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Volumn 473, Issue 5, 2016, Pages 605-614

Circulating FGF21 proteolytic processing mediated by fibroblast activation protein

Author keywords

Dipeptidyl peptidase IV; Fibroblast activation protein; Fibroblast growth factor 21; Post transcriptional processing; Prolyl peptidase

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; FIBROBLAST ACTIVATION PROTEIN; FIBROBLAST GROWTH FACTOR 21; PROLINE; PROTEINASE; UNCLASSIFIED DRUG;

EID: 84975144995     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20151085     Document Type: Article
Times cited : (99)

References (51)
  • 1
    • 82955247909 scopus 로고    scopus 로고
    • IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030
    • Whiting, D.R., Guariguata, L., Weil, C. and Shaw, J. (2011) IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res. Clin. Pract. 94, 311-321
    • (2011) Diabetes Res. Clin. Pract. , vol.94 , pp. 311-321
    • Whiting, D.R.1    Guariguata, L.2    Weil, C.3    Shaw, J.4
  • 2
    • 84901821975 scopus 로고    scopus 로고
    • FGF21-based pharmacotherapy - Potential utility for metabolic disorders
    • Gimeno, R.E. and Moller, D.E. (2014) FGF21-based pharmacotherapy - potential utility for metabolic disorders. Trends Endocrinol. Metab. 25, 303-311
    • (2014) Trends Endocrinol. Metab. , vol.25 , pp. 303-311
    • Gimeno, R.E.1    Moller, D.E.2
  • 6
    • 79251501315 scopus 로고    scopus 로고
    • Fibroblast growth factors: From molecular evolution to roles in development, metabolism and disease
    • Itoh, N. and Ornitz, D.M. (2011) Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. J. Biochem. 149, 121-130
    • (2011) J. Biochem. , vol.149 , pp. 121-130
    • Itoh, N.1    Ornitz, D.M.2
  • 12
    • 84874616515 scopus 로고    scopus 로고
    • Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: Application to various FGF21 modalities
    • Hager, T., Spahr, C., Xu, J., Salimi-Moosavi, H. and Hall, M. (2013) Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities. Anal. Chem. 85, 2731-2738
    • (2013) Anal. Chem. , vol.85 , pp. 2731-2738
    • Hager, T.1    Spahr, C.2    Xu, J.3    Salimi-Moosavi, H.4    Hall, M.5
  • 13
    • 70350455732 scopus 로고    scopus 로고
    • Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models - Association with liver and adipose tissue effects
    • Xu, J., Stanislaus, S., Chinookoswong, N., Lau, Y.Y., Hager, T., Patel, J., Ge, H., Weiszmann, J., Lu, S.C., Graham, M. et al. (2009) Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models - association with liver and adipose tissue effects. Am. J. Physiol. Endocrinol. Metab. 297, E1105-E1114
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297 , pp. E1105-E1114
    • Xu, J.1    Stanislaus, S.2    Chinookoswong, N.3    Lau, Y.Y.4    Hager, T.5    Patel, J.6    Ge, H.7    Weiszmann, J.8    Lu, S.C.9    Graham, M.10
  • 16
    • 84870278211 scopus 로고    scopus 로고
    • Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes
    • Hecht, R., Li, Y.S., Sun, J., Belouski, E., Hall, M., Hager, T., Yie, J., Wang, W., Winters, D., Smith, S. et al. (2012) Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes. PLoS One 7, e49345
    • (2012) PLoS One , vol.7 , pp. e49345
    • Hecht, R.1    Li, Y.S.2    Sun, J.3    Belouski, E.4    Hall, M.5    Hager, T.6    Yie, J.7    Wang, W.8    Winters, D.9    Smith, S.10
  • 17
    • 84863011453 scopus 로고    scopus 로고
    • FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents
    • Mu, J., Pinkstaff, J., Li, Z., Skidmore, L., Li, N., Myler, H., Dallas-Yang, Q., Putnam, A.M., Yao, J., Bussell, S. et al. (2012) FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents. Diabetes 61, 505-512
    • (2012) Diabetes , vol.61 , pp. 505-512
    • Mu, J.1    Pinkstaff, J.2    Li, Z.3    Skidmore, L.4    Li, N.5    Myler, H.6    Dallas-Yang, Q.7    Putnam, A.M.8    Yao, J.9    Bussell, S.10
  • 19
    • 84885484874 scopus 로고    scopus 로고
    • Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice
    • Camacho, R.C., Zafian, P.T., Achanfuo-Yeboah, J., Manibusan, A. and Berger, J.P. (2013) Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice. Eur. J. Pharmacol. 715, 41-45
    • (2013) Eur. J. Pharmacol. , vol.715 , pp. 41-45
    • Camacho, R.C.1    Zafian, P.T.2    Achanfuo-Yeboah, J.3    Manibusan, A.4    Berger, J.P.5
  • 20
    • 77956717491 scopus 로고    scopus 로고
    • Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein
    • Tsai, T.Y., Yeh, T.K., Chen, X., Hsu, T., Jao, Y.C., Huang, C.H., Song, J.S., Huang, Y.C., Chien, C.H., Chiu, J.H. et al. (2010) Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein. J. Med. Chem. 53, 6572-6583
    • (2010) J. Med. Chem. , vol.53 , pp. 6572-6583
    • Tsai, T.Y.1    Yeh, T.K.2    Chen, X.3    Hsu, T.4    Jao, Y.C.5    Huang, C.H.6    Song, J.S.7    Huang, Y.C.8    Chien, C.H.9    Chiu, J.H.10
  • 21
    • 72849125358 scopus 로고    scopus 로고
    • Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
    • Santos, A.M., Jung, J., Aziz, N., Kissil, J.L. and Pure, E. (2009) Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J. Clin. Invest. 119, 3613-3625
    • (2009) J. Clin. Invest. , vol.119 , pp. 3613-3625
    • Santos, A.M.1    Jung, J.2    Aziz, N.3    Kissil, J.L.4    Pure, E.5
  • 22
    • 0018636932 scopus 로고
    • A new and highly sensitive fluorescence assay for collagenase-like peptidase activity
    • Kojima, K., Kinoshita, H., Kato, T., Nagatsu, T., Takada, K. and Sakakibara, S. (1979) A new and highly sensitive fluorescence assay for collagenase-like peptidase activity. Anal. Biochem. 100, 43-50
    • (1979) Anal. Biochem. , vol.100 , pp. 43-50
    • Kojima, K.1    Kinoshita, H.2    Kato, T.3    Nagatsu, T.4    Takada, K.5    Sakakibara, S.6
  • 23
    • 33344475312 scopus 로고    scopus 로고
    • Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity
    • Edosada, C.Y., Quan, C., Tran, T., Pham, V., Wiesmann, C., Fairbrother, W. and Wolf, B.B. (2006) Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity. FEBS Lett. 580, 1581-1586
    • (2006) FEBS Lett. , vol.580 , pp. 1581-1586
    • Edosada, C.Y.1    Quan, C.2    Tran, T.3    Pham, V.4    Wiesmann, C.5    Fairbrother, W.6    Wolf, B.B.7
  • 24
    • 67049132659 scopus 로고    scopus 로고
    • Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design
    • Lee, K.N., Jackson, K.W., Terzyan, S., Christiansen, V.J. and McKee, P.A. (2009) Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design. Biochemistry 48, 5149-5158
    • (2009) Biochemistry , vol.48 , pp. 5149-5158
    • Lee, K.N.1    Jackson, K.W.2    Terzyan, S.3    Christiansen, V.J.4    McKee, P.A.5
  • 26
    • 84870568785 scopus 로고    scopus 로고
    • Circulating fibroblast growth factors as metabolic regulators - A critical appraisal
    • Angelin, B., Larsson, T.E. and Rudling, M. (2012) Circulating fibroblast growth factors as metabolic regulators - a critical appraisal. Cell Metab. 16, 693-705
    • (2012) Cell Metab. , vol.16 , pp. 693-705
    • Angelin, B.1    Larsson, T.E.2    Rudling, M.3
  • 28
    • 0043073112 scopus 로고    scopus 로고
    • Prolyl peptidases: A serine protease subfamily with high potential for drug discovery
    • Rosenblum, J.S. and Kozarich, J.W. (2003) Prolyl peptidases: a serine protease subfamily with high potential for drug discovery. Curr. Opin. Chem. Biol. 7, 496-504
    • (2003) Curr. Opin. Chem. Biol. , vol.7 , pp. 496-504
    • Rosenblum, J.S.1    Kozarich, J.W.2
  • 29
    • 0023692420 scopus 로고
    • Membrane orientation of rat gp110 as studied by in vitro translation
    • Hong, W.J. and Doyle, D. (1988) Membrane orientation of rat gp110 as studied by in vitro translation. J. Biol. Chem. 263, 16892-16898
    • (1988) J. Biol. Chem. , vol.263 , pp. 16892-16898
    • Hong, W.J.1    Doyle, D.2
  • 30
    • 32644446428 scopus 로고    scopus 로고
    • Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein
    • Lee, K.N., Jackson, K.W., Christiansen, V.J., Lee, C.S., Chun, J.G. and McKee, P.A. (2006) Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein. Blood 107, 1397-1404
    • (2006) Blood , vol.107 , pp. 1397-1404
    • Lee, K.N.1    Jackson, K.W.2    Christiansen, V.J.3    Lee, C.S.4    Chun, J.G.5    McKee, P.A.6
  • 31
    • 0033780088 scopus 로고    scopus 로고
    • Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8. Eur
    • Abbott, C.A., Yu, D.M., Woollatt, E., Sutherland, G.R., McCaughan, G.W. and Gorrell, M.D. (2000) Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8. Eur. J. Biochem. 267, 6140-6150
    • (2000) J. Biochem. , vol.267 , pp. 6140-6150
    • Abbott, C.A.1    Yu, D.M.2    Woollatt, E.3    Sutherland, G.R.4    McCaughan, G.W.5    Gorrell, M.D.6
  • 32
    • 0037121086 scopus 로고    scopus 로고
    • Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV
    • Olsen, C. and Wagtmann, N. (2002) Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV. Gene 299, 185-193
    • (2002) Gene , vol.299 , pp. 185-193
    • Olsen, C.1    Wagtmann, N.2
  • 33
    • 0033607516 scopus 로고    scopus 로고
    • Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase
    • Underwood, R., Chiravuri, M., Lee, H., Schmitz, T., Kabcenell, A.K., Yardley, K. and Huber, B.T. (1999) Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase. J. Biol. Chem. 274, 34053-34058
    • (1999) J. Biol. Chem. , vol.274 , pp. 34053-34058
    • Underwood, R.1    Chiravuri, M.2    Lee, H.3    Schmitz, T.4    Kabcenell, A.K.5    Yardley, K.6    Huber, B.T.7
  • 35
    • 0034279642 scopus 로고    scopus 로고
    • Catalysis of serine oligopeptidases is controlled by a gating filter mechanism
    • Fulop, V., Szeltner, Z. and Polgar, L. (2000) Catalysis of serine oligopeptidases is controlled by a gating filter mechanism. EMBO Rep. 1, 277-281
    • (2000) EMBO Rep. , vol.1 , pp. 277-281
    • Fulop, V.1    Szeltner, Z.2    Polgar, L.3
  • 36
    • 0024291209 scopus 로고
    • Proline residues in the maturation and degradation of peptide hormones and neuropeptides
    • Mentlein, R. (1988) Proline residues in the maturation and degradation of peptide hormones and neuropeptides. FEBS Lett. 234, 251-256
    • (1988) FEBS Lett. , vol.234 , pp. 251-256
    • Mentlein, R.1
  • 37
    • 0036158954 scopus 로고    scopus 로고
    • Biological actions and therapeutic potential of the glucagon-like peptides
    • Drucker, D.J. (2002) Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122, 531-544
    • (2002) Gastroenterology , vol.122 , pp. 531-544
    • Drucker, D.J.1
  • 39
    • 0033852128 scopus 로고    scopus 로고
    • Molecular characterization of dipeptidyl peptidase activity in serum: Soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides. Eur
    • Durinx, C., Lambeir, A.M., Bosmans, E., Falmagne, J.B., Berghmans, R., Haemers, A., Scharpe, S. and De Meester, I. (2000) Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides. Eur. J. Biochem. 267, 5608-5613
    • (2000) J. Biochem. , vol.267 , pp. 5608-5613
    • Durinx, C.1    Lambeir, A.M.2    Bosmans, E.3    Falmagne, J.B.4    Berghmans, R.5    Haemers, A.6    Scharpe, S.7    De Meester, I.8
  • 41
    • 0028286026 scopus 로고
    • Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers
    • Scanlan, M.J., Raj, B.K., Calvo, B., Garin-Chesa, P., Sanz-Moncasi, M.P., Healey, J.H., Old, L.J. and Rettig, W.J. (1994) Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc. Natl. Acad. Sci. U.S.A. 91, 5657-5661
    • (1994) Proc. Natl. Acad. Sci. U.S.A , vol.91 , pp. 5657-5661
    • Scanlan, M.J.1    Raj, B.K.2    Calvo, B.3    Garin-Chesa, P.4    Sanz-Moncasi, M.P.5    Healey, J.H.6    Old, L.J.7    Rettig, W.J.8
  • 42
    • 84903215652 scopus 로고    scopus 로고
    • Fibroblast activation protein, a potential diagnostic and therapeutic target for cancer-reply
    • Tchou, J. and Conejo-Garcia, J. (2014) Fibroblast activation protein, a potential diagnostic and therapeutic target for cancer-reply. Hum. Pathol. 45, 1553-1554
