Immunomodulatory effects of unselected haematopoietic stem cells autotransplantation in refractory Crohn's disease

Digestive and Liver Disease

Volumn 43, Issue 12, 2011, Pages 946-952

  Clerici, Mario ^a,b   Cassinotti, Andrea ^c   Onida, Francesco ^a   Trabattoni, Daria ^a   Annaloro, Claudio ^a   Della Volpe, Aldo ^a   Rainone, Veronica ^a   Lissoni, Francesca ^a   Duca, Piergiorgio ^c   Sampietro, Gianluca ^c   Fociani, Paolo ^c   Vago, Gianluca ^c   Foschi, Diego ^c   Ardizzone, Sandro ^c   Deliliers, Giorgio Lambertenghi ^a   Porro, Gabriele Bianchi ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Crohn's disease; Immunomodulation; Refractory disease; Stem cells; Transplantation

Indexed keywords

CD14 ANTIGEN; CD4 ANTIGEN; CYCLOPHOSPHAMIDE; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR ALPHA; METHYLPREDNISOLONE; THYMOCYTE ANTIBODY; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; AUTOTRANSPLANTATION; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; FEMALE; HEMATOPOIETIC STEM CELL AUTOTRANSPLANTATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; MALE; MONOCYTE; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE;

ADULT; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CROHN DISEASE; DRUG RESISTANCE; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNOMODULATION; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LONGITUDINAL STUDIES; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MONOCYTES; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TRANSPLANTATION, AUTOLOGOUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80055072032     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2011.07.021     Document Type: Article

References (26)

1. Baumgart D.C., Sandborn W.J. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 2007, 369:1641-1657.
2. Travis S.P., Stange E.F., Lémann M., et al. European evidence-based consensus on the diagnosis and management of Crohn's disease: current management. Gut 2006, 55(Suppl. 1):i16-i35.
3. Munkholm P., Langholz E., Davidsen M., et al. Frequency of glucocorticoid resistance and dependency in Crohn's disease. Gut 1994, 35:360-362.
4. Oyama Y., Craig R.M., Traynor A.E., et al. Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease. Gastroenterology 2005, 128:552-563.
5. + cell selection in refractory Crohn's disease. Gut 2008, 57:211-217.
6. Hough R.E., Snowden J.A., Wulffraat N.M. Haematopoietic stem cell transplantation in autoimmune diseases: a European perspective. Br J Haematol 2004, 128:432-459.
7. Burt R.K., Slavin S., Burns W.H., et al. Induction of tolerance in autoimmune diseases by haematopoietic stem cell transplantation: getting closer to a cure?. Blood 2002, 99:768-784.
8. Ardizzone S., Bianchi Porro G. Inflammatory bowel disease: new insights into pathogenesis and treatment. J Intern Med 2002, 252:4675-4696.
9. Baumgart D.C., Carding S.R. Inflammatory bowel disease: cause and immunobiology. Lancet 2007, 369:1627-1640.
10. Best W.R., Becktel J.M., Singleton J.W., et al. Development of a Crohn's disease activity index. National cooperative Crohn's disease study. Gastroenterology 1976, 70:439-444.
11. Daperno M., D'Haens G., Van Assche G., et al. Development and validation of a new simplified endoscopic activity score for Crohn's disease: the SES-CD. Gastrointest Endosc 2004, 60:505-512.
12. Leung Y., Geddes M., Storek J., et al. Hematopoietic cell transplantation for Crohn's disease; is it time?. World J Gastroenterol 2006, 12:6665-6673.
13. Deane S., Meyers F.J., Gershwin E. On reversing the persistence of memory: hematopoietic stem cell transplant for autoimmune disease in the first ten years. J Autoimmun 2008, 30:180-196.
14. + immune regulatory network. Blood 2006, 107:1696-1702.
15. Burt R.K., Testori A., Craig R., et al. Hematopoietic stem cell transplantation for autoimmune diseases: what have we learned?. J Autoimmun 2008, 30:116-120.
16. Chen T.C., Cobbold S.P., Fairchild P.J., et al. Generation of anergic and regulatory T cells following prolonged exposure to a harmless antigen. J Immunol 2004, 172:5900-5907.
17. Touraine J.L., Roncarolo M.G., Raudrant D., et al. Induction of transplantation tolerance in humans using fetal cell transplants. Transplant Proc 2005, 37:65-66.
18. Khalil P.N., Weiler V., Nelson P.J., et al. Nonmyeloablative stem cell therapy enhances microcirculation and tissue regeneration in murine inflammatory bowel disease. Gastroenterology 2007, 132:944-954.
19. Elson C.O. Genes, microbes and T cells - new therapeutic targets in Crohn's disease. N Engl J Med 2002, 346:614-616.
20. Korzenik J.R., Dieckgraefe B.K. An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease. Aliment Pharmacol Ther 2005, 21:391-400.
21. Fukuda Y., Matsui T., Suzuki Y., et al. Adsorbitive granulocyte and monocyte apheresis for refractory Crohn's disease: an open multicenter prospective study. J Gastroenterol 2004, 39:1158-1164.
22. Lytton S., Denton C., Nutzenberger A. Treatment of autoimmune disease with rabbit anti-T lymphocyte globulin. Clinical efficacy and potential mechanisms of action. Ann N Y Acad Sci 2007, 1110:285-296.
23. + regulatory T cells. J Immunol 2003, 170:3939-3943.
24. + T cells during cure of colitis. J Immunol 2006, 177:5852-5860.
25. Fukata M., Abreu M.T. TLR4 signalling in the intestine in health and disease. Biochem Soc Trans 2007, 35:1473-1478.
26. Hausmann M., Kiessling S., Mestermann S., et al. Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology 2002, 122:1987-2000.