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Volumn 7, Issue MAY, 2016, Pages

Resveratrol ameliorates the anxiety- and depression-like behavior of subclinical hypothyroidism rat: Possible involvement of the HPT axis, HPA axis, and Wnt/β-catenin pathway

Author keywords

Depression; Hypothalamic pituitary thyroid axis; Hypothalamus pituitary adrenal axis; Resveratrol; Subclinical hypothyroidism; Wnt catenin pathwa

Indexed keywords

BETA CATENIN; CORTICOSTERONE; GLYCOGEN SYNTHASE KINASE 3BETA; PROTIRELIN; RESVERATROL; THYROTROPIN; WNT PROTEIN;

EID: 84975256620     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2016.00044     Document Type: Article
Times cited : (86)

References (55)
  • 1
    • 79957704523 scopus 로고    scopus 로고
    • Functional magnetic resource imaging assessment of altered brain function in hypothyroidism during working memory processing
    • He XS, Ma N, Pan ZL, Wang ZX, Li N, Zhang XC, et al. Functional magnetic resource imaging assessment of altered brain function in hypothyroidism during working memory processing. Eur J Endocrinol (2011) 164:951-9. doi: 10.1530/EJE-11-0046
    • (2011) Eur J Endocrinol , vol.164 , pp. 951-959
    • He, X.S.1    Ma, N.2    Pan, Z.L.3    Wang, Z.X.4    Li, N.5    Zhang, X.C.6
  • 2
    • 33750590558 scopus 로고    scopus 로고
    • fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism
    • Zhu DF, Wang ZX, Zhang DR, Pan ZL, He S, Hu XP, et al. fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism. Brain (2006) 129:2923-30. doi:10.1093/brain/awl215
    • (2006) Brain , vol.129 , pp. 2923-2930
    • Zhu, D.F.1    Wang, Z.X.2    Zhang, D.R.3    Pan, Z.L.4    He, S.5    Hu, X.P.6
  • 3
    • 33751025091 scopus 로고    scopus 로고
    • Subclinical hypothyroidism increases the risk for depression in the elderly
    • Chueire VB, Romaldini JH, Ward LS. Subclinical hypothyroidism increases the risk for depression in the elderly. Arch Gerontol Geriatr (2007) 44:21-8. doi:10.1016/j.archger.2006.02.001
    • (2007) Arch Gerontol Geriatr , vol.44 , pp. 21-28
    • Chueire, V.B.1    Romaldini, J.H.2    Ward, L.S.3
  • 4
    • 0642336294 scopus 로고    scopus 로고
    • Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: significance in the elderly
    • Davis JD, Stern RA, Flashman LA. Cognitive and neuropsychiatric aspects of subclinical hypothyroidism: significance in the elderly. Curr Psychiatry Rep (2003) 5:384-90. doi:10.1007/s11920-003-0073-6
    • (2003) Curr Psychiatry Rep , vol.5 , pp. 384-390
    • Davis, J.D.1    Stern, R.A.2    Flashman, L.A.3
  • 6
    • 84897101309 scopus 로고    scopus 로고
    • Depression-like behavior in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization
    • Ge JF, Peng YY, Qi CC, Chen FH, Zhou JN. Depression-like behavior in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization. Endocrine (2014) 45:430-8. doi:10.1007/s12020-013-0001-4
    • (2014) Endocrine , vol.45 , pp. 430-438
    • Ge, J.F.1    Peng, Y.Y.2    Qi, C.C.3    Chen, F.H.4    Zhou, J.N.5
  • 7
    • 20844432889 scopus 로고    scopus 로고
    • Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression
    • Bauer M, London ED, Rasgon N, Berman SM, Frye MA, Altshuler LL, et al. Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression. Mol Psychiatry (2005) 10:456-69. doi:10.1038/sj.mp.4001647
