메뉴 건너뛰기




Volumn , Issue , 2013, Pages 3-22

Antibody directed delivery for treatment of cancer: Antibody drug conjugates and immunotoxins

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84973351563     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-5456-4_1     Document Type: Chapter
Times cited : (8)

References (89)
  • 1
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495-497
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 2
    • 33646352962 scopus 로고    scopus 로고
    • Potent antibody therapeutics by design
    • Carter PJ (2006) Potent antibody therapeutics by design. Nat Rev Immunol 6:343-357
    • (2006) Nat Rev Immunol , vol.6 , pp. 343-357
    • Carter, P.J.1
  • 3
    • 0344212970 scopus 로고    scopus 로고
    • The long-awaited magic bullets: Therapeutic human monoclonal antibodies from transgenic mice
    • Jakobovits A (1998) The long-awaited magic bullets: therapeutic human monoclonal antibodies from transgenic mice. Expert Opin Investig Drugs 7:607-614
    • (1998) Expert Opin Investig Drugs , vol.7 , pp. 607-614
    • Jakobovits, A.1
  • 4
    • 27144532832 scopus 로고    scopus 로고
    • Human antibodies from transgenic animals
    • Lonberg N (2005) Human antibodies from transgenic animals. Nat Biotechnol 23:1117-1125
    • (2005) Nat Biotechnol , vol.23 , pp. 1117-1125
    • Lonberg, N.1
  • 5
    • 84986305124 scopus 로고    scopus 로고
    • Radioactive antibodies: A historical review of selective targeting and treatment of cancer
    • Goldenberg DM, Sharkey RM (2010) Radioactive antibodies: a historical review of selective targeting and treatment of cancer. Hosp Pract (Minneap) 38:82-93
    • (2010) Hosp Pract (Minneap) , vol.38 , pp. 82-93
    • Goldenberg, D.M.1    Sharkey, R.M.2
  • 6
    • 80054092984 scopus 로고    scopus 로고
    • Antibody-radionuclide conjugates for cancer therapy: Historical considerations and new trends
    • Steiner M, Neri D (2011) Antibody-radionuclide conjugates for cancer therapy: historical considerations and new trends. Clin Cancer Res 17:6406-6416
    • (2011) Clin Cancer Res , vol.17 , pp. 6406-6416
    • Steiner, M.1    Neri, D.2
  • 7
    • 79953766810 scopus 로고    scopus 로고
    • Antibody-based targeting of interferon-alpha to the tumor neovasculature: A critical evaluation
    • Frey K, Zivanovic A, Schwager K, Neri D (2011) Antibody-based targeting of interferon-alpha to the tumor neovasculature: a critical evaluation. Integr Biol (Camb) 3:468-478
    • (2011) Integr Biol (Camb) , vol.3 , pp. 468-478
    • Frey, K.1    Zivanovic, A.2    Schwager, K.3    Neri, D.4
  • 8
    • 0037058313 scopus 로고    scopus 로고
    • Tumor-targeting properties of antibody-vascular endothelial growth factor fusion proteins
    • Halin C, Niesner U, Villani ME, Zardi L, Neri D (2002) Tumor-targeting properties of antibody-vascular endothelial growth factor fusion proteins. Int J Cancer 102:109-116
    • (2002) Int J Cancer , vol.102 , pp. 109-116
    • Halin, C.1    Niesner, U.2    Villani, M.E.3    Zardi, L.4    Neri, D.5
  • 9
    • 81555214408 scopus 로고    scopus 로고
    • A guide to taming a toxin-recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer
    • Weldon JE, Pastan I (2011) A guide to taming a toxin-recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer. FEBS J 278:4683-4700
    • (2011) FEBS J , vol.278 , pp. 4683-4700
    • Weldon, J.E.1    Pastan, I.2
  • 10
    • 79955104910 scopus 로고    scopus 로고
    • Human toxin-based recombinant immunotoxins/chimeric proteins as a drug delivery system for targeted treatment of human diseases
    • Lorberboum-Galski H (2011) Human toxin-based recombinant immunotoxins/chimeric proteins as a drug delivery system for targeted treatment of human diseases. Expert Opin Drug Deliv 8:605-621
    • (2011) Expert Opin Drug Deliv , vol.8 , pp. 605-621
    • Lorberboum-Galski, H.1
  • 11
    • 79958187876 scopus 로고    scopus 로고
    • Therapeutic potential of anticancer immunotoxins
    • Choudhary S, Mathew M, Verma RS (2011) Therapeutic potential of anticancer immunotoxins. Drug Discov Today 16:495-503
    • (2011) Drug Discov Today , vol.16 , pp. 495-503
    • Choudhary, S.1    Mathew, M.2    Verma, R.S.3
  • 13
    • 0027194197 scopus 로고
    • Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: A novel and potent family of antitumor antibiotics
