Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial

Phytotherapy Research

Volumn 30, Issue 10, 2016, Pages 1634-1640

  An, Jee Hyun ^a   Kim, Dong Lim ^b   Lee, Tae Bum ^c   Kim, Kyeong Jin ^a   Kim, Sun Hwa ^a   Kim, Nam Hoon ^a   Kim, Hee Young ^a   Choi, Dong Seop ^a   Kim, Sin Gon ^a  

^a Korea University College of Medicine   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

^c Berry Bio Food Research Institute   (South Korea)

Author keywords

atherosclerosis; black raspberry; metabolic syndrome; prediabetes; Rubus occidentalis

Indexed keywords

ANTIDIABETIC AGENT; HEMOGLOBIN A1C; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; PLACEBO; PLANT EXTRACT; RUBUS OCCIDENTALIS EXTRACT; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL;

ABDOMINAL PAIN; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FATIGUE; FEMALE; FEVER; GLYCEMIC CONTROL; HOMOEOSTASIS MODEL ASSESSMENT B; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSOMNIA; LIPID ANALYSIS; LOW DRUG DOSE; MALE; MEDICAL PARAMETERS; NAUSEA; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RASH; RUBUS; RUBUS OCCIDENTALIS; AGED; CHEMISTRY; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; METABOLISM; MIDDLE AGED; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PREDIABETIC STATE; RUBUS; YOUNG ADULT;

EID: 84973650054     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5664     Document Type: Article

References (33)

1. Association AD. 2014. Standards of medical care in diabetes–2014. Diabetes Care 37(Suppl 1): S14–80.
2. Arakelyan A, Petrkova J, Hermanova Z, Boyajyan A, Lukl J, Petrek M. 2005. Serum levels of the MCP-1 chemokine in patients with ischemic stroke and myocardial infarction. Mediat Inflamm 14: 175–179.
3. Centers for Disease Control and Prevention. 2014. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States. U.S. Department of Health and Human Services: Atlanta, GA.
4. Cheplick S, Kwon YI, Bhowmik P, Shetty K. 2007. Clonal variation in raspberry fruit phenolics and relevance for diabetes and hypertension management. J Food Biochem 31: 656–679.
5. Choi HR, Lee SJ, Lee JH, et al. 2013. Cholesterol-lowering effects of unripe black raspberry water extract. J Korean Soc Food Sci Nutr 42: 1899–1907.
6. de Lemos JA, Morrow DA, Sabatine MS, et al. 2003. Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes. Circulation 107: 690–695.
7. Deo R, Khera A, McGuire DK, et al. 2004. Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis. J Am Coll Cardiol 44: 1812–1818.
8. Hakkinen SH, Torronen AR. 2000. Content of flavonols and selected phenolic acids in strawberries and Vaccinium species: influence of cultivar, cultivation site and technique. Food Res Int 33: 517–524.
9. Han C, Ding H, Casto B, Stoner GD, D'Ambrosio SM. 2005. Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries. Nutr Cancer 51: 207–217.
10. Higa JK, Panee J. 2011. Bamboo extract reduces interleukin 6 (IL-6) overproduction under lipotoxic conditions through inhibiting the activation of NF-kappa B and AP-1 pathways. Cytokine 55: 18–23.
11. Hoggard N, Cruickshank M, Moar KM, et al. 2013. A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle. J Nutr Sci 2: e22.
12. Holvoet P, Lee DH, Steffes M, Gross M, Jacobs DR. 2008. Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome. Jama-J Am Med Assoc 299: 2287–2293.
13. Izzo AA, Hoon-Kim S, Radhakrishnan R, Williamson EM. 2016. A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies. Phytother Res 30: 691–700.
14. Jayaprakasam B, Vareed SK, Olson LK, Nair MG. 2005. Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. J Agric Food Chem 53: 28–31.
15. Jeong HS, Hong SJ, Lee TB, et al. 2014. Effects of black raspberry on lipid profiles and vascular endothelial function in patients with metabolic syndrome. Phytother Res 28: 1492–1498.
16. Kahkonen MP, Hopia AI, Vuorela HJ, et al. 1999. Antioxidant activity of plant extracts containing phenolic compounds. J Agric Food Chem 47: 3954–3962.
17. Kim EJ, Lee YJ, Shin HK, Park JH. 2005. Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. Nutrition 21: 1141–1148.
18. Lee J, Dossett M, Finn CE. 2014. Mistaken identity: clarification of Rubus coreanus miquel (bokbunja). Molecules 19: 10524–10533.
19. Martin MA, Fernandez-Millan E, Ramos S, Bravo L, Goya L. 2014. Cocoa flavonoid epicatechin protects pancreatic beta cell viability and function against oxidative stress. Mol Nutr Food Res 58: 447–456.
20. Matsui T, Ueda T, Oki T, Sugita K, Terahara N, Matsumoto K. 2001. alpha-Glucosidase inhibitory action of natural acylated anthocyanins. 2. alpha-Glucosidase inhibition by isolated acylated anthocyanins. J Agric Food Chem 49: 1952–1956.
21. Matthews DR, Hosker JP, Rudenski AS, et al. 1985. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412–419.
22. McDougall GJ, Shpiro F, Dobson P, Smith P, Blake A, Stewart D. 2005. Different polyphenolic components of soft fruits inhibit alpha-amylase and alpha-glucosidase. J Agric Food Chem 53: 2760–2766.
23. Meisinger C, Baumert J, Khuseyinova N, Loewel H, Koenig W. 2005. Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population. Circulation 112: 651–657.
24. Nathan DM, Davidson MB, DeFronzo RA, et al. 2007. Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care 30: 753–759.
25. Norris SL, Zhang X, Avenell A, Gregg E, Schmid CH, Lau J. 2005. Long-term non-pharmacological weight loss interventions for adults with prediabetes. Cochrane Database Syst Rev 2: CD005270.
26. Panee J. 2012. Monocyte chemoattractant protein 1 (MCP-1) in obesity and diabetes. Cytokine 60: 1–12.
27. Peiffer DS, Zimmerman NP, Wang LS, et al. 2014. Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid. Cancer Prev Res (Phila) 7: 574–584.
28. Piemonti L, Calori G, Lattuada G, et al. 2009. Association between plasma monocyte chemoattractant protein-1 concentration and cardiovascular disease mortality in middle-aged diabetic and nondiabetic individuals. Diabetes Care 32: 2105–2110.
29. UK Prospective Diabetes Study Group. 1990. UK Prospective Diabetes Study 7: response of fasting plasma glucose to diet therapy in newly presenting type II diabetic patients, UKPDS Group. Metabolism 39: 905–912.
30. Wang SY, Lin HS. 2000. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 48: 140–146.
31. World Health Organization, Geneva 2016. Global report on diabetes
32. Zhang Y, Jayaprakasam B, Seeram NP, Olson LK, DeWitt D, Nair MG. 2004. Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds. J Agric Food Chem 52: 228–233.
33. Zhu J, Yong W, Wu XH, et al. 2008. Anti-inflammatory effect of resveratrol on TNF-alpha-induced MCP-1 expression in adipocytes. Biochem Bioph Res Co 369: 471–477.