    • (2005) Mol Psychiatry , vol.10 , pp. 456-469
    • Bauer, M.1    London, E.D.2    Rasgon, N.3    Berman, S.M.4    Frye, M.A.5    Altshuler, L.L.6
  • 8
    • 84904857659 scopus 로고    scopus 로고
    • Influence of levothyroxine in augmentation therapy for bipolar depression on central serotonergic function
    • Uhl I, Bez JA, Stamm T, Pilhatsch M, Assion HJ, Norra C, et al. Influence of levothyroxine in augmentation therapy for bipolar depression on central serotonergic function. Pharmacopsychiatry (2014) 47:180-3. doi:10.1055/s-0034-1383654
    • (2014) Pharmacopsychiatry , vol.47 , pp. 180-183
    • Uhl, I.1    Bez, J.A.2    Stamm, T.3    Pilhatsch, M.4    Assion, H.J.5    Norra, C.6
  • 9
    • 84886015444 scopus 로고    scopus 로고
    • Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans
    • Cottart CH, Nivet-Antoine V, Beaudeux JL. Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans. Mol Nutr Food Res (2014) 58:7-21. doi:10.1002/mnfr.201200589
    • (2014) Mol Nutr Food Res , vol.58 , pp. 7-21
    • Cottart, C.H.1    Nivet-Antoine, V.2    Beaudeux, J.L.3
  • 10
    • 70349324339 scopus 로고    scopus 로고
    • Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway
    • Shin SM, Cho IJ, Kim SG. Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway. Mol Pharmacol (2009) 76:884-95. doi:10.1124/mol.109.058479
    • (2009) Mol Pharmacol , vol.76 , pp. 884-895
    • Shin, S.M.1    Cho, I.J.2    Kim, S.G.3
  • 11
    • 84887602261 scopus 로고    scopus 로고
    • Antidepressant-like effect of resveratrol: involvement of antioxidant effect and peripheral regulation on HPA axis
    • 4-115
    • Ge JF, Peng L, Cheng JQ, Pan CX, Tang J, Chen FH, et al. Antidepressant-like effect of resveratrol: involvement of antioxidant effect and peripheral regulation on HPA axis. Pharmacol Biochem Behav (2013) 11(4-115):64-9. doi:10.1016/j.pbb.2013.10.028
    • (2013) Pharmacol Biochem Behav , vol.11 , pp. 64-69
    • Ge, J.F.1    Peng, L.2    Cheng, J.Q.3    Pan, C.X.4    Tang, J.5    Chen, F.H.6
  • 12
    • 84898904662 scopus 로고    scopus 로고
    • Antidepressant effects of resveratrol in an animal model of depression
    • Hurley LL, Akinfiresoye L, Kalejaiye O, Tizabi Y. Antidepressant effects of resveratrol in an animal model of depression. Behav Brain Res (2014) 268:1-7. doi:10.1016/j.bbr.2014.03.052
    • (2014) Behav Brain Res , vol.268 , pp. 1-7
    • Hurley, L.L.1    Akinfiresoye, L.2    Kalejaiye, O.3    Tizabi, Y.4
  • 13
    • 79958088436 scopus 로고    scopus 로고
    • Animal models of depression: molecular perspectives
    • Krishnan V, Nestler EJ. Animal models of depression: molecular perspectives. Curr Top Behav Neurosci (2011) 7:121-47. doi:10.1007/7854_2010_108
    • (2011) Curr Top Behav Neurosci , vol.7 , pp. 121-147
    • Krishnan, V.1    Nestler, E.J.2
  • 14
    • 84888803842 scopus 로고    scopus 로고
    • Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats
    • Liu D, Zhang Q, Gu J, Wang X, Xie K, Xian X, et al. Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats. Prog Neuropsychopharmacol Biol Psychiatry (2014) 49:21-9. doi:10.1016/j.pnpbp.2013.10.017
    • (2014) Prog Neuropsychopharmacol Biol Psychiatry , vol.49 , pp. 21-29
    • Liu, D.1    Zhang, Q.2    Gu, J.3    Wang, X.4    Xie, K.5    Xian, X.6
  • 15