    • Hinman LM, Hamann PR, Wallace R, Menendez AT, Durr FE, Upeslacis J (1993) Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: a novel and potent family of antitumor antibiotics. Cancer Res 53:3336-3342
    • (1993) Cancer Res , vol.53 , pp. 3336-3342
    • Hinman, L.M.1    Hamann, P.R.2    Wallace, R.3    Menendez, A.T.4    Durr, F.E.5    Upeslacis, J.6
  • 14
    • 0031047177 scopus 로고    scopus 로고
    • The development of antibody delivery systems to target cancer with highly potent maytansinoids
    • Liu C, Chari RV (1997) The development of antibody delivery systems to target cancer with highly potent maytansinoids. Expert Opin Investig Drugs 6:169-172
    • (1997) Expert Opin Investig Drugs , vol.6 , pp. 169-172
    • Liu, C.1    Chari, R.V.2
  • 16
    • 79960843919 scopus 로고    scopus 로고
    • A phase I study of a combination of anti-CD19 and anti-CD22 immunotoxins (Combotox) in adult patients with refractory B-lineage acute lymphoblastic leukaemia
    • Schindler J, Gajavelli S, Ravandi F, Shen Y, Parekh S, Braunchweig I et al (2011) A phase I study of a combination of anti-CD19 and anti-CD22 immunotoxins (Combotox) in adult patients with refractory B-lineage acute lymphoblastic leukaemia. Br J Haematol 154:471-476
    • (2011) Br J Haematol , vol.154 , pp. 471-476
    • Schindler, J.1    Gajavelli, S.2    Ravandi, F.3    Shen, Y.4    Parekh, S.5    Braunchweig, I.6
  • 17
    • 80054095609 scopus 로고    scopus 로고
    • SAR3419: An anti-CD 19-maytansinoid immunoconjugate for the treatment of B-cell malignancies
    • Blanc V, Bousseau A, Caron A, Carrez C, Lutz RJ, Lambert JM (2011) SAR3419: an anti-CD 19-maytansinoid immunoconjugate for the treatment of B-cell malignancies. Clin Cancer Res 17:6448-6458
    • (2011) Clin Cancer Res , vol.17 , pp. 6448-6458
    • Blanc, V.1    Bousseau, A.2    Caron, A.3    Carrez, C.4    Lutz, R.J.5    Lambert, J.M.6
  • 18
    • 77953681398 scopus 로고    scopus 로고
    • Antibody drug-conjugates targeting the tumor vasculature: Current and future developments
    • Gerber HP, Senter PD, Grewal IS (2009) Antibody drug-conjugates targeting the tumor vasculature: current and future developments. MAbs 1:247-253
    • (2009) MAbs , vol.1 , pp. 247-253
    • Gerber, H.P.1    Senter, P.D.2    Grewal, I.S.3
  • 19
    • 0030858765 scopus 로고    scopus 로고
    • Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin
    • Seon BK, Matsuno F, Haruta Y, Kondo M, Barcos M (1997) Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin. Clin Cancer Res 3:1031-1044
    • (1997) Clin Cancer Res , vol.3 , pp. 1031-1044
    • Seon, B.K.1    Matsuno, F.2    Haruta, Y.3    Kondo, M.4    Barcos, M.5
  • 20
    • 0029611184 scopus 로고
    • Up-regulation of endoglin on vascular endothelial cells in human solid tumors: Implications for diagnosis and therapy
    • Burrows FJ, Derbyshire EJ, Tazzari PL, Amlot P, Gazdar AF, King SW et al (1995) Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy. Clin Cancer Res 1:1623-1634
    • (1995) Clin Cancer Res , vol.1 , pp. 1623-1634
    • Burrows, F.J.1    Derbyshire, E.J.2    Tazzari, P.L.3    Amlot, P.4    Gazdar, A.F.5    King, S.W.6
  • 21
    • 34548462642 scopus 로고    scopus 로고
    • Expression of prostate-specific membrane antigen in tumor-associated neovasculature of renal neoplasms
    • Baccala A, Sercia L, Li J, Heston W, Zhou M (2007) Expression of prostate-specific membrane antigen in tumor-associated neovasculature of renal neoplasms. Urology 70:385-390
    • (2007) Urology , vol.70 , pp. 385-390
    • Baccala, A.1    Sercia, L.2    Li, J.3    Heston, W.4    Zhou, M.5
  • 22
    • 70449532104 scopus 로고    scopus 로고
    • Prostate- specific membrane antigen expression in the neovasculature of gastric and colorectal cancers
    • Haffner MC, Kronberger IE, Ross JS, Sheehan CE, Zitt M, Muhlmann G et al (2009) Prostate- specific membrane antigen expression in the neovasculature of gastric and colorectal cancers. Hum Pathol 40:1754-1761
    • (2009) Hum Pathol , vol.40 , pp. 1754-1761
    • Haffner, M.C.1    Kronberger, I.E.2    Ross, J.S.3    Sheehan, C.E.4    Zitt, M.5    Muhlmann, G.6
  • 23
    • 7444263583 scopus 로고    scopus 로고
    • A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer
