Role of the satiety factor oleoylethanolamide in alcoholism

Addiction Biology

Volumn 21, Issue 4, 2016, Pages 859-872

  Bilbao, Ainhoa ^a,b   Serrano, Antonia ^a,c   Cippitelli, Andrea ^d   Pavón, Francisco J ^a,c   Giuffrida, Andrea ^e   Suárez, Juan ^a   García Marchena, Nuria ^a,f   Baixeras, Elena ^a   Gómez de Heras, Raquel ^f   Orio, Laura ^f   Alén, Francisco ^f   Ciccocioppo, Roberto ^d   Cravatt, Benjamin F ^c   Parsons, Loren H ^c   Piomelli, Daniele ^g,h   Rodríguez de Fonseca, Fernando ^a,f  

^a HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CAMERINO   (Italy)

^e Mays Cancer Center at UT Health San Antonio   (United States)

^f UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

Alcohol self administration; alcoholism; oleoylethanolamide; PPAR ; relapse

Indexed keywords

CAPSAICIN; N OLEOYLETHANOLAMINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ALCOHOL USE DISORDER; ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; CONDITIONING; DISEASE SEVERITY; DRINKING BEHAVIOR; DRUG DOSE COMPARISON; HOMEOSTASIS; LONG TERM EXPOSURE; MALE; MOTIVATION; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PSYCHOSOMATIC DISORDER; RAT; SATIETY; SENSORY NERVE CELL; TREATMENT OUTCOME;

EID: 84975044145     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/adb.12276     Document Type: Article

References (38)