    • 84905563669 scopus 로고    scopus 로고
    • Social deficits induced by peripubertal stress in rats are reversed by resveratrol
    • Poirier GL, Imamura N, Zanoletti O, Sandi C. Social deficits induced by peripubertal stress in rats are reversed by resveratrol. J Psychiatr Res (2014) 57:157-64. doi:10.1016/j.jpsychires.2014.05.017
    • (2014) J Psychiatr Res , vol.57 , pp. 157-164
    • Poirier, G.L.1    Imamura, N.2    Zanoletti, O.3    Sandi, C.4
  • 16
    • 84873523154 scopus 로고    scopus 로고
    • Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences
    • Yu Y, Wang R, Chen C, Du X, Ruan L, Sun J, et al. Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences. J Psychiatr Res (2013) 47:315-22. doi:10.1016/j.jpsychires.2012.10.018
    • (2013) J Psychiatr Res , vol.47 , pp. 315-322
    • Yu, Y.1    Wang, R.2    Chen, C.3    Du, X.4    Ruan, L.5    Sun, J.6
  • 17
    • 84901810516 scopus 로고    scopus 로고
    • Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults
    • Witte AV, Kerti L, Margulies DS, Floel A. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J Neurosci (2014) 34:7862-70. doi:10.1523/JNEUROSCI.0385-14.2014
    • (2014) J Neurosci , vol.34 , pp. 7862-7870
    • Witte, A.V.1    Kerti, L.2    Margulies, D.S.3    Floel, A.4
  • 18
    • 84906735201 scopus 로고    scopus 로고
    • A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones
    • Chow HH, Garland LL, Heckman-Stoddard BM, Hsu CH, Butler VD, Cordova CA, et al. A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones. J Transl Med (2014) 12:223. doi:10.1186/s12967-014-0223-0
    • (2014) J Transl Med , vol.12 , pp. 223
    • Chow, H.H.1    Garland, L.L.2    Heckman-Stoddard, B.M.3    Hsu, C.H.4    Butler, V.D.5    Cordova, C.A.6
  • 19
    • 77952543441 scopus 로고    scopus 로고
    • Antidepressant-like effect of trans-resveratrol: involvement of serotonin and noradrenaline system
    • Xu Y, Wang Z, You W, Zhang X, Li S, Barish PA, et al. Antidepressant-like effect of trans-resveratrol: involvement of serotonin and noradrenaline system. Eur Neuropsychopharmacol (2010) 20:405-13. doi:10.1016/j.euroneuro.2010.02.013
    • (2010) Eur Neuropsychopharmacol , vol.20 , pp. 405-413
    • Xu, Y.1    Wang, Z.2    You, W.3    Zhang, X.4    Li, S.5    Barish, P.A.6
  • 20
    • 33244467253 scopus 로고    scopus 로고
    • Factor analysis of forced swimming test, sucrose preference test and open field test on enriched, social and isolated reared rats
    • Brenes Saenz JC, Villagra OR, Fornaguera Trias J. Factor analysis of forced swimming test, sucrose preference test and open field test on enriched, social and isolated reared rats. Behav Brain Res (2006) 169:57-65. doi:10.1016/j.bbr.2005.12.001
    • (2006) Behav Brain Res , vol.169 , pp. 57-65
    • Brenes Saenz, J.C.1    Villagra, O.R.2    Fornaguera Trias, J.3
  • 21
    • 84924330827 scopus 로고    scopus 로고
    • Lithium increases platelet serine-9 phosphorylated GSK-3beta levels in drug-free bipolar disorder during depressive episodes
    • de Sousa RT, Zanetti MV, Talib LL, Serpa MH, Chaim TM, Carvalho AF, et al. Lithium increases platelet serine-9 phosphorylated GSK-3beta levels in drug-free bipolar disorder during depressive episodes. J Psychiatr Res (2015) 62:78-83. doi:10.1016/j.jpsychires.2015.01.016
