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Volumn 9, Issue 3, 2016, Pages 128-138

Pharmacometabolomics in Early-Phase Clinical Development

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ATENOLOL; CAPECITABINE; CITALOPRAM; ESCITALOPRAM; FLUOROURACIL; PARACETAMOL; SERTRALINE; SIMVASTATIN; TACROLIMUS;

EID: 84975089443     PISSN: 17528054     EISSN: 17528062     Source Type: Journal    
DOI: 10.1111/cts.12396     Document Type: Review
Times cited : (31)

References (54)
  • 1
    • 33750475205 scopus 로고    scopus 로고
    • Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials?
    • van der Greef, J., Hankemeier, T. & McBurney, R.N. Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials? Pharmacogenomics 7, 1087–1094 (2006).
    • (2006) Pharmacogenomics , vol.7 , pp. 1087-1094
    • van der Greef, J.1    Hankemeier, T.2    McBurney, R.N.3
  • 2
    • 70149092771 scopus 로고    scopus 로고
    • Drugs, bugs, and personalized medicine: pharmacometabonomics enters the ring
    • Wilson, I.D. Drugs, bugs, and personalized medicine: pharmacometabonomics enters the ring. Proc. Natl. Acad. Sci. USA 106, 14187–14188 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 14187-14188
    • Wilson, I.D.1
  • 4
    • 33646198860 scopus 로고    scopus 로고
    • Pharmaco-metabonomic phenotyping and personalized drug treatment
    • Clayton, T.A. et al. Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 440, 1073–1077 (2006).
    • (2006) Nature , vol.440 , pp. 1073-1077
    • Clayton, T.A.1
  • 5
    • 32444433438 scopus 로고    scopus 로고
    • Symbiosis of chemometrics and metabolomics: past, present, and future
    • van der Greef, J. & Smilde, A.K. Symbiosis of chemometrics and metabolomics: past, present, and future. J. Chemometrics 19, 376–386 (2005).
    • (2005) J. Chemometrics , vol.19 , pp. 376-386
    • van der Greef, J.1    Smilde, A.K.2
  • 6
    • 84880453290 scopus 로고    scopus 로고
    • Pharmacogenomics in early-phase clinical development
    • Burt, T. & Dhillon, S. Pharmacogenomics in early-phase clinical development. Pharmacogenomics 14, 1085–1097 (2013).
    • (2013) Pharmacogenomics , vol.14 , pp. 1085-1097
    • Burt, T.1    Dhillon, S.2
  • 7
    • 84893763297 scopus 로고    scopus 로고
    • Pharmacometabolomics: implications for clinical pharmacology and systems pharmacology
    • Kaddurah-Daouk, R., Weinshilboum, R.M. & Pharmacometabolomics Research Network. Pharmacometabolomics: implications for clinical pharmacology and systems pharmacology. Clin. Pharmacol. Ther. 95, 154–167 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.95 , pp. 154-167
    • Kaddurah-Daouk, R.1    Weinshilboum, R.M.2
  • 8
    • 0032694577 scopus 로고    scopus 로고
    • Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson, J.K., Lindon, J.C. & Holmes, E. ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29, 1181–1189 (1999).
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 10
    • 70149096873 scopus 로고    scopus 로고
    • Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
    • Clayton, T.A., Baker, D., Lindon, J.C., Everett, J.R. & Nicholson, J.K. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc. Natl. Acad. Sci. USA 106, 14728–14733 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 14728-14733
    • Clayton, T.A.1    Baker, D.2    Lindon, J.C.3    Everett, J.R.4    Nicholson, J.K.5
  • 11
    • 84856120472 scopus 로고    scopus 로고
    • Longitudinal pharmacometabonomics for predicting patient responses to therapy: drug metabolism, toxicity and efficacy
    • Nicholson, J.K., Everett, J.R. & Lindon, J.C. Longitudinal pharmacometabonomics for predicting patient responses to therapy: drug metabolism, toxicity and efficacy. Expert Opin. Drug Metab. Toxicol. 8, 135–139 (2012).
