Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions

Neuropharmacology

Volumn 106, Issue , 2016, Pages 85-90

  Rapanelli, Maximiliano ^a   Pittenger, Christopher ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

H3 receptor; Histamine; Narcolepsy; Tourette syndrome

Indexed keywords

AMPHETAMINE; ANTIHISTAMINIC AGENT; AZD 5213; CIPROXIFAN; CLOBENPROPIT; DIPHENHYDRAMINE; DIZOCILPINE; HISTAMINE; HISTAMINE H3 RECEPTOR; HISTIDINE DECARBOXYLASE; MODAFINIL; PITOLISANT; THIOPERAMIDE; UNCLASSIFIED DRUG; HISTAMINE RECEPTOR;

ALCOHOL ABUSE; ATTENTION DEFICIT DISORDER; CONTROLLED CLINICAL TRIAL (TOPIC); DAYTIME SOMNOLENCE; DRUG ANTAGONISM; DRUG EFFICACY; ELECTROENCEPHALOGRAM; GENE DOSAGE; GENETIC ASSOCIATION; GILLES DE LA TOURETTE SYNDROME; HDC GENE; HUMAN; HUNTINGTON CHOREA; HYPERSOMNIA; IN VITRO STUDY; IN VIVO STUDY; MICRODIALYSIS; NARCOLEPSY; NEUROPSYCHIATRY; NEUROTRANSMISSION; NONHUMAN; OPEN STUDY; PARKINSON DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PSYCHOSIS; REVIEW; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP DISORDERED BREATHING; ANIMAL; MENTAL DISEASE; METABOLISM;

ANIMALS; HISTAMINE; HUMANS; MENTAL DISORDERS; RECEPTORS, HISTAMINE; TOURETTE SYNDROME;

EID: 84974653268     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.08.019     Document Type: Review

References (78)

