Double standards in global health: Medicine, human rights law and multidrug-resistant TB treatment policy

Health and Human Rights

Volumn 18, Issue 1, 2016, Pages 85-102

  Nicholson, Thomas ^a   Admay, Catherine ^a,b   Shakow, Aaron ^c,d   Keshavjee, Salmaan ^c  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE TREATMENT; GLOBALIZATION; HEALTH CARE; HEALTH POLICY; HUMAN RIGHTS; INTERNATIONAL ORGANIZATION; LOW INCOME POPULATION; POLICY IMPLEMENTATION; STANDARD (REGULATION); TUBERCULOSIS; WORLD HEALTH ORGANIZATION;

PYRONIA TITHONUS;

DEVELOPING COUNTRY; ECONOMICS; GLOBAL HEALTH; HEALTH CARE POLICY; HEALTH CARE QUALITY; HUMAN; HUMAN RIGHTS; LEGISLATION AND JURISPRUDENCE; STANDARDS; TUBERCULOSIS, MULTIDRUG-RESISTANT; WORLD HEALTH ORGANIZATION;

DEVELOPING COUNTRIES; GLOBAL HEALTH; HEALTH POLICY; HUMAN RIGHTS; HUMANS; STANDARD OF CARE; TUBERCULOSIS, MULTIDRUG-RESISTANT; WORLD HEALTH ORGANIZATION;

EID: 84975274967     PISSN: 10790969     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (173)

1. Joint United Nations Programme on HIV/AIDS (UNAIDS), UNAIDS FactSheet 2014 Statistics (July 2014). Available at http://files.unaids.org/en/media/unaids/contentassets/documents/ factsheet/2014/20140716_FactSheet_en.pdf.
2. World Health Organization, Global TB report 2014 (Geneva: WHO, 2014).
3. H. Jenkins, A. Tolman, C. Yuen, et al, "Incidence of multidrug-resistant TB disease in children: systematic review and global estimates," Lancet 383/9928 (2014), pp. 1572-1579.
4. Z. Obermeyer, J. Abbott-Klafter, and C. Murray, "Has the DOTS strategy improved case-finding or treatment success? An empirical assessment," PLoS One 3 (2008), p. e1721.
5. J. Crofton and D. Mitchison, "Streptomycin resistance in pulmonary TB," British Medical Journal 2/4588 (1948), pp. 1009-1015.
6. S. Keshavjee and P. Farmer, "Picking up the pace - Scale-up of MDR-TB treatment programs," New England Journal of Medicine 369/19 (2010), pp. 1781-1784.
7. World Health Organization, Global TB report 2015 (Geneva: WHO, 2015).
8. C. Mitnick, B. McGee, and C. A. Peloquin, "TB pharmacotherapy: strategies to optimize patient care," Expert Opinion on Pharmacotherapy 10/3 (2009), pp. 381-401
9. C. Bonilla, A. Crossa, H. O. Jave, et al., "Management of extensively drug-resistant TB in Peru: cure is possible," PLoS ONE 3/8 (2008), p. e2957.
10. World Health Organization, Guidelines for the management of drug-resistant TB (Geneva: WHO, 1997), WHO Doc. WHO/TB/96.210.
11. S. Keshavjee and P. Farmer, "Tuberculosis, drug resistance, and the history of modern medicine," New England Journal of Medicine 367 (2012), pp. 931-936
12. C. McMillan, Discovering TB: a Global History 1900 to the Present (New Haven, CT: Yale University Press, 2015).
13. T. Daniel, "Selective primary health care: strategies for control of disease in the developing world. II. Tuberculosis," Reviews of Infectious Diseases 4/6 (1982), pp. 1254-1265.
14. P. Hunt, G. Backman, J. B. de Mesquita, et al., "The right to the highest attainable standard of health," in R. Detels, M. Guilliford, Q. A. Karim, and C. C. Tan (eds.) Oxford Textbook of Global Public Health (Oxford: Oxford University Press, 2015), p. 277.
15. World Health Organization, Guidelines of the Management for Latent TB Infection (Geneva: WHO, 2015).
16. P. Sensi, "History of the development of rifampin," Reviews of Infectious Diseases 5/Suppl 3 (1983), pp. S402-S406.
17. C. McMillan, Discovering TB: a Global History 1900 to the Present (New Haven, CT: Yale University Press, 2015). p. 165.
