Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats

Archives of Medical Science

Volumn 12, Issue 3, 2016, Pages 486-493

  Çetin, Aslý ^a   Çiftçi, Osman ^a   Otlu, Ali ^a  

^a INONU UNIVERSITY   (Turkey)

Author keywords

Carbon tetrachloride; Hepatotoxicity; Hesperidin; Liver

Indexed keywords

CARBON TETRACHLORIDE; CASPASE 3; CATALASE; GLUTATHIONE; HESPERIDIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; CONTROLLED STUDY; LIVER HISTOLOGY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; REVIEW; WISTAR RAT;

EID: 84973468648     PISSN: 17341922     EISSN: 18969151     Source Type: Journal    
DOI: 10.5114/aoms.2015.49484     Document Type: Review

References (39)

1. Tirkey N, Pilkhwal S, Chopra K. Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacol 2005;5:2.
2. Lee KJ, Choi JH, Khanal T, Hwang YP, Chung YC, Jeong HG. Protective effect of caffeic acid phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice. Toxicology 2008;248:18-24.
3. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006;10:1-40.
4. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44-84.
5. Yahuaca P, Amaya A, Rojkind M, Mourelle M. Cryptic adenosine triphosphatase activities in plasma membranes of CCl4-cirrhotic rats. Its modulation by changes in cholesterol/phospholipids ratios. Lab Invest 1985;53:541-5.
6. Muriel P. Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride. Biochem Pharmacol 1998;56:773-9.
7. Miyake Y, Yamamoto K, Tsujihara N, Osawa T. Protective effects of lemon flavonoids on oxidative stress in diabetic rats. Lipids 1998;33:689-95.
8. Chiba H, Uehara M, Wu J, et al. Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. J Nutr 2003;133:1892-7.
9. Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized cross over study in healthy volunteers. Am J Clin Nutr 2011;93:73-80.
10. Choi MS. Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids. J Nutr 1999;129:1182-5.
11. Lee SH, Jeong TS, Park YB, Kwon YK, Choi MS, Bok SH. Hypocholesterolemic effect of hesperetin mediated by inhibition of 3-hydroxy-3-methyl glutaryl coenzyme A reductase and acylcoenzyme A: cholesterol acyltranseferase in rats fed high-cholesterol diet. Nutr Res 1999;19:1245-58.
12. Park YB, Do KM, Bok SH, Lee MK, Jeong TS, Choi MS. Interactive effect of hesperidin and vitamin E supplements on cholesterol metabolism in high cholesterol-fed rats. Int J Vitam Nutr Res 2001;71:36-44.
13. Yagi K. Simple assay for the level of total lipid peroxides in serum or plasma. Methods Mol Biol 1998;108:101-6.
14. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968;25:192-205.
15. Sun Y, Oberley LW, Li YA. Simple method for clinical assay of superoxide dismutase. Clin Chem 1988;34:497-500.
16. Aebi H. Catalase. In: Methods of Enzymatic Analysis. Bergmeyer HU (eds). Academic Press, New York 1974;673-7.
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RI. Protein measurement with folin phenol reagent. J Biol Chem 1951;193:265-75.
18. Ciftci O, Vardi N, Ozdemir I. Effects of quercetin and chrysin on 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induced hepatotoxicity in rats. Environ Toxicol 2013;28:146-54.
19. Cheeseman KH. Mechanisms and effects of lipid peroxidation. Mol Aspects Med 1993;14:191-7.
20. Huang X, Wang X, Lv Y, Xu L, Lin J, Diano Y. Protection effect of kallistatin on carbon tetrachloride-induced liver fibrosis in rats via antioxidative stress. PLoS One 2014;9:e88498.
21. Ohta Y, Kongo M, Sasaki E, Nishida K, Ishiguro I. Therapeutic effect of melatonin on carbon tetrachloride-induced acute liver injury in rats. J Pineal Res 2000;28:119-26.
22. Girish C, Koner BC, Jayanthi S, Rao KR, Rajesh B, Pradhan SC. Hepatoprotective activity of six polyherbal formulation in CCl4 induced liver toxicity in mice. Indian J Exp Biol 2009;47:257-63.
23. Huo HZ, Wang B, Liang YK, Bao YY, Gu Y. Hepatoprotective and antioxidant effects of licorice extract against CCl4-induced oxidative damage in rats. Int J Mol Sci 2011;12:6529-43.
24. Pingle BR, Apte KG, Gupta M, Chakraborthy GS. Hepatoprotective activity of different extracts of grains of Eleusinecoracana. Pharmacol Online 2011;2:279-86.
25. Liu J, Tan H, Sun Y, Zhou S, Cao J, Wang F. The preventive effects of heparin-superoxide dismutase on carbon tetrachlorideinduced acute liver failure and hepatic fibrosis in mice. Mol Cell Biochem 2009;327:219-28.
26. Kim HY, Kim JK, Choi JH, et al. Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice. J Pharmacol Sci 2010;112:105-12.
27. Ganie SA, Haq E, Maood A, Zargar MA. Amelioration of carbon tetrachloride induced oxidative stress in kidney and lung tissues by ethanolicrhizome extract of Podophyllum hexandrum in Wistar rats. J Med Plants Res 2010;4:1673-7.
28. Ozturk F, Gul M, Ates B, et al. Protective effect of apricot (Prunus armeniaca L.) on hepatic steatosis and damage induced by carbon tetrachloride in Wistar rats. Br J Nutr Dec. 2009;102:1767-75.
29. Lu B, Xu Y, Xu L, et al. Mechanism investigation of dioscin against CCl4-induced acute liver damage in mice. Environ Toxicol Pharmacol 2012;34:127-35.
30. Shaaban AA, Shaker ME, Zalata KR, El-Kashef HA, Ibrahim TM. Modulation of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis by olmesartan and omega-3. Chem Biol Interact 2014;207:81-91.
31. Timoshin AA, Dorkina EG, Paukova EO, Vanin AF. Quercetin and hesperidin decrease the formation of nitric oxide radicals in rat liver and heart under the conditions of hepatosis. Biofizika 2005;50:1145-9.
32. Yeh YH, Hsieh YL, Lee YT. Effects of yam peel extract against carbon tetrachloride-induced hepatotoxicity in rats. J Agric Food Chem 2013;61:7387-96.
33. Bentli R, Ciftci O, Cetin A, Unlu M, Basak N, Cay M. Oral administration of hesperidin, a citrus flavonone, in rats counteracts the oxidative stress, the inflammatory cytokine production, and the hepatotoxicity induced by the ingestion of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Eur Cytokine Netw 2013;24:91-6.
34. Chen M, Gu H, Ye Y, et al. Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes. Food Chem Toxicol 2010;48:2980-7.
35. Heffner JE, Repine JE. Pulmonary strategies of antioxidant defense. Am Rev Respir Dis 1989;140:531-54.
36. Ebaid H, Bashandy SA, Alhazza IM, Rady A, El-Shehry S. Folic acid and melatonin ameliorate carbon tetrachlorideinduced hepatic injury, oxidative stres and inflammation in rats. Nutr Metabol 2013;10, 20.
37. Cui Y, Han Y, Yang X, Sun Y, Zhao Y. Protective effects of quercetin and quercetin-5', 8-disulfonate against carbon tetrachloride-caused oxidative liver injury in mice. Molecules 2013;19:291-305.
38. PerezTamayo R. Is cirrhosis of the liver experimentally produced by CCl4 and adequate model of human cirrhosis? Hepatology 1983;3:112-20.
39. Das Neves RN, Carvalho F, Carvalho M, et al. Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice. Toxicol Pathol 2004;32:527-35.