Effects of quercetin and chrysin on 2,3,7,8-tetrachlorodibenzo-p-dioxin induced hepatotoxicity in rats

Environmental Toxicology

Volumn 28, Issue 3, 2013, Pages 146-154

  Ciftci, Osman ^a   Vardi, Nigar ^a   Ozdemir, Ilknur ^a  

^a INONU UNIVERSITY   (Turkey)

Author keywords

2,3,7,8 TCDD; Chrysin; Hepatotoxicity; Quercetin

Indexed keywords

2 , 3 , 7 , 8-TCDD; 2 ,3 ,7 ,8 TETRACHLORODIBENZO P DIOXINS; ADVERSE EFFECT; CHRYSIN; CORN OIL; HEPATOTOXICITY; HISTOLOGICAL CHANGES; LIPID PEROXIDATION; QUERCETIN; RAT LIVERS;

COPPER COMPOUNDS; FATTY ACIDS; PHENOLS; RATS; TOXICITY; VEGETABLE OILS;

FLAVONOIDS;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CASPASE 3; CATALASE; CHRYSIN; COPPER ZINC SUPEROXIDE DISMUTASE; CORN OIL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; QUERCETIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANTIOXIDANT; BIOCHEMICAL COMPOSITION; ENZYME ACTIVITY; HISTOLOGY; LIPID; RODENT; TCDD; TOXICITY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; DRUG EFFECT; EOSINOPHIL; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER CELL; LIVER HISTOLOGY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; DIOXINS; DRUG INTERACTIONS; DRUG-INDUCED LIVER INJURY; ENVIRONMENTAL POLLUTANTS; FLAVONOIDS; GLUTATHIONE; LIVER; MALE; QUERCETIN; RATS; RATS, WISTAR; TETRACHLORODIBENZODIOXIN;

RATTUS; ZEA MAYS;

EID: 84874218962     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20707     Document Type: Article

References (35)