18. T. Daniel, "Selective primary health care: strategies for control of disease in the developing world. II. Tuberculosis," Reviews of Infectious Diseases 4/6 (1982), pp. 1255.
19. D. Mitchison and A. Nunn, "Influence of initial drug resistance on the response to short-course chemotherapy of pulmonary TB," American Review of Respiratory Disease 133/3 (1986), pp. 423-430.
20. J. Grosset, "Present status of chemotherapy for TB," Review of Infectious Diseases 11/Suppl 2 (1989), pp. S347-352.
21. W. Fox, G. A. Ellard, and D. A. Mitchison, "Studies on the treatment of tuberculosis undertaken by the British Medical Research Council TB units (1946-1986)," International Journal of TB and Lung Disease 3/10 Suppl 2 (1999), pp. S231-S279.
22. C. Gradmann, "Magic bullets and moving targets: antibiotic resistance and experimental chemotherapy (1900-1940)," Dynamis 31/2 (2011), pp. 305-321
23. "Drop in efficacy of two drugs noted: Germs develop resistance to penicillin and streptomycin, research chemist says," New York Times (March 14 1946) p. 27
24. M. Pyle, "Relative number of resistant tubercle bacilli in sputa of patients before and during treatment with streptomycin," Proceedings of the Mayo Clinic 22 (1947), pp. 465-473.
25. B. Müller, R. M. Warren, M. Williams, et al., "Acquisition, transmission and amplification of drug- resistant TB," in P. R. Donald and P. D. van Helden (eds.) Antituberculosis chemotherapy. Progress in Respiratory Research, Vol. 40 (Basel: Karger, 2011), pp. 96-104.
26. M. Goble, M. D. Iseman, L. A. Madsen, et al., "Treatment of 171 Patients with pulmonary tuberculosis resistant to isoniazid and rifampin," New England Journal of Medicine 328 (1993), pp. 527-532.
27. T. R. Frieden, P. I. Fujiwara, R. M. Washko, and M. A. Hamburg, "1995 TB in New York City-turning the tide," New England Journal of Medicine 333/4 (1995), pp. 229-33.
28. K. Seung, I. E. Gelmanova, G. G. Permitin, et al., "The effect of initial drug resistance on treatment response and acquired drug resistance during standardized shortcourse chemotherapy for TB," Clinical Infectious Disease 39/9 (2004 Nov 1), pp. 1321-1328.
29. D. Mitchison and A. Nunn, "Influence of initial drug resistance on the response to short-course chemotherapy of pulmonary TB," American Review of Respiratory Disease 133/3 (1986), pp. 423-430.
30. P. Farmer, J. Bayona, M. Becerra, et al., "The dilemma of MDR-TB in the global era," International Journal of TB and Lung Disease 2/11 (1998), pp. 869-876.
31. P. Suárez, et al., "Aplicación del Esquema Estandarizado de Retratamiento para TB MDR en el Perú: una Estrategia DOTS-Plus, Octubre 1997-Marzo 2000," in Perú. Ministerio de Salud. Informe 1999: Evaluación del Programa Nacional de Control de la Tuberculosis en el Perú. (Líma: Dirección General de Salud de las Personas, July 2000), pp. 81, 83.
32. Global Health Delivery Project, "The Peruvian National Tuberculosis Control Program," Harvard Medical School and Brigham and Women's Hospital Cases in Global Health Delivery, No. GHD-002 (Cambridge, MA: Harvard University, 2011), pp. 4-5.
33. L. Vásquez-Campos, L. Asencios-Solis, E. Leo-Hurtado, et al., "Drug resistance trends among previously treated tuberculosis patients in a national registry in Peru, 1994-2001," International Journal Tuberculosis and Lung Disease 8/4 (2004), pp. 465-472.
34. World Health Organization, Guidelines for the treatment of drug-resistant TB (Geneva: WHO, 1997).
35. Perú. Ministerio de Salud, "Actualización en la Atención de Pacientes con Tuberculosis Multidrogorresistente (TB MDR)," Estrategia Sanitaria Nacional de Prevención y Control de Tuberculosis Norma Tecnica No. 25 -/MINSA/DGSP V. 01, Resolución Ministerial No. 162, (Líma: Dirección General de Salud de las Personas, 2005), Annex 1, p. 1.
