NT-3 promotes proprioceptive axon regeneration when combined with activation of the mTor intrinsic growth pathway but not with reduction of myelin extrinsic inhibitors

Experimental Neurology

Volumn 283, Issue , 2016, Pages 73-84

  Liu, Yingpeng ^a   Kelamangalath, Lakshmi ^a   Kim, Hyukmin ^a   Han, Seung Baek ^a   Tang, Xiaoqing ^a   Zhai, Jinbin ^a   Hong, Jee W ^a   Lin, Shen ^a   Son, Young Jin ^a   Smith, George M ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axonal regeneration; Dorsal root ganglion (DRG); MTOR signaling pathway; Neurotrophin 3 (NT 3); Rheb

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MYELIN; NEUROTROPHIN 3; RHEB PROTEIN; S6 KINASE; MAG PROTEIN, MOUSE; MTOR PROTEIN, HUMAN; MYELIN ASSOCIATED GLYCOPROTEIN; PROTEIN NOGO; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROPRIOCEPTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SENSORY NERVE; SPINAL GANGLION; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DEFICIENCY; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HYPERALGESIA; MALE; MAMMALIAN EMBRYO; METABOLISM; MOUSE; NERVE REGENERATION; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SOMATOSENSORY DISORDER; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; FEMALE; GANGLIA, SPINAL; GENE EXPRESSION REGULATION; HYPERALGESIA; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYELIN-ASSOCIATED GLYCOPROTEIN; NERVE REGENERATION; NEUROTROPHIN 3; NOGO PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SIROLIMUS; SOMATOSENSORY DISORDERS; SPINAL CORD INJURIES; TOR SERINE-THREONINE KINASES;

EID: 84973483942     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2016.05.021     Document Type: Article

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