Acute stress responses are early molecular events of retinal degeneration in Abca4-/-Rdh8-/- mice after light exposure

Investigative Ophthalmology and Visual Science

Volumn 57, Issue 7, 2016, Pages 3257-3267

  Parmar, Tanu ^a   Parmar, Vipul M ^a   Arai, Eisuke ^a   Sahu, Bhubanananda ^a   Perusek, Lindsay ^a   Maeda, Akiko ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Abca4 Rdh8 mice; Early stress response; RPE; Visual cycle

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; BETA6 INTEGRIN; CALGRANULIN B; CCAAT ENHANCER BINDING PROTEIN; CELL DEATH INDUCING FACTOR 1; CERULOPLASMIN; COLLAGEN TYPE 3 ALPHA; COLLAGEN TYPE 5 ALPHA; COLLAGEN TYPE 9 ALPHA; CXCL1 CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOSYLATION DEPENDENT ADHESION MOLECULE 1; JANUS KINASE 3; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MATRIX METALLOPEPTIDASE 12; MEMBRANE PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PROTEIN C JUN; RHODOPSIN; STAT1 PROTEIN; STAT2 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TIMP1METALLOPEPTIDASE INHIBITOR 1; TRANSCRIPTOME; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCA4 PROTEIN, MOUSE; ALCOHOL DEHYDROGENASE; LCN2 PROTEIN, MOUSE; RDH8 PROTEIN, MOUSE; RNA;

ARTICLE; CELL DEATH; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENE EXPRESSION; HISTOPATHOLOGY; LIGHT EXPOSURE; PHOTORECEPTOR; PHOTORECEPTOR OUTER SEGMENT; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA DEGENERATION; RETINITIS PIGMENTOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA SEQUENCE; SECRETION (PROCESS); SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; STRESS; UPREGULATION; ACUTE DISEASE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIGHT; METABOLISM; MOUSE; MUTANT MOUSE STRAIN; OPTICAL COHERENCE TOMOGRAPHY; OXIDATIVE STRESS; PATHOLOGY; RADIATION RESPONSE; REAL TIME POLYMERASE CHAIN REACTION; RETINAL PIGMENT EPITHELIUM;

ACUTE DISEASE; ALCOHOL OXIDOREDUCTASES; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL DEATH; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMANS; LIGHT; LIPOCALIN-2; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL DEGENERATION; RETINAL PIGMENT EPITHELIUM; RNA; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84975291680     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.15-18993     Document Type: Article

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