36. Global Health Delivery Project, "The Peruvian National Tuberculosis Control Program," Harvard Medical School and Brigham and Women's Hospital Cases in Global Health Delivery, No. GHD-002 (Cambridge, MA: Harvard University, 2011), pp. 16.
37. P. Suárez, K. Floyd, J. Protocarrero, et al., "Feasibility and cost-effectiveness of standardised second-line drug treatment for chronic TB patients: a national cohort study in Peru," Lancet 359/9322 (2002), pp. 1980-1989.
38. P. Suárez, et al., "Aplicación del Esquema Estandarizado de Retratamiento para TB MDR en el Perú: una Estrategia DOTS-Plus, Octubre 1997-Marzo 2000," in Perú. Ministerio de Salud. Informe 1999: Evaluación del Programa Nacional de Control de la Tuberculosis en el Perú. (Líma: Dirección General de Salud de las Personas, July 2000), pp. 81, 83.
39. L. Han, A. Sloutsky, R. Canales, et al., "Acquisition of drug resistance in multidrug-resistant Mycobacterium TB during directly observed empiric retreatment with standardized regimens," International Journal of TB and Lung Disease 9/7 (2005), pp. 818-821.
40. C. Mitnick, J. Bayona, E. Palacios, et al., "Community- based therapy for multi-drug resistant tuberculosis in Lima, Peru," New England Journal of Medicine 348 (2003), pp. 1219-1228
41. C. Mitnick, S. Shin, S. Kwonjune, et al., "Comprehensive treatment of extensively drug-resistant tuberculosis," New England Journal of Medicine 359 (2008), pp. 563-574.
42. World Health Assembly, Forty-Sixth World Health Assembly, Geneva, 3-14 May 1993. Verbatim records of plenary meetings (Geneva: WHO, 1993), WHO Doc. WHA46/1993/REC/2: 38.
43. China TB Control Collaboration, "Results of directly observed short-course chemotherapy in 112,842 Chinese patients with smear-positive TB," Lancet 347/8998 (1996 Feb 10), pp. 358-362
44. World Health Assembly, Forty-Ninth World Health Assembly. Geneva, 20-25 May 1996. Verbatim records of plenary meetings (Geneva: WHO, 1996), WHA Doc. WHA49/1996/REC/2: 20.
45. World Health Organization, Guidelines for the Treatment of Drug Resistant TB (Geneva: WHO, 1997), p. 5.
46. A. Cowell, "U.N. Agency Is Optimistic On Treatment To Fight TB," New York Times (March 20, 1997), p. 5
47. A. Kochi, "Is DOTS the health breakthrough of the 1990s?" World Health Forum 18 (1997), pp. 225-247.
48. M. Specter, "The new TB epidemic: public health officials say federal laxity led to revival," Orange County Register (November 8, 1992), p. M01 [synd. New York Times Oct 11 1992): 1]
49. World Health Organization Executive Board, 93, Tuberculosis programme: progress report by the Director-General (Geneva: WHO, 1993b), WHO Doc. EB93/25
50. "Outbreak of multidrug-resistant tuberculosis: Texas, California, and Pennsylvania," Morbidity and Mortality Weekly Report 39/22 (1990), pp. 369-372.
51. R. E. Brown, B. Miller, W. R. Taylor, et al., "Healthcare expenditures for tuberculosis in the United States," Archives of Internal Medicine 155/15 (1995), pp. 1595-1600.
52. D. T. Jamison, J. G. Breman, A. R. Measham et al. (eds.) Disease Control Priorities in Developing Countries (Oxford: Oxford University Press, 1993), p. 256
53. World Health Organization. Groups at risk: WHO report on the TB Epidemic 1996 (Geneva: WHO, 1996), p. 14.
54. World Bank. "Technical Note for the Procurement of Health Sector Goods," In Procurement of Health Sector Goods: Pharmaceuticals, Vaccines, and Condoms (Washington, D.C.: World Bank, revised 2001), p. 41
