Prevention and mitigation of experimental autoimmune encephalomyelitis by murine β-defensins via induction of regulatory T cells

Journal of Investigative Dermatology

Volumn 136, Issue 1, 2016, Pages 173-181

  Bruhs, Anika ^a   Schwarz, Thomas ^a   Schwarz, Agatha ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 14; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; POLYPEPTIDE ANTIBIOTIC AGENT; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; BETA DEFENSIN; BETA-DEFENSIN 3, HUMAN; CYTOKINE; DEFB14 PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; HUMAN; HUMAN CELL; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN METHYLATION; REGULATORY T LYMPHOCYTE; T CELL DEPLETION; T LYMPHOCYTE SUBPOPULATION; ULTRAVIOLET RADIATION; ANIMAL; C57BL MOUSE; DISEASE MODEL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; NEEDLE BIOPSY; RANDOMIZATION; REFERENCE VALUE;

ANIMALS; BETA-DEFENSINS; BIOPSY, NEEDLE; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HUMANS; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; RANDOM ALLOCATION; REFERENCE VALUES; T-LYMPHOCYTES, REGULATORY; ULTRAVIOLET RAYS;

EID: 84973409204     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/JID.2015.405     Document Type: Article

References (33)

1. Braff MH, Gallo RL. Antimicrobial peptides: An essential component of the skin defensive barrier. Curr Top Microbiol Immunol 2006; 306: 91-110.
2. Breuer J, Schwab N, Schneider-Hohendorf T, Marziniak M, Mohan H, Bhatia U, et al. Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity. Ann Neurol 2014; 75: 739-58.
3. Chaudhary B, Khaled YS, Ammori BJ, Elkord E. Neuropilin 1: Function and therapeutic potential in cancer. Cancer Immunol Immunother 2014; 63: 81-99.
4. Collison LW, Vignali DA. In vitro Treg suppression assays. Methods Mol Biol 2011; 707: 21-37.
5. Cua DJ, Groux H, Hinton DR, Stohlman SA, Coffman RL. Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomy elitis. J Exp Med 1999; 189: 1005-10.
6. Gläser R, Navid F, Schuller W, Jantschitsch C, Harder J, Schroder JM, et al. UV-B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo. J Allergy Clin Immunol 2009; 123: 1117-23.
7. Hauser SL, Weiner HL, Che M, Shapiro ME, Gilles F, Letvin NL. Prevention of experimental allergic encephalomyelitis (EAE) in the SJL/J mouse by whole body ultraviolet irradiation. J Immunol 1984; 132: 1276-81.
8. Hinrichsen K, Podschun R, Schubert S, Schroder JM, Harder J, Proksch E. Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defen-sin-3. Antimicrob Agents Chemother 2008; 52: 1876-9.
9. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-61.
10. Horwitz DA, Zheng SG, Gray JD. The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets. J Leukoc Biol 2003; 74: 471-8.
11. Imitola J, Chitnis T, Khoury SJ. Cytokines in multiple sclerosis: From bench to bedside. Pharmacol Ther 2005; 106: 163-77.
12. Kalathil S, Lugade AA, Miller A, Iyer R, Thanavala Y. Higher frequencies of GARP(+)CTLA-4(+)Foxp3(+) T regulatory cells and myeloid-derived suppressor cells in hepatocellular carcinoma patients are associated with impaired T-cell functionality. Cancer Res 2013; 73: 2435-44.
13. Kim HP, Leonard WJ. CREB/ATF-dependent Tcell receptor-induced FoxP3 gene expression: A role for DNA methylation. J Exp Med 2007; 204: 1543-51.
14. Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, et al. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 2007; 204: 57-63.
15. Lal G, Bromberg JS. Epigenetic mechanisms of regulation of Foxp3 expression. Blood 2009; 114: 3727-35.
16. Lal G, Zhang N, van der Touw W, Ding Y, Ju W, Bottinger EP, et al. Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol 2009; 182: 259-73.
17. Leong S, Chan AH, Levy JG, Hunt DW. Transcutaneous photodynamic therapy alters the development of an adoptively transferred form of murine experimental autoimmune encephalomyelitis. Photochem Photobiol 1996; 64: 751-7.
18. Maeda A, Beissert S, Schwarz T, Schwarz A. Phenotypic and functional characterization of ultraviolet radiation-induced regulatory T cells. J Immunol 2008; 180: 3065-71.
19. Menni C, Lowell WE, Bentzen J, Bergamaschi R, Martinelli Boneschi F, Martinelli V, et al. Short and long term variation in ultraviolet radiation and multiple sclerosis. Int J Environ Res Public Health 2012; 9: 685-97.
20. Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S, Kawaji H, et al. Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation. Proc Natl Acad Sci USA 2014; 111: 5289-94.
21. Mustafa MI, Diener P, Bo H, Van der Meide P, Olsson T. T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats. J Neuroimmunol 1991; 31: 165-77.
22. Navid F, Boniotto M, Walker C, Ahrens K, Proksch E, Sparwasser T, et al. Induction of regulatory T cells by a murine beta-defensin. J Immunol 2012; 188: 735-43.
23. Rouse M, Nagarkatti M, Nagarkatti PS. The role of IL-2 in the activation and expansion of regulatory T-cells and the development of experimental autoimmune encephalomyelitis. Immunobiology 2013; 218: 674-82.
24. Sahraian MA, Pakdaman H, Harandi AA. Is it time to revise the classification of geographical distribution of multiple sclerosis? Iran J Neurol 2012; 11: 77-8.
25. Schwarz A, Maeda A, Wild MK, Kernebeck K, Gross N, Aragane Y, et al. Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivity. J Immunol 2004; 172: 1036-43.
26. Schwarz A, Navid F, Sparwasser T, Clausen BE, Schwarz T. In vivo reprogramming of UV radiation-induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity. J Allergy Clin Immunol 2011; 128: 826-33.
27. Schwarz A, Schwarz T. UVR-induced regulatory T cells switch antigenpresenting cells from a stimulatory to a regulatory phenotype. J Invest Dermatol 2010; 130: 1914-21.
28. Schwarz T. The dark and the sunny sides of UVR-induced immunosuppression: Photoimmunology revisited. J Invest Dermatol 2010; 130: 49-54.
29. Simpson S Jr, Blizzard L, Otahal P, Van der Mei I, Taylor B. Latitude is significantly associated with the prevalence of multiple sclerosis: A metaanalysis. J Neurol Neurosurg Psychiatry 2011; 82: 1132-41.
30. Turka LA, Walsh PT. IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells. Front Biosci 2008; 13: 1440-6.
31. Wang Y, Marling SJ, McKnight SM, Danielson AL, Severson KS, Deluca HF. Suppression of experimental autoimmune encephalomyelitis by 300-315 nm ultraviolet light. Arch Biochem Biophys 2013; 536: 81-6.
32. Weichenthal M, Schwarz T. Phototherapy: How does UV work? Photodermatol Photoimmunol Photomed 2005; 21: 260-6.
33. Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008; 322: 271-5.