    • (2015) J Psychiatr Res , vol.62 , pp. 78-83
    • de Sousa, R.T.1    Zanetti, M.V.2    Talib, L.L.3    Serpa, M.H.4    Chaim, T.M.5    Carvalho, A.F.6
  • 22
    • 84857049145 scopus 로고    scopus 로고
    • Protein levels of beta-catenin and activation state of glycogen synthase kinase-3beta in major depression. A study with postmortem prefrontal cortex
    • Karege F, Perroud N, Burkhardt S, Fernandez R, Ballmann E, La Harpe R, et al. Protein levels of beta-catenin and activation state of glycogen synthase kinase-3beta in major depression. A study with postmortem prefrontal cortex. J Affect Disord (2012) 136:185-8. doi:10.1016/j.jad.2011.09.024
    • (2012) J Affect Disord , vol.136 , pp. 185-188
    • Karege, F.1    Perroud, N.2    Burkhardt, S.3    Fernandez, R.4    Ballmann, E.5    La Harpe, R.6
  • 23
    • 84855974464 scopus 로고    scopus 로고
    • The roles of neurotrophic factor and Wnt signaling in depression
    • Voleti B, Duman RS. The roles of neurotrophic factor and Wnt signaling in depression. Clin Pharmacol Ther (2012) 91:333-8. doi:10.1038/clpt.2011.296
    • (2012) Clin Pharmacol Ther , vol.91 , pp. 333-338
    • Voleti, B.1    Duman, R.S.2
  • 24
    • 1842420631 scopus 로고    scopus 로고
    • Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus
    • Kaidanovich-Beilin O, Milman A, Weizman A, Pick CG, Eldar-Finkelman H. Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol Psychiatry (2004) 55:781-4. doi:10.1016/j.biopsych.2004.01.008
    • (2004) Biol Psychiatry , vol.55 , pp. 781-784
    • Kaidanovich-Beilin, O.1    Milman, A.2    Weizman, A.3    Pick, C.G.4    Eldar-Finkelman, H.5
  • 25
    • 38749083863 scopus 로고    scopus 로고
    • Thyroid hormone interacts with the Wnt/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes
    • Wang L, Shao YY, Ballock RT. Thyroid hormone interacts with the Wnt/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes. J Bone Miner Res (2007) 22:1988-95. doi:10.1359/jbmr.070806
    • (2007) J Bone Miner Res , vol.22 , pp. 1988-1995
    • Wang, L.1    Shao, Y.Y.2    Ballock, R.T.3
  • 26
    • 0000650706 scopus 로고
    • The open-field test: a critical review
    • Walsh RN, Cummins RA. The open-field test: a critical review. Psychol Bull (1976) 83:482-504. doi:10.1037/0033-2909.83.3.482
    • (1976) Psychol Bull , vol.83 , pp. 482-504
    • Walsh, R.N.1    Cummins, R.A.2
  • 27
    • 0035954660 scopus 로고    scopus 로고
    • Clinical practice. Subclinical hypothyroidism
    • Cooper DS. Clinical practice. Subclinical hypothyroidism. N Engl J Med (2001) 345:260-5. doi:10.1056/NEJM200107263450406
    • (2001) N Engl J Med , vol.345 , pp. 260-265
    • Cooper, D.S.1
  • 29
    • 84936932310 scopus 로고    scopus 로고
    • Depressive symptoms in patients with subclinical hypothyroidism-the effect of treatment with levothyroxine: a double-blind randomized clinical trial
    • Najafi L, Malek M, Hadian A, Ebrahim Valojerdi A, Khamseh ME, Aghili R. Depressive symptoms in patients with subclinical hypothyroidism-the effect of treatment with levothyroxine: a double-blind randomized clinical trial. Endocr Res (2015) 40(3):121-6. doi:10.3109/07435800.2014.896924
    • (2015) Endocr Res , vol.40 , Issue.3 , pp. 121-126
    • Najafi, L.1    Malek, M.2    Hadian, A.3    Ebrahim Valojerdi, A.4    Khamseh, M.E.5    Aghili, R.6
