The Assessment of Blood Loss During Total Knee Arthroplasty When Comparing Intravenous vs Intracapsular Administration of Tranexamic Acid

Journal of Arthroplasty

Volumn 31, Issue 11, 2016, Pages 2452-2457

  May, Jedediah H ^a   Rieser, Geoffrey R ^a   Williams, Chad G ^a   Markert, Ronald J ^a   Bauman, Ryan D ^b   Lawless, Matthew W ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b Orthopaedic Institute of Dayton   (United States)

Author keywords

blood conservation; intra articular; intracapsular; intravenous; total knee arthroplasty; tranexamic acid

Indexed keywords

PLACEBO; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ADULT; ARTICLE; BLOOD TRANSFUSION; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; FEMALE; HOSPITALIZATION; HUMAN; LENGTH OF STAY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATIENT ASSESSMENT; POSTOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; RANDOMIZED CONTROLLED TRIAL; SURGICAL INFECTION; TOTAL KNEE ARTHROPLASTY; WOUND DEHISCENCE; ADVERSE EFFECTS; AGED; BLOOD LOSS, SURGICAL; COMPARATIVE STUDY; INTRAARTICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; KNEE REPLACEMENT; MIDDLE AGED; POSTOPERATIVE PERIOD; STATISTICS AND NUMERICAL DATA;

ADMINISTRATION, INTRAVENOUS; AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; FEMALE; HUMANS; INJECTIONS, INTRA-ARTICULAR; LENGTH OF STAY; MALE; MIDDLE AGED; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; TRANEXAMIC ACID;

EID: 84973864177     PISSN: 08835403     EISSN: 15328406     Source Type: Journal    
DOI: 10.1016/j.arth.2016.04.018     Document Type: Article

References (41)