1. H. Abe, S. Honma, H. Ohtsu, and K. Honma Circadian rhythms in behavior and clock gene expressions in the brain of mice lacking histidine decarboxylase Brain Res. Mol. Brain Res. 124 2 2004 178 187
2. S.F. Acevedo, H. Ohtsu, T.S. Benice, A. Rizk-Jackson, and J. Raber Age-dependent measures of anxiety and cognition in male histidine decarboxylase knockout (Hdc-/-) mice Brain Res. 1071 1 2006 113 123
3. S.F. Acevedo, T. Pfankuch, H. Ohtsu, and J. Raber Anxiety and cognition in female histidine decarboxylase knockout (Hdc(-/-)) mice Behav. Brain Res. 168 1 2006 92 99
4. M. Akhtar, P. Uma Devi, A. Ali, K.K. Pillai, and D. Vohora Antipsychotic-like profile of thioperamide, a selective H3-receptor antagonist in mice Fundam. Clin. Pharmacol. 20 4 2006 373 378
5. C. Anaclet, and et al. Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models J. Neurosci. Off. J. Soc. Neurosci. 29 46 2009 14423 14438
6. I. Arnulf Excessive daytime sleepiness in parkinsonism Sleep. Med. Rev. 9 3 2005 185 200
7. M.E. Bardgett, M. Points, J. Roflow, M. Blankenship, and M.S. Griffith Effects of the H(3) antagonist, thioperamide, on behavioral alterations induced by systemic MK-801 administration in rats Psychopharmacology 205 4 2009 589 597
8. M.E. Bardgett, M. Points, J. Kleier, M. Blankenship, and M.S. Griffith The H3 antagonist, ciproxifan, alleviates the memory impairment but enhances the motor effects of MK-801 (dizocilpine) in rats Neuropharmacology 59 6 2010 492 502
9. M.H. Bloch Emerging treatments for Tourette's disorder Curr. Psychiatry Rep. 10 4 2008 323 330
10. M.H. Bloch, K.E. Panza, A. Landeros-Weisenberger, and J.F. Leckman Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders J. Am. Acad. Child Adolesc. Psychiatry 48 9 2009 884 893
11. M.H. Bloch Clinical course and adult outcome in Tourette syndrome D. Martino, J.F. Leckman, Tourette Syndrome 2013 Oxford University Press New York 107 120
12. P. Bonaventure, and et al. Histamine H3 receptor antagonists: from target identification to drug leads Biochem. Pharmacol. 73 8 2007 1084 1096
13. C. Brabant, and et al. The psychostimulant and rewarding effects of cocaine in histidine decarboxylase knockout mice do not support the hypothesis of an inhibitory function of histamine on reward Psychopharmacology 190 2 2007 251 263
14. K.E. Browman, and et al. Enhancement of prepulse inhibition of startle in mice by the H3 receptor antagonists thioperamide and ciproxifan Behav. Brain Res. 153 1 2004 69 76
15. A. Burban, and et al. Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists Psychopharmacology 210 4 2010 591 604
16. L. Castellan Baldan, and et al. Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice Neuron 81 1 2014 77 90
17. A. Chepkova, and et al. Histamine receptor expression, hippocampal plasticity and ammonia in histidine decarboxylase knockout mice Cell. Mol. Neurobiol. 32 1 2012 17 25
18. Y. Dauvilliers, and et al. Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial Lancet. Neurology 12 11 2013 1068 1075
19. D. Denys, and et al. Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder Eur. Neuropsychopharmacol. J. Eur. Coll. Neuropsychopharmacol. 23 11 2013 1423 1431
20. E. Dere, and et al. Histidine-decarboxylase knockout mice show deficient nonreinforced episodic object memory, improved negatively reinforced water-maze performance, and increased neo- and ventro-striatal dopamine turnover Learn. Mem. 10 6 2003 510 519
21. E. Dere, and et al. Changes in motoric, exploratory and emotional behaviours and neuronal acetylcholine content and 5-HT turnover in histidine decarboxylase-KO mice Eur. J. Neurosci. 20 4 2004 1051 1058
22. C.M. Eddy, H.E. Rickards, and A.E. Cavanna Treatment strategies for tics in Tourette syndrome Ther. Adv. neurological Disord. 4 1 2011 25 45
23. F.M. Egan, and et al. Randomized crossover study of the histamine H3 inverse agonist MK-0249 for the treatment of cognitive impairment in patients with schizophrenia Schizophrenia Res. 146 1-3 2013 224 230
24. A.G. Ercan-Sencicek, and et al. L-histidine decarboxylase and Tourette's syndrome N. Engl. J. Med. 362 20 2010 1901 1908
25. T.A. Esbenshade, and et al. The histamine H3 receptor: an attractive target for the treatment of cognitive disorders Br. J. Pharmacol. 154 6 2008 1166 1181