  • 31
    • 84862287737 scopus 로고    scopus 로고
    • Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder
    • Behr GA, Moreira JC, Frey BN. Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder. Oxid Med Cell Longev (2012) 2012:609421. doi:10.1155/2012/609421
    • (2012) Oxid Med Cell Longev , vol.2012
    • Behr, G.A.1    Moreira, J.C.2    Frey, B.N.3
  • 32
    • 84959574642 scopus 로고    scopus 로고
    • Antioxidant treatment ameliorates experimental diabetes-induced depressive-like behavior and reduces oxidative stress in brain and pancreas
    • Reus GZ, Dos Santos MA, Abelaira HM, Titus SE, Carlessi AS, Matias BI, et al. Antioxidant treatment ameliorates experimental diabetes-induced depressive-like behavior and reduces oxidative stress in brain and pancreas. Diabetes Metab Res Rev (2016) 32:278-88. doi:10.1002/dmrr.2732
    • (2016) Diabetes Metab Res Rev , vol.32 , pp. 278-288
    • Reus, G.Z.1    Dos Santos, M.A.2    Abelaira, H.M.3    Titus, S.E.4    Carlessi, A.S.5    Matias, B.I.6
  • 33
    • 78650837168 scopus 로고    scopus 로고
    • Neuroprotective effects of resveratrol on ischemic injury mediated by improving brain energy metabolism and alleviating oxidative stress in rats
    • Li H, Yan Z, Zhu J, Yang J, He J. Neuroprotective effects of resveratrol on ischemic injury mediated by improving brain energy metabolism and alleviating oxidative stress in rats. Neuropharmacology (2011) 60:252-8. doi:10.1016/j.neuropharm.2010.09.005
    • (2011) Neuropharmacology , vol.60 , pp. 252-258
    • Li, H.1    Yan, Z.2    Zhu, J.3    Yang, J.4    He, J.5
  • 34
    • 77955452426 scopus 로고    scopus 로고
    • SIRT1 regulates thyroid-stimulating hormone release by enhancing PIP5Kgamma activity through deacetylation of specific lysine residues in mammals
    • Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, et al. SIRT1 regulates thyroid-stimulating hormone release by enhancing PIP5Kgamma activity through deacetylation of specific lysine residues in mammals. PLoS One (2010) 5:e11755. doi:10.1371/journal.pone.0011755
    • (2010) PLoS One , vol.5
    • Akieda-Asai, S.1    Zaima, N.2    Ikegami, K.3    Kahyo, T.4    Yao, I.5    Hatanaka, T.6
  • 35
    • 0029081299 scopus 로고
    • Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants
    • Detke MJ, Rickels M, Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (1995) 121:66-72. doi:10.1007/BF02245592
    • (1995) Psychopharmacology , vol.121 , pp. 66-72
    • Detke, M.J.1    Rickels, M.2    Lucki, I.3
  • 38
    • 34147189574 scopus 로고    scopus 로고
    • Health status, psychological symptoms, mood, and cognition in l-thyroxine-treated hypothyroid subjects
    • Samuels MH, Schuff KG, Carlson NE, Carello P, Janowsky JS. Health status, psychological symptoms, mood, and cognition in l-thyroxine-treated hypothyroid subjects. Thyroid (2007) 17:249-58. doi:10.1089/thy.2006.0252
    • (2007) Thyroid , vol.17 , pp. 249-258
    • Samuels, M.H.1    Schuff, K.G.2    Carlson, N.E.3    Carello, P.4    Janowsky, J.S.5
  • 39
    • 23644431529 scopus 로고    scopus 로고
    • The stress system in the human brain in depression and neurodegeneration
    • Swaab DF, Bao AM, Lucassen PJ. The stress system in the human brain in depression and neurodegeneration. Ageing Res Rev (2005) 4:141-94. doi:10.1016/j.arr.2005.03.003
