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Volumn 26, Issue 7, 2016, Pages 761-774

RANKL/RANK control Brca1 mutation-driven mammary tumors

(34)  Sigl, Verena a   Owusu Boaitey, Kwadwo b   Joshi, Purna A c   Kavirayani, Anoop a   Wirnsberger, Gerald a   Novatchkova, Maria a   Kozieradzki, Ivona a   Schramek, Daniel d,e   Edokobi, Nnamdi b   Hersl, Jerome f   Sampson, Aishia f   Odai Afotey, Ashley g   Lazaro, Conxi h   Gonzalez Suarez, Eva h   Pujana, Miguel A h   Heyn, Holger h   Vidal, Enrique i   Cruickshank, Jennifer c   Berman, Hal c   Sarao, Renu a   more..


Author keywords

BRCA1; inherited breast cancer; mammary progenitor cells; RANK; RANKL

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; ESTROGEN RECEPTOR ALPHA; HYBRID PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROGESTERONE RECEPTOR; PROTEIN P53; RANK-FC; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B;

EID: 84973167255     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2016.69     Document Type: Article
Times cited : (124)

References (46)
  • 1
    • 0028113345 scopus 로고
    • A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
    • Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994; 266:66-71.
    • (1994) Science , vol.266 , pp. 66-71
    • Miki, Y.1    Swensen, J.2    Shattuck-Eidens, D.3
  • 2
    • 84886718942 scopus 로고    scopus 로고
    • The sex hormone system in carriers of BRCA1/2 mutations: A case-control study
    • Widschwendter M, Rosenthal AN, Philpott S , et al. The sex hormone system in carriers of BRCA1/2 mutations: a case-control study. Lancet Oncol 2013; 14:1226-1232.
    • (2013) Lancet Oncol , vol.14 , pp. 1226-1232
    • Widschwendter, M.1    Rosenthal, A.N.2    Philpott, S.3
  • 3
    • 33845315093 scopus 로고    scopus 로고
    • Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist
    • Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY. Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science 2006; 314:1467-1470.
    • (2006) Science , vol.314 , pp. 1467-1470
    • Poole, A.J.1    Li, Y.2    Kim, Y.3    Lin, S.C.4    Lee, W.H.5    Lee, E.Y.6
  • 4
    • 0033568341 scopus 로고    scopus 로고
    • RANK is essential for osteoclast and lymph node development
    • Dougall WC, Glaccum M, Charrier K, et al. RANK is essential for osteoclast and lymph node development. Genes Dev 1999; 13:2412-2424.
    • (1999) Genes Dev , vol.13 , pp. 2412-2424
    • Dougall, W.C.1    Glaccum, M.2    Charrier, K.3
  • 5
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymphnode organogenesis
    • Kong YY, Yoshida H, Sarosi I, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymphnode organogenesis. Nature 1999; 397:315-323.
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3
  • 6
    • 69049083492 scopus 로고    scopus 로고
    • Denosumab for prevention of fractures in postmenopausal women with osteoporosis
    • Cummings SR, San Martin J, McClung MR, et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009; 361:756-765
    • (2009) N Engl J Med , vol.361 , pp. 756-765
    • Cummings, S.R.1    San Martin, J.2    McClung, M.R.3
  • 7
    • 33344469853 scopus 로고    scopus 로고
    • Denosumab in postmenopausal women with low bone mineral density
    • McClung MR, Lewiecki EM, Cohen SB, et al. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 2006; 354:821-831.
    • (2006) N Engl J Med , vol.354 , pp. 821-831
    • McClung, M.R.1    Lewiecki, E.M.2    Cohen, S.B.3
  • 8
    • 69049105440 scopus 로고    scopus 로고
    • Denosumab in men receiving androgen-deprivation therapy for prostate cancer
    • Smith MR, Egerdie B, Hernandez Toriz N, et al. Denosumab in men receiving androgen-deprivation therapy for prostate cancer. N Engl J Med 2009; 361:745-755.
    • (2009) N Engl J Med , vol.361 , pp. 745-755
    • Smith, M.R.1    Egerdie, B.2    Hernandez Toriz, N.3
  • 9
    • 79955476478 scopus 로고    scopus 로고
    • RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis
    • Schramek D, Sigl V, Penninger JM. RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis. Trends Endocrinol Metab 2011; 22:188-194.
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 188-194
    • Schramek, D.1    Sigl, V.2    Penninger, J.M.3
  • 10
    • 0034730327 scopus 로고    scopus 로고
    • The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
    • Fata JE, Kong YY, Li J, et al. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell 2000; 103:41-50.
    • (2000) Cell , vol.103 , pp. 41-50
    • Fata, J.E.1    Kong, Y.Y.2    Li, J.3
  • 11
    • 77953388315 scopus 로고    scopus 로고
    • Progesterone induces adult mammary stem cell expansion
    • Joshi PA, Jackson HW, Beristain AG, et al. Progesterone induces adult mammary stem cell expansion. Nature 2010; 465:803-807.