26. T.V. Fernandez, and et al. Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism Biol. psychiatry 71 5 2012 392 402
27. T. Fernandez, M.W. State, and C. Pittenger D.H. Geschwind, H.L. Paulson, Tourette's Disorder and Tic Disorders Neurogenetics: Handbook of Clinical Neurology, 3rd Series 2015 Elsevier New York (in press)
28. C. Ferrada, and et al. Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function Neuropharmacology 55 2 2008 190 197
29. C. Ferrada, and et al. Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors Br. J. Pharmacol. 157 1 2009 64 75
30. C.P. Fitzsimons, and et al. Histamine deficiency induces tissue-specific down-regulation of histamine H2 receptor expression in histidine decarboxylase knockout mice FEBS Lett. 508 2 2001 245 248
31. Y.X. Gong, and et al. Ameliorating effect of histamine on impairment of cued fear extinction induced by morphine withdrawal in histidine decarboxylase gene knockout mice Acta Pharmacol. Sin. 31 11 2010 1431 1437
32. Y.X. Gong, W.P. Zhang, W.T. Shou, K. Zhong, and Z. Chen Morphine induces conditioned place preference behavior in histidine decarboxylase knockout mice Neurosci. Lett. 468 2 2010 115 119
33. G. Griebel, M. Decobert, A. Jacquet, and S. Beeske Awakening properties of newly discovered highly selective H(3) receptor antagonists in rats Behav. brain Res. 232 2 2012 416 420
34. R.X. Guo, and et al. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice Br. J. Pharmacol. 157 1 2009 104 117
35. H.L. Haas, O.A. Sergeeva, and O. Selbach Histamine in the nervous system Physiol. Rev. 88 3 2008 1183 1241
36. G.M. Haig, and et al. A randomized trial of the efficacy and safety of the H3 antagonist ABT-288 in cognitive impairment associated with schizophrenia Schizophr. Bull. 40 6 2014 1433 1442
37. A. Hartmann, Y. Worbe, and I. Arnulf Increasing histamine neurotransmission in Gilles de la Tourette syndrome J. Neurology 259 2 2012 375 376
38. W.J. Herring, and et al. Randomized controlled study of the histamine H3 inverse agonist MK-0249 in adult attention-deficit/hyperactivity disorder J. Clin. psychiatry 73 7 2012 e891 898
39. Z.L. Huang, and et al. Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice Proc. Natl. Acad. Sci. U. S. A. 103 12 2006 4687 4692
40. L.F. Jarskog, and et al. A Phase II study of a histamine H3 receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy Schizophrenia Res. 164 1-3 2015 136 142
41. C.Y. Jin, O. Anichtchik, and P. Panula Altered histamine H3 receptor radioligand binding in post-mortem brain samples from subjects with psychiatric diseases Br. J. Pharmacol. 157 1 2009 118 129
42. I. Karagiannidis, and et al. Support of the histaminergic hypothesis in Tourette syndrome: association of the histamine decarboxylase gene in a large sample of families J. Med. Genet. 50 11 2013 760 764
43. V.A. Komater, and et al. H3 receptor blockade by thioperamide enhances cognition in rats without inducing locomotor sensitization Psychopharmacology 167 4 2003 363 372
44. Y. Kubota, and et al. Increased methamphetamine-induced locomotor activity and behavioral sensitization in histamine-deficient mice J. Neurochem. 83 4 2002 837 845
45. S. Leu-Semenescu, N. Nittur, J.L. Golmard, and I. Arnulf Effects of pitolisant, a histamine H3 inverse agonist, in drug-resistant idiopathic and symptomatic hypersomnia: a chart review Sleep. Med. 15 6 2014 681 687
46. J.S. Lin Brain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on the posterior hypothalamus and histaminergic neurons Sleep. Med. Rev. 4 5 2000 471 503
47. J.S. Lin, and et al. An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients Neurobiol. Dis. 30 1 2008 74 83
48. J.S. Lin, O.A. Sergeeva, and H.L. Haas Histamine H3 receptors and sleep-wake regulation J. Pharmacol. Exp. Ther. 336 1 2011 17 23
49. L. Liu, and et al. Improved learning and memory of contextual fear conditioning and hippocampal CA1 long-term potentiation in histidine decarboxylase knock-out mice Hippocampus 17 8 2007 634 641
50. D. Mahmood, R. Khanam, K.K. Pillai, and M. Akhtar Protective effects of histamine H3-receptor ligands in schizophrenic behaviors in experimental models Pharmacol. Rep. P. R. 64 1 2012 191 204
51. T. Mochizuki, and et al. Circadian rhythm of histamine release from the hypothalamus of freely moving rats Physiology Behav. 51 2 1992 391 394