    • Henry MD, Wen S, Silva MD, Chandra S, Milton M, Worland PJ (2004) A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer. Cancer Res 64:7995-8001
    • (2004) Cancer Res , vol.64 , pp. 7995-8001
    • Henry, M.D.1    Wen, S.2    Silva, M.D.3    Chandra, S.4    Milton, M.5    Worland, P.J.6
  • 24
    • 43749092340 scopus 로고    scopus 로고
    • Phase I trial of the prostate-specific membrane antigen-directed immunoconjugate MLN2704 in patients with progressive metastatic castration-resistant prostate cancer
    • Galsky MD, Eisenberger M, Moore-Cooper S, Kelly WK, Slovin SF, DeLaCruz A et al (2008) Phase I trial of the prostate-specific membrane antigen-directed immunoconjugate MLN2704 in patients with progressive metastatic castration-resistant prostate cancer. J Clin Oncol 26:2147-2154
    • (2008) J Clin Oncol , vol.26 , pp. 2147-2154
    • Galsky, M.D.1    Eisenberger, M.2    Moore-Cooper, S.3    Kelly, W.K.4    Slovin, S.F.5    DeLaCruz, A.6
  • 25
    • 33646385331 scopus 로고    scopus 로고
    • Potent antitumor activity of an auristatin-conjugated, fully human monoclonal antibody to prostate- specific membrane antigen
    • Ma D, Hopf CE, Malewicz AD, Donovan GP, Senter PD, Goeckeler WF et al (2006) Potent antitumor activity of an auristatin-conjugated, fully human monoclonal antibody to prostate- specific membrane antigen. Clin Cancer Res 12:2591-2596
    • (2006) Clin Cancer Res , vol.12 , pp. 2591-2596
    • Ma, D.1    Hopf, C.E.2    Malewicz, A.D.3    Donovan, G.P.4    Senter, P.D.5    Goeckeler, W.F.6
  • 26
    • 80052740269 scopus 로고    scopus 로고
    • In vitro and in vivo responses of advanced prostate tumors to PSMA ADC, an auristatin-conjugated antibody to prostate-specific membrane antigen
    • Wang X, Ma D, Olson WC, Heston WD (2011) In vitro and in vivo responses of advanced prostate tumors to PSMA ADC, an auristatin-conjugated antibody to prostate-specific membrane antigen. Mol Cancer Ther 10:1728-1739
    • (2011) Mol Cancer Ther , vol.10 , pp. 1728-1739
    • Wang, X.1    Ma, D.2    Olson, W.C.3    Heston, W.D.4
  • 27
    • 0026102824 scopus 로고
    • Immunotoxins containing ricin or its A chain
    • Vitetta ES, Thorpe PE (1991) Immunotoxins containing ricin or its A chain. Semin Cell Biol 2:47-58
    • (1991) Semin Cell Biol , vol.2 , pp. 47-58
    • Vitetta, E.S.1    Thorpe, P.E.2
  • 28
    • 0024349836 scopus 로고
    • Arecombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin
    • Chaudhary VK, Queen C, Junghans RP, Waldmann TA, FitzGerald DJ, Pastan I (1989) Arecombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin. Nature 339:394-397
    • (1989) Nature , vol.339 , pp. 394-397
    • Chaudhary, V.K.1    Queen, C.2    Junghans, R.P.3    Waldmann, T.A.4    FitzGerald, D.J.5    Pastan, I.6
  • 30
    • 0033840526 scopus 로고    scopus 로고
    • In vitro anti-tumour activity of anti-CD80 and anti-CD86 immunotoxins containing type 1 ribosome-inactivating proteins
    • Bolognesi A, Polito L, Tazzari PL, Lemoli RM, Lubelli C, Fogli M et al (2000) In vitro anti-tumour activity of anti-CD80 and anti-CD86 immunotoxins containing type 1 ribosome-inactivating proteins. Br J Haematol 110:351-361
    • (2000) Br J Haematol , vol.110 , pp. 351-361
    • Bolognesi, A.1    Polito, L.2    Tazzari, P.L.3    Lemoli, R.M.4    Lubelli, C.5    Fogli, M.6
  • 31
    • 16544374300 scopus 로고    scopus 로고
    • Immunotoxins and toxin constructs in the treatment of leukemia and lymphoma
    • Rosenblum M (2004) Immunotoxins and toxin constructs in the treatment of leukemia and lymphoma. Adv Pharmacol 51:209-228
    • (2004) Adv Pharmacol , vol.51 , pp. 209-228
    • Rosenblum, M.1
  • 32
    • 4043133131 scopus 로고    scopus 로고
    • Ribosome-inactivating proteins
    • Stirpe F (2004) Ribosome-inactivating proteins. Toxicon 44:371-383
    • (2004) Toxicon , vol.44 , pp. 371-383
    • Stirpe, F.1
  • 33
    • 33749432146 scopus 로고    scopus 로고
    • Immunotoxins in the treatment of hematologic malignancies
    • Kreitman RJ, Pastan I (2006) Immunotoxins in the treatment of hematologic malignancies. Curr Drug Targets 7:1301-1311
    • (2006) Curr Drug Targets , vol.7 , pp. 1301-1311
    • Kreitman, R.J.1    Pastan, I.2
  • 34
    • 0026354658 scopus 로고
    • An immuno- toxin prepared with blocked ricin: A natural plant toxin adapted for therapeutic use
