Neuromodulatory role of the endocannabinoid signaling system in alcoholism: An overview

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 66, Issue 2-3, 2002, Pages 287-299

  Basavarajappa, B S ^a,b   Hungund, B L ^c  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Columbia University ^*  (United States)

^c NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ALCOHOL; ANANDAMIDE; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CANNABIS; DRONABINOL; G PROTEIN COUPLED RECEPTOR; ION CHANNEL; PSYCHOTROPIC AGENT; RIMONABANT; CANNABINOID RECEPTOR; DRUG RECEPTOR; ENDOCANNABINOID; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; ICOSANOID; TETRAHYDROCANNABINOL;

ALCOHOLISM; BEHAVIOR; DRUG ABUSE; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REVIEW; SIGNAL TRANSDUCTION; TASTE PREFERENCE; WITHDRAWAL SYNDROME; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; HUMAN; METABOLISM; PATHOPHYSIOLOGY;

CANNABIS SATIVA; RODENTIA;

ALCOHOLISM; ANIMALS; CANNABINOIDS; EICOSANOIDS; ENDOCANNABINOIDS; ETHANOL; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SIGNAL TRANSDUCTION; TETRAHYDROCANNABINOL;

EID: 0036019414     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1054/plef.2001.0352     Document Type: Article

References (164)

1. Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism
2. Chronic ethanol consumption: From neuroadaptation to neurodegeneration
3. Cellular and molecular physiology of alcohol actions in the nervous system
4. Molecular biology of alcohol dependence
5. Molecular and cellular mechanisms of general anesthesia
6. Glutamate receptors in alcohol withdrawal-induced neurotoxicity
7. Chronic ethanol treatment up regulates the NMDA receptor function and binding in mammalian cortical neurons
8. Chronic ethanol treatment produces a selective up regulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons
9. Excitotoxicity and the NMDA receptor: Still lethal after eight years
10. Factors affecting actions of ethanol on GABA-activated chloride channels
11. Gamma-aminobutyric acid-A (GABAA) agonists down-regulate GABAA/benzodiazepine receptor polypeptides from the surface of chick cortical neurons
12. Ethanol-stress interaction on dopamine metabolism in the medial prefrontal cortex
13. Neurobiology of alcohol abuse
14. Noradrenergic role in the self-administration of ethanol
15. Actions of drugs of abuse on brain reward systems: Reconsideration with specific attention to alcohol
16. Reduction of ethanol intake by aerosol inhalation of a beta-adrenergic agonist: New route-new treatment approach?
17. Alcohol, amines, and alkaloids: A possible biochemical basis for alcohol addiction
18. Tests of opioid deficiency hypotheses of alcoholism
19. Opiates and alcohol self-administration in animals
20. Ethanol preference in the rat: Interactions between brain serotonin and ethanol, acetaldehyde, paraldehyde, 5-HTP and 5-HTOL
21. Serotonin uptake blockers and voluntary alcohol consumption. A review of recent studies
22. Ethanol consumption following acute fenfluramine, fluoxetine, and dietary tryptophan
23. Cholinergic-rich brain transplants reverse alcohol-induced memory deficits
24. The effects of cholinergic drugs and cholinergic-rich fetal neural transplants on alcohol-induced deficits in radial maze performance in rats
25. Chronic ethanol consumption in rats: Correlation between memory performance and hippocampal acetylcholine release in vivo
26. Cellular and molecular neuroscience of alcoholism
27. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
28. Molecular characterization of a peripheral receptor for cannabinoids
29. Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: Evidence for a Gs linkage to the CB1 receptor
30. Cannabinoid receptor localization in brain
31. Pharmacology of cannabinoid receptor ligands
32. 'Endocannabinoids' and other fatty acid derivatives with cannabimimetic properties: Biochemistry and possible
33. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
34. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
35. 2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
36. Endogenous cannabinoid as a retrograde messenger from depolarized postsynaptic neurons to presynaptic terminals
37. Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals
38. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
39. Formation and inactivation of endogenous cannabinoid anandamide in central neurons
40. Anandamide, an endogenous cannabinomimetic eicosanoid: 'Killing two birds with one stone'
41. Natural and synthetic endocannabinoids and their structure-activity relationships
42. Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents
43. The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice
44. Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse spleenocytes
45. 2+ in neuroblastoma x glioma hybrid NG108-15 cells
46. Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase
47. Endogenous cannabinoid receptor binding activity released from rat brain slices by depolarization
48. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
49. Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells
50. Effects of cannabinoids on the activities of mouse brain lipases
51. G-protein mediation of cannabinoid-induced phospholipase activation
52. Phospholipase participation in cannabinoid-induced release of free arachidonic acid
53. The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide
54. Cognitive loss and recovery in long-term alcohol abusers
55. Computerized measures of CT scans of alcoholics: Thalamic region related to memory
56. Cannabinoid structure-activity relationships: Correlation of receptor binding and in vivo activities
57. Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study
58. Learning and memory impairments in young and old alcoholics: Evidence for the premature-aging hypothesis
59. Chronic ethanol administration down-regulates cannabinoid receptors in mouse brain synaptic plasma membrane
60. 35S] GTPγS binding in synaptic plasma membrane from chronic ethanol exposed mouse
61. Chronic ethanol increases the cannabinoid receptor agonist, anandamide and its precursor N-arachidonyl phosphatidyl ethanolamine in SK-N-SH cells
62. Are anandamide and cannabinoid receptors involved in ethanol tolerance? A review of the evidence
63. Role of brain's own marijuana, anandamide and its cannabinoid receptors (CB1) in alcoholism
64. 2 in human neuroblastoma cells after chronic alcohol exposure: Prevention by GMI ganglioside
65. 2
66. Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse
67. Formation of fatty acid ethyl esters during chronic ethanol treatment in mice
68. Stimulation of cannabinoid receptor agonist 2-arachidonylglycerol by chronic ethanol and its modulation by specific neuromodulators in cerebellar granule neurons
69. Ethanol regulation of adenosine receptor-stimulated cAMP levels in a clonal neural cell line: An in vitro model of cellular tolerance to ethanol
70. The role of protein kinase C in cellular tolerance to ethanol
71. Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: Signal transduction cascades and site of ethanol action
72. Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain
73. Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat
74. Isotope dilution mass spectrometric measurements indicate that arachidonylethanolamide, the proposed endogenous ligand of the cannabinoid receptor, accumulates in rat brain tissue post mortem but is contained at low levels in or is absent from fresh tissue
75. Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta9-tetrahydrocannabinol-tolerant rats
76. Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide synthesis
77. Cooperative effects of ethanol and protein kinase C activators on phospholipase-D-mediated hydrolysis of phosphatidylethanolamine in NIH 3T3 fibroblasts
78. Phosphatidylethanol formation and degradation in brains of acutely and repeatedly ethanol-treated rats
79. ESBRA 1994 Award Lecture. Phosphatidylethanol formation: Specific effects of ethanol mediated via phospholipase D
80. A second endogenous cannabinoid that modulates long-term potentiation
81. Endocarmabinoids: Endogenous cannabinoid receptor ligands with neuromodulatory action
82. Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin
83. Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells
84. Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol
85. Delta-9-tetrahydrocannabinol regulates substance P and enkephalin mRNAs levels in the caudate-putamen
86. Activation of the cannabinoid receptor by delta 9-tetrahydrocannabinol reduces gamma-aminobutyric acid uptake in the globus pallidus
87. Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mul opioid receptor mechanism
88. Cannabinoid transmission and reward-related events
89. Endocannabinoids
90. Glutamate stimulates the formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cortical neurons in culture
91. Chronic exposure of cerebellar granule cells to ethanol results in increased NMDA receptor function
92. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
93. Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
94. Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: A quantitative autoradiographic study
95. Down regulation of rat brain cannabinoid binding sites after chronic delta 9-THC treatment
96. Chronic CP-55,940 alters cannabinoid receptor mRNA in the rat brain: An in situ hybridization study
97. Cannabinoid receptor down-regulation without alteration of the inhibitory effect of CP 55,940 on adenylyl cyclase in the cerebellum of CP 55,940-tolerant mice
98. Effects of chronic exposure to delta9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions
99. 35S]guanylyl-5′O-(thio)-triphosphate binding in the basal ganglia of aged rats
100. 35S]GTP gamma S binding and cannabinoid receptor mRNA levels in the basal ganglia and the cerebellum of adult male rats chronically exposed to delta 9-tetrahydrocannabinol
101. Regulation of adenylate cyclase by chronic exposure to cannabimimetic drugs
102. Downregulation of rat brain cannabinoid binding sites after chronic delta 9-tetrahydrocannabinol treatment
103. 9- tetrahydrocannabinol
104. Ethanol, γ-aminobutyrate type A receptors, and protein kinase c phosphorylation
105. Chronic ethanol inhibits inositol metabolism in specific brain regions
106. Pharmacology of cannabinoid receptors
107. Complete adaptation to the memory disruptive effects on δ-9-THC following 35 days of exposure
108. Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor
109. Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism
110. i in the inhibition of adenylate cyclase by cannabimimetic drugs
111. Chronic treatment with a synthetic cannabinoid CP-55,940 alters G-protein expression in the rat central nervous system
112. Effects of long-term exposure to delta9-THC on expression of cannabinoid receptor (CB1) mRNA in different rat brain regions
113. Chronic delta9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain
114. 35S]GTPgammaS autoradiography in rat brain
115. Ethanol stimulates γ-aminobutyric acid receptor mediated chloride transport in rat brain synaptoneurosomes
116. Multiple agonist-affinity states of opioid receptors: Regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes
117. Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylyl cyclase activity in the central nervous system of two lines of ethanol-sensitive mice
118. Ethanol differentially regulates guanine nucleotide-binding protein alpha subunit expression in NG108-15 cells independently of extracellular adenosine
119. 35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells
120. Quantitative changes in G protein do not mediate ethanol-induced down-regulation of adenylate cyclase in mouse cerebral cortex
121. Ethanol differentially regulates G proteins in neural cells
122. Chronic ethanol exposure of PC 12 cells alters adenylate cyclase activity and intracellular cyclic AMP content
123. Mechanism of action of ethanol: Initial central nervous system actions
124. Genetics of alcohol misuse
125. Genetic selection for voluntary alcohol consumption in the albino rat
126. Intragastric self-infusion of ethanol by ethanol-preferring and nonpreferring lines of rats
127. New duplicate lines of rats that differ in voluntary alcohol consumption
128. Animal models of alcoholism: Neurobiology of high alcohol-drinking behavior in rodents
129. Differences in gamma-aminobutyric acid receptor sensitivity in inbred strains of mice
130. Differences in the kappa opioid receptor mRNA content in distinct brain regions of two inbred mice strains
131. Characterization of the mu and delta opioid receptors in the brain of the C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption
132. Endogenous opioids and alcohol dependence: Opioid alkaloids and the propensity to drink alcoholic beverages
133. Distinct difference in the cannabinoid receptor binding in the brain of C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption
134. 35S]Guanosine TriphosphateγS binding in the brain of C57BL/6 and DBA/2 mice
135. Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats
136. Self-administration of WIN55121-2 and morphine in mice: Interaction between cannabinoid and opioid systems
137. Cannabinoid CB(1) receptor knockout mice fail to self-administer morphine but not other drugs of abuse
138. Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors
139. Reduction of voluntary ethanol intake in ethanol-preferring sP rats by the cannabinoid antagonist SR-141716
140. Cannabinoid receptor antagonist SR 141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers
141. The motivation for beer in rats: Effects of ritanserin, naloxone and SR 141716
142. Increased motivation for beer in rats following administration of a cannabinoid CB1 receptor agonist
143. Morphine increases intake of beer among rats
144. Endogenous opioid systems and alcohol addiction
145. CB1 carmabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats
146. Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys
147. Marijuana, ethanol, and dextroamphetamine. Mood and mental function alterations
148. Effect of acute and chronic pretreatment with delta 1-tetrahydrocannabinol on motor impairment by ethanol in the rat
149. 9-Tetrahydrocannabinol and ethyl alcohol: Evidence for cross-tolerance in the rat
150. Ethanol and delta-9-tetrahydrocannabinol: Mechanism for cross-tolerance in mice
151. Cross-tolerance between delta9-tetrahydrocannabinol and ethanol: The role of drug disposition
152. Effects of two cannabinoids upon abstinence signs in ethanol-dependent mice
153. Tetrahydrocannabinol: Inhibition of alcohol-induced withdrawal symptoms in mice
154. Effects of acute and chronic administration of delta 9-tetrahydrocannabinol or cocaine on ethanol intake in a rat model
155. Comparative effects of alcohol and marijuana on mood, memory, and performance
156. Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent
157. 2 activity in synaptosomal preparations from mice
158. The effects of cannabinoids on the brain
159. Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes
160. Anandamide- and delta9-tetrahydrocannabinol-evoked arachidonic acid mobilization and blockade by SR141716A[N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4- methyl-1H-pyrazole-3-carboximide hydrochloride]
161. Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1
162. The CB(1) cannabinoid receptor is coupled to the activation of c-Jun N-terminal kinase