    • (2005) Ageing Res Rev , vol.4 , pp. 141-194
    • Swaab, D.F.1    Bao, A.M.2    Lucassen, P.J.3
  • 40
    • 84862741341 scopus 로고    scopus 로고
    • Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc
    • Li D, Dammer EB, Sewer MB. Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc. Endocrinology (2012) 153:3258-68. doi:10.1210/en.2011-2088
    • (2012) Endocrinology , vol.153 , pp. 3258-3268
    • Li, D.1    Dammer, E.B.2    Sewer, M.B.3
  • 41
    • 84887103262 scopus 로고    scopus 로고
    • Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERK
    • Wang Z, Gu J, Wang X, Xie K, Luan Q, Wan N, et al. Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: the HPA axis, BDNF expression and phosphorylation of ERK. Pharmacol Biochem Behav (2013) 112:104-10. doi:10.1016/j.pbb.2013.10.007
    • (2013) Pharmacol Biochem Behav , vol.112 , pp. 104-110
    • Wang, Z.1    Gu, J.2    Wang, X.3    Xie, K.4    Luan, Q.5    Wan, N.6
  • 42
    • 33846095133 scopus 로고    scopus 로고
    • Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims
    • Karege F, Perroud N, Burkhardt S, Schwald M, Ballmann E, La Harpe R, et al. Alteration in kinase activity but not in protein levels of protein kinase B and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims. Biol Psychiatry (2007) 61:240-5. doi:10.1016/j.biopsych.2006.04.036
    • (2007) Biol Psychiatry , vol.61 , pp. 240-245
    • Karege, F.1    Perroud, N.2    Burkhardt, S.3    Schwald, M.4    Ballmann, E.5    La Harpe, R.6
  • 43
    • 33750866196 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions
    • Jope RS, Roh MS. Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions. Curr Drug Targets (2006) 7:1421-34. doi:10.2174/1389450110607011421
    • (2006) Curr Drug Targets , vol.7 , pp. 1421-1434
    • Jope, R.S.1    Roh, M.S.2
  • 44
    • 3342955475 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium
    • O'Brien WT, Harper AD, Jove F, Woodgett JR, Maretto S, Piccolo S, et al. Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci (2004) 24:6791-8. doi:10.1523/JNEUROSCI.4753-03.2004
    • (2004) J Neurosci , vol.24 , pp. 6791-6798
    • O'Brien, W.T.1    Harper, A.D.2    Jove, F.3    Woodgett, J.R.4    Maretto, S.5    Piccolo, S.6
  • 45
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus
    • Peifer M, Polakis P. Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus. Science (2000) 287:1606-9. doi:10.1126/science.287.5458.1606
    • (2000) Science , vol.287 , pp. 1606-1609
    • Peifer, M.1    Polakis, P.2
  • 46
    • 0242384747 scopus 로고    scopus 로고
    • Beta-catenin is critical for dendritic morphogenesis
    • Yu X, Malenka RC. Beta-catenin is critical for dendritic morphogenesis. Nat Neurosci (2003) 6:1169-77. doi:10.1038/nn1132
    • (2003) Nat Neurosci , vol.6 , pp. 1169-1177
    • Yu, X.1    Malenka, R.C.2
  • 47
    • 0032518695 scopus 로고    scopus 로고
    • Signal transduction by the Wnt family of ligands
    • Dale TC. Signal transduction by the Wnt family of ligands. Biochem J (1998) 329(Pt 2):209-23. doi:10.1042/bj3290209
    • (1998) Biochem J , vol.329 , pp. 209-223
    • Dale, T.C.1
  • 48
    • 84856332025 scopus 로고    scopus 로고
    • Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, beta-catenin and antidepressant-like effects