    • (2012) Expert Opin. Drug Metab. Toxicol. , vol.8 , pp. 135-139
    • Nicholson, J.K.1    Everett, J.R.2    Lindon, J.C.3
  • 12
    • 84886649758 scopus 로고    scopus 로고
    • Metabolomics in drug discovery and development
    • Robertson, D.G. & Frevert, U. Metabolomics in drug discovery and development. Clin. Pharmacol. Ther. 94, 559–561 (2013).
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 559-561
    • Robertson, D.G.1    Frevert, U.2
  • 13
    • 33745361258 scopus 로고    scopus 로고
    • Metabonomics techniques and applications to pharmaceutical research & development
    • Lindon, J.C., Holmes, E. & Nicholson, J.K. Metabonomics techniques and applications to pharmaceutical research & development. Pharm. Res. 23, 1075–1088 (2006).
    • (2006) Pharm. Res. , vol.23 , pp. 1075-1088
    • Lindon, J.C.1    Holmes, E.2    Nicholson, J.K.3
  • 14
    • 0018137689 scopus 로고
    • Quantitative metabolic profiling based on gas chromatography
    • Gates, S.C. & Sweeley, C.C. Quantitative metabolic profiling based on gas chromatography. Clin. Chem. 24, 1663–1673 (1978).
    • (1978) Clin. Chem. , vol.24 , pp. 1663-1673
    • Gates, S.C.1    Sweeley, C.C.2
  • 15
    • 0013970755 scopus 로고
    • Gas-liquid chromatographic study and estimation of several urinary aromatic acids
    • Horning, M.G., Knox, K.L., Dalgliesh, C.E. & Horning, E.C. Gas-liquid chromatographic study and estimation of several urinary aromatic acids. Anal. Biochem. 17, 244–257 (1966).
    • (1966) Anal. Biochem. , vol.17 , pp. 244-257
    • Horning, M.G.1    Knox, K.L.2    Dalgliesh, C.E.3    Horning, E.C.4
  • 16
    • 0001486502 scopus 로고
    • Mass spectrometry in lipid research
    • Ryhage, R. & Stenhagen, E. Mass spectrometry in lipid research. J. Lipid Res. 1, 361–390 (1960).
    • (1960) J. Lipid Res. , vol.1 , pp. 361-390
    • Ryhage, R.1    Stenhagen, E.2
  • 17
    • 0016942108 scopus 로고
    • Gas chromatographic mass spectrometric evaluation of free organic acids in human saliva
    • Ward, M.E., Politzer, I.R., Laseter, J.L. & Alam, S.Q. Gas chromatographic mass spectrometric evaluation of free organic acids in human saliva. Biomed. Mass Spectrom. 3, 77–80 (1976).
    • (1976) Biomed. Mass Spectrom. , vol.3 , pp. 77-80
    • Ward, M.E.1    Politzer, I.R.2    Laseter, J.L.3    Alam, S.Q.4
  • 18
    • 0016522802 scopus 로고
    • Quantitative metabolic profiling of urinary organic acids by gas chromatography-mass spectrometry: comparison of isolation methods
    • Thompson, J.A. & Markey, S.P. Quantitative metabolic profiling of urinary organic acids by gas chromatography-mass spectrometry: comparison of isolation methods. Anal. Chem. 47, 1313–1321 (1975).
    • (1975) Anal. Chem. , vol.47 , pp. 1313-1321
    • Thompson, J.A.1    Markey, S.P.2
  • 19
    • 0017751595 scopus 로고
    • Urinary organic acids quantitated by age groups in a healthy pediatric population
    • Thompson, J.A., Miles, B.S. & Fennessey, P.V. Urinary organic acids quantitated by age groups in a healthy pediatric population. Clin. Chem. 23, 1734–1738 (1977).
