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Volumn 9, Issue 4, 2016, Pages 533-547

Stem cell-based therapies in inflammatory bowel disease: Promises and pitfalls

Author keywords

Crohn's disease; hematopoietic stem cells; inflammatory bowel disease; mesenchymal stem cells; stem cell therapy

Indexed keywords

AZATHIOPRINE; CYCLOPHOSPHAMIDE; GRANULOCYTE COLONY STIMULATING FACTOR; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; METHYLPREDNISOLONE; STEROID; THYMOCYTE ANTIBODY; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

EID: 84975029002     PISSN: 1756283X     EISSN: 17562848     Source Type: Journal    
DOI: 10.1177/1756283X16642190     Document Type: Review
Times cited : (38)

References (125)
  • 1
    • 79952195585 scopus 로고    scopus 로고
    • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    • Anderson C., Boucher G, Lees C., Franke A., D'Amato M., Taylor K., et al. (2011) Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 43: 246-252.
    • (2011) Nat Genet , vol.43 , pp. 246-252
    • Anderson, C.1    Boucher, G.2    Lees, C.3    Franke, A.4    D'Amato, M.5    Taylor, K.6
  • 2
    • 84898466874 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Immune evasive, not immune privileged
    • Ankrum J., Ong J., Karp J., (2014) Mesenchymal stem cells: immune evasive, not immune privileged. Nat Biotech 32: 252-260.
    • (2014) Nat Biotech , vol.32 , pp. 252-260
    • Ankrum, J.1    Ong, J.2    Karp, J.3
  • 3
    • 18844404360 scopus 로고    scopus 로고
    • Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway
    • Augello A., Tasso R., Negrini S., Amateis A., Indiveri F., Cancedda R., et al. (2005) Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway. Eur J Immunol 35: 1482-1490.
    • (2005) Eur J Immunol , vol.35 , pp. 1482-1490
    • Augello, A.1    Tasso, R.2    Negrini, S.3    Amateis, A.4    Indiveri, F.5    Cancedda, R.6
  • 4
    • 0031918404 scopus 로고    scopus 로고
    • Bronchiolitis obliterans organizing pneumonia and ulcerative colitis after allogeneic bone marrow transplantation
    • Baron F., Hermanne J., Dowlati A., Weber T., Thiry A., Fassotte M., et al. (1998) Bronchiolitis obliterans organizing pneumonia and ulcerative colitis after allogeneic bone marrow transplantation. Bone Marrow Transpl 21: 951-954.
    • (1998) Bone Marrow Transpl , vol.21 , pp. 951-954
    • Baron, F.1    Hermanne, J.2    Dowlati, A.3    Weber, T.4    Thiry, A.5    Fassotte, M.6
  • 5
    • 0036142769 scopus 로고    scopus 로고
    • Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    • Bartholomew A., Sturgeon C., Siatskas M., Ferrer K., Mcintosh K., Patil S., et al. (2002) Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 30: 42-48.
    • (2002) Exp Hematol , vol.30 , pp. 42-48
    • Bartholomew, A.1    Sturgeon, C.2    Siatskas, M.3    Ferrer, K.4    Mcintosh, K.5    Patil, S.6
  • 6
    • 84868212109 scopus 로고    scopus 로고
    • Crohn's disease
    • Baumgart D., Sandborn W., (2012) Crohn's disease. Lancet 380: 1590-1605.
    • (2012) Lancet , vol.380 , pp. 1590-1605
    • Baumgart, D.1    Sandborn, W.2
  • 7
    • 84927139183 scopus 로고    scopus 로고
    • Cancers complicating inflammatory bowel disease
    • Beaugerie L., Itzkowitz S.H., (2015) Cancers complicating inflammatory bowel disease. New England J Med 372: 1441-1452.
    • (2015) New England J Med , vol.372 , pp. 1441-1452
    • Beaugerie, L.1    Itzkowitz, S.H.2
  • 8
    • 0034467038 scopus 로고    scopus 로고
    • Immune ablation and stem-cell therapy in autoimmune disease. Experimental basis for autologous stem-cell transplantation
    • Bekkum D., (2000) Immune ablation and stem-cell therapy in autoimmune disease. Experimental basis for autologous stem-cell transplantation. Arthritis Res 2: 281-284.
    • (2000) Arthritis Res , vol.2 , pp. 281-284
    • Bekkum, D.1
  • 9
    • 35148856663 scopus 로고    scopus 로고
    • Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms
    • Bernardo M., Zaffaroni N., Novara F., Cometa A., Avanzini M., Moretta A., et al. (2007) Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms. Cancer Res 67: 9142-9149.
    • (2007) Cancer Res , vol.67 , pp. 9142-9149
    • Bernardo, M.1    Zaffaroni, N.2    Novara, F.3    Cometa, A.4    Avanzini, M.5    Moretta, A.6
  • 11
    • 0142023893 scopus 로고    scopus 로고
    • Syngeneic hematopoietic stem-cell transplantation for non-Hodgkin's lymphoma: A comparison with allogeneic and autologous transplantation-the lymphoma working committee of the international bone marrow transplant registry and the European group for blood and marrow transplantation
    • Bierman P., Sweetenham J., Loberiza F., Taghipour G., Lazarus H., Rizzo J., et al. (2003) Syngeneic hematopoietic stem-cell transplantation for non-Hodgkin's lymphoma: a comparison with allogeneic and autologous transplantation-the lymphoma working committee of the international bone marrow transplant registry and the European group for blood and marrow transplantation. J Clin Oncol 21: 3744-3753.
    • (2003) J Clin Oncol , vol.21 , pp. 3744-3753
    • Bierman, P.1    Sweetenham, J.2    Loberiza, F.3    Taghipour, G.4    Lazarus, H.5    Rizzo, J.6
  • 13
    • 79955140577 scopus 로고    scopus 로고
    • Cell therapy bioprocessing
    • Brandenberger R., (2011) Cell therapy bioprocessing. BioProcess Int 30-37.
    • (2011) BioProcess Int , pp. 30-37
    • Brandenberger, R.1
  • 14
    • 0001470388 scopus 로고
    • Autoantibodies in human ulcerative colitis
    • Broberger O., Perlmann P., (1959) Autoantibodies in human ulcerative colitis. J Exp Med 110: 657-674.
