAL STUDY; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN RNA BINDING; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TAKOTSUBO CARDIOMYOPATHY; UPREGULATION; DRUG EFFECTS; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS REGULATORY PROTEINS; EPINEPHRINE; FEMALE; HUMANS; MICRORNAS; MUTATION; MYOCYTES, CARDIAC; TAKOTSUBO CARDIOMYOPATHY; UP-REGULATION;

EID: 84975316857     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.280     Document Type: Article

References (43)

1. Akashi YJ, Goldstein DS, Barbaro G, Ueyama T. Takotsubo cardiomyopathy. a new form of acute, reversible heart failure. Circulation 2008; 118: 2754-2762.
2. Paur H, Wright PT, Sikkel MB, Tranter MH, Mansfield C, O'Gara P et al. High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy. Circulation 2012; 126: 697-706.
3. Takayama S, Xie Z, Reed JC. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem 1999; 274: 781-786.
4. Hishiya A, Kitazawa T, Takayama S. BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress. Circ Res 2010; 107: 1220-1231.
5. De Marco M, Turco MC, Rosati A. BAG3 protein is induced during cardiomyoblast differentiation and modulates myogenin expression. Cell Cycle 2011; 10: 850-852.
6. De Marco M, Falco A, Basile A, Rosati A, Festa M, d'Avenia M et al. Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failure. Cell Death Dis 2013; 4: e495.
7. Pagliuca MG, Lerose R, Cigliano S, Leone A. Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity. FEBS Lett 2003; 541: 11-15.
8. Rosati A, Di Salle E, Luberto L, Quinto I, Scala G, Turco MC et al. Identification of a Btk-BAG3 complex induced by oxidative stress. Leukemia 2009; 23: 823-824.
9. Ammirante M, Rosati A, Arra C, Basile A, Falco A, Festa M et al. IKK protein is a target of BAG3 regulatory activity in human tumor growth. Proc Natl Acad Sci USA 2010; 107: 7497-7502.
10. Siu PM, Bryner RW, Murlasits Z, Always SE. Response of XIAP, ARC, and FLIPapoptotic suppressors to 8 wk of treadmill running in rat heart and skeletal muscle. J Appl Physiol 2005; 99: 204-209.
11. Matsui T, Nagoshi T, Rosenzweig A. Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival. Cell Cycle 2003; 2: 220-223.
12. Homma S, Iwasaki M, Shelton GD, Engvall E, Reed JC, Takayama S. BAG3 deficiency results in fulminant myopathy and early lethality. Am J Pathol 2006; 169: 761-773.
13. Selcen D, Muntoni F, Burton BK, Pegoraro E, Sewry C, Bite AV et al. Mutation in BAG3 causes severe dominant childhood muscular dystrophy. Ann Neurol 2009; 65: 83-89.
14. Villard E, Perret C, Gary F, Proust C, Dilanian G, Hengstenberg C et al. A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. Eur Heart J 2011; 32: 1065-1076.
15. Citro R, d'Avenia M, De Marco M, Giudice R, Mirra M, Ravera A et al. Polymorphisms of the antiapoptotic protein bag3 may play a role in the pathogenesis of tako-tsubo cardiomyopathy. Int J Cardiol 2013; 168: 1663-1665.
16. Arimura T, Ishikawa T, Nunoda S, Kawai S, Kimura A. Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes. Hum Mutat 2011; 32: 1481-1491.
17. Ambros V. The functions of animal microRNAs. Nature 2004; 431: 350-355.
18. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857-866.
19. Bostjancic E, Glavac D. miRNome in myocardial infarction: Future directions and perspective. World J Cardiol 2014; 6: 939-958.
20. Lau P, Bossers K, Janky R, Salta E, Frigerio CS, Barbash S et al. Alteration of the microRNA network during the progression of Alzheimer's disease. EMBO Mol Med 2013; 5: 1613-1634.
21. Wu H, Kong L, Zhou S, Cui W, Xu F, Luo M et al. The role of microRNAs in Diabetic nephropathy. J Diabetes Res 2014; 2014: 920134.