52. J.M. Monti Involvement of histamine in the control of the waking state Life Sci. 53 17 1993 1331 1338
53. E. Moreno, and et al. Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway J. Biol. Chem. 286 7 2011 5846 5854
54. E. Moreno, and et al. Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: sigma1-D1-H3 receptor complexes as key targets for reducing cocaine's effects J. Neurosci. Off. J. Soc. Neurosci. 34 10 2014 3545 3558
55. S. Morisset, and et al. High constitutive activity of native H3 receptors regulates histamine neurons in brain Nature 408 6814 2000 860 864
56. L. Munari, G. Provensi, M.B. Passani, and P. Blandina Selective brain region activation by histamine H(3) receptor antagonist/inverse agonist ABT-239 enhances acetylcholine and histamine release and increases c-Fos expression Neuropharmacology 70 2013 131 140
57. H. Ohtsu, and et al. Mice lacking histidine decarboxylase exhibit abnormal mast cells FEBS Lett. 502 1-2 2001 53 56
58. P. Panula, and S. Nuutinen The histaminergic network in the brain: basic organization and role in disease Nat. Rev. Neurosci. 14 7 2013 472 487
59. R. Parmentier, and et al. Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep-wake control J. Neurosci. Off. J. Soc. Neurosci. 22 17 2002 7695 7711
60. R. Parmentier, and et al. The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders Biochem. Pharmacol. 73 8 2007 1157 1171
61. C. Pittenger Tourette syndrome M.S. LeDoux, Movement Disorders: Genetics and Models 2014 Elsevier San Diego 748 766
62. G.D. Prell, and et al. Histamine metabolites in cerebrospinal fluid of patients with chronic schizophrenia: their relationships to levels of other aminergic transmitters and ratings of symptoms Schizophrenia Res. 14 2 1995 93 104
63. M. Rapanelli, and et al. Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome Eur. Neuropsychopharmacol. J. Eur. Coll. Neuropsychopharmacol. 24 12 2014 1896 1906
64. S.V. Rozov, J.C. Zant, K. Karlstedt, T. Porkka-Heiskanen, and P. Panula Periodic properties of the histaminergic system of the mouse brain Eur. J. Neurosci. 39 2 2014 218 228
65. K. Sander, T. Kottke, and H. Stark Histamine H3 receptor antagonists go to clinics Biol. Pharm. Bull. 31 12 2008 2163 2181
66. L. Scahill, and K. Bradbury The prevalence of Tourette syndrome and its relationship to clinical features D. Martino, J.F. Leckman, Tourette Syndrome 2013 Oxford University Press New York 121 133
67. J.M. Scharf, and et al. Genome-wide association study of Tourette's syndrome Mol. psychiatry 18 6 2013 721 728
68. E. Schlicker, B. Malinowska, M. Kathmann, and M. Gothert Modulation of neurotransmitter release via histamine H3 heteroreceptors Fundam. Clin. Pharmacol. 8 2 1994 128 137
69. E.H. Schneider, D. Neumann, and R. Seifert Modulation of behavior by the histaminergic system: lessons from H(1)R-and H(2)R-deficient mice Neurosci. Biobehav. Rev. 42 2014 252 266
70. J.C. Schwartz The histamine H3 receptor: from discovery to clinical trials with pitolisant Br. J. Pharmacol. 163 4 2011 713 721
71. L. Shan, A.M. Bao, and D.F. Swaab The human histaminergic system in neuropsychiatric disorders Trends Neurosci. 38 3 2015 167 177
72. L. Shan, Y. Dauvilliers, and J.M. Siegel Interactions of the histamine and hypocretin systems in CNS disorders Nat. Rev. Neurol. 11 7 Jul 2015 401 413
73. E.M. Stocking, and M.A. Letavic Histamine H3 antagonists as wake-promoting and pro-cognitive agents Curr. Top. Med. Chem. 8 11 2008 988 1002
74. M.J. Thorpy, and Y. Dauvilliers Clinical and practical considerations in the pharmacologic management of narcolepsy Sleep. Med. 16 1 2015 9 18
75. D. Vohora, and M. Bhowmik Histamine H3 receptor antagonists/inverse agonists on cognitive and motor processes: relevance to Alzheimer's disease, ADHD, schizophrenia, and drug abuse Front. Syst. Neurosci. 6 2012 72
76. R.H. Weisler, and et al. Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder CNS drugs 26 5 2012 421 434
77. K. Williams, M.H. Bloch, M.W. State, and C. Pittenger Tourette syndrome and tic disorders D.S. Charney, J.D. Buxbaum, P. Sklar, E.J. Nestler, Neurobiology of Mental Illness fourth ed. 2013 Oxford New York
78. M. Xu, L. Li, H. Ohtsu, and C. Pittenger Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show enhanced stereotypy following stress Neurosci. Lett. 595 2015 50 53