    • (1959) J Exp Med , vol.110 , pp. 657-674
    • Broberger, O.1    Perlmann, P.2
  • 15
    • 0029051088 scopus 로고
    • Bone marrow transplantation for multiple sclerosis
    • Burt R., Burns W., Hess A., (1995) Bone marrow transplantation for multiple sclerosis. Bone Marrow Transpl 16: 1-6.
    • (1995) Bone Marrow Transpl , vol.16 , pp. 1-6
    • Burt, R.1    Burns, W.2    Hess, A.3
  • 16
    • 78650653452 scopus 로고    scopus 로고
    • Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn's disease: Long-term follow up
    • Burt R., Craig R., Milanetti F., Quigley K., Gozdziak P., Bucha J., et al. (2010) Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn's disease: long-term follow up. Blood 116: 6123-6132.
    • (2010) Blood , vol.116 , pp. 6123-6132
    • Burt, R.1    Craig, R.2    Milanetti, F.3    Quigley, K.4    Gozdziak, P.5    Bucha, J.6
  • 17
    • 38549137308 scopus 로고    scopus 로고
    • Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn's disease
    • Cassinotti A., Annaloro C., Ardizzone S., Onida F., Della Volpe A., Clerici M., et al. (2008) Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn's disease. Gut 57: 211-217.
    • (2008) Gut , vol.57 , pp. 211-217
    • Cassinotti, A.1    Annaloro, C.2    Ardizzone, S.3    Onida, F.4    Della Volpe, A.5    Clerici, M.6
  • 18
    • 84879990805 scopus 로고    scopus 로고
    • P362 autologous haematopoietic stem cell transplantation without cd34+ cell selection for refractory Crohn's disease: The Milan experience after 5 years
    • Cassinotti A., Onida F., Annaloro C., Sampietro G., Fociani P., Fichera M., et al. (2012) P362 autologous haematopoietic stem cell transplantation without cd34+ cell selection for refractory Crohn's disease: the Milan experience after 5 years. J Crohns Colitis 6: S153-S154.
    • (2012) J Crohns Colitis , vol.6 , pp. S153-S154
    • Cassinotti, A.1    Onida, F.2    Annaloro, C.3    Sampietro, G.4    Fociani, P.5    Fichera, M.6
  • 19
    • 0001395982 scopus 로고    scopus 로고
    • Prolonged clinical remission in patients with inflammatory bowel disease (IBD) after high dose chemotherapy (HDC) and autologous blood stem cell transplantation
    • Castro J., Benich H., Smith L., Kalter S., Bachier C., Meneghetti C., et al. (1996) Prolonged clinical remission in patients with inflammatory bowel disease (IBD) after high dose chemotherapy (HDC) and autologous blood stem cell transplantation. Blood 88: 133A.
    • (1996) Blood , vol.88 , pp. 133A
    • Castro, J.1    Benich, H.2    Smith, L.3    Kalter, S.4    Bachier, C.5    Meneghetti, C.6
  • 20
    • 79955554300 scopus 로고    scopus 로고
    • The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases
    • Chassaing B., Darfeuille-Michaud A., (2011) The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases. Gastroenterology 140: 1720-1728.
    • (2011) Gastroenterology , vol.140 , pp. 1720-1728
    • Chassaing, B.1    Darfeuille-Michaud, A.2
  • 21
    • 79955853222 scopus 로고    scopus 로고
    • Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease
    • Ciccocioppo R., Bernardo M., Sgarella A., Maccario R., Avanzini M., Ubezio C., et al. (2011) Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease. Gut 60: 788-798.
    • (2011) Gut , vol.60 , pp. 788-798
    • Ciccocioppo, R.1    Bernardo, M.2    Sgarella, A.3    Maccario, R.4    Avanzini, M.5    Ubezio, C.6
  • 22
    • 80055072032 scopus 로고    scopus 로고
    • Immunomodulatory effects of unselected haematopoietic stem cells autotransplantation in refractory Crohn's disease
    • Clerici M., Cassinotti A., Onida F., Trabattoni D., Annaloro C., Della Volpe A., et al. (2011) Immunomodulatory effects of unselected haematopoietic stem cells autotransplantation in refractory Crohn's disease. Dig Liver Dis 43: 946-952.
    • (2011) Dig Liver Dis , vol.43 , pp. 946-952
    • Clerici, M.1    Cassinotti, A.2    Onida, F.3    Trabattoni, D.4    Annaloro, C.5    Della Volpe, A.6
  • 23
    • 79955561083 scopus 로고    scopus 로고
    • Epidemiology and natural history of inflammatory bowel diseases
    • Cosnes J., Gower-Rousseau C., Seksik P., Cortot A., (2011) Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology 140: 1785-1794.
    • (2011) Gastroenterology , vol.140 , pp. 1785-1794
    • Cosnes, J.1    Gower-Rousseau, C.2    Seksik, P.3    Cortot, A.4
  • 24
    • 33745503987 scopus 로고    scopus 로고
    • Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    • Da Silva Meirelles L., Chagastelles P., Nardi N., (2006) Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 119: 2204-2213.
    • (2006) J Cell Sci , vol.119 , pp. 2204-2213
    • Da Silva Meirelles, L.1    Chagastelles, P.2    Nardi, N.3
  • 26
    • 77955018921 scopus 로고    scopus 로고
    • Is IBD an autoimmune disorder?
    • Das K., Biancone L., (2008) Is IBD an autoimmune disorder? Inflamm Bowel Dis 14: S97-S101.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. S97-S101
    • Das, K.1    Biancone, L.2
  • 27
    • 84879459518 scopus 로고    scopus 로고
    • Expanded allogeneic adipose-derived stem cells (eascs) for the treatment of complex perianal fistula in Crohn's disease: Results from a multicenter phase I/IIa clinical trial
    • De La Portilla F., Alba F., Garcia-Olmo D., Herrerias J., Gonzalez F., Galindo A., (2013) Expanded allogeneic adipose-derived stem cells (eascs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial. Int J Colorectal Dis 28: 313-323.