1. Basavarajappa BS, Hungund BL (2002) Neuromodulatory role of the endocannabinoid signaling system in alcoholism: an overview. Prostaglandins Leukot Essent Fatty Acids 66:287–299.
2. Basavarajappa BS, Ninan I, Arancio O (2008) Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons. J Neurochem 107:1001–1013.
3. Caillé S, Álvarez-Jaimes L, Polis I, Stouffer DG, Parsons LH (2007) Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration. J Neurosci 27:3695–3702.
4. Campolongo P, Roozendaal B, Trezza V, Cuomo V, Astarita G, Fu J, McGaugh JL, Piomelli D (2009) Fat-induced satiety factor oleoylethanolamide enhances memory consolidation. Proc Natl Acad Sci U S A 106:8027–8031.
5. Ceccarini J, Casteels C, Koole M, Bormans G, Van Laere K (2013) Transient changes in the endocannabinoid system after acute and chronic ethanol exposure and abstinence in the rat: a combined PET and microdialysis study. Eur J Nucl Med Mol Imaging 40:1582–1594.
6. Cippitelli A, Bilbao A, Hansson AC, del Arco I, Sommer W, Heilig M, Massi M, Bermúdez-Silva FJ, Navarro M, Ciccocioppo R, Rodríguez de Fonseca F (2005) Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats. Eur J Neurosci 21:2243–2251.
7. Ferrer B, Bermúdez-Silva FJ, Bilbao A, Álvarez-Jaimes L, Sánchez-Vera I, Giuffrida A, Serrano A, Baixeras E, Khaturia S, Navarro M, Parsons LH, Piomelli D, Rodríguez de Fonseca F (2007) Regulation of brain anandamide by acute administration of ethanol. Biochem J 404:97–104.
8. Fu J, Astarita G, Gaetani S, Kim J, Cravatt BF, Mackie K, Piomelli D (2007) Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. J Biol Chem 282:1518–1528.
9. Fu J, Dipatrizio NV, Guijarro A, Schwartz GJ, Li X, Gaetani S, Astarita G, Piomelli D (2011) Sympathetic activity controls fat-induced oleoylethanolamide signaling in small intestine. J Neurosci 31:5730–5736.
10. Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodríguez de Fonseca F, Rosengarth A, Luecke H, Di Giacomo B, Tarzia G, Piomelli D (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425:90–93.
11. Gaetani S, Fu J, Cassano T, Dipasquale P, Romano A, Righetti L, Cianci S, Laconca L, Giannini E, Scaccianoce S, Mairesse J, Cuomo V, Piomelli D (2010) The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin. J Neurosci 30:8096–8101.
12. Giuffrida A, Rodríguez de Fonseca F, Piomelli D (2000) Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry. Anal Biochem 280:87–93.
13. Gómez R, Navarro M, Ferrer B, Trigo JM, Bilbao A, del Arco I, Cippitelli A, Nava F, Piomelli D, Rodríguez de Fonseca F (2002) A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci 22:9612–9617.
14. González-Yanes C, Serrano A, Bermúdez-Silva FJ, Hernández-Domínguez M, Páez-Ochoa MA, Rodríguez de Fonseca F, Sánchez-Margalet V (2005) Oleoylethanolamide impairs glucose tolerance and inhibits insulin-stimulated glucose uptake in rat adipocytes through p38 and JNK MAPK pathways. Am J Physiol Endocrinol Metab 289:E923–E929.
15. Guzmán M, Lo Verme J, Fu J, Oveisi F, Blázquez C, Piomelli D (2004) Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). J Biol Chem 279:27849–27854.
16. Hansson AC, Bermúdez-Silva FJ, Malinen H, Hyytia P, Sánchez-Vera I, Rimondini R, Rodríguez de Fonseca F, Kunos G, Sommer WH, Heilig M (2007) Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference. Neuropsychopharmacology 32:117–126.
17. Kaneko H, Kaunitz J, Tache Y (1998) Vagal mechanisms underlying gastric protection induced by chemical activation of raphe pallidus in rats. Am J Physiol 275:G1056–G1062.
18. LoVerme J, Guzman M, Gaetani S, Piomelli D (2006) Cold exposure stimulates synthesis of the bioactive lipid oleoylethanolamide in rat adipose tissue. J Biol Chem 281:22815–22818.
19. Martínez de Ubago M, García-Oya I, Pérez-Pérez A, Canfran-Duque A, Quintana-Portillo R, Rodríguez de Fonseca F, González-Yanes C, Sánchez-Margalet V (2009) Oleoylethanolamide, a natural ligand for PPAR-alpha, inhibits insulin receptor signalling in HTC rat hepatoma cells. Biochim Biophys Acta 1791:740–745.
20. Mascia P, Pistis M, Justinova Z, Panlilio LV, Luchicchi A, Lecca S, Scherma M, Fratta W, Fadda P, Barnes C, Redhi GH, Yasar S, Le Foll B, Tanda G, Piomelli D, Goldberg SR (2011) Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry 69:633–641.
21. Melis M, Pillolla G, Luchicchi A, Muntoni AL, Yasar S, Goldberg SR, Pistis M (2008) Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. J Neurosci 28:13985–13994.
22. Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C (2006) Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab 3:167–175.
23. Paxinos G, Watson C (1998) The Rat Brain in Stereotaxic Coordinates, New York: Academic Press, Spiral Bound.
24. Piomelli D (2003) The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4:873–884.
25. Piomelli D (2013) A fatty gut feeling. Trends Endocrinol Metab 24:332–341.
26. Provensi G, Coccurello R, Umehara H, Munari L, Giacovazzo G, Galeotti N, Nosi D, Gaetani S, Romano A, Moles A, Blandina P, Passani MB (2014) Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake. Proc Natl Acad Sci U S A 111:11527–11532.
27. Rivera P, Arrabal S, Cifuentes M, Grondona JM, Pérez-Martín M, Rubio L, Vargas A, Serrano A, Pavón FJ, Suárez J, Rodríguez de Fonseca F (2014) Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLalpha) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus. Front Neuroanat 8:56.
28. Rodríguez de Fonseca F, del Arco I, Bermúdez-Silva FJ, Bilbao A, Cippitelli A, Navarro M (2005) The endocannabinoid system: physiology and pharmacology. Alcohol Alcohol 40:2–14.
29. Rodríguez de Fonseca F, Navarro M, Gómez R, Escuredo L, Nava F, Fu J, Murillo-Rodríguez E, Giuffrida A, Lo Verme J, Gaetani S, Kathuria S, Gall C, Piomelli D (2001) An anorexic lipid mediator regulated by feeding. Nature 414:209–212.
30. Samson HH (1986) Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats. Alcohol Clin Exp Res 10:436–442.
31. Schwartz GJ, Fu J, Astarita G, Li X, Gaetani S, Campolongo P, Cuomo V, Piomelli D (2008) The lipid messenger OEA links dietary fat intake to satiety. Cell Metab 8:281–288.
32. Serrano A, Pavón FJ, del Arco I, Rojo-Martínez G, Valenzuela M, Bermúdez-Silva FJ, Soriguer F, Rodríguez de Fonseca F (2006) Oleoylethanolamide reverses changes in both fatty acid composition and desaturase mRNA expression in a new model of liver steatosis. Obe Metab 2:155–164.
33. Serrano A, Pavón FJ, Tovar S, Casanueva F, Señaris R, Diéguez C, Rodríguez de Fonseca F (2011) Oleoylethanolamide: effects on hypothalamic transmitters and gut peptides regulating food intake. Neuropharmacology 60:593–601.
34. Spanagel R (2009) Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev 89:649–705.
35. Stella N, Piomelli D (2001) Receptor-dependent formation of endogenous cannabinoids in cortical neurons. Eur J Pharmacol 425:189–196.
36. Suárez J, Rivera P, Arrabal S, Crespillo A, Serrano A, Baixeras E, Pavón FJ, Cifuentes M, Nogueiras R, Ballesteros J, Diéguez C, Rodríguez de Fonseca F (2014) Oleoylethanolamide enhances beta-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7:129–141.
37. Tellez LA, Medina S, Han W, Ferreira JG, Licona-Limon P, Ren X, Lam TT, Schwartz GJ, de Araujo IE (2013) A gut lipid messenger links excess dietary fat to dopamine deficiency. Science 341:800–802.
38. Weiss F, Lorang MT, Bloom FE, Koob GF (1993) Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther 267:250–258.