1. 1 National and regional estimates on hospital use for all patients from the HCUP Nationwide Inpatient Sample (NIS). U.S. Department of Health and Human Services.
2. 2 Lavernia, C.J., Alcerro, J.C., Rossi, M.D., Fear in arthroplasty surgery: the role of race. Clin Orthop Relat Res, 468(2), 2010, 547.
3. 3 Kagoma, Y.K., Crowther, M.A., Douketis, J., et al. Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials. Thromb Res, 123(5), 2009, 687.
4. 4 Wong, J., Abrishami, A., El Beheiry, H., et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am, 92(15), 2010, 2503.
5. 5 Freedman, J., Luke, K., Monga, N., et al. A provincial program of blood conservation: the Ontario Transfusion Coordinators (ONTraC). Transfus Apher Sci, 33(3), 2005, 343.
6. 6 Innerhofer, P., Klingler, A., Klimmer, C., et al. Risk for postoperative infection after transfusion of white blood cell-filtered allogeneic or autologous blood components in orthopedic patients undergoing primary arthroplasty. Transfusion, 45(1), 2005, 103.
7. 7 Bierbaum, B.E., Callaghan, J.J., Galante, J.O., et al. An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am, 81(1), 1999, 2.
8. 8 Kuriyan, M., Carson, J.L., Anemia and clinical outcomes. Anesthesiol Clin North America, 23(2), 2005, 315.
9. 9 Dunn, C.J., Goa, K.L., Tranexamic acid: a review of its use in surgery and other indications. Drugs, 57(6), 1999, 1005.
10. 10 Hoylaerts, M., Lijnen, H.R., Collen, D., Studies on the mechanism of the antifibrinolytic action of tranexamic acid. Biochim Biophys Acta, 673(1), 1981, 75.
11. 11 Henry, D.A., Carless, P.A., Moxey, A.J., et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev(1), 2011, CD001886.
12. 12 Zufferey, P., Merquiol, F., Laporte, S., et al. Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery?. Anesthesiology, 105(5), 2006, 1034.
13. 13 Aguilera, X., Martinez-Zapata, M.J., Hinarejos, P., et al. Topical and intravenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty: a multicenter, randomized, controlled trial. Arch Orthop Trauma Surg, 135(7), 2015, 1017.
14. 14 Garneti, N., Field, J., Bone bleeding during total hip arthroplasty after administration of tranexamic acid. J Arthroplasty, 19(4), 2004, 488.
15. 15 Husted, H., Blond, L., Sonne-Holm, S., et al. Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplasty: a prospective randomized double-blind study in 40 patients. Acta Orthop Scand, 74(6), 2003, 665.
16. 16 Tan, J., Chen, H., Liu, Q., et al. A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty. J Surg Res, 184(2), 2013, 880.
17. 17 Wind, T.C., Barfield, W.R., Moskal, J.T., The effect of tranexamic acid on blood loss and transfusion rate in primary total knee arthroplasty. J Arthroplasty, 28(7), 2013, 1080.
18. 18 Sepah, Y.J., Umer, M., Ahmad, T., et al. Use of tranexamic acid is a cost effective method in preventing blood loss during and after total knee replacement. J Orthop Surg Res, 6, 2011, 22.
19. 19 Slover, J., Bosco, J., Cost analysis of use of tranexamic acid to prevent major bleeding complications in hip and knee arthroplasty surgery. Am J Orthop (Belle Mead NJ), 43(10), 2014, E217.
20. 20 Alshryda, S., Mason, J., Sarda, P., et al. Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total hip replacement: a randomized controlled trial (TRANX-H). J Bone Joint Surg Am, 95(21), 2013, 1969.
21. 21 Alshryda, S., Mason, J., Vaghela, M., et al. Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total knee replacement: a randomized controlled trial (TRANX-K). J Bone Joint Surg Am, 95(21), 2013, 1961.
22. 22 Jang, B., Kao, M., Bohm, M.T., et al. Intra-articular injection of tranexamic acid to reduce blood loss after total knee arthroplasty. J Orthop Surg (Hong Kong), 22(2), 2014, 146.
23. 23 Roy, S.P., Tanki, U.F., Dutta, A., et al. Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc, 20(12), 2012, 2494.
24. 24 Yang, Y., Lv, Y.M., Ding, P.J., et al. The reduction in blood loss with intra-articular injection of tranexamic acid in unilateral total knee arthroplasty without operative drains: a randomized controlled trial. Eur J Orthop Surg Traumatol, 25(1), 2015, 135.
25. 25 Gillette, B.P., DeSimone, L.J., Trousdale, R.T., et al. Low risk of thromboembolic complications with tranexamic acid after primary total hip and knee arthroplasty. Clin Orthop Relat Res, 471(1), 2012, 150.
26. 26 Shakur, H., Roberts, I., Bautista, R., et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet, 376(9734), 2010, 23.
27. 27 Whiting, D.R., Gillette, B.P., Duncan, C., et al. Preliminary results suggest tranexamic acid is safe and effective in arthroplasty patients with severe comorbidities. Clin Orthop Relat Res, 472(1), 2014, 66.
28. 28 Graham, I.D., Alvarez, G., Tetroe, J., et al. Factors influencing the adoption of blood alternatives to minimize allogeneic transfusion: the perspective of eight Ontario hospitals. Can J Surg, 45(2), 2002, 132.
29. 29 Nadler, S., Hidalgo, J., Blouch, T., Prediction of blood volume in normal human adults. Surgery, 51, 1962, 224.
30. 30 Charlson, M.E., Pompei, P., Ales, K.L., et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis, 40(5), 1987, 373.
31. 31 Dodd, R.Y., The risk of transfusion-transmitted infection. N Engl J Med, 327(6), 1992, 419.
32. 32 Aguilera, X., Martinez-Zapata, M.J., Bosch, A., et al. Efficacy and safety of fibrin glue and tranexamic acid to prevent postoperative blood loss in total knee arthroplasty: a randomized controlled clinical trial. J Bone Joint Surg Am, 95(22), 2013, 2001.
33. 33 Sarzaeem, M.M., Razi, M., Kazemian, G., et al. Comparing efficacy of three methods of tranexamic acid administration in reducing hemoglobin drop following total knee arthroplasty. J Arthroplasty, 29(8), 2014, 1521.
34. 34 Gomez-Barrena, E., Ortega-Andreu, M., Padilla-Eguiluz, N.G., et al. Topical intra-articular compared with intravenous tranexamic acid to reduce blood loss in primary total knee replacement: a double-blind, randomized, controlled, noninferiority clinical trial. J Bone Joint Surg Am, 96(23), 2015, 1937.
35. 35 Patel, J.N., Spanyer, J.M., Smith, L.S., et al. Comparison of intravenous versus topical tranexamic acid in total knee arthroplasty: a prospective randomized study. J Arthroplasty, 29(8), 2014, 1528.
36. 36 Soni, A., Saini, R., Gulati, A., et al. Comparison between intravenous and intra-articular regimens of tranexamic acid in reducing blood loss during total knee arthroplasty. J Arthroplasty, 29(8), 2014, 1525.
37. 37 Hamlin, B.R., DiGioia, A.M., Plakseychuk, A.Y., et al. Topical versus intravenous tranexamic acid in total knee arthroplasty. J Arthroplasty, 30(3), 2014, 384.
38. 38 Seo, J.G., Moon, Y.W., Park, S.H., et al. The comparative efficacies of intra-articular and IV tranexamic acid for reducing blood loss during total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc, 21(8), 2012, 1869.
39. 39 Iwai, T., Tsuji, S., Tomita, T., et al. Repeat-dose intravenous tranexamic acid further decreases blood loss in total knee arthroplasty. Int Orthop, 37(3), 2013, 441.
40. 40 Lin, P.C., Hsu, C.H., Chen, W.S., et al. Does tranexamic acid save blood in minimally invasive total knee arthroplasty?. Clin Orthop Relat Res, 469(7), 2014, 1995.
41. 41 Ishida, K., Tsumura, N., Kitagawa, A., et al. Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty. Int Orthop, 35(11), 2011, 1639.