    • (2013) Int J Colorectal Dis , vol.28 , pp. 313-323
    • De La Portilla, F.1    Alba, F.2    Garcia-Olmo, D.3    Herrerias, J.4    Gonzalez, F.5    Galindo, A.6
  • 28
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M., Carlo-Stella C., Magni M., Milanesi M., Longoni P., Matteucci P., et al. (2002) Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99: 3838-3843.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.5    Matteucci, P.6
  • 29
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. the International Society for Cellular Therapy position statement
    • Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F., Krause D., et al. (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8: 315-317.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.5    Krause, D.6
  • 30
    • 0027322191 scopus 로고
    • Case of Crohn's disease in bone marrow transplantation
    • Drakos P., Nagler A., Or R., (1993) Case of Crohn's disease in bone marrow transplantation. Am J Hematol 43: 157-158.
    • (1993) Am J Hematol , vol.43 , pp. 157-158
    • Drakos, P.1    Nagler, A.2    Or, R.3
  • 31
    • 0025910090 scopus 로고
    • Neutrophil cytoplasmic antibodies: A link between primary sclerosing cholangitis and ulcerative colitis
    • Duerr R., Targan S., Landers C., Larusso N., Lindsay K., Wiesner R., et al. (1991) Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 100: 1385-1391.
    • (1991) Gastroenterology , vol.100 , pp. 1385-1391
    • Duerr, R.1    Targan, S.2    Landers, C.3    Larusso, N.4    Lindsay, K.5    Wiesner, R.6
  • 32
    • 80052875315 scopus 로고    scopus 로고
    • Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease
    • Duijvestein M., Molendijk I., Roelofs H., Vos A., Verhaar A., Reinders M., et al. (2011) Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease. Cytotherapy 13: 1066-1073.
    • (2011) Cytotherapy , vol.13 , pp. 1066-1073
    • Duijvestein, M.1    Molendijk, I.2    Roelofs, H.3    Vos, A.4    Verhaar, A.5    Reinders, M.6
  • 33
    • 78649895490 scopus 로고    scopus 로고
    • Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: Results of a phase i study
    • Duijvestein M., Vos A., Roelofs H., Wildenberg M., Wendrich B., Verspaget H., et al. (2010) Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study. Gut 59: 1662-1669.
    • (2010) Gut , vol.59 , pp. 1662-1669
    • Duijvestein, M.1    Vos, A.2    Roelofs, H.3    Wildenberg, M.4    Wendrich, B.5    Verspaget, H.6
  • 34
    • 72949087768 scopus 로고    scopus 로고
    • Antibody to tropomyosin isoform 5 and complement induce the lysis of colonocytes in ulcerative colitis
    • Ebert E., Geng X., Bajpai M., Pan Z., Tatar E., Das K., (2009) Antibody to tropomyosin isoform 5 and complement induce the lysis of colonocytes in ulcerative colitis. Am J Gastroenterology 104: 2996-3003.
    • (2009) Am J Gastroenterology , vol.104 , pp. 2996-3003
    • Ebert, E.1    Geng, X.2    Bajpai, M.3    Pan, Z.4    Tatar, E.5    Das, K.6
  • 35
    • 76549116862 scopus 로고    scopus 로고
    • Autologous hematopoietic stem cell transplantation for autoimmune diseases: An observational study on 12 years' experience from the European group for blood and marrow transplantation working party on autoimmune diseases
    • Farge D., Labopin M., Tyndall A., Fassas A., Mancardi G., Van Laar J., et al. (2010) Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European group for blood and marrow transplantation working party on autoimmune diseases. Haematologica 95: 284-292.
    • (2010) Haematologica , vol.95 , pp. 284-292
    • Farge, D.1    Labopin, M.2    Tyndall, A.3    Fassas, A.4    Mancardi, G.5    Van Laar, J.6
  • 36
    • 84872089246 scopus 로고    scopus 로고
    • Genes and 'in-vironment': How will our concepts on the pathophysiology of inflammatory bowel disease develop in the future?
    • Fiocchi C., (2012) Genes and 'in-vironment': how will our concepts on the pathophysiology of inflammatory bowel disease develop in the future? Dig Dis 30: 2-11.
    • (2012) Dig Dis , vol.30 , pp. 2-11
    • Fiocchi, C.1
  • 37
    • 84890190232 scopus 로고    scopus 로고
    • A phase II study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy
    • Forbes G., Sturm M., Leong R., Sparrow M., Segarajasingam D., Cummins A., et al. (2014) A phase II study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy. Clin Gastroenterol Hepatol 12: 64-71.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 64-71
    • Forbes, G.1    Sturm, M.2    Leong, R.3    Sparrow, M.4    Segarajasingam, D.5    Cummins, A.6
  • 38
    • 55049111426 scopus 로고    scopus 로고
    • Sequence variants in il10, arpc2 and multiple other loci contribute to ulcerative colitis susceptibility
    • Franke A., Balschun T., Karlsen T., Sventoraityte J., Nikolaus S., Mayr G., et al. (2008) Sequence variants in il10, arpc2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 40: 1319-1323.
    • (2008) Nat Genet , vol.40 , pp. 1319-1323
    • Franke, A.1    Balschun, T.2    Karlsen, T.3    Sventoraityte, J.4    Nikolaus, S.5    Mayr, G.6
  • 39
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A., McGovern D., Barrett J., Wang K., Radford-Smith G., Ahmad T., et al. (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 42: 1118-1125.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.2    Barrett, J.3    Wang, K.4    Radford-Smith, G.5    Ahmad, T.6
  • 40
    • 0016269155 scopus 로고
    • Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo
    • Friedenstein A., Chailakhyan R., Latsinik N., Panasyuk A., Keiliss-Borok I., (1974) Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation 17: 331-340.
    • (1974) Transplantation , vol.17 , pp. 331-340
    • Friedenstein, A.1    Chailakhyan, R.2    Latsinik, N.3    Panasyuk, A.4    Keiliss-Borok, I.5
  • 41
    • 84902141658 scopus 로고    scopus 로고
    • Stem cells as potential targeted therapy for inflammatory bowel disease
    • Gazouli M., Roubelakis M., Theodoropoulos G., (2014) Stem cells as potential targeted therapy for inflammatory bowel disease. Inflamm Bowel Dis 20: 952-955.