    • Lambert JM, Goldmacher VS, Collinson AR, Nadler LM, Blattler WA (1991) An immuno- toxin prepared with blocked ricin: a natural plant toxin adapted for therapeutic use. Cancer Res 51:6236-6242
    • (1991) Cancer Res , vol.51 , pp. 6236-6242
    • Lambert, J.M.1    Goldmacher, V.S.2    Collinson, A.R.3    Nadler, L.M.4    Blattler, W.A.5
  • 35
    • 0023689869 scopus 로고
    • Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages
    • Thorpe PE, Wallace PM, Knowles PP, Relf MG, Brown AN, Watson GJ et al (1988) Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages. Cancer Res 48:6396-6403
    • (1988) Cancer Res , vol.48 , pp. 6396-6403
    • Thorpe, P.E.1    Wallace, P.M.2    Knowles, P.P.3    Relf, M.G.4    Brown, A.N.5    Watson, G.J.6
  • 36
    • 0034935042 scopus 로고    scopus 로고
    • Chemical construction of immunotoxins
    • Ghetie V, Vitetta ES (2001) Chemical construction of immunotoxins. Mol Biotechnol 18:251-268
    • (2001) Mol Biotechnol , vol.18 , pp. 251-268
    • Ghetie, V.1    Vitetta, E.S.2
  • 37
    • 0028062734 scopus 로고
    • Immunotoxins in the therapy of cancer: From bench to clinic
    • Ghetie V, Vitetta E (1994) Immunotoxins in the therapy of cancer: from bench to clinic. Pharmacol Ther 63:209-234
    • (1994) Pharmacol Ther , vol.63 , pp. 209-234
    • Ghetie, V.1    Vitetta, E.2
  • 38
    • 0023100497 scopus 로고
    • Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy 1.1 antibody
    • Blakey DC, Watson GJ, Knowles PP, Thorpe PE (1987) Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy 1.1 antibody. Cancer Res 47:947-952
    • (1987) Cancer Res , vol.47 , pp. 947-952
    • Blakey, D.C.1    Watson, G.J.2    Knowles, P.P.3    Thorpe, P.E.4
  • 39
    • 0028044582 scopus 로고
    • Successful treatment of disseminated human Hodgkin's disease in SCID mice with deglycosylated ricin A-chain immunotoxins
    • Winkler U, Gottstein C, Schon G, Kapp U, Wolf J, Hansmann ML et al (1994) Successful treatment of disseminated human Hodgkin's disease in SCID mice with deglycosylated ricin A-chain immunotoxins. Blood 83:466-475
    • (1994) Blood , vol.83 , pp. 466-475
    • Winkler, U.1    Gottstein, C.2    Schon, G.3    Kapp, U.4    Wolf, J.5    Hansmann, M.L.6
  • 40
    • 0013379930 scopus 로고    scopus 로고
    • Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin's lymphoma
    • Schnell R, Borchmann P, Staak JO, Schindler J, Ghetie V, Vitetta ES et al (2003) Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin's lymphoma. Ann Oncol 14:729-736
    • (2003) Ann Oncol , vol.14 , pp. 729-736
    • Schnell, R.1    Borchmann, P.2    Staak, J.O.3    Schindler, J.4    Ghetie, V.5    Vitetta, E.S.6
  • 41
    • 0037331050 scopus 로고    scopus 로고
    • Treatment of SCID/human B cell precursor ALL with anti-CD19 and anti-CD22 immunotoxins
    • Herrera L, Yarbrough S, Ghetie V, Aquino DB, Vitetta ES (2003) Treatment of SCID/human B cell precursor ALL with anti-CD19 and anti-CD22 immunotoxins. Leukemia 17:334-338
    • (2003) Leukemia , vol.17 , pp. 334-338
    • Herrera, L.1    Yarbrough, S.2    Ghetie, V.3    Aquino, D.B.4    Vitetta, E.S.5
  • 42
    • 79952265972 scopus 로고    scopus 로고
    • Toxin-based therapeutic approaches
    • Shapira A, Benhar I (2010) Toxin-based therapeutic approaches. Toxins (Basel) 2:2519-2583
    • (2010) Toxins (Basel) , vol.2 , pp. 2519-2583
    • Shapira, A.1    Benhar, I.2
  • 43
    • 79960820705 scopus 로고    scopus 로고
    • Immunotoxins and anticancer drug conjugate assemblies: The role of the linkage between components
    • Dosio F, Brusa P, Cattel L (2011) Immunotoxins and anticancer drug conjugate assemblies: the role of the linkage between components. Toxins (Basel) 3:848-883
    • (2011) Toxins (Basel) , vol.3 , pp. 848-883
    • Dosio, F.1    Brusa, P.2    Cattel, L.3
  • 44
    • 70350145130 scopus 로고    scopus 로고
    • Development of novel, highly cytotoxic fusion constructs containing granzyme B: Unique mechanisms and functions
    • Rosenblum MG, Barth S (2009) Development of novel, highly cytotoxic fusion constructs containing granzyme B: unique mechanisms and functions. Curr Pharm Des 15:2676-2692
    • (2009) Curr Pharm Des , vol.15 , pp. 2676-2692
    • Rosenblum, M.G.1    Barth, S.2
  • 45
    • 1642284083 scopus 로고    scopus 로고
