MiR-153 regulates apoptosis and autophagy of cardiomyocytes by targeting Mcl-1

Molecular Medicine Reports

Volumn 14, Issue 1, 2016, Pages 1033-1039

  Zou, Yuhai ^a,b   Liu, Wenting ^c   Zhang, Jinxia ^b   Xiang, Dingcheng ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^c GUANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

Author keywords

Apoptosis; Autophagy; Cardiomyocyte; MicroRNA 153

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CASPASE 3; CASPASE 9; MICRORNA; MICRORNA 153; PROTEIN MCL 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; MIRN153 MICRORNA, RAT;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CARDIAC MUSCLE CELL; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; MALE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BINDING SITE; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; RNA INTERFERENCE;

3' UNTRANSLATED REGIONS; ANIMALS; APOPTOSIS; AUTOPHAGY; BINDING SITES; CASPASE 3; CASPASE 9; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; MALE; MICRORNAS; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; MYOCYTES, CARDIAC; OXIDATIVE STRESS; RATS; RNA INTERFERENCE;

EID: 84973495168     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.5309     Document Type: Article

References (26)

1. Hafstad AD, Nabeebaccus AA and Shah AM: Novel aspects of ROS signalling in heart failure. Basic Res Cardiol 108: 359, 2013.
2. Wang J and Martin JF: Macro advances in microRNAs and myocardial regeneration. Curr Opin Cardiol 29: 207-213, 2014.
3. Sala V, Bergerone S, Gatti S, Gallo S, Ponzetto A, Ponzetto C and Crepaldi T: MicroRNAs in myocardial ischemia: Identifying new targets and tools for treating heart disease. New frontiers for miR-medicine. Cell Mol Life Sci 71: 1439-1452, 2014.
4. Port JD and Sucharov C: Role of microRNAs in cardiovascular disease: Therapeutic challenges and potentials. J Cardiovasc Pharmacol 56: 444-453, 2010.
5. Xia W, Ma X, Li X, Dong H, Yi J, Zeng W and Yang Z: miR-153 inhibits epithelial-to-mesenchymal transition in hepatocellular carcinoma by targeting Snail. Oncol Rep 34: 655-662, 2015.
6. Zhou J, Xie M, Shi Y, Luo B, Gong G, Li J, Wang J, Zhao W, Zi Y, Wu X and Wen J: MicroRNA-153 functions as a tumor suppressor by targeting SET7 and ZEB2 in ovarian cancer cells. Oncol Rep 34: 111-120, 2015.
7. Hua HW, Jiang F, Huang Q, Liao Z and Ding G: MicroRNA-153 promotes Wnt/?-catenin activation in hepatocellular carcinoma through suppression of WWOX. Oncotarget 6: 3840-3847, 2015.
8. Shan N, Shen L, Wang J, He D and Duan C: MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19. Biochem Biophys Res Commun 456: 385-391, 2015.
9. Carroll RG, Hollville E and Martin SJ: Parkin sensitizes toward apoptosis induced by mitochondrial depolarization through promoting degradation of Mcl-1. Cell Rep 9: 1538-1553, 2014.
10. Thomas RL, Roberts DJ, Kubli DA, Lee Y, Quinsay MN, Owens JB, Fischer KM, Sussman MA, Miyamoto S and Gustafsson ÅB: Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure. Genes Dev 27: 1365-1377, 2013.
11. Jokinen E and Koivunen JP: Bcl-xl and Mcl-1 are the major determinants of the apoptotic response to dual PI3K and MEK blockage. Int J Oncol 47: 1103-1110, 2015.
12. Cerella C, Muller F, Gaigneaux A, Radogna F, Viry E, Chateauvieux S, Dicato M and Diederich M: Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450. Cell Death Dis 6: e1782, 2015.
13. Varadarajan S, Poornima P, Milani M, Gowda K, Amin S, Wang HG and Cohen GM: Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and-independent manner. Oncotarget 6: 12668-12681, 2015.
14. Wang X, Bathina M, Lynch J, Koss B, Calabrese C, Frase S, Schuetz JD, Rehg JE and Opferman JT: Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction. Genes Dev 27: 1351-1364, 2013.
15. Li L, Xu J, He L, Peng L, Zhong Q, Chen L and Jiang Z: The role of autophagy in cardiac hypertrophy. Acta Biochim Biophys Sin, 2016.
16. Jia Z, Liu Y, Su H, Li M, Zhang M, Zhu Y, Li T, Fang Y and Liang S: Safflower extract inhibiting apoptosis by inducing autophagy in myocardium derived H9C2 cell. Int J Clin Exp Med 8: 20254-20262, 2015.
17. Schiattarella GG and Hill JA: Therapeutic targeting of autophagy in cardiovascular disease. J Mol Cell Cardiol, 2015.
18. Wang K, Liu F, Zhou LY, Ding SL, Long B, Liu CY, Sun T, Fan YY, Sun L and Li PF: miR-874 regulates myocardial necrosis by targeting caspase-8. Cell Death Dis 4: e709, 2013.
19. Xu J, Liao X and Wong C. Downregulations of B-cell lymphoma 2 and myeloid cell leukemia sequence 1 by microRNA 153 induce apoptosis in a glioblastoma cell line DBTRG-05MG. Int J Cancer 126: 1029-1035, 2010.
20. Wang K, Liu CY, Zhang XJ, Feng C, Zhou LY, Zhao Y and Li PF: miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury. Cell Death Differ 22: 1058-1068, 2015.
21. Xu C, Hu Y, Hou L, Ju J, Li X, Du N, Guan X, Liu Z, Zhang T, Qin W, et al: Blocker carvedilol protects cardiomyocytes against oxidative stress-induced apoptosis by up-regulating miR-133 expression. J Mol Cell Cardiol 75: 111-121, 2014.
22. Bai Z, Sun J, Wang X, Wang H, Pei H and Zhang Z: MicroRNA-153 is a prognostic marker and inhibits cell migration and invasion by targeting SNAI1 in human pancreatic ductal adenocarcinoma. Oncol Rep 34: 595-602, 2015.
23. Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, Asahi M, et al: The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 13: 619-624, 2007.
24. Dutta D, Xu J, Kim JS, Dunn WA Jr and Leeuwenburgh C: Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity. Autophagy 9: 328-344, 2013.
25. Wang JX, Jiao JQ, Li Q, Long B, Wang K, Liu JP, Li YR and Li PF: miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med 17: 71-78, 2011.
26. Zhao Y, Samal E and Srivastava D: Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 436: 214-220, 2005.