    • (2014) Inflamm Bowel Dis , vol.20 , pp. 952-955
    • Gazouli, M.1    Roubelakis, M.2    Theodoropoulos, G.3
  • 42
    • 85027538617 scopus 로고    scopus 로고
    • Autoimmunity against human tropomyosin isoform 5 (HTM5) in ulcerative colitis: Antigen specific T cell response against the c terminal domain of HTM5
    • Geng X., Liu J., Lin J., Taniguchi M., Kosa E., Glazier K., et al. (2001) Autoimmunity against human tropomyosin isoform 5 (HTM5) in ulcerative colitis: antigen specific T cell response against the c terminal domain of HTM5. Gastroenterology 120: A520-A521.
    • (2001) Gastroenterology , vol.120 , pp. A520-A521
    • Geng, X.1    Liu, J.2    Lin, J.3    Taniguchi, M.4    Kosa, E.5    Glazier, K.6
  • 43
    • 37249068050 scopus 로고    scopus 로고
    • Impact of inflammatory bowel disease on quality of life: Results of the European federation of Crohn's and ulcerative colitis associations (EFCCA) patient survey
    • Ghosh S., Mitchell R., (2007) Impact of inflammatory bowel disease on quality of life: results of the European federation of Crohn's and ulcerative colitis associations (EFCCA) patient survey. J Crohns Colitis 1: 10-20.
    • (2007) J Crohns Colitis , vol.1 , pp. 10-20
    • Ghosh, S.1    Mitchell, R.2
  • 45
    • 0000155376 scopus 로고
    • The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles
    • Gurdon J., (1962) The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. J Embryol Exp Morphol 10: 622-640.
    • (1962) J Embryol Exp Morphol , vol.10 , pp. 622-640
    • Gurdon, J.1
  • 46
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: The Accent i randomised trial
    • Hanauer S., Feagan B., Lichtenstein G., Mayer L., Schreiber S., Colombel J., et al. (2002) Maintenance infliximab for Crohn's disease: the Accent I randomised trial. Lancet 359: 1541-1549.
    • (2002) Lancet , vol.359 , pp. 1541-1549
    • Hanauer, S.1    Feagan, B.2    Lichtenstein, G.3    Mayer, L.4    Schreiber, S.5    Colombel, J.6
  • 47
    • 84864125056 scopus 로고    scopus 로고
    • Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity
    • Haque R., Lei F., Xiong X., Bian Y., Zhao B., Wu Y., et al. (2012) Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity. J Immunol 189: 1228-1236.
    • (2012) J Immunol , vol.189 , pp. 1228-1236
    • Haque, R.1    Lei, F.2    Xiong, X.3    Bian, Y.4    Zhao, B.5    Wu, Y.6
  • 48
    • 84866390341 scopus 로고    scopus 로고
    • Remission of refractory Crohn's disease by high-dose cyclophosphamide and autologous peripheral blood stem cell transplantation
    • Hasselblatt P., Drognitz K., Potthoff K., Bertz H., Kruis W., Schmidt C., et al. (2012) Remission of refractory Crohn's disease by high-dose cyclophosphamide and autologous peripheral blood stem cell transplantation. Aliment Pharmacol Ther 36: 725-735.
    • (2012) Aliment Pharmacol Ther , vol.36 , pp. 725-735
    • Hasselblatt, P.1    Drognitz, K.2    Potthoff, K.3    Bertz, H.4    Kruis, W.5    Schmidt, C.6
  • 49
    • 84941600535 scopus 로고    scopus 로고
    • OC-007 haemopoetic stem cell transplantation for severe resistant Crohn's disease: Preliminary evidence for durable benefit
    • Hawkey C., (2014) OC-007 haemopoetic stem cell transplantation for severe resistant Crohn's disease: preliminary evidence for durable benefit. Gut 63: A4.
    • (2014) Gut , vol.63 , pp. A4
    • Hawkey, C.1
  • 50
    • 84950111817 scopus 로고    scopus 로고
    • Autologous hematopoetic stem cell transplantation for refractory Crohn disease: A randomized clinical trial
    • Hawkey C., Allez M., Clark M., Labopin M., Lindsay J., Ricart E., et al. (2015) Autologous hematopoetic stem cell transplantation for refractory crohn disease: a randomized clinical trial. JAMA 314: 2524-2534.
    • (2015) JAMA , vol.314 , pp. 2524-2534
    • Hawkey, C.1    Allez, M.2    Clark, M.3    Labopin, M.4    Lindsay, J.5    Ricart, E.6
  • 51
    • 0018903830 scopus 로고
    • Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease
    • Hellers G., Bergstrand O., Ewerth S., Holmstrom B., (1980) Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease. Gut 21: 525-527.
    • (1980) Gut , vol.21 , pp. 525-527
    • Hellers, G.1    Bergstrand, O.2    Ewerth, S.3    Holmstrom, B.4
  • 52
    • 0036141470 scopus 로고    scopus 로고
    • Clinical aspects and pathophysiology of inflammatory bowel disease
    • Hendrickson B., Gokhale R., Cho J., (2002) Clinical aspects and pathophysiology of inflammatory bowel disease. Clinical Microbiology Reviews 15: 79-94.
    • (2002) Clinical Microbiology Reviews , vol.15 , pp. 79-94
    • Hendrickson, B.1    Gokhale, R.2    Cho, J.3
  • 53
    • 84930477917 scopus 로고    scopus 로고
    • Concise review: Workshop review: Understanding and assessing the risks of stem cell-based therapies
    • Heslop J., Hammond T., Santeramo I., Tort Piella A., Hopp I., Zhou J., et al. (2015) Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies. Stem Cells Transl Med 4: 389-400.
    • (2015) Stem Cells Transl Med , vol.4 , pp. 389-400
    • Heslop, J.1    Hammond, T.2    Santeramo, I.3    Tort Piella, A.4    Hopp, I.5    Zhou, J.6
  • 54
    • 84859059470 scopus 로고    scopus 로고
    • Changing Crohn's disease management: Need for new goals and indices to prevent disability and improve quality of life
    • Hommes D., Colombel J., Emery P., Greco M., Sandborn W., (2012) Changing Crohn's disease management: need for new goals and indices to prevent disability and improve quality of life. J Crohns Colitis 6: S224-S234.
    • (2012) J Crohns Colitis , vol.6 , pp. S224-S234
    • Hommes, D.1    Colombel, J.2    Emery, P.3    Greco, M.4    Sandborn, W.5
  • 55
    • 84959352397 scopus 로고    scopus 로고
    • Stem cells: HSCT for Crohn's disease: Work in progress or a bridge too far?