    • Targeted delivery of human pro- apoptotic enzymes to tumor cells: In vitro studies describing a novel class of recombinant highly cytotoxic agents
    • Liu Y, Cheung LH, Hittelman WN, Rosenblum MG (2003) Targeted delivery of human pro- apoptotic enzymes to tumor cells: in vitro studies describing a novel class of recombinant highly cytotoxic agents. Mol Cancer Ther 2:1341-1350
    • (2003) Mol Cancer Ther , vol.2 , pp. 1341-1350
    • Liu, Y.1    Cheung, L.H.2    Hittelman, W.N.3    Rosenblum, M.G.4
  • 46
    • 67650678448 scopus 로고    scopus 로고
    • Humanized immunotoxins: A new generation of immunotoxins for targeted cancer therapy
    • Mathew M, Verma RS (2009) Humanized immunotoxins: a new generation of immunotoxins for targeted cancer therapy. Cancer Sci 100:1359-1365
    • (2009) Cancer Sci , vol.100 , pp. 1359-1365
    • Mathew, M.1    Verma, R.S.2
  • 47
    • 49649091350 scopus 로고    scopus 로고
    • An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes
    • Onda M, Beers R, Xiang L, Nagata S, Wang QC, Pastan I (2008) An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proc Natl Acad Sci USA 105:11311-11316
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11311-11316
    • Onda, M.1    Beers, R.2    Xiang, L.3    Nagata, S.4    Wang, Q.C.5    Pastan, I.6
  • 48
  • 49
    • 67651163873 scopus 로고    scopus 로고
    • Engineering and biological characterization of VB6-845, an anti-EpCAM immunotoxin containing a T-cell epitope-depleted variant of the plant toxin bouganin
    • Cizeau J, Grenkow DM, Brown JG, Entwistle J, MacDonald GC (2009) Engineering and biological characterization of VB6-845, an anti-EpCAM immunotoxin containing a T-cell epitope-depleted variant of the plant toxin bouganin. J Immunother 32:574-584
    • (2009) J Immunother , vol.32 , pp. 574-584
    • Cizeau, J.1    Grenkow, D.M.2    Brown, J.G.3    Entwistle, J.4    MacDonald, G.C.5
  • 50
    • 69349100450 scopus 로고    scopus 로고
    • Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P
    • Kreitman RJ, Hassan R, Fitzgerald DJ, Pastan I (2009) Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P. Clin Cancer Res 15:5274-5279
    • (2009) Clin Cancer Res , vol.15 , pp. 5274-5279
    • Kreitman, R.J.1    Hassan, R.2    Fitzgerald, D.J.3    Pastan, I.4
  • 51
    • 0033180164 scopus 로고    scopus 로고
    • Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs
    • Dubowchik GM, Walker MA (1999) Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs. Pharmacol Ther 83:67-123
    • (1999) Pharmacol Ther , vol.83 , pp. 67-123
    • Dubowchik, G.M.1    Walker, M.A.2
  • 52
    • 0032872567 scopus 로고    scopus 로고
    • Monoclonal antibody drug conjugates in the treatment of cancer
    • Trail PA, Bianchi AB (1999) Monoclonal antibody drug conjugates in the treatment of cancer. Curr Opin Immunol 11:584-588
    • (1999) Curr Opin Immunol , vol.11 , pp. 584-588
    • Trail, P.A.1    Bianchi, A.B.2
  • 55
    • 80054742117 scopus 로고    scopus 로고
    • Seattle Genetics rare cancer drug sails through accelerated approval
    • DeFrancesco L (2011) Seattle Genetics rare cancer drug sails through accelerated approval. Nat Biotechnol 29:851-852
    • (2011) Nat Biotechnol , vol.29 , pp. 851-852
    • DeFrancesco, L.1
  • 56
    • 67449119398 scopus 로고    scopus 로고
    • The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo
    • Ikeda H, Hideshima T, Fulciniti M, Lutz RJ, Yasui H, Okawa Y et al (2009) The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin Cancer Res 15:4028-4037
    • (2009) Clin Cancer Res , vol.15 , pp. 4028-4037
    • Ikeda, H.1    Hideshima, T.2    Fulciniti, M.3    Lutz, R.J.4    Yasui, H.5    Okawa, Y.6
  • 57
    • 79551575923 scopus 로고    scopus 로고
    • Advances in the assessment and control of the effector functions of therapeutic antibodies
    • Jiang XR, Song A, Bergelson S, Arroll T, Parekh B, May K et al (2011) Advances in the assessment and control of the effector functions of therapeutic antibodies. Nat Rev Drug Discov 10:101-111
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 101-111
    • Jiang, X.R.1    Song, A.2    Bergelson, S.3    Arroll, T.4    Parekh, B.5    May, K.6
  • 58
    • 79959700509 scopus 로고    scopus 로고
    • Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
    • Junttila TT, Li G, Parsons K, Phillips GL, Sliwkowski MX (2011) Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer. Breast Cancer Res Treat 128:347-356