55. World Bank. World development report 1993: investing in health (Washington, D.C.: World Bank, 1993), pp. 145-146.
56. World Bank. "Technical Note for the Procurement of Health Sector Goods," In Procurement of Health Sector Goods: Pharmaceuticals, Vaccines, and Condoms (Washington, D.C.: World Bank, revised 1993), p. 41
57. "The WB-funded TB control program in China procured only first-line TB drugs listed on the WHO's EDL." Bids for Infectious and Endemic Disease Control Project Factiva Database, (Xinhua 1993 Sep. 27; 1995 Jan. 27; 1995 Sep. 12)
58. World Bank. "Technical Note for the Procurement of Health Sector Goods," In Procurement of Health Sector Goods: Pharmaceuticals, Vaccines, and Condoms (Washington, D.C.: World Bank, revised 1993), p. 146
59. World Health Organization. TB: A clinical manual for Southeast Asia (Geneva: WHO, 1997b), p. 63.
60. WHO Expert Committee on the Selection and Use of Essential Medicines, Technical Report Series no. 914 Section 4.2 The selection and use of essential medicines (Geneva: WHO, 2002).
61. World Health Organization Executive Board, 93, Tuberculosis programme: progress report by the Director-General (Geneva: WHO, 1993b), WHO Doc. EB93/25
62. R. Gupta et al. "Responding to market failures in TB control," Science 293 (2001), pp. 1048-1051
63. S. S. Shin, A. D. Pasechnikov, I. Y. Gelmanova, et al., "Treatment outcomes in an integrated civilian and prison MDR-TB treatment program in Russia," International Journal of Tuberculosis and Lung Disease 10/4 (2006), pp. 402-408
64. V. Leimane, V. Riekstina, T. H. Holtz, et al., "Clinical outcome of individualized treatment of multidrug-resistant TB in Latvia: a retrospective cohort study," Lancet 365/9456 (2005), pp. 318-326
65. C. Mitnick, S. Shin, S. Kwonjune, et al., "Comprehensive treatment of extensively drug-resistant tuberculosis," New England Journal of Medicine 359 (2008), pp. 119- 28.
66. T. Tupasi, R. Gupta, M. I. Quelapio, et al., "Feasibility and cost-effectiveness of treating multidrug-resistant TB: a cohort study in the Philippines," Public Library of Science - Medicine 3/9 (2006), p. e352.
67. K. Tahaoğlu, et al. "The treatment of multidrug-resistant tuberculosis in Turkey," New England Journal of Medicine 345 (2001 Jul), pp. 170-174
68. D. Tatar, G Senolemail, S. Alpetkin, et al., "Tuberculosis in older adults," European Geriatric Medicine 4/1 (2012), pp. 15-19.
69. L. Reichman, Timebomb: The Global Epidemic of Multi-drug Resistant Tuberculosis (New York: Mc- Graw-Hill, 2001), p. 115
70. D. Tatar, G Senolemail, S. Alpetkin, et al., "Tuberculosis in older adults," European Geriatric Medicine 4/1 (2012), pp. 15-19.
71. D. Agrawal, et al. "Increasing incidence of fluoroquinolone- resistant Mycobacterium tuberculosis in Mumbai, India." International Journal of Tuberculosis and Lung Disease. (2009); 13(1):79-83.
72. "Tuberculosis in the Russian Federation, 2010. Analytical Review of TB Statistical Indicators". Moscow, (2011), p.18.
73. A. Skrahina, H. Hurevich, A. Zalutskaya, et al., "Multidrug-resistant tuberculosis in Belarus: The size of the problem and associated risk factors," WHO Bulletin 91 (2013), pp. 36-45.
74. A. Yamin, "Toward transformative accountability: applying a rights-based approach to fulfill maternal health obligations," SUR International Journal on Human Rights 7/12 (2010), pp. 96, 97, 112.
75. See Report of the International Law Commission on the Work of its Sixty-third Session. Gen. Ass. Off. Recs., Sixty-sixth Session. Supp. No. 10 (A/66/10) Available at http://legal.un.org/ilc/texts/instruments/english/commentaries/ 9_11_2011.pdf
76. ETO Consortium, Maastricht Principles on Extraterritorial Obligations of States in the Area of Economic, Social and Cultural Rights (Fian International; Heidelberg, Germany, 2013), Principles 21 & 43, Available at http://www.etoconsortium.org/en/library/ maastricht-principles/
77. M. Salomon & I. Seiderman. "Human Rights Norms for a Globalized World." 3(4) Global Policy (2012) p. 459.
78. P. Klein, "International Organizations or Institutions, Internal Law and Rules," Max Planck Encyclopedia of Public International Law (2006), para. 3.