    • Hommes D., Lacey P., (2016) Stem cells: HSCT for Crohn's disease: work in progress or a bridge too far? Nat Rev Gastroenterol Hepatol 13: 128-130.
    • (2016) Nat Rev Gastroenterol Hepatol , vol.13 , pp. 128-130
    • Hommes, D.1    Lacey, P.2
  • 56
    • 49649123332 scopus 로고    scopus 로고
    • Surgery for inflammatory bowel disease
    • Hwang J., Varma M., (2008) Surgery for inflammatory bowel disease. World J Gastroenterol 14: 2678-2690.
    • (2008) World J Gastroenterol , vol.14 , pp. 2678-2690
    • Hwang, J.1    Varma, M.2
  • 57
    • 0034987358 scopus 로고    scopus 로고
    • Treatment of autoimmune diseases by hematopoietic stem cell transplantation
    • Ikehara S., (2001) Treatment of autoimmune diseases by hematopoietic stem cell transplantation. Exp Hematol 29: 661-669.
    • (2001) Exp Hematol , vol.29 , pp. 661-669
    • Ikehara, S.1
  • 58
    • 27444434871 scopus 로고    scopus 로고
    • Recent advances in the treatment of graft-versus-host disease
    • Iwasaki T., (2004) Recent advances in the treatment of graft-versus-host disease. Clin Med Res 2: 243-252.
    • (2004) Clin Med Res , vol.2 , pp. 243-252
    • Iwasaki, T.1
  • 59
    • 0022946085 scopus 로고
    • Prolonged remission of severe refractory rheumatoid arthritis following allogeneic bone marrow transplantation for drug-induced aplastic anaemia
    • Jacobs P., Vincent M., Martell R., (1986) Prolonged remission of severe refractory rheumatoid arthritis following allogeneic bone marrow transplantation for drug-induced aplastic anaemia. Bone Marrow Transpl 1: 237-239.
    • (1986) Bone Marrow Transpl , vol.1 , pp. 237-239
    • Jacobs, P.1    Vincent, M.2    Martell, R.3
  • 61
    • 85027538198 scopus 로고    scopus 로고
    • P471 hematopoietic stem cell transplantation in refractory Crohn's disease: Feasibility and toxicity
    • Jauregui-Amezaga A., Rovira M., Pinó Donnay S., Marín P., Feu F., Elizalde J., et al. (2014) P471 hematopoietic stem cell transplantation in refractory Crohn's disease: feasibility and toxicity. J Crohns Colitis 8: S263-S263.
    • (2014) J Crohns Colitis , vol.8 , pp. S263-S263
    • Jauregui-Amezaga, A.1    Rovira, M.2    Pinó Donnay, S.3    Marín, P.4    Feu, F.5    Elizalde, J.6
  • 62
    • 0031729219 scopus 로고    scopus 로고
    • Autologous bone marrow transplantation for non-hodgkin's lymphoma resulting in long-term remission of coincidental Crohn's disease
    • Kashyap A., (1998) Autologous bone marrow transplantation for non-hodgkin's lymphoma resulting in long-term remission of coincidental Crohn's disease. Brit J Haematol 103: 651-652.
    • (1998) Brit J Haematol , vol.103 , pp. 651-652
    • Kashyap, A.1
  • 63
    • 79960321883 scopus 로고    scopus 로고
    • Hematopoietic stem cell homing to injured tissues
    • Kavanagh D., Kalia N., (2011) Hematopoietic stem cell homing to injured tissues. Stem Cell Rev 7: 672-682.
    • (2011) Stem Cell Rev , vol.7 , pp. 672-682
    • Kavanagh, D.1    Kalia, N.2
  • 64
    • 66149179125 scopus 로고    scopus 로고
    • Deconstructing stem cell tumorigenicity: A roadmap to safe regenerative medicine
    • Knoepfler P., (2009) Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells (Dayton, Ohio) 27: 1050-1056.
    • (2009) Stem Cells (Dayton, Ohio) , vol.27 , pp. 1050-1056
    • Knoepfler, P.1
  • 65
    • 0016777627 scopus 로고
    • Lymphocytotoxic antibody in inflammatory bowel disease: A family study
    • Korsmeyer S., Williams R., Wilson I., Strickland R., (1975) Lymphocytotoxic antibody in inflammatory bowel disease: a family study. New England J Med 293: 1117-1120.
    • (1975) New England J Med , vol.293 , pp. 1117-1120
    • Korsmeyer, S.1    Williams, R.2    Wilson, I.3    Strickland, R.4
  • 66
    • 0038204193 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells inhibit the response of naïve and memory antigen-specific T cells to their cognate peptide
    • Krampera M., Glennie S., Dyson J., Scott D., Laylor R., Simpson E., et al. (2003) Bone marrow mesenchymal stem cells inhibit the response of naïve and memory antigen-specific T cells to their cognate peptide. Blood 101: 3722-3729.
    • (2003) Blood , vol.101 , pp. 3722-3729
    • Krampera, M.1    Glennie, S.2    Dyson, J.3    Scott, D.4    Laylor, R.5    Simpson, E.6
  • 67
  • 68
    • 33745801062 scopus 로고    scopus 로고
    • Boost of CD34+-selected peripheral blood cells without further conditioning in patients with poor graft function following allogeneic stem cell transplantation
    • Larocca A., Piaggio G., Podesta M., Pitto A., Bruno B., Di Grazia C., et al. (2006) Boost of CD34+-selected peripheral blood cells without further conditioning in patients with poor graft function following allogeneic stem cell transplantation. Haematologica 91: 935-940.
    • (2006) Haematologica , vol.91 , pp. 935-940
    • Larocca, A.1    Piaggio, G.2    Podesta, M.3    Pitto, A.4    Bruno, B.5    Di Grazia, C.6
  • 70
    • 84875603586 scopus 로고    scopus 로고
    • Treatment of experimental ulcerative colitis
    • Lazebnik L., Lychkova A., Knyazev O., (2012b) Treatment of experimental ulcerative colitis. Bull Exp Biol Med 153: 889-892.
    • (2012) Bull Exp Biol Med , vol.153 , pp. 889-892
    • Lazebnik, L.1    Lychkova, A.2    Knyazev, O.3
  • 71
    • 0141484485 scopus 로고    scopus 로고
    • HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells
    • Le Blanc K., Tammik C., Rosendahl K., Zetterberg E., Ringden O., (2003a) HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 31: 890-896.