    • (2014) Hum. Pathol. , vol.45 , pp. 1553-1554
    • Tchou, J.1    Conejo-Garcia, J.2
  • 43
    • 84902107760 scopus 로고    scopus 로고
    • Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy
    • Hamson, E.J., Keane, F.M., Tholen, S., Schilling, O. and Gorrell, M.D. (2014) Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy. Proteomics Clin. Appl. 8, 454-463
    • (2014) Proteomics Clin. Appl. , vol.8 , pp. 454-463
    • Hamson, E.J.1    Keane, F.M.2    Tholen, S.3    Schilling, O.4    Gorrell, M.D.5
  • 44
    • 79953729051 scopus 로고    scopus 로고
    • Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha
    • Keane, F.M., Nadvi, N.A., Yao, T.W. and Gorrell, M.D. (2011) Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha. FEBS J. 278, 1316-1332
    • (2011) FEBS J. , vol.278 , pp. 1316-1332
    • Keane, F.M.1    Nadvi, N.A.2    Yao, T.W.3    Gorrell, M.D.4
  • 45
    • 2342447229 scopus 로고    scopus 로고
    • A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion
    • Lee, K.N., Jackson, K.W., Christiansen, V.J., Chung, K.H. and McKee, P.A. (2004) A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion. Blood 103, 3783-3788
    • (2004) Blood , vol.103 , pp. 3783-3788
    • Lee, K.N.1    Jackson, K.W.2    Christiansen, V.J.3    Chung, K.H.4    McKee, P.A.5
  • 46
    • 0033034717 scopus 로고    scopus 로고
    • Fibroblast activation protein: A cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis
    • Levy, M.T., McCaughan, G.W., Abbott, C.A., Park, J.E., Cunningham, A.M., Muller, E., Rettig, W.J. and Gorrell, M.D. (1999) Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis. Hepatology 29, 1768-1778
    • (1999) Hepatology , vol.29 , pp. 1768-1778
    • Levy, M.T.1    McCaughan, G.W.2    Abbott, C.A.3    Park, J.E.4    Cunningham, A.M.5    Muller, E.6    Rettig, W.J.7    Gorrell, M.D.8
  • 47
    • 33846018363 scopus 로고    scopus 로고
    • Effect of fibroblast activation protein and alpha2-antiplasmin cleaving enzyme on collagen types I, III, and IV
    • Christiansen, V.J., Jackson, K.W., Lee, K.N. and McKee, P.A. (2007) Effect of fibroblast activation protein and alpha2-antiplasmin cleaving enzyme on collagen types I, III, and IV. Arch. Biochem. Biophys. 457, 177-186
    • (2007) Arch. Biochem. Biophys. , vol.457 , pp. 177-186
    • Christiansen, V.J.1    Jackson, K.W.2    Lee, K.N.3    McKee, P.A.4
  • 48
    • 84899809867 scopus 로고    scopus 로고
    • A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation
    • Osborne, B., Yao, T.W., Wang, X.M., Chen, Y., Kotan, L.D., Nadvi, N.A., Herdem, M., McCaughan, G.W., Allen, J.D., Yu, D.M. et al. (2014) A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. Biochim. Biophys. Acta 1844, 1248-1259
    • (2014) Biochim. Biophys. Acta , vol.1844 , pp. 1248-1259
    • Osborne, B.1    Yao, T.W.2    Wang, X.M.3    Chen, Y.4    Kotan, L.D.5    Nadvi, N.A.6    Herdem, M.7    McCaughan, G.W.8    Allen, J.D.9    Yu, D.M.10
  • 50
    • 4143063726 scopus 로고    scopus 로고
    • Purification, identification and characterisation of seprase from bovine serum
    • Collins, P.J., McMahon, G., O'Brien, P. and O'Connor, B. (2004) Purification, identification and characterisation of seprase from bovine serum. Int. J. Biochem. Cell Biol. 36, 2320-2333
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 2320-2333
    • Collins, P.J.1    McMahon, G.2    O'Brien, P.3    O'Connor, B.4
  • 51
    • 0033517124 scopus 로고    scopus 로고
    • A role for dipeptidyl peptidase IV in suppressing the malignant phenotype of melanocytic cells
    • Wesley, U.V., Albino, A.P., Tiwari, S. and Houghton, A.N. (1999) A role for dipeptidyl peptidase IV in suppressing the malignant phenotype of melanocytic cells. J. Exp. Med. 190, 311-322
    • (1999) J. Exp. Med. , vol.190 , pp. 311-322
    • Wesley, U.V.1    Albino, A.P.2    Tiwari, S.3    Houghton, A.N.4


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