    • (1977) Clin. Chem. , vol.23 , pp. 1734-1738
    • Thompson, J.A.1    Miles, B.S.2    Fennessey, P.V.3
  • 20
    • 0001489431 scopus 로고
    • Analysis of pepper and capsicum oleoresins by high-performance liquid chromatography—mass spectrometry and field desorption mass spectrometry
    • Games, D.E. et al. Analysis of pepper and capsicum oleoresins by high-performance liquid chromatography—mass spectrometry and field desorption mass spectrometry. J. Chromatography A 294, 269–279 (1984).
    • (1984) J. Chromatography A , vol.294 , pp. 269-279
    • Games, D.E.1
  • 21
    • 5844331926 scopus 로고
    • Evaluation of field-desorption and fast atom-bombardment mass spectrometric profiles by pattern recognition techniques
    • van der Greef, J., Tas, A.C., Bouwman, J., Ten Noever de Brauw, M.C. & Schreurs, W.H.P. Evaluation of field-desorption and fast atom-bombardment mass spectrometric profiles by pattern recognition techniques. Anal. Chim. Acta 150, 45–52 (1983).
    • (1983) Anal. Chim. Acta , vol.150 , pp. 45-52
    • van der Greef, J.1    Tas, A.C.2    Bouwman, J.3    Ten Noever de Brauw, M.C.4    Schreurs, W.H.P.5
  • 22
    • 70350560562 scopus 로고    scopus 로고
    • Metabolomics applied to diabetes research: moving from information to knowledge
    • Bain, J.R., Stevens, R.D., Wenner, B.R., Ilkayeva, O., Muoio, D.M. & Newgard, C.B. Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes 58, 2429–2443 (2009).
    • (2009) Diabetes , vol.58 , pp. 2429-2443
    • Bain, J.R.1    Stevens, R.D.2    Wenner, B.R.3    Ilkayeva, O.4    Muoio, D.M.5    Newgard, C.B.6
  • 24
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics–the link between genotypes and phenotypes
    • Fiehn, O. Metabolomics–the link between genotypes and phenotypes. Plant Mol. Biol. 48, 155–171 (2002).
    • (2002) Plant Mol. Biol. , vol.48 , pp. 155-171
    • Fiehn, O.1
  • 26
    • 84886668782 scopus 로고    scopus 로고
    • Metabolomics: integration of a new “omics” with clinical pharmacology
    • James, L.P. Metabolomics: integration of a new “omics” with clinical pharmacology. Clin. Pharmacol. Ther. 94, 547–551 (2013).
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 547-551
    • James, L.P.1
  • 27
    • 36749021607 scopus 로고    scopus 로고
    • Metabolomic biomarkers: their role in the critical path
    • Schnackenberg, L.K. & Beger, R.D. Metabolomic biomarkers: their role in the critical path. Drug Discov. Today Technol. 4, 13–16 (2007).
    • (2007) Drug Discov. Today Technol. , vol.4 , pp. 13-16
    • Schnackenberg, L.K.1    Beger, R.D.2
  • 29
    • 79952281264 scopus 로고    scopus 로고
    • From discovery to cure: accelerating the development of new and personalized interventions for mental illnesses
    • NIMH. From discovery to cure: accelerating the development of new and personalized interventions for mental illnesses. (The National Advisory Mental Health Council's Workgroup, 2010).
    • (2010) The National Advisory Mental Health Council's Workgroup
  • 30
    • 84975065243 scopus 로고    scopus 로고
    • Continuing America's Leadership: The Future of Medical Innovation for Patients Testimony before the Committee on Health, Education, Labor and Pensions, United States Senate
    • Washington, D.C
    • Woodcock, J. Continuing America's Leadership: The Future of Medical Innovation for Patients. Testimony before the Committee on Health, Education, Labor and Pensions, United States Senate. (US Food and Drug Administration, Washington, D.C., 2015).
    • (2015) US Food and Drug Administration
    • Woodcock, J.1
  • 31
    • 84858433310 scopus 로고    scopus 로고
    • Personal omics profiling reveals dynamic molecular and medical phenotypes
    • Chen, R. et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 148, 1293–1307 (2012).