    • (2010) Nature , vol.465 , pp. 803-807
    • Joshi, P.A.1    Jackson, H.W.2    Beristain, A.G.3
  • 12
    • 77953384898 scopus 로고    scopus 로고
    • Control of mammary stem cell function by steroid hormone signalling
    • Asselin-Labat ML, Vaillant F, Sheridan JM, et al. Control of mammary stem cell function by steroid hormone signalling. Nature 2010; 465:798-802.
    • (2010) Nature , vol.465 , pp. 798-802
    • Asselin-Labat, M.L.1    Vaillant, F.2    Sheridan, J.M.3
  • 13
    • 78149284013 scopus 로고    scopus 로고
    • Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
    • Schramek D, Leibbrandt A, Sigl V, et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature 2010; 468:98-102.
    • (2010) Nature , vol.468 , pp. 98-102
    • Schramek, D.1    Leibbrandt, A.2    Sigl, V.3
  • 14
    • 78149284767 scopus 로고    scopus 로고
    • RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis
    • Gonzalez-Suarez E, Jacob AP, Jones J, et al RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature 2010; 468:103-107.
    • (2010) Nature , vol.468 , pp. 103-107
    • Gonzalez-Suarez, E.1    Jacob, A.P.2    Jones, J.3
  • 15
    • 40349100163 scopus 로고    scopus 로고
    • BRCA1 regulates human mammary stem/progenitor cell fate
    • Liu S, Ginestier C, Charafe-Jauffret E, et al. BRCA1 regulates human mammary stem/progenitor cell fate. Proc Natl Acad Sci USA 2008; 105:1680-1685.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 1680-1685
    • Liu, S.1    Ginestier, C.2    Charafe-Jauffret, E.3
  • 16
    • 70849096810 scopus 로고    scopus 로고
    • Central control of fever and female body temperature by RANKL/RANK
    • Hanada R, Leibbrandt A, Hanada T, et al. Central control of fever and female body temperature by RANKL/RANK. Nature 2009; 462:505-509.
    • (2009) Nature , vol.462 , pp. 505-509
    • Hanada, R.1    Leibbrandt, A.2    Hanada, T.3
  • 17
    • 0042836597 scopus 로고    scopus 로고
    • Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues
    • Berton TR, Matsumoto T, Page A, et al. Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues. Oncogene 2003; 22:5415-5426.
    • (2003) Oncogene , vol.22 , pp. 5415-5426
    • Berton, T.R.1    Matsumoto, T.2    Page, A.3
  • 18
    • 34547496282 scopus 로고    scopus 로고
    • Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer
    • Liu X, Holstege H, van der Gulden H, et al. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci USA 2007; 104:12111-12116.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12111-12116
    • Liu, X.1    Holstege, H.2    Van Der Gulden, H.3
  • 19
    • 2442701845 scopus 로고    scopus 로고
    • Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis
    • Lin SC, Lee KF, Nikitin AY, et al. Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res 2004; 64:3525-3532.
    • (2004) Cancer Res , vol.64 , pp. 3525-3532
    • Lin, S.C.1    Lee, K.F.2    Nikitin, A.Y.3
  • 20
    • 84887398348 scopus 로고    scopus 로고
    • Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts
    • Pfefferle AD, Herschkowitz JI, Usary J, et al. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol 2013; 14:R125.
    • (2013) Genome Biol , vol.14 , pp. R125
    • Pfefferle, A.D.1    Herschkowitz, J.I.2    Usary, J.3
  • 21
    • 84875741884 scopus 로고    scopus 로고
    • Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk
    • Couch FJ, Wang X, McGuffog L, et al. Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet 2013; 9:e1003212.
    • (2013) PLoS Genet , vol.9 , pp. e1003212
    • Couch, F.J.1    Wang, X.2    McGuffog, L.3
  • 22
    • 84875733563 scopus 로고    scopus 로고
    • Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk
    • Gaudet MM, Kuchenbaecker KB, Vijai J, et al. Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet 2013; 9:e1003173.
    • (2013) PLoS Genet , vol.9 , pp. e1003173
    • Gaudet, M.M.1    Kuchenbaecker, K.B.2    Vijai, J.3
  • 23
    • 84860331458 scopus 로고    scopus 로고
    • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals loci associated with risk of fracture
    • Estrada K, Styrkarsdottir U, Evangelou E, et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals loci associated with risk of fracture. Nat Genet 2012; 44:491-501.
    • (2012) Nat Genet , vol.44 , pp. 491-501
    • Estrada, K.1    Styrkarsdottir, U.2    Evangelou, E.3
  • 24
    • 70350646912 scopus 로고    scopus 로고
    • Genetic Factors for Osteoporosis (GEFOS) Consortium, Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
    • Rivadeneira F, Styrkarsdottir U, Estrada K, et al. Genetic Factors for Osteoporosis (GEFOS) Consortium, Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet 2009; 41:1199-1206.
    • (2009) Nat Genet , vol.41 , pp. 1199-1206