    • (2003) Exp Hematol , vol.31 , pp. 890-896
    • Le Blanc, K.1    Tammik, C.2    Rosendahl, K.3    Zetterberg, E.4    Ringden, O.5
  • 72
    • 0042740515 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex
    • Le Blanc K., Tammik L., Sundberg B., Haynesworth S., Ringden O., (2003b) Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 57: 11-20.
    • (2003) Scand J Immunol , vol.57 , pp. 11-20
    • Le Blanc, K.1    Tammik, L.2    Sundberg, B.3    Haynesworth, S.4    Ringden, O.5
  • 74
    • 84887040879 scopus 로고    scopus 로고
    • Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn's fistula
    • Lee W., Park K., Cho Y., Yoon S., Song K., Kim Do S., et al. (2013) Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn's fistula. Stem Cells 31: 2575-2581.
    • (2013) Stem Cells , vol.31 , pp. 2575-2581
    • Lee, W.1    Park, K.2    Cho, Y.3    Yoon, S.4    Song, K.5    Kim Do, S.6
  • 75
    • 84975070260 scopus 로고    scopus 로고
    • Athersys announces results from phase II study of multistem(r) cell therapy for ulcerative colitis; Multistem demonstrates good tolerability and safety profile but fails to show efficacy over 8 weeks in patients with chronic, advanced ulcerative colitis
    • Available at
    • Lehmann W., (2014) Athersys announces results from phase II study of multistem(r) cell therapy for ulcerative colitis; multistem demonstrates good tolerability and safety profile but fails to show efficacy over 8 weeks in patients with chronic, advanced ulcerative colitis. Press release Athersys Inc. Available at: Athersys.com.
    • (2014) Press Release Athersys Inc
    • Lehmann, W.1
  • 76
    • 84857047378 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cell transplantation in seven patients with refractory inflammatory bowel disease
    • Liang J., Zhang H., Wang D., Feng X., Wang H., Hua B., et al. (2012) Allogeneic mesenchymal stem cell transplantation in seven patients with refractory inflammatory bowel disease. Gut 61: 468-469.
    • (2012) Gut , vol.61 , pp. 468-469
    • Liang, J.1    Zhang, H.2    Wang, D.3    Feng, X.4    Wang, H.5    Hua, B.6
  • 77
    • 0031889085 scopus 로고    scopus 로고
    • Course of Crohn's disease after allogeneic marrow transplantation
    • Lopez-Cubero S., Sullivan K., McDonald G., (1998) Course of Crohn's disease after allogeneic marrow transplantation. Gastroenterology 114: 422-440.
    • (1998) Gastroenterology , vol.114 , pp. 422-440
    • Lopez-Cubero, S.1    Sullivan, K.2    McDonald, G.3
  • 78
    • 0027499768 scopus 로고
    • Apparent cure of rheumatoid arthritis by bone marrow transplantation
    • Lowenthal R., Cohen M., Atkinson K., Biggs J., (1993) Apparent cure of rheumatoid arthritis by bone marrow transplantation. J Rheumatol 20: 137-140.
    • (1993) J Rheumatol , vol.20 , pp. 137-140
    • Lowenthal, R.1    Cohen, M.2    Atkinson, K.3    Biggs, J.4
  • 79
    • 78149283882 scopus 로고    scopus 로고
    • Isolation and characterization of true mesenchymal stem cells derived from human term decidua capable of multilineage differentiation into all 3 embryonic layers
    • e499, e423
    • Macias M., Grande J., Moreno A., Dominguez I., Bornstein R., Flores A., (2010) Isolation and characterization of true mesenchymal stem cells derived from human term decidua capable of multilineage differentiation into all 3 embryonic layers. Am J Obstet Gynecol 203: 495, e499, e423.
    • (2010) Am J Obstet Gynecol , vol.203 , pp. 495
    • Macias, M.1    Grande, J.2    Moreno, A.3    Dominguez, I.4    Bornstein, R.5    Flores, A.6
  • 80
    • 0034903908 scopus 로고    scopus 로고
    • PBSC autotransplant for inflammatory bowel disease (IBD): A case of ulcerative colitis
    • Marti J., Mayordomo J., Isla M., Saenz A., Escudero P., Tres A., (2001) PBSC autotransplant for inflammatory bowel disease (IBD): a case of ulcerative colitis. Bone Marrow Transpl 28: 109-110.
    • (2001) Bone Marrow Transpl , vol.28 , pp. 109-110
    • Marti, J.1    Mayordomo, J.2    Isla, M.3    Saenz, A.4    Escudero, P.5    Tres, A.6
  • 82
    • 84975052054 scopus 로고    scopus 로고
    • Mesoblast provides update on clinical programs of prochymal for Crohn's disease and acute graft versus host disease
    • 28 2014. Available at
    • Meldrum J., (2014) Mesoblast provides update on clinical programs of prochymal for Crohn's disease and acute graft versus host disease. Mesoblast Ltd. Press release 28 2014. Available at: mesoblast.com.
    • (2014) Mesoblast Ltd. Press Release
    • Meldrum, J.1
  • 83
    • 84883614526 scopus 로고    scopus 로고
    • Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages
    • Melief S., Schrama E., Brugman M., Tiemessen M., Hoogduijn M., Fibbe W., et al. (2013) Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages. Stem Cells 31: 1980-1991.
    • (2013) Stem Cells , vol.31 , pp. 1980-1991
    • Melief, S.1    Schrama, E.2    Brugman, M.3    Tiemessen, M.4    Hoogduijn, M.5    Fibbe, W.6
  • 85
    • 84942328578 scopus 로고    scopus 로고
    • Allogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn's disease
    • e6
    • Molendijk I., Bonsing B., Roelofs H., Peeters K., Wasser M., Dijkstra G., et al. (2015) Allogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn's disease. Gastroenterology 149: 918-27, e6.
    • (2015) Gastroenterology , vol.149 , pp. 918-927
    • Molendijk, I.1    Bonsing, B.2    Roelofs, H.3    Peeters, K.4    Wasser, M.5    Dijkstra, G.6
  • 87
    • 83755219473 scopus 로고    scopus 로고
    • Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review
    • quiz e30 e42
    • Molodecky N., Soon I., Rabi D., Ghali W., Ferris M., Chernoff G., et al. (2012) Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 142: 46-54 e42, quiz e30.