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 347-356
    • Junttila, T.T.1    Li, G.2    Parsons, K.3    Phillips, G.L.4    Sliwkowski, M.X.5
  • 59
    • 0023606654 scopus 로고
    • The mode of action of methotrexate-monoclonal antibody conjugates
    • Smyth MJ, Pietersz GA, McKenzie IF (1987) The mode of action of methotrexate-monoclonal antibody conjugates. Immunol Cell Biol 65(Pt 2):189-200
    • (1987) Immunol Cell Biol , vol.65 , pp. 189-200
    • Smyth, M.J.1    Pietersz, G.A.2    McKenzie, I.F.3
  • 60
    • 0026092021 scopus 로고
    • Regression of human melanoma xenografts in nude mice injected with methotrexate linked to monoclonal antibody 225.28 to human high molecular weight-melanoma associated antigen
    • Ghose T, Ferrone S, Blair AH, Kralovec Y, Temponi M, Singh M et al (1991) Regression of human melanoma xenografts in nude mice injected with methotrexate linked to monoclonal antibody 225.28 to human high molecular weight-melanoma associated antigen. Cancer Immunol Immunother 34:90-96
    • (1991) Cancer Immunol Immunother , vol.34 , pp. 90-96
    • Ghose, T.1    Ferrone, S.2    Blair, A.H.3    Kralovec, Y.4    Temponi, M.5    Singh, M.6
  • 61
  • 62
    • 0026650468 scopus 로고
    • Long-term growth suppression of human glioma xenografts by chemoimmunoconjugates of 4-desacetylvinblastine-3-carboxyhydrazide and monoclonal antibody 9.2.27
    • Schrappe M, Bumol TF, Apelgren LD, Briggs SL, Koppel GA, Markowitz DD et al (1992) Long-term growth suppression of human glioma xenografts by chemoimmunoconjugates of 4-desacetylvinblastine-3-carboxyhydrazide and monoclonal antibody 9.2.27. Cancer Res 52:3838-3844
    • (1992) Cancer Res , vol.52 , pp. 3838-3844
    • Schrappe, M.1    Bumol, T.F.2    Apelgren, L.D.3    Briggs, S.L.4    Koppel, G.A.5    Markowitz, D.D.6
  • 63
    • 0025854110 scopus 로고
    • The human immune response to KS1/4-desacetylvinblastine (LY256787) and KS1/4-desacetylvinblastine hydrazide (LY203728) in single and multiple dose clinical studies
    • Petersen BH, DeHerdt SV, Schneck DW, Bumol TF (1991) The human immune response to KS1/4-desacetylvinblastine (LY256787) and KS1/4-desacetylvinblastine hydrazide (LY203728) in single and multiple dose clinical studies. Cancer Res 51:2286-2290
    • (1991) Cancer Res , vol.51 , pp. 2286-2290
    • Petersen, B.H.1    DeHerdt, S.V.2    Schneck, D.W.3    Bumol, T.F.4
  • 64
    • 0001577078 scopus 로고
    • Doxorubicin conjugated with a monoclonal antibody directed to a human melanoma-associated proteoglycan suppresses the growth of established tumor xenografts in nude mice
    • Yang HM, Reisfeld RA (1988) Doxorubicin conjugated with a monoclonal antibody directed to a human melanoma-associated proteoglycan suppresses the growth of established tumor xenografts in nude mice. Proc Natl Acad Sci USA 85:1189-1193
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 1189-1193
    • Yang, H.M.1    Reisfeld, R.A.2
  • 65
    • 0037615112 scopus 로고    scopus 로고
    • Monoclonal antibody drug immunoconjugates for targeted treatment of cancer
    • Trail PA, King HD, Dubowchik GM (2003) Monoclonal antibody drug immunoconjugates for targeted treatment of cancer. Cancer Immunol Immunother 52:328-337
    • (2003) Cancer Immunol Immunother , vol.52 , pp. 328-337
    • Trail, P.A.1    King, H.D.2    Dubowchik, G.M.3
  • 67
    • 0026671282 scopus 로고
    • Antigen- specific activity of carcinoma-reactive BR64-doxorubicin conjugates evaluated in vitro and in human tumor xenograft models
    • Trail PA, Willner D, Lasch SJ, Henderson AJ, Greenfield RS, King D et al (1992) Antigen- specific activity of carcinoma-reactive BR64-doxorubicin conjugates evaluated in vitro and in human tumor xenograft models. Cancer Res 52:5693-5700
    • (1992) Cancer Res , vol.52 , pp. 5693-5700
    • Trail, P.A.1    Willner, D.2    Lasch, S.J.3    Henderson, A.J.4    Greenfield, R.S.5    King, D.6
  • 68
    • 0033106074 scopus 로고    scopus 로고
    • Monoclonal antibody conjugates of doxorubicin prepared with branched linkers: A novel method for increasing the potency of doxorubicin immunoconjugates