22. Orenes-Piñero E, Montoro-García S, Patel JV, Valdés M, Marín F, Lip GY. Role of microRNAs in cardiac remodelling: new insights and future perspectives. Int J Cardiol 2013; 167: 1651-1659.
23. Latronico MV, Catalucci D, Condorelli G. MicroRNA and cardiac pathologies. Physiol Genomics 2008; 34: 239-242.
24. Dangwal S, Hartmann D, Thum T. MicroRNAs deciding cardiac stem cell fate. J Mol Cell Cardiol 2012; 53: 747-748.
25. Jaguszewski M, Osipova J, Ghadri JR, Napp LC, Widera C, Franke J et al. A signature of circulating microRNAs differentiates Takotsubo cardiomyopathy from acute myocardial infarction. Eur Heart J 2014; 35: 999-1006.
26. Mortensen RD, Serra M, Steitz JA, Vasudevan S. Posttranscriptional activation of gene expression in Xenopus laevis oocytes by microRNA-protein complexes (microRNPs). Proc Natl Acad Sci USA 2011; 108: 8281-8286.
27. Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: microRNAs can upregulate translation. Science 2007; 318: 1931-1934.
28. Kurisu S, Kihara Y. Tako-tsubo cardiomyopathy: clinical presentation and underlying mechanism. J Cardiol 2012; 60: 429-437.
29. Norton N, Li D, Rieder MJ, Siegfried JD, Rampersaud E, Züchner S et al. Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy. Am J Hum Genet 2011; 88: 273-282.
30. Frazer KA, Pachter L, Poliakov A, Rubin EM, Dubchak I. VISTA: computational tools for comparative genomics. Nucleic Acids Res 2004; 32(Web Server issue): W273-W279.
31. Yang JH, Li JH, Shao P, Zhou H, Chen YQ, Qu LH. starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res 2011; 39(Database issue): D202-D209.
32. Li JH, Liu S, Zhou H, Qu LH, Yang JH. starBase v2.0: decoding miRNA-ceRNA, miRNAncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res 2014; 42(Database issue): D92-D97.
33. Laínez B, Ureña M, Alvarez V, Lezaun R. Iatrogenic tako-tsubo cardiomyopathy secondary to catecholamine administration. Rev Esp Cardiol 2009; 62: 1498-1499.
34. Kume T, Kawamoto T, Okura H, Toyota E, Neishi Y, Watanabe N et al. Local release of catecholamines from the hearts of patients with tako-tsubo-like left ventricular dysfunction. Circ J 2008; 72: 106-108.
35. Zhou AD, Diao LT, Xu H, Xiao ZD, Li JH, Zhou H et al. β-Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin-signaling pathway. Oncogene 2012; 31: 2968-2978.
36. Vasudevan S. Posttranscriptional upregulation by microRNAs. Wiley Interdiscip Rev RNA 2012; 3: 311-330.
37. Lin CC, Liu LZ, Addison JB, Wonderlin WF, Ivanov AV, Ruppert JM. A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Mol Cell Biol 2011; 31: 2513-2527.
38. Ulbricht A, Höhfeld J. Tension-induced autophagy: may the chaperone be with you. Autophagy 2013; 9: 920-922.
39. Ulbricht A, Eppler FJ, Tapia VE, van der Ven PF, Hampe N, Hersch N et al. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Curr Biol 2013; 23: 430-435.
40. Feldman AM, Begay RL, Knezevic T, Myers VD, Slavov DB, Zhu W et al. Decreased levels of BAG3 in a family with a rare variant and in idiopathic dilated cardiomyopathy. J Cell Physiol 2014; 229: 1697-1702.
41. da Costa Martins PA, Salic K, Gladka MM, Armand AS, Leptidis S, el Azzouzi H et al. MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling. Nat Cell Biol 2010; 12: 1220-1227.
42. Zennadi R, Whalen EJ, Soderblom EJ, Alexander SC, Thompson JW, Dubois LG et al. Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. Blood 2012; 119: 1217-1227.
43. Ji H, Wang J, Nika H, Hawke D, Keezer S, Ge Q et al. EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell 2009; 36: 547-559.