The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities

Protein Science

Volumn 19, Issue 9, 2010, Pages 1627-1638

  Chung, Kuei Min ^a   Cheng, Jai Hong ^a   Suen, Ching Shu ^b   Huang, Chih Hsiang ^a   Tsai, Cheng Han ^a   Huang, Li Hao ^a   Chen, Yi Rong ^a   Wang, Andrew H J ^c   Jiaang, Weir Torn ^a   Hwang, Ming Jing ^b   Chen, Xin ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

Author keywords

Dimerization; Dipeptidyl peptidase IV; Prolyl dipeptidase; Transmembrane domain; Type II membrane protein

Indexed keywords

DIMER; MEMBRANE PROTEIN; MONOMER; PEPTIDE; PROLINE; PROLYL DIPEPTIDASE; PROLYL DIPEPTIDASE DPP IV; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INSECT CELL; MAMMAL CELL; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DATA BANK; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN ELECTROPHORESIS; PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; DIPEPTIDYL PEPTIDASE 4; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT;

MAMMALIA;

EID: 77956389799     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.443     Document Type: Article

References (46)

1. Rosenblum JS, Kozarich JW (2003) Prolyl peptidases: a serine protease subfamily with high potential for drug discovery. Curr Opin Chem Biol 7:496-504.
2. Hong WJ, Doyle D (1988) Membrane orientation of rat gp110 as studied by in vitro translation. J Biol Chem 263:16892-16898.
3. Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, Kina S, Tanaka H, Lin X, Dang NH, Morimoto C (2007) Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1. J Biol Chem 282:10117-10131.
4. Low SH, Tang BL, Wong SH, Hong W (1994) Golgi retardation in Madin-Darby canine kidney and Chinese hamster ovary cells of a transmembrane chimera of two surface proteins. J Biol Chem 269:1985-1994.
5. Munro S (1991) Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention. EMBO J 10:3577-3588.
6. Hong WJ, Doyle D (1990) Molecular dissection of the NH2-terminal signal/anchor sequence of rat dipeptidyl peptidase IV. J Cell Biol 111:323-328.
7. Engel M, Hoffmann T, Wagner L, Wermann M, Heiser U, Kiefersauer R, Huber R, Bode W, Demuth HU, Brandstetter H (2003) The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism. Proc Natl Acad Sci USA 100:5063-5068. (Pubitemid 36542658)
8. Rasmussen HB, Branner S, Wiberg FC, Wagtmann N (2003) Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog. Nat Struct Biol 10:19-25. (Pubitemid 36034172)
9. Thoma R, Loffler B, Stihle M, Huber W, Ruf A, Hennig M (2003) Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV. Structure 11:947-959. (Pubitemid 36966784)
10. Fulop V, Bocskei Z, Polgar L (1998) Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis. Cell 94:161-170. (Pubitemid 28348004)
11. Chien CH, Huang LH, Chou CY, Chen YS, Han YS, Chang GG, Liang PH, Chen X (2004) One site mutation disrupts dimer formation in human DPP-IV proteins. J Biol Chem 279:52338-52345.
12. Chien CH, Tsai CH, Lin CH, Chou CY, Chen X (2006) Identification of hydrophobic residues critical for DPPIV dimerization. Biochemistry 45:7006-7012. (Pubitemid 43877389)
13. Dobers J, Grams S, Reutter W, Fan H (2000) Roles of cysteines in rat dipeptidyl peptidase IV/CD26 in processing and proteolytic activity. Eur J Biochem 267: 5093-5100. (Pubitemid 30641304)
14. Danielsen EM (1994) Dimeric assembly of enterocyte brush border enzymes. Biochemistry 33:1599-1605.
15. Deber CM, Wang C, Liu LP, Prior AS, Agrawal S, Muskat BL, Cuticchia AJ (2001) TM Finder: a prediction program for transmembrane protein segments using a combination of hydrophobicity and nonpolar phase helicity scales. Protein Sci 10:212-219. (Pubitemid 32221178)
16. Rath A, Melnyk RA, Deber CM (2006) Evidence for assembly of smallmultidrug resistance proteins by a "two-faced" transmembrane helix. J Biol Chem 281:15546-15553.
17. Xu Y, Piston DW, Johnson CH (1999) A bioluminescence resonance energy transfer (BRET) system: application to interacting circadian clock proteins. Proc Natl Acad Sci USA 96:151-156.
18. Pfleger KD, Eidne KA (2006) Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET). Nat Methods 3:165-174.
19. Lupas A, Van Dyke M, Stock J (1991) Predicting coiled coils from protein sequences. Science 252:1162-1164.