1. Aebi H. 1974. Catalase. In: Bergmeyer HV, editor. Methods of Enzymatic Analysis. Weinheim, Germany: Verlag Chemie. pp. 673-674.
2. Alsharif NZ, Hassoun EA. 2004. Protective effects of vitamin A and vitamin E succinate against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced body wasting, hepatomegaly, thymic atrophy, production of reactive oxygen species and DNA damage in C57BL/6J mice. Basic Clin Pharmacol Toxicol 95: 131-138.
3. Bischoff SC. 2008. Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 11: 733-740.
4. Ciftci O, Tanyildizi S, Godekmerdan A. 2010. Protective effect of curcumin on immune system and body weight gain on rats intoxicated with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Immunopharmacol Immunotoxicol 32: 99-104.
5. Czepiel J, Biesiada G, Gajda M, Szczepánski W, Szypuswslla K, Dabrowski Z, Mach T. 2010. The effect of TCDD dioxin on the rat liver in biochemical and histological assessment. Folia Biol (Krakow) 58: 85-90.
6. Dhanabalan S, Mathur PP. 2009. Low dose of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induces testicular oxidative stress in adult rats under the influence of corticosterone. Exp Toxicol Pathol 61: 415-423.
7. Fu B, Xue J, Li Z, Shi X, Jiang BH, Fang J. 2007. Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis. Mol Cancer Ther 6: 220-226.
8. Guo X, Longnecker MP, Michalek JE. 2001. Relation of serum tetrachlorodibenzo-p-dioxin concentration to diet among veterans in the Air Force Health Study with background-level exposure. J Toxicol Environ Health A 63: 159-172.
9. Hassoun EA, Li F, Abushaman A, Stohs SJ. 2000. The relative abilities of TCDD and its congeners to induce oxidative stress in the hepatic and brain tissues of rats after subchronic exposure. Toxicology 145: 103-113.
10. Hassoun EA, Al-Ghafri M, Abushaman A. 2003. The role of antioxidant enzymes in TCDD-induced oxidative stress in various brain regions of rats after subchronic exposure. Free Radic Biol Med 35: 1028-1036.
11. Hassoun EA, Vodhanel J, Abushaban A. 2004. The modulatory effects of ellagic acid and vitamin E succinate on TCDD-induced oxidative stress in different brain regions of rats after subchronic exposure. J Biochem Mol Toxicol 18: 196-203.
12. Hassoun EA, Vodhanel J, Holden B, Abushaban A. 2006. The effects of ellagic acid and vitamin E succinate on antioxidant enzymes activities and glutathione levels in different brain regions of rats after subchronic exposure to TCDD. J Toxicol Environ Health A 69: 381-393.
13. Josephy PD, Mannervik B, De Montellano PO. 1997. Hydrogen peroxide, catalase and peroxidases. In: Josephy PD, Mannervik B, De Montellano PO, editor. Molecular Toxicology. New York: Oxford University Press. pp. 81-89.
14. Kern PA, Fishman RB, Song W, Brown AD, Fonseca V. 2002. The effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on oxidative enzymes in adipocytes and liver. Toxicology 171: 117-125.
15. Lim J, Dewitt JC, Sanders RA, Watkins JB, III, Henshel DS. 2007. Suppression of endogenous antioxidant enzymes by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in chicken liver during development. Arch Environ Contam Toxicol 52: 590-595.
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RI. 1951. Protein measurement with folin phenol reagent. J Biol Chem 193: 265-275.
17. Maiti K, Mukherjee K, Gantait A, Ahamed HN, Saha BP, Mukherjee PK. 2005. Enhanced Therapeutic benefit of quercetin-phospholipid complex in carbon tetrachloride-induced acute liver injury in rats: A comparative study. Iran J Pharmacol Therap 4: 84-90.
18. Mimura J, Fujii-Kuriyama Y. 2003. Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta 1619: 263-268.
19. Moskaug JO, Carlsen H, Myhrstad M, Blomhoff R. 2004. Molecular imaging of the biological effects of quercetin and quercetin-rich foods. Mech Age Develop 125: 315-324.
20. Mostafavi-Pour Z, Zal F, Monabati A, Vessal M. 2008. Protective effects of a combination of quercetin and vitamin E against cyclosporine A-induced oxidative stress and hepatotoxicity in rats. Hepatol Res 38: 385-392.
21. Paglia DE, Valantine WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158-169.
22. Patterson RM, Stachlewitz R, Germolec D. 2003. Induction of apoptosis by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin following endotoxin exposure. Toxicol Appl Pharmacol 190: 120-134.
23. Pushpavalli G, Kalaiarasi P, Veeramani C, Pugalendi KV. 2010. Effect of chrysin on hepatoprotective and antioxidant status in D-galactosamine-induced hepatitis in rats. Eur J Pharmacol 631: 36-41.
24. Sanders RA, Rauscher FM, Watkins JB, III. 2001. Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 15: 143-149.
25. Sathiavelu J, Senapathy GJ, Devaraj R, Namasivayam N. 2009. Hepatoprotective effect of CH on prooxidant-antioxidant status during ethanol-induced toxicity in female albino rats. J Pharm Pharmacol 61: 809-617.
26. Sedlak J, Lindsay RH. 1968. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 25: 192-205.
27. Seufi AM, Ibrahim SS, Elmaghraby TK, Hafez EE. 2009. Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant/antioxidant activity: Molecular and histological evidences. J Exp Clin Cancer Res 11: 28-80.
28. Slezak BP, Hatch GE, Devito MJ, Diliberto JJ, Slade R, Crissman K, Hassoun E, Birnbaum LS. 2000. Oxidative stress in female B6C3F1 mice following acute and subchronic exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Sci 54: 390-398.
29. Stohs SJ, Alsharif NZ, Shara MA, Al-Bayati ZA, Wahba ZZ. 1991. Evidence for the induction of an oxidative stress in rat hepatic mitochondria by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Adv Exp Med Biol 283: 827-831.
30. Sun Y, Oberley LW, Li YA. 1988. Simple method for clinical assay of superoxide dismutase. Clin Chem 34: 497-500.
31. Sweeney G, Basford D, Rowley B, Goddard G. 1984. Mechanisms underlying the hepatotoxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. In: Poland A, Kimbrough R, editor. Biological Mechanisms of Dioxin Action. New York: Cold Spring Harbor. pp. 225-239.
32. Vicente-Sánchez C, Egido J, Sánchez-González PD, Pérez-Barriocanal F, López-Novoa JM, Morales AI. 2008. Effect of the flavonoid quercetin on cadmium-induced hepatotoxicity. Food Chem Toxicol 46: 2279-2287.
33. Wang X, Morris ME. 2007. Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos 35: 268-274.
34. Yagi K. 1998. Simple assay for the level of total lipid peroxides in serum or plasma. Methods Mol Biol 108: 101-106.
35. Yousef MI, Omar SA, El-Guendi MI, Abdelmegid LA. 2010. Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem Toxicol 48: 3246-3261.