    • King HD, Yurgaitis D, Willner D, Firestone RA, Yang MB, Lasch SJ et al (1999) Monoclonal antibody conjugates of doxorubicin prepared with branched linkers: a novel method for increasing the potency of doxorubicin immunoconjugates. Bioconjug Chem 10:279-288
    • (1999) Bioconjug Chem , vol.10 , pp. 279-288
    • King, H.D.1    Yurgaitis, D.2    Willner, D.3    Firestone, R.A.4    Yang, M.B.5    Lasch, S.J.6
  • 69
    • 0037068501 scopus 로고    scopus 로고
    • Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: Inhibition of aggregation by methoxytriethyleneglycol chains
    • King HD, Dubowchik GM, Mastalerz H, Willner D, Hofstead SJ, Firestone RA et al (2002) Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: inhibition of aggregation by methoxytriethyleneglycol chains. J Med Chem 45: 4336-4343
    • (2002) J Med Chem , vol.45 , pp. 4336-4343
    • King, H.D.1    Dubowchik, G.M.2    Mastalerz, H.3    Willner, D.4    Hofstead, S.J.5    Firestone, R.A.6
  • 70
    • 0025987026 scopus 로고
    • Anthracycline immu- noconjugates prepared by a site-specific linkage via an amino-dextran intermediate carrier
    • Shih LB, Goldenberg DM, Xuan H, Lu H, Sharkey RM, Hall TC (1991) Anthracycline immu- noconjugates prepared by a site-specific linkage via an amino-dextran intermediate carrier. Cancer Res 51:4192-4198
    • (1991) Cancer Res , vol.51 , pp. 4192-4198
    • Shih, L.B.1    Goldenberg, D.M.2    Xuan, H.3    Lu, H.4    Sharkey, R.M.5    Hall, T.C.6
  • 71
    • 0007887541 scopus 로고    scopus 로고
    • Immunoconjugate therapy of solid tumors: Studies with BR96-doxorubicin
    • Grossbard ML (ed) Marcel Dekker, Inc., New York
    • Saleh MN, LoBuglio AF, Trail PA (1998) Immunoconjugate therapy of solid tumors: studies with BR96-doxorubicin. In: Grossbard ML (ed) Monoclonal antibody-based therapy of cancer, Ith edn. Marcel Dekker, Inc., New York, pp 397-416
    • (1998) Monoclonal antibody-based therapy of cancer, Ith edn , pp. 397-416
    • Saleh, M.N.1    LoBuglio, A.F.2    Trail, P.A.3
  • 72
    • 0034900174 scopus 로고    scopus 로고
    • Approval summary: Gemtuzumab ozogamicin in relapsed acute myeloid leukemia
    • Bross PF, Beitz J, Chen G, Chen XH, Duffy E, Kieffer L et al (2001) Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia. Clin Cancer Res 7:1490-1496
    • (2001) Clin Cancer Res , vol.7 , pp. 1490-1496
    • Bross, P.F.1    Beitz, J.2    Chen, G.3    Chen, X.H.4    Duffy, E.5    Kieffer, L.6
  • 73
    • 25144485908 scopus 로고    scopus 로고
    • Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence
    • Larson RA, Sievers EL, Stadtmauer EA, Lowenberg B, Estey EH, Dombret H et al (2005) Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence. Cancer 104:1442-1452
    • (2005) Cancer , vol.104 , pp. 1442-1452
    • Larson, R.A.1    Sievers, E.L.2    Stadtmauer, E.A.3    Lowenberg, B.4    Estey, E.H.5    Dombret, H.6
  • 74
    • 84859238174 scopus 로고    scopus 로고
    • What happened to anti-CD33 therapy for acute myeloid leukemia
    • Jurcic JG (2012) What happened to anti-CD33 therapy for acute myeloid leukemia? Curr Hematol Malig Rep 7:65-73
    • (2012) Curr Hematol Malig Rep , vol.7 , pp. 65-73
    • Jurcic, J.G.1
  • 75
    • 79954448903 scopus 로고    scopus 로고
    • Preclinical anti-tumor activity of antibody-targeted chemotherapy with CMC-544 (inotuzumab ozogamicin), a CD22-specific immunoconjugate of calicheamicin, compared with non-targeted combination chemotherapy with CVP or CHOP
    • DiJoseph JF, Dougher MM, Evans DY, Zhou BB, Damle NK (2011) Preclinical anti-tumor activity of antibody-targeted chemotherapy with CMC-544 (inotuzumab ozogamicin), a CD22-specific immunoconjugate of calicheamicin, compared with non-targeted combination chemotherapy with CVP or CHOP. Cancer Chemother Pharmacol 67:741-749
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 741-749
    • DiJoseph, J.F.1    Dougher, M.M.2    Evans, D.Y.3    Zhou, B.B.4    Damle, N.K.5
  • 76
    • 77951648118 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immuno- conjugate for the treatment of B-cell non-Hodgkin's lymphoma: Results of a phase I study
    • Advani A, Coiffier B, Czuczman MS, Dreyling M, Foran J, Gine E et al (2010) Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immuno- conjugate for the treatment of B-cell non-Hodgkin's lymphoma: results of a phase I study. J Clin Oncol 28:2085-2093
    • (2010) J Clin Oncol , vol.28 , pp. 2085-2093
