Anomalous uptake and circulatory characteristics of the plant-based small RNA MIR2911

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Yang, Jian ^a   Hotz, Tremearne ^b   Broadnax, LaCassidy ^a   Yarmarkovich, Mark ^c   Elbaz Younes, Ismail ^a   Hirschi, Kendal D ^a,d  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b BATES COLLEGE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; NANOPARTICLE; PROTEINASE K;

ANGIOSPERM; ANIMAL; ANIMAL FOOD; BIOAVAILABILITY; BLOOD; BRASSICA; CHEMISTRY; DIGESTION; EXOSOME; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; RNA STABILITY;

ANIMAL FEED; ANIMALS; BIOLOGICAL AVAILABILITY; BRASSICA; DIGESTION; ENDOPEPTIDASE K; EXOSOMES; MAGNOLIOPSIDA; MALE; MICE, INBRED ICR; MICRORNAS; NANOPARTICLES; RNA STABILITY;

EID: 84973304985     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep26834     Document Type: Article

References (23)

1. Zhou, Z. et al. Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Cell Research 25, 39-49, doi: 10.1038/cr.2014.130 (2015).
2. Zhang, L. et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: Evidence of cross-kingdom regulation by microRNA. Cell Research 22, 107-126, doi: 10.1038/cr.2011.158 (2012).
3. Mlotshwa, S. et al. A novel chemopreventive strategy based on therapeutic microRNAs produced in plants. Cell Research 25, 521-524, doi: 10.1038/cr.2015.25 (2015).
4. Hirschi, K. D., Pruss, G. J. & Vance, V. Dietary delivery: A new avenue for microRNA therapeutics? Trends Biotechnology 33, 431-432, doi: 10.1016/j.tibtech.2015.06.003 (2015).
5. Snow, J. W., Hale, A. E., Isaacs, S. K., Baggish, A. L. & Chan, S. Y. Ineffective delivery of diet-derived microRNAs to recipient animal organisms. RNA biology 10, 1107-1116, doi: 10.4161/rna.24909 (2013).
6. Witwer, K. W., McAlexander, M. A., Queen, S. E. & Adams, R. J. Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs: limited evidence for general uptake of dietary plant xenomiRs. RNA biology 10, 1080-1086, doi: 10.4161/rna.25246 (2013).
7. Dickinson, B. et al. Lack of detectable oral bioavailability of plant microRNAs after feeding in mice. Nature Biotechnology 31, 965-967, doi: 10.1038/nbt.2737 (2013).
8. Yang, J., Farmer, L. M., Agyekum, A. A. A. & Hirschi, K. D. Detection of dietary plant-based small RNAs in animals. Cell Research 25, 517-520, doi: 10.1038/cr.2015.26 (2015).
9. Yang, J., Farmer, L. M., Agyekum, A. A. A., Elbaz-Younes, I. & Hirschi, K. D. Detection of an abundant plant-based small RNA in healthy consumers. PLoS One 10, e0137516, p. 0137511-0137514, doi: 10.1371/journal.pone.0137516 (2015).
10. Yang, J., Hirschi, K. D. & Farmer, L. M. Dietary RNAs: New stories regarding oral delivery. Nutrients 7, 3184-3199, doi: 10.3390/nu7053184 (2015).
11. Etheridge, A., Gomes, C. P., Pereira, R. W., Galas, D. & Wang, K. The complexity, function and applications of RNA in circulation. Frontiers in genetics 4, 115, doi: 10.3389/fgene.2013.00115 (2013).
12. Valadi, H. et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nature cell biology 9, 654-659, doi: 10.1038/ncb1596 (2007).
13. Zampetaki, A., Willeit, P., Drozdov, I., Kiechl, S. & Mayr, M. Profiling of circulating microRNAs: from single biomarkers to re-wired networks. Cardiovasc Res 93, 555-562, doi: 10.1093/cvr/cvr266 (2012).
14. Arroyo, J. D. et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proceedings of the National Academy of Sciences USA 108, 5003-5008, doi: 10.1073/pnas.1019055108 (2011).
15. Ju, S. et al. Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis. Molecular Therapy : J American Society of Gene Therapy 21, 1345-1357, doi: 10.1038/mt.2013.64 (2013).
16. Mu, J. et al. Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles. Molecular Nutrition & Food Ressearch 58, 1561-1573, doi: 10.1002/mnfr.201300729 (2014).
17. Minekus, M. et al. A standardised static in vitro digestion method suitable for food-an international consensus. Food & function 5, 1113-1124, doi: 10.1039/c3fo60702j (2014).
18. Baier, S. R., Nguyen, C., Xie, F., Wood, J. R. & Zempleni, J. MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers. Journal of Nutrition 144, 1495-1500, doi: 10.3945/jn.114.196436 (2014).
19. Zempleni, J., Baier, S. R. & Hirschi, K. D. Diet-responsive MicroRNAs are likely exogenous. Journal of Biological Chemistry 290, 25197, doi: 10.1074/jbc.L115.687830 (2015).
20. Philip, A., Ferro, V. A. & Tate, R. J. Determination of the potential bioavailability of plant microRNAs using a simulated human digestion process. Molecular Nutrition & Food Ressearch 59, 1962-72, doi: 10.1002/mnfr.201500137 (2015).
21. Witwer, K. W. & Hirschi, K. D. Transfer and functional consequences of dietary microRNAs in vertebrates: Concepts in search of corroboration: Negative results challenge the hypothesis that dietary xenomiRs cross the gut and regulate genes in ingesting vertebrates, but important questions persist. Bioessays 36, 394-406, doi: 10.1002/bies.201300150 (2014).
22. Chen, X. et al. A combination of Let-7d, Let-7g and Let-7i serves as a stable reference for normalization of serum microRNAs. PLoS One 8, e79652, doi: 10.1371/journal.pone.0079652 (2013).
23. Wang, Y. et al. Diagnostic and prognostic value of circulating miR-21 for cancer: A systematic review and meta-analysis. Gene 533, 389-397, doi: 10.1016/j.gene.2013.09.038 (2014).