    • (2012) Gastroenterology , vol.142 , pp. 46-54
    • Molodecky, N.1    Soon, I.2    Rabi, D.3    Ghali, W.4    Ferris, M.5    Chernoff, G.6
  • 88
    • 33746514768 scopus 로고    scopus 로고
    • Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting
    • Nauta A., Westerhuis G., Kruisselbrink A., Lurvink E., Willemze R., Fibbe W., (2006) Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting. Blood 108: 2114-2120.
    • (2006) Blood , vol.108 , pp. 2114-2120
    • Nauta, A.1    Westerhuis, G.2    Kruisselbrink, A.3    Lurvink, E.4    Willemze, R.5    Fibbe, W.6
  • 91
    • 15744405106 scopus 로고    scopus 로고
    • Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
    • Oyama Y., Craig R., Traynor A., Quigley K., Statkute L., Halverson A., et al. (2005) Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease. Gastroenterology 128: 552-563.
    • (2005) Gastroenterology , vol.128 , pp. 552-563
    • Oyama, Y.1    Craig, R.2    Traynor, A.3    Quigley, K.4    Statkute, L.5    Halverson, A.6
  • 93
    • 79952788410 scopus 로고    scopus 로고
    • Review article: Remission rates achievable by current therapies for inflammatory bowel disease
    • Peyrin-Biroulet L., Lemann M., (2011) Review article: remission rates achievable by current therapies for inflammatory bowel disease. Aliment Pharmacol Ther 33: 870-879.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 870-879
    • Peyrin-Biroulet, L.1    Lemann, M.2
  • 94
  • 95
    • 84975034326 scopus 로고    scopus 로고
    • Evaluation of Prochymal® adult human stem cells for treatment-resistant moderate-to-severe Crohn's disease
    • identifier: NCT00482092
    • Raina P., (2007) Evaluation of Prochymal® adult human stem cells for treatment-resistant moderate-to-severe Crohn's disease. ClinicalTrials.gov identifier: NCT00482092.
    • (2007) ClinicalTrials.gov
    • Raina, P.1
  • 96
    • 33845258906 scopus 로고    scopus 로고
    • Reoperative inflammatory bowel disease surgery
    • Ramirez R., Fleshner P., (2006) Reoperative inflammatory bowel disease surgery. Clin Colon Rectal Surg 19: 195-206.
    • (2006) Clin Colon Rectal Surg , vol.19 , pp. 195-206
    • Ramirez, R.1    Fleshner, P.2
  • 97
    • 84975041637 scopus 로고    scopus 로고
    • Prochymal - First stem cell drug approved
    • 22 2012
    • Rattue P., (2012) Prochymal-first stem cell drug approved. Medical News Today 22 2012.
    • (2012) Medical News Today
    • Rattue, P.1
  • 98
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya T., Morrison S., Clarke M., Weissman I., (2001) Stem cells, cancer, and cancer stem cells. Nature 414: 105-111.
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1    Morrison, S.2    Clarke, M.3    Weissman, I.4
  • 100
    • 0026678037 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) secretion by adherent monocytes measured by quantitative immunoassays
    • Sallerfors B., Olofsson T., (1992) Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) secretion by adherent monocytes measured by quantitative immunoassays. Eur J Haematol 49: 199-207.
    • (1992) Eur J Haematol , vol.49 , pp. 199-207
    • Sallerfors, B.1    Olofsson, T.2
  • 101
    • 0026517799 scopus 로고
    • Structure of the gene encoding CD34, a human hematopoietic stem cell antigen
    • Satterthwaite A., Burn T., Le Beau M., Tenen D., (1992) Structure of the gene encoding CD34, a human hematopoietic stem cell antigen. Genomics 12: 788-794.
    • (1992) Genomics , vol.12 , pp. 788-794
    • Satterthwaite, A.1    Burn, T.2    Le Beau, M.3    Tenen, D.4
  • 102
    • 67650280836 scopus 로고    scopus 로고
    • Suppression of glomerulonephritis in NZB/NZW lupus prone mice by adoptive transfer of ex vivo expanded regulatory T cells
    • Scalapino K., Daikh D., (2009) Suppression of glomerulonephritis in NZB/NZW lupus prone mice by adoptive transfer of ex vivo expanded regulatory T cells. PLoS One 4: e6031.
    • (2009) PLoS One , vol.4 , pp. e6031
    • Scalapino, K.1    Daikh, D.2
  • 103
    • 84862278489 scopus 로고    scopus 로고
    • Inflammatory bowel disease pathogenesis: What is new?
    • Scharl M., Rogler G., (2012) Inflammatory bowel disease pathogenesis: what is new? Curr Opin Gastroenterology 28: 301-309.
    • (2012) Curr Opin Gastroenterology , vol.28 , pp. 301-309
    • Scharl, M.1    Rogler, G.2
  • 107
    • 84870513464 scopus 로고    scopus 로고
    • Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease
    • Shah N., Kammermeier J., Elawad M., Glocker E., (2012) Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease. Curr Allergy Asthma Rep 12: 373-379.
    • (2012) Curr Allergy Asthma Rep , vol.12 , pp. 373-379
    • Shah, N.1    Kammermeier, J.2    Elawad, M.3    Glocker, E.4
  • 108
    • 0026515407 scopus 로고
    • Molecular cloning of a CDNA encoding CD34, a sialomucin of human hematopoietic stem cells
    • Simmons D., Satterthwaite A., Tenen D., Seed B., (1992) Molecular cloning of a CDNA encoding CD34, a sialomucin of human hematopoietic stem cells. J Immunol 148: 267-271.
    • (1992) J Immunol , vol.148 , pp. 267-271
    • Simmons, D.1    Satterthwaite, A.2    Tenen, D.3    Seed, B.4
  • 109
    • 33845248271 scopus 로고    scopus 로고
    • WHO health promotion glossary: New terms
    • Smith B., Tang K., Nutbeam D., (2006) WHO health promotion glossary: new terms. Health Promot Int 21: 340-345.