    • (2012) Cell , vol.148 , pp. 1293-1307
    • Chen, R.1
  • 32
    • 84893779701 scopus 로고    scopus 로고
    • Pharmacometabonomics and personalized medicine
    • Everett, J.R., Loo, R.L. & Pullen, F.S. Pharmacometabonomics and personalized medicine. Ann Clin Biochem 50(Pt 6), 523–545 (2013).
    • (2013) Ann Clin Biochem , vol.50 , pp. 523-545
    • Everett, J.R.1    Loo, R.L.2    Pullen, F.S.3
  • 33
    • 0242607632 scopus 로고    scopus 로고
    • Parallel analysis of transcript and metabolic profiles: a new approach in systems biology
    • Urbanczyk-Wochniak, E. et al. Parallel analysis of transcript and metabolic profiles: a new approach in systems biology. EMBO Rep. 4, 989–993 (2003).
    • (2003) EMBO Rep. , vol.4 , pp. 989-993
    • Urbanczyk-Wochniak, E.1
  • 34
    • 79951678399 scopus 로고    scopus 로고
    • Predicting idiopathic toxicity of cisplatin by a pharmacometabonomic approach
    • Kwon, H.N. et al. Predicting idiopathic toxicity of cisplatin by a pharmacometabonomic approach. Kidney Int. 79, 529–537 (2011).
    • (2011) Kidney Int. , vol.79 , pp. 529-537
    • Kwon, H.N.1
  • 35
    • 84884502711 scopus 로고    scopus 로고
    • Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics
    • Yerges-Armstrong, L.M. et al. Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin. Pharmacol. Ther. 94, 525–532 (2013).
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 525-532
    • Yerges-Armstrong, L.M.1
  • 36
    • 77949875295 scopus 로고    scopus 로고
    • An integrative approach for identifying a metabolic phenotype predictive of individualized pharmacokinetics of tacrolimus
    • Phapale, P.B. et al. An integrative approach for identifying a metabolic phenotype predictive of individualized pharmacokinetics of tacrolimus. Clin. Pharmacol. Ther. 87, 426–436 (2010).
    • (2010) Clin. Pharmacol. Ther. , vol.87 , pp. 426-436
    • Phapale, P.B.1
  • 37
    • 77952091681 scopus 로고    scopus 로고
    • Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study
    • Kaddurah-Daouk, R. et al. Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study. Metabolomics 6, 191–201 (2010).
    • (2010) Metabolomics , vol.6 , pp. 191-201
    • Kaddurah-Daouk, R.1
  • 38
    • 79960775080 scopus 로고    scopus 로고
    • Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept
    • Kaddurah-Daouk, R. et al. Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept. Transl. Psychiatry 1, e26 (2011).
    • (2011) Transl. Psychiatry , vol.1
    • Kaddurah-Daouk, R.1
  • 39
    • 79955510058 scopus 로고    scopus 로고
    • Pharmacometabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine
    • Backshall, A., Sharma, R., Clarke, S.J. & Keun, H.C. Pharmacometabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine. Clin. Cancer Res. 17, 3019–3028 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 3019-3028
    • Backshall, A.1    Sharma, R.2    Clarke, S.J.3    Keun, H.C.4
  • 40
    • 84859509386 scopus 로고    scopus 로고
    • A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumour responses to chemotherapy
    • Stebbing, J. et al. A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumour responses to chemotherapy. Ann. Oncol. 23, 860–866 (2012).
    • (2012) Ann. Oncol. , vol.23 , pp. 860-866
    • Stebbing, J.1
  • 41
    • 84863617024 scopus 로고    scopus 로고
    • Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment
    • Trupp, M. et al. Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. PLoS One 7, e38386 (2012).
    • (2012) PLoS One , vol.7
    • Trupp, M.1
  • 42
    • 84880405465 scopus 로고    scopus 로고
    • Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder – possible role for methoxyindole pathway
    • Zhu, H. et al. Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder – possible role for methoxyindole pathway. PLoS One 8, e68283 (2013).