    • Pilar-Cuellar F, Vidal R, Pazos A. Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, beta-catenin and antidepressant-like effects. Br J Pharmacol (2012) 165:1046-57. doi:10.1111/j.1476-5381.2011.01516.x
    • (2012) Br J Pharmacol , vol.165 , pp. 1046-1057
    • Pilar-Cuellar, F.1    Vidal, R.2    Pazos, A.3
  • 49
    • 17444408560 scopus 로고    scopus 로고
    • Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis
    • Li YJ, Wei ZM, Meng YX, Ji XR. Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis. World J Gastroenterol (2005) 11:2117-23. doi:10.3748/wjg.v11.i14.2117
    • (2005) World J Gastroenterol , vol.11 , pp. 2117-2123
    • Li, Y.J.1    Wei, Z.M.2    Meng, Y.X.3    Ji, X.R.4
  • 50
    • 84888811107 scopus 로고    scopus 로고
    • Epigenetic regulation of DACH1, a novel Wnt signaling component in colorectal cancer
    • Yan W, Wu K, Herman JG, Brock MV, Fuks F, Yang L, et al. Epigenetic regulation of DACH1, a novel Wnt signaling component in colorectal cancer. Epigenetics (2013) 8:1373-83. doi:10.4161/epi.26781
    • (2013) Epigenetics , vol.8 , pp. 1373-1383
    • Yan, W.1    Wu, K.2    Herman, J.G.3    Brock, M.V.4    Fuks, F.5    Yang, L.6
  • 51
    • 0034572042 scopus 로고    scopus 로고
    • beta-Catenin induces invasive growth by activating matrix metalloproteinases in colorectal carcinoma
    • Brabletz T, Jung A, Dag S, Reu S, Kirchner T. [beta-Catenin induces invasive growth by activating matrix metalloproteinases in colorectal carcinoma]. Verh Dtsch Ges Pathol (2000) 84:175-81.
    • (2000) Verh Dtsch Ges Pathol , vol.84 , pp. 175-181
    • Brabletz, T.1    Jung, A.2    Dag, S.3    Reu, S.4    Kirchner, T.5
  • 52
    • 34250901592 scopus 로고    scopus 로고
    • Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
    • Boocock DJ, Faust GE, Patel KR, Schinas AM, Brown VA, Ducharme MP, et al. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev (2007) 16:1246-52. doi:10.1158/1055-9965.EPI-07-0022
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 1246-1252
    • Boocock, D.J.1    Faust, G.E.2    Patel, K.R.3    Schinas, A.M.4    Brown, V.A.5    Ducharme, M.P.6
  • 53
    • 0345743542 scopus 로고    scopus 로고
    • Preventive Services Task Force. Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force
    • Helfand MU.S. Preventive Services Task Force. Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med (2004) 140:128-41. doi:10.7326/0003-4819-140-2-200401200-00015
    • (2004) Ann Intern Med , vol.140 , pp. 128-141
    • Helfand, M.U.S.1
  • 54
    • 84887937515 scopus 로고    scopus 로고
    • Neuroprotection by resveratrol in diabetic neuropathy: concepts & mechanisms
    • Kumar A, Negi G, Sharma SS. Neuroprotection by resveratrol in diabetic neuropathy: concepts & mechanisms. Curr Med Chem (2013) 20:4640-5. doi:10.2174/09298673113209990151
    • (2013) Curr Med Chem , vol.20 , pp. 4640-4645
    • Kumar, A.1    Negi, G.2    Sharma, S.S.3
  • 55
    • 84880349078 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?
    • Timmers S, Hesselink MK, Schrauwen P. Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits? Ann N Y Acad Sci (2013) 1290:83-9. doi:10.1111/nyas.12185
    • (2013) Ann N Y Acad Sci , vol.1290 , pp. 83-89
    • Timmers, S.1    Hesselink, M.K.2    Schrauwen, P.3


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