Dietary delivery: A new avenue for microRNA therapeutics?

Trends in Biotechnology

Volumn 33, Issue 8, 2015, Pages 431-432

  Hirschi, Kendal D ^a   Pruss, Gail J ^b   Vance, Vicki ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; GENE THERAPY; RNA;

HUMAN DISEASE; MICRORNAS; RECENT RESEARCHES; SMALL RNA;

DISEASE CONTROL;

MICRORNA; MICRORNA 2911; PLANT RNA; UNCLASSIFIED DRUG; SMALL INTERFERING RNA;

ANTIVIRAL ACTIVITY; BIOGENESIS; COLON CANCER; DIETARY INTAKE; GASTROINTESTINAL TRACT; GENE EXPRESSION; HUMAN; INFLUENZA A; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; ANIMAL; DRUG DELIVERY SYSTEM; DRUG EFFECTS; FOOD; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; DRUG DELIVERY SYSTEMS; FOOD; GENE EXPRESSION; HUMANS; MICRORNAS; RNA, SMALL INTERFERING;

EID: 84937515262     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2015.06.003     Document Type: Short Survey

References (12)

1. Witwer K.W., Hirschi K.D. Transfer and functional consequences of dietary microRNAs in vertebrates: concepts in search of corroboration: negative results challenge the hypothesis that dietary xenomiRs cross the gut and regulate genes in ingesting vertebrates, but important questions persist. Bioessays 2014, 36:394-406.
2. Zhang L., et al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res. 2012, 22:107-126.
3. Wang K., et al. The complex exogenous RNA spectra in human plasma: an interface with human gut biota?. PLoS ONE 2012, 7:e51009.
4. Beatty M., et al. Small RNAs from plants, bacteria and fungi within the order Hypocreales are ubiquitous in human plasma. BMC Genomics 2014, 15:933.
5. Dickinson B., et al. Lack of detectable oral bioavailability of plant microRNAs after feeding in mice. Nat. Biotechnol. 2013, 31:965-967.
6. Witwer K.W., et al. Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs: limited evidence for general uptake of dietary plant xenomiRs. RNA Biol. 2013, 10:1080-1086.
7. Mlotshwa S., et al. A novel chemopreventive strategy based on therapeutic microRNAs produced in plants. Cell Res. 2015, 25:521-524.
8. Yang J., et al. Detection of dietary plant-based small RNAs in animals. Cell Res. 2015, 25:517-520.
9. Zhou Z., et al. Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Cell Res. 2014, 25:39-49.
10. Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
11. Roume H., et al. A biomolecular isolation framework for eco-systems biology. ISME J. 2013, 7:110-121.
12. Ghosal A., et al. The extracellular RNA complement of Escherichia coli. Microbiologyopen 2015, 4:252-266.