    • (2013) PLoS One , vol.8
    • Zhu, H.1
  • 43
    • 84874875065 scopus 로고    scopus 로고
    • Pharmacometabolomics reveals racial differences in response to atenolol treatment
    • Wikoff, W.R. et al. Pharmacometabolomics reveals racial differences in response to atenolol treatment. PLoS One 8, e57639 (2013).
    • (2013) PLoS One , vol.8
    • Wikoff, W.R.1
  • 44
    • 84905390793 scopus 로고    scopus 로고
    • Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability
    • Ellero-Simatos, S. et al. Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst. Pharmacol. 3, e125 (2014).
    • (2014) CPT Pharmacometrics Syst. Pharmacol. , vol.3
    • Ellero-Simatos, S.1
  • 45
    • 78650513748 scopus 로고    scopus 로고
    • Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics
    • Ji, Y. et al. Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. Clin. Pharmacol. Ther. 89, 97–104 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 97-104
    • Ji, Y.1
  • 46
    • 79957880949 scopus 로고    scopus 로고
    • Mining for therapeutic gold
    • Collins, F.S. Mining for therapeutic gold. Nat. Rev. Drug Discov. 10, 397 (2011).
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 397
    • Collins, F.S.1
  • 47
    • 77649234756 scopus 로고    scopus 로고
    • How to improve R&D productivity: the pharmaceutical industry's grand challenge
    • Paul, S.M. et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat. Rev. Drug Discov. 9, 203–214 (2010).
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 203-214
    • Paul, S.M.1
  • 48
    • 77149155968 scopus 로고    scopus 로고
    • Trends in risks associated with new drug development: success rates for investigational drugs
    • DiMasi, J.A., Feldman, L., Seckler, A. & Wilson, A. Trends in risks associated with new drug development: success rates for investigational drugs. Clin. Pharmacol. Ther. 87, 272–277 (2010).
    • (2010) Clin. Pharmacol. Ther. , vol.87 , pp. 272-277
    • DiMasi, J.A.1    Feldman, L.2    Seckler, A.3    Wilson, A.4
  • 49
    • 84860690620 scopus 로고    scopus 로고
    • Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving phase II survival
    • Morgan, P. et al. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving phase II survival. Drug Discov. Today 17, 419–424 (2012).
    • (2012) Drug Discov. Today , vol.17 , pp. 419-424
    • Morgan, P.1
  • 50
    • 7944220068 scopus 로고    scopus 로고
    • Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects
    • Lenz, E.M. et al. Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects. J. Pharm. Biomed. Anal. 36, 841–849 (2004).
    • (2004) J. Pharm. Biomed. Anal. , vol.36 , pp. 841-849
    • Lenz, E.M.1
  • 51
    • 33750213694 scopus 로고    scopus 로고
    • Susceptibility of human metabolic phenotypes to dietary modulation
    • Stella, C. et al. Susceptibility of human metabolic phenotypes to dietary modulation. J. Proteome Res. 5, 2780–2788 (2006).
    • (2006) J. Proteome Res. , vol.5 , pp. 2780-2788
    • Stella, C.1
  • 52
    • 77949301888 scopus 로고    scopus 로고
    • Ongoing challenges in drug interaction safety: from exposure to pharmacogenomics
    • Bai, J.P. Ongoing challenges in drug interaction safety: from exposure to pharmacogenomics. Drug Metab. Pharmacokinet. 25, 62–71 (2010).
    • (2010) Drug Metab. Pharmacokinet. , vol.25 , pp. 62-71
    • Bai, J.P.1
  • 53
    • 84885726676 scopus 로고    scopus 로고
    • Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration
    • McShane, L.M. et al. Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration. BMC Med. 11, 220 (2013).
    • (2013) BMC Med. , vol.11 , pp. 220
    • McShane, L.M.1
  • 54
    • 84880091814 scopus 로고    scopus 로고
    • Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo
    • Kaddurah-Daouk, R. et al. Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. Transl. Psychiatry 3, e223 (2013).
    • (2013) Transl. Psychiatry , vol.3
    • Kaddurah-Daouk, R.1


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