Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design

Biochemistry

Volumn 48, Issue 23, 2009, Pages 5149-5158

  Lee, Kyung N ^a   Jackson, Kenneth W ^a   Terzyan, Simon ^b   Christiansen, Victoria J ^a   McKee, Patrick A ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-PLASMIN; CANCER GROWTH; CLEAVAGE RATES; DIPEPTIDYL PEPTIDASE; PEPTIDE LIBRARY; PEPTIDE SEQUENCES; PEPTIDE SUBSTRATES; PROTEIN INHIBITORS; SCISSILE BOND; SERINE PROTEINASE; SPECIFIC INHIBITORS; SUBSTRATE SPECIFICITY;

AMINATION; AMINES; AMINO ACIDS; CELL CULTURE; ENZYMES; FIBROBLASTS; ORGANIC ACIDS;

SUBSTRATES;

ALPHA 2 ANTIPLASMIN; ANTIPLASMIN CLEAVING ENZYME; ARGININE; DIPEPTIDYL PEPTIDASE IV; ENZYME INHIBITOR; FIBROBLAST ACTIVATION PROTEIN; GLYCINE; MEMBRANE PROTEIN; PHENYLALANYLARGINYL (8 AMINO 3,6 DIOXAOCTANOIC ACID)GLYCYLFLUOROPYRROLIDIDE; PHENYLALANYLARGINYL (8 AMINO 3,6 DIOXAOCTANOIC ACID)GLYCYLPIPECOLINAMIDE; PHENYLALANYLARGINYL (8 AMINO 3,6 DIOXAOCTANOIC ACID)GLYCYLPIPECOLINYLASPARAGINYLGLUTAMINYLGLUTAMYLGLUTAMINYLVALINE; PHENYLALANYLARGINYL (8 AMINO 3,6 DIOXAOCTANOIC ACID)GLYCYLPIPECOLINYLASPARAGINYLGLUTAMINYLGLYCYLGLUTAMINYLVALINE; PHENYLALANYLARGINYL (8 AMINO 3,6 DIOXAOCTANOIC ACID)GLYCYLPIPERIDIDE; PHENYLALANYLARGINYL (8 AMINO 3,6 DIOXAOCTANOIC ACID)GLYCYLPYRROLIDIDE; PHENYLALANYLARGINYL (8 AMINO 3,6 DIOXAOCTANOIC ACID)PYRROLIDIDE; PHENYLALANYLARGINYLGLUTAMINYLLEUCYLTHREONYLSERYLGLYCYLPIPECOLINYLASPARAGINYLGLUTAMINYLGLUTAMYLGLUTAMINYLVALINE; PHENYLALANYLGLYCYL (8 AMINO 3,6 DIOXAOCTANOIC ACID)GLYCYLPIPECOLINYLASPARAGINYLGLUTAMINYLGLUTAMYLGLUTAMINYLVALINE; PHENYLALANYLGLYCYL (8 AMINO 3,6 DIOXAOCTANOIC ACID)GLYCYLPYRROLIDIDE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; ENZYME BINDING; ENZYME INHIBITION; ENZYME SPECIFICITY; GENETIC POLYMORPHISM; PRIORITY JOURNAL; PROTEIN CLEAVAGE;

AMINO ACID SEQUENCE; ANTIPLASMIN; BINDING SITES; ENDOPEPTIDASES; FIBROBLASTS; GELATINASES; HUMANS; HYDROLYSIS; KINETICS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 67049132659     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900257m     Document Type: Article

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