    • (2006) Health Promot Int , vol.21 , pp. 340-345
    • Smith, B.1    Tang, K.2    Nutbeam, D.3
  • 110
    • 0141757420 scopus 로고    scopus 로고
    • Fulminant Crohn's colitis after allogeneic stem cell transplantation
    • Sonwalkar S., James R., Ahmad T., Zhang L., Verbeke C., Barnard D., et al. (2003) Fulminant Crohn's colitis after allogeneic stem cell transplantation. Gut 52: 1518-1521.
    • (2003) Gut , vol.52 , pp. 1518-1521
    • Sonwalkar, S.1    James, R.2    Ahmad, T.3    Zhang, L.4    Verbeke, C.5    Barnard, D.6
  • 111
    • 79551686425 scopus 로고    scopus 로고
    • Directed Differentiation of human pluripotent stem cells into intestinal tissue in vitro
    • Spence J., Mayhew C., Rankin S., Kuhar M., Vallance J., Tolle K., et al. (2011) Directed Differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470: 105-109.
    • (2011) Nature , vol.470 , pp. 105-109
    • Spence, J.1    Mayhew, C.2    Rankin, S.3    Kuhar, M.4    Vallance, J.5    Tolle, K.6
  • 112
    • 0021199171 scopus 로고
    • Ulcerative colitis after bone-marrow transplantation for acute leukemia
    • Spiers A., (1984) Ulcerative colitis after bone-marrow transplantation for acute leukemia. N Engl J Med 311: 1259.
    • (1984) N Engl J Med , vol.311 , pp. 1259
    • Spiers, A.1
  • 113
    • 67649988997 scopus 로고    scopus 로고
    • The role of stromal stem cells in tissue regeneration and wound repair
    • Stappenbeck T., Miyoshi H., (2009) The role of stromal stem cells in tissue regeneration and wound repair. Science 324: 1666-1669.
    • (2009) Science , vol.324 , pp. 1666-1669
    • Stappenbeck, T.1    Miyoshi, H.2
  • 114
    • 77953441885 scopus 로고    scopus 로고
    • Stem cell therapeutics: Potential in the treatment of inflammatory bowel disease
    • Swenson E., Theise N., (2010) Stem cell therapeutics: potential in the treatment of inflammatory bowel disease. Clin Exp Gastroenterol 3: 1-10.
    • (2010) Clin Exp Gastroenterol , vol.3 , pp. 1-10
    • Swenson, E.1    Theise, N.2
  • 115
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K., Yamanaka S., (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 116
    • 77949890037 scopus 로고    scopus 로고
    • Clinical-grade production of human mesenchymal stromal cells: Occurrence of aneuploidy without transformation
    • Tarte K., Gaillard J., Lataillade J., Fouillard L., Becker M., Mossafa H., et al. (2010) Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation. Blood 115: 1549-1553.
    • (2010) Blood , vol.115 , pp. 1549-1553
    • Tarte, K.1    Gaillard, J.2    Lataillade, J.3    Fouillard, L.4    Becker, M.5    Mossafa, H.6
  • 117
    • 84900541030 scopus 로고    scopus 로고
    • Advanced therapy for inflammatory bowel disease: A guide for the primary care physician
    • Thomas A., Lodhia N., (2014) Advanced therapy for inflammatory bowel disease: a guide for the primary care physician. J Am Board Fam Med 27: 411-420.
    • (2014) J Am Board Fam Med , vol.27 , pp. 411-420
    • Thomas, A.1    Lodhia, N.2
  • 118
    • 0034081050 scopus 로고    scopus 로고
    • Stem cell transplantation in experimental models of autoimmune disease
    • Van Bekkum D., (2000) Stem cell transplantation in experimental models of autoimmune disease. J Clin Immunol 20: 10-16.
    • (2000) J Clin Immunol , vol.20 , pp. 10-16
    • Van Bekkum, D.1
  • 120
    • 84899907895 scopus 로고    scopus 로고
    • Disease course and surgery rates in inflammatory bowel disease: A population-based, 7-year follow-up study in the era of immunomodulating therapy
    • Vester-Andersen M., Prosberg M., Jess T., Andersson M., Bengtsson B., Blixt T., et al. (2014) Disease course and surgery rates in inflammatory bowel disease: a population-based, 7-year follow-up study in the era of immunomodulating therapy. Am J Gastroenterol 109: 705-714.
    • (2014) Am J Gastroenterol , vol.109 , pp. 705-714
    • Vester-Andersen, M.1    Prosberg, M.2    Jess, T.3    Andersson, M.4    Bengtsson, B.5    Blixt, T.6
  • 121
    • 7044274559 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Autoimmune or immune-mediated pathogenesis?
    • Wen Z., Fiocchi C., (2004) Inflammatory bowel disease: autoimmune or immune-mediated pathogenesis? Clin Dev Immunol 11: 195-204.
    • (2004) Clin Dev Immunol , vol.11 , pp. 195-204
    • Wen, Z.1    Fiocchi, C.2
  • 122
    • 73149093194 scopus 로고    scopus 로고
    • Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis
    • Wright G., Notley C., Xue S., Bendle G., Holler A., Schumacher T., et al. (2009) Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proc Nat Acad Sci USA 106: 19078-19083.
    • (2009) Proc Nat Acad Sci USA , vol.106 , pp. 19078-19083
    • Wright, G.1    Notley, C.2    Xue, S.3    Bendle, G.4    Holler, A.5    Schumacher, T.6
  • 123
    • 0026505616 scopus 로고
    • Resolution of immune-mediated diseases following allogeneic bone marrow transplantation for leukaemia
    • Yin J., Jowitt S., (1992) Resolution of immune-mediated diseases following allogeneic bone marrow transplantation for leukaemia. Bone Marrow Transpl 9: 31-33.
    • (1992) Bone Marrow Transpl , vol.9 , pp. 31-33
    • Yin, J.1    Jowitt, S.2
  • 124
    • 84932092328 scopus 로고    scopus 로고
    • Presenteeism in inflammatory bowel diseases: A hidden problem with significant economic impact
    • Zand A., Van Deen W., Inserra E., Hall L., Kane E., Centeno A., et al. (2015) Presenteeism in inflammatory bowel diseases: a hidden problem with significant economic impact. Inflamm Bowel Dis 21: 1623-1630.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 1623-1630
    • Zand, A.1    Van Deen, W.2    Inserra, E.3    Hall, L.4    Kane, E.5    Centeno, A.6


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