79. Constitution of the World Health Organization (1946, enacted 1948), Preamble, Articles 1 and 2.
80. Constitution of the World Health Organization (1946, enacted 1948), Article 75.
81. Constitution of the World Health Organization (1946, enacted 1948), Preamble, Article 1
82. L. Gostin, G. Ooms, M. Heywood, et al., "The Joint Action Learning Initiative on National and Global Responsibilities for Health." Joint Action and Learning Initiative: World Health Report Background Paper 53 (2010), pp. e4, e9.
83. World Health Organization Media Centre, "Health and Human Rights," Fact Sheet Number 323 (December 2015), p. e1, Available at http://www.who.int/mediacentre/ factsheets/fs323/en/
84. ETO Consortium, Maastricht Principles on Extraterritorial Obligations of States in the Area of Economic, Social and Cultural Rights (Fian International; Heidelberg, Germany, 2013), Principle 15 ("Obligations of States as members of international organizations"), Available at http://www.etoconsortium.org/en/library/maastricht-principles/ Maastricht Principle 15 ("Obligations of States as members of international organizations").
85. L. Gostin, G. Ooms, M. Heywood, et al., "The Joint Action Learning Initiative on National and Global Responsibilities for Health." Joint Action and Learning Initiative: World Health Report Background Paper 53 (2010), pp. e10.
86. International Covenant on Economic, Social and Cultural Rights (ICESCR), G.A. Res 2200A (XXI) (1966), Article 12
87. Vienna Convention on the Law of Treaties (1969), Article 26
88. for the absence of reservations, see J. Tobin, The Right to Health in International Law (Oxford: Oxford University Press, 2011), p. 11 n. 34.
89. C. Jochnick, "Confronting the impunity of non-state actors: new fields for the promotion of human rights," Human Rights Quarterly 21/56 (1999), p. 57
90. F. MacKay, "Universal rights or a universe unto itself? indigenous peoples' human rights and the World Bank's Draft Operational Policy 4.10 on Indigenous Peoples," American University International Law Review 17/527 (2002), p. 562-563.
91. F. Gianviti, "Economic, social and cultural human rights and the IMF," in P. Alston, Non-State Actors and Human Rights (Oxford: Oxford University Press, 2005), p. 138
92. P. Alston, "The 'Not-a-Cat' syndrome: can't the international human rights regime accommodate non-state actors," Non-State Actors and Human Rights (Oxford: Oxford University Press, 2005), p. 30.
93. F. Gianviti, "Economic, social and cultural human rights and the IMF," in P. Alston, Non-State Actors and Human Rights (Oxford: Oxford University Press, 2005), p. 114.
94. B. M. Meier, "Global health governance and the contentious politics of Human Rights: mainstreaming the right to health for public health advancement," Stanford Journal International Law 46/1 (2010), p. 6-7.
95. A. Reinisch, "Securing the accountability of international organizations," Global Governance 7/131 (2001), p. 136
96. M. Wood, "International organizations and CIL." Vanderbilt Journal of Transnational Law 48/609 (2014), p. 619
97. A. Reinisch, "The changing international legal framework for dealing with non-state actors," in P. Alston, Non-State Actors and Human Rights (Oxford: Oxford University Press, 2005) p. 46.
98. See Report of the International Law Commission on the Work of its Sixty-third Session. Gen. Ass. Off. Recs., Sixty-sixth Session. Supp. No. 10 (A/66/10) Available at http://legal.un.org/ilc/texts/instruments/english/commentaries/ 9_11_2011.pdf
99. citing International Court of Justice advisory opinion on the Interpretation of the Agreement of 25 March 1951 between the WHO and Egypt. International Court of Justice Reports (1980), pp. 89-90, para. 37.
100. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
101. A. Clapham. Human Rights Obligations of Non-State Actors. Oxford: Oxford University Press. (2006) pp. 327-28 (Section 8.3).
102. K. Mechlem. "Treaty Bodies and the Interpretation of Human Rights." Vanderbilt Journal of Transnational Law 42:905 (2009) pp. 933-935.
103. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
104. P. Hunt, UN Special Rapporteur on the right of everyone to the enjoyment of the highest attainable standard of physical and mental health. Report to the Human Rights Commission (February 2003), UN Doc. E/CN.4/2003/58, para. 30
105. A. Yamin, "Not just a tragedy: access to medications as a right under international law," Boston University International Law Journal 21/2 (2003), p. 364
106. See Report of the International Law Commission on the Work of its Sixty-third Session. Gen. Ass. Off. Recs., Sixty-sixth Session. Supp. No. 10 (A/66/10) Available at http://legal.un.org/ilc/texts/instruments/english/commentaries/ 9_11_2011.pdf
107. K. Daugirdas, "Reputation and the responsibility of international organizations," European Journal of International Law 25/4 (2014), pp. 991-1018.
108. Human Rights Based Approach Portal. "The Human Rights Based Approach to Development Cooperation: Towards a Common Understanding Among UN Agencies." United Nations Development Group-Human Rights Working Group (2003), pp. e1-e3. Available at http://hrbaportal. org/the-un-and-hrba.
109. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
110. B. M. Meier and L. Mori, "The highest attainable standard: advancing a collective human right to public health," Columbia Human Rights Law Review 101-147 37 (2005), pp. 121, 127.
111. Constitution of the World Health Organization (1946, enacted 1948), preamble.
112. Constitution of the World Health Organization (1946, enacted 1948), Article 1.
113. J. P. Ruger, "Toward a theory of a right to health: capability and incompletely theorized agreements," Yale Journal of Law and the Humanities 18/2 (2006), pp. 273-326.
114. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
115. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
116. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
117. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
118. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
119. International Covenant on Economic, Social and Cultural Rights (ICESCR), G.A. Res 2200A (XXI) (1966), Article 12
120. International Covenant on Economic, Social and Cultural Rights (ICESCR), G.A. Res 2200A (XXI) (1966), Article 12
121. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
122. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
123. M. Sepulveda. The Nature of the Obligations Under the IESCR. Antwerp, Belgium: School of Human Rights Research Series/INTERSENTIA. (2003) p. 321
124. P. Harvey, "Monitoring mechanisms for international agreements respecting economic and social human rights." Yale Journal of International Law. 12:2 (1987) p. 416.
125. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
126. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
127. International Covenant on Economic, Social and Cultural Rights (ICESCR), G.A. Res 2200A (XXI) (1966), Article 12
128. B. Saul, D. Kinley, J. Mowbray, The International Covenant on Economic, Social and Cultural Rights: Commentary, Cases and Materials (Oxford: Oxford University Press, 2014), p. 1007.
129. International Covenant on Economic, Social and Cultural Rights (ICESCR), G.A. Res 2200A (XXI) (1966), Article 12
130. ETO Consortium, Maastricht Principles on Extraterritorial Obligations of States in the Area of Economic, Social and Cultural Rights (Fian International; Heidelberg, Germany, 2013), Principles 26, 29, 31, Available at http://www.etoconsortium.org/en/ library/maastricht-principles/
131. L. Gostin, G. Ooms, M. Heywood, et al., "The Joint Action Learning Initiative on National and Global Responsibilities for Health." Joint Action and Learning Initiative: World Health Report Background Paper 53 (2010), pp. e2, e16, e33.
132. L. Reichman, Timebomb: The Global Epidemic of Multi-drug Resistant Tuberculosis (New York: Mc- Graw-Hill, 2001), p. 115
133. P. Hunt and G. Backman, "Health systems and the right to the highest attainable standard of health," Health and Human Rights Journal 10/1 (2008), p. 84.
134. B. M. Meier and L. Mori, "The highest attainable standard: advancing a collective human right to public health," Columbia Human Rights Law Review 101-147 37 (2005), p. 116.
135. D. Fidler, International Law and Infectious Diseases (Oxford: Oxford University Press, 1999), p. 184.
136. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
137. D. Fidler, International Law and Public Health: Materials on and Analysis of Global Health Jurisprudence (Ardsley, NY: Transnational Publishers, 2000), p. 306.
138. World Health Organization. TB: A clinical manual for Southeast Asia (Geneva: WHO, 1997b), p. 63.
139. for the absence of reservations, see J. Tobin, The Right to Health in International Law (Oxford: Oxford University Press, 2011), p. 242 n. 34.
140. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
141. B. Saul, D. Kinley, J. Mowbray, The International Covenant on Economic, Social and Cultural Rights: Commentary, Cases and Materials (Oxford: Oxford University Press, 2014), p. 171.
142. P. Farmer, Pathologies of Power: Health, human rights and the new war on the poor (Berkeley, CA: University of California, Berkeley, 2003), p. 219.
143. A. Grover, UN Special Rapporteur on the right of everyone to the enjoyment of the highest attainable standard of physical and mental health. Report to the General Assembly (August 2014), UN Doc. A/69/299, para. 9.
144. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
145. for the absence of reservations, see J. Tobin, The Right to Health in International Law (Oxford: Oxford University Press, 2011), p. 172 n. 34.
146. L. Reichman, Timebomb: The Global Epidemic of Multi-drug Resistant Tuberculosis (New York: Mc- Graw-Hill, 2001), p. 115
147. L. Gostin and E. Friedman, "Towards a framework convention on global health," Yale Journal of Health Policy, Law & Ethics 13 (2013) pp. 1-75
148. World Health Organization, Groups at risk: WHO report on the TB epidemic (Geneva: WHO, 1996), WHO Doc. WHO_96_198_Groups At Risk
149. World Health Organization, TB: a clinical manual for South East Asia (Geneva: WHO, 1997), WHO Doc. WHO_TB_96.200 (SEA)
150. World Health Organization, Treatment of TB: Guidelines for National Program (Geneva: WHO, 1997), WHO Doc. WHO_TB_97.220
151. J. Crofton, Guidelines for the management of drug resistant TB (Geneva: WHO, 1997), WHO Doc. WHO_96_210 (Rev).
152. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
153. GC14, para. 12(d).
154. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
155. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
156. D. Puras, Report of the Special Rapporteur on the right of everyone to the enjoyment of the highest attainable standard of physical and mental health. Report to the Human Rights Council (April 2015), UN Doc. A/HRC/29/33, para. 51.
157. C. Mitnick, S. Shin, S. Kwonjune, et al., "Comprehensive treatment of extensively drug-resistant tuberculosis," New England Journal of Medicine 359 (2008), pp. 1219-1228.
158. C. Mitnick, S. Shin, S. Kwonjune, et al., "Comprehensive treatment of extensively drug-resistant tuberculosis," New England Journal of Medicine 359 (2008), pp. 563-574.
159. World Health Organization, Global TB Report 2015 (Geneva: WHO, 2015), Executive Summary.
160. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
161. P. Chaulet. "The supply of antituberculosis drugs: price evolution." Tubercle and Lung Disease. (1995); 76. 261-263.
162. World Health Organization Media Centre, "Health and Human Rights," Fact Sheet Number 323 (December 2015), p. e1, Available at http://www.who.int/mediacentre/ factsheets/fs323/en/
163. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
164. GC14, para. 32.
165. CESCR. "Evaluation of the Obligation to Take Steps to the 'Maximum of Available Resources' Under an Optional Protocol to the Covenant" (2007) para. 5
166. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
167. D. Puras, Report of the Special Rapporteur on the right of everyone to the enjoyment of the highest attainable standard of physical and mental health. Report to the Human Rights Council (April 2015), UN Doc. A/HRC/29/33, para. 51.
168. A. Grover, UN Special Rapporteur on the right of everyone to the enjoyment of the highest attainable standard of physical and mental health. Report to the General Assembly (August 2014), UN Doc. A/69/299, para. 4.
169. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
170. UN Committee on Economic, Social and Cultural Rights, General Comment No. 14 (GC14), "The right to the highest attainable standard of health," UN Doc. E/C.12/2000/4 (2000), reprinted in Compilation of General Comments and General Recommendations Adopted by Human Rights Treaty Bodies, U.N. Doc. HRI/GEN/1/ Rev.6, (2003), Part V "Obligations of Actors Other than States Parties;"
171. P. Hunt and G. Backman, "Health systems and the right to the highest attainable standard of health," Health and Human Rights Journal 10/1 (2008), p. 84.
172. Constitution of the World Health Organization (1946, enacted 1948), Preamble.
173. World Health Organization, Guidelines of the Management for Latent TB Infection (Geneva: WHO, 2015).