    • Advani, A.1    Coiffier, B.2    Czuczman, M.S.3    Dreyling, M.4    Foran, J.5    Gine, E.6
  • 77
    • 31544441685 scopus 로고    scopus 로고
    • Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: Effects of linker technology on efficacy and toxicity
    • Doronina SO, Mendelsohn BA, Bovee TD, Cerveny CG, Alley SC, Meyer DL et al (2006) Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem 17:114-124
    • (2006) Bioconjug Chem , vol.17 , pp. 114-124
    • Doronina, S.O.1    Mendelsohn, B.A.2    Bovee, T.D.3    Cerveny, C.G.4    Alley, S.C.5    Meyer, D.L.6
  • 78
    • 0042738861 scopus 로고    scopus 로고
    • CAC10- vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity
    • Francisco JA, Cerveny CG, Meyer DL, Mixan BJ, Klussman K, Chace DF et al (2003) cAC10- vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood 102:1458-1465
    • (2003) Blood , vol.102 , pp. 1458-1465
    • Francisco, J.A.1    Cerveny, C.G.2    Meyer, D.L.3    Mixan, B.J.4    Klussman, K.5    Chace, D.F.6
  • 80
    • 77958059151 scopus 로고    scopus 로고
    • Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability
    • Oroudjev E, Lopus M, Wilson L, Audette C, Provenzano C, Erickson H et al (2010) Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability. Mol Cancer Ther 9:2700-2713
    • (2010) Mol Cancer Ther , vol.9 , pp. 2700-2713
    • Oroudjev, E.1    Lopus, M.2    Wilson, L.3    Audette, C.4    Provenzano, C.5    Erickson, H.6
  • 82
    • 0036074253 scopus 로고    scopus 로고
    • Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: Model studies of enzymatic drug release and antigen-specific in vitro anticancer activity
    • Dubowchik GM, Firestone RA, Padilla L, Willner D, Hofstead SJ, Mosure K et al (2002) Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity. Bioconjug Chem 13:855-869
    • (2002) Bioconjug Chem , vol.13 , pp. 855-869
    • Dubowchik, G.M.1    Firestone, R.A.2    Padilla, L.3    Willner, D.4    Hofstead, S.J.5    Mosure, K.6
  • 85
    • 56449085913 scopus 로고    scopus 로고
    • A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo
    • Jackson D, Gooya J, Mao S, Kinneer K, Xu L, Camara M et al (2008) A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo. Cancer Res 68:9367-9374
    • (2008) Cancer Res , vol.68 , pp. 9367-9374
    • Jackson, D.1    Gooya, J.2    Mao, S.3    Kinneer, K.4    Xu, L.5    Camara, M.6
  • 86
    • 58149161759 scopus 로고    scopus 로고
    • Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker
    • Oflazoglu E, Stone IJ, Gordon K, Wood CG, Repasky EA, Grewal IS et al (2008) Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker. Clin Cancer Res 14:6171-6180
    • (2008) Clin Cancer Res , vol.14 , pp. 6171-6180
    • Oflazoglu, E.1    Stone, I.J.2    Gordon, K.3    Wood, C.G.4    Repasky, E.A.5    Grewal, I.S.6
  • 87
    • 56449129810 scopus 로고    scopus 로고
    • Targeting HER2-positive breast cancer with trastuzumab-DM1 an antibody-cytotoxic drug conjugate
    • Lewis Phillips GD, Li G, Dugger DL, Crocker LM, Parsons KL, Mai E et al (2008) Targeting HER2-positive breast cancer with trastuzumab-DM1 an antibody-cytotoxic drug conjugate. Cancer Res 68:9280-9290
    • (2008) Cancer Res , vol.68 , pp. 9280-9290
    • Lewis Phillips, G.D.1    Li, G.2    Dugger, D.L.3    Crocker, L.M.4    Parsons, K.L.5    Mai, E.6
  • 88
    • 77954031486 scopus 로고    scopus 로고
    • Phase I study of trastu- zumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2- positive metastatic breast cancer
    • Krop IE, Beeram M, Modi S, Jones SF, Holden SN, Yu W et al (2010) Phase I study of trastu- zumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2- positive metastatic breast cancer. J Clin Oncol 28:2698-2704
    • (2010) J Clin Oncol , vol.28 , pp. 2698-2704
    • Krop, I.E.1    Beeram, M.2    Modi, S.3    Jones, S.F.4    Holden, S.N.5    Yu, W.6
  • 89
    • 79952092706 scopus 로고    scopus 로고
    • Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
    • Burris HA 3rd, Rugo HS, Vukelja SJ, Vogel CL, Borson RA, Limentani S et al (2011) Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol 29:398-405
    • (2011) J Clin Oncol , vol.29 , pp. 398-405
    • Burris, H.A.1    Rugo, H.S.2    Vukelja, S.J.3    Vogel, C.L.4    Borson, R.A.5    Limentani, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.