20. McDonnell AV, Jiang T, Keating AE, Berger B (2006) Paircoil2: improved prediction of coiled coils from sequence. Bioinformatics 22:356-358.
21. Lemmon MA, Flanagan JM, Treutlein HR, Zhang J, Engelman DM (1992) Sequence specificity in the dimerization of transmembrane alpha-helices. Biochemistry 31:12719-12725.
22. MacKenzie KR, Prestegard JH, Engelman DM (1997) A transmembrane helix dimer: structure and implications. Science 276:131-133.
23. Petrache HI, Grossfield A, MacKenzie KR, Engelman DM, Woolf TB (2000) Modulation of glycophorin A transmembrane helix interactions by lipid bilayers: molecular dynamics calculations. J Mol Biol 302:727-746.
24. Gurezka R, Laage R, Brosig B, Langosch D (1999) A heptad motif of leucine residues found in membrane proteins can drive self-assembly of artificial transmembrane segments. J Biol Chem 274:9265-9270.
25. Gurezka R, Langosch D (2001) In vitro selection of membrane-spanning leucine zipper protein-protein interaction motifs using POSSYCCAT. J Biol Chem 276:45580-45587.
26. Noordeen NA, Carafoli F, Hohenester E, Horton MA, Leitinger B (2006) A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1. J Biol Chem 281:22744-22751.
27. Senes A, Engel DE, DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol 14:465-479.
28. Monne M, Hermansson M, von Heijne G (1999) A turn propensity scale for transmembrane helices. J Mol Biol 288:141-145.
29. Chou PY, Fasman GD (1978) Empirical predictions of protein conformation. Annu Rev Biochem 47:251-276.
30. O'Neil KT, DeGrado WF (1990) A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids. Science 250:646-651.
31. Zhou FX, Cocco MJ, Russ WP, Brunger AT, Engelman DM (2000) Interhelical hydrogen bonding drives strong interactions in membrane proteins. Nat Struct Biol 7:154-160.
32. Choma C, Gratkowski H, Lear JD, DeGrado WF (2000) Asparagine-mediated self-association of a model transmembrane helix. Nat Struct Biol 7:161-166. (Pubitemid 30082515)
33. Dawson JP, Weinger JS, Engelman DM (2002) Motifs of serine and threonine can drive association of transmembrane helices. J Mol Biol 316:799-805. (Pubitemid 34729255)
34. Gratkowski H, Lear JD, DeGrado WF (2001) Polar side chains drive the association of model transmembrane peptides. Proc Natl Acad Sci USA 98:880-885. (Pubitemid 32121156)
35. Govaerts C, Blanpain C, Deupi X, Ballet S, Ballesteros JA, Wodak SJ, Vassart G, Pardo L, Parmentier M (2001) The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation. J Biol Chem 276:13217-13225.
36. Cordes FS, Bright JN, Sansom MS (2002) Proline-induced distortions of transmembrane helices. J Mol Biol 323:951-960.
37. Adams PD, Engelman DM, Brunger AT (1996) Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching. Proteins 26:257-261.
38. Fleming KG, Ackerman AL, Engelman DM (1997) The effect of point mutations on the free energy of transmembrane alpha-helix dimerization. J Mol Biol 272: 266-275.
39. Bowie JU (2005) Solving the membrane protein folding problem. Nature 438:581-589. (Pubitemid 41740561)
40. Walkenhorst WF, Merzlyakov M, Hristova K, Wimley WC (2009) Polar residues in transmembrane helices can decrease electrophoretic mobility in polyacrylamide gels without causing helix dimerization. Biochim Biophys Acta 1788:1321-1331.
41. Ozkan SB, Wu GA, Chodera JD, Dill KA (2007) Protein folding by zipping and assembly. Proc Natl Acad Sci USA 104:11987-11992.
42. Chen X, Wen S, Fukuda MN, Gavva NR, Hsu D, Akama TO, Yang-Feng T, Shen CK (2001) Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2. Genomics 73:238-241.
43. Goin JC, Nathanson NM (2006) Quantitative analysis of muscarinic acetylcholine receptor homo- and heterodimerization in live cells: regulation of receptor downregulation by heterodimerization. J Biol Chem 281: 5416-5425.
44. Tusnady GE, Dosztanyi Z, Simon I (2005) PDB-TM: selection and membrane localization of transmembrane proteins in the protein data bank. Nucleic Acids Res 33:D275-D278.
45. Kraulis PJ (1991) MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J Appl Cryst 24:946-950.
46. Merritt EA, Bacon DJ (1997) Raster3D photorealistic molecular graphics. Methods Enzymol 277:505-524.