    • Rivadeneira, F.1    Styrkarsdottir, U.2    Estrada, K.3
  • 25
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas N
    • Cancer Genome Atlas N. Comprehensive molecular portraits of human breast tumours. Nature 2012; 490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 26
    • 84954304973 scopus 로고    scopus 로고
    • Rankl impairs lactogenic differentiation through inhibition of the prolactin/Stat5 pathway at midgestation
    • Cordero A, Pellegrini P, Sanz-Moreno A, et al. Rankl impairs lactogenic differentiation through inhibition of the prolactin/Stat5 pathway at midgestation. Stem Cells 2016; 34:1027-1039.
    • (2016) Stem Cells , vol.34 , pp. 1027-1039
    • Cordero, A.1    Pellegrini, P.2    Sanz-Moreno, A.3
  • 27
    • 84875079780 scopus 로고    scopus 로고
    • Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells
    • Lee HJ, Gallego-Ortega D, Ledger A, et al. Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development 2013; 140:1397-1401.
    • (2013) Development , vol.140 , pp. 1397-1401
    • Lee, H.J.1    Gallego-Ortega, D.2    Ledger, A.3
  • 28
    • 84886419490 scopus 로고    scopus 로고
    • Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells
    • Obr AE, Grimm SL, Bishop KA, Pike JW, Lydon JP, Edwards DP. Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells. Mol Endocrinol 2013; 27:1808-1824.
    • (2013) Mol Endocrinol , vol.27 , pp. 1808-1824
    • Obr, A.E.1    Grimm, S.L.2    Bishop, K.A.3    Pike, J.W.4    Lydon, J.P.5    Edwards, D.P.6
  • 29
    • 0033591295 scopus 로고    scopus 로고
    • BRCA1 inhibition of estrogen receptor signaling in transfected cells
    • Fan S, Wang J, Yuan R, Rosen EM, et al. BRCA1 inhibition of estrogen receptor signaling in transfected cells. Science 1999; 284:1354-1356.
    • (1999) Science , vol.284 , pp. 1354-1356
    • Fan, S.1    Wang, J.2    Yuan, R.3    Rosen, E.M.4
  • 30
    • 29444434177 scopus 로고    scopus 로고
    • The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells
    • Ma Y, Katiyar P, Jones LP, et al. The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells. Mol Endocrinol 2006; 20:14-34.
    • (2006) Mol Endocrinol , vol.20 , pp. 14-34
    • Ma, Y.1    Katiyar, P.2    Jones, L.P.3
  • 31
    • 19944401190 scopus 로고    scopus 로고
    • Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer
    • Jones LP, Li M, Halama ED, et al. Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Oncogene 2005; 24:3554-3562.
    • (2005) Oncogene , vol.24 , pp. 3554-3562
    • Jones, L.P.1    Li, M.2    Halama, E.D.3
  • 32
    • 84878113369 scopus 로고    scopus 로고
    • The shaping and functional consequences of the microRNA landscape in breast cancer
    • Dvinge H, Git A, Graf S, et al. The shaping and functional consequences of the microRNA landscape in breast cancer. Nature 2013; 497:378-382.
    • (2013) Nature , vol.497 , pp. 378-382
    • Dvinge, H.1    Git, A.2    Graf, S.3
  • 33
    • 3042856262 scopus 로고    scopus 로고
    • Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    • Srinivas S, Watanabe T, Lin CS, et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 2001; 1:4.
    • (2001) BMC Dev Biol , vol.1 , pp. 4
    • Srinivas, S.1    Watanabe, T.2    Lin, C.S.3
  • 34
    • 84937959927 scopus 로고    scopus 로고
    • STAT3 regulated ARF expression suppresses prostate cancer metastasis
    • Pencik J, Schlederer M, Gruber W, et al. STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun 2015; 6:7736.
    • (2015) Nat Commun , vol.6 , pp. 7736
    • Pencik, J.1    Schlederer, M.2    Gruber, W.3
  • 35
    • 84872035480 scopus 로고    scopus 로고
    • Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbals, preputial, and clitoral glands
    • Rudmann D, Cardiff R, Chouinard L, et al. Proliferative and nonproliferative lesions of the rat and mouse mammary, Zymbals, preputial, and clitoral glands. Toxicol Pathol 2012; 40:7S-39S.
    • (2012) Toxicol Pathol , vol.40 , pp. 7S-39S
    • Rudmann, D.1    Cardiff, R.2    Chouinard, L.3
  • 36
    • 0034696279 scopus 로고    scopus 로고
    • The mammary pathology of genetically engineered mice: The consensus report and recommendations from the Annapolis meeting
    • Cardiff RD, Anver MR, Gusterson BA, et al. The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene 2000; 19:968-988.
    • (2000) Oncogene , vol.19 , pp. 968-988
    • Cardiff, R.D.1    Anver, M.R.2    Gusterson, B.A.3
  • 37
    • 13444272959 scopus 로고    scopus 로고
    • Deregulated estrogen receptor a expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ
    • Frech MS, Halama ED, Tilli MT, et al. Deregulated estrogen receptor a expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ. Cancer Res 2005; 65:681-685.
    • (2005) Cancer Res , vol.65 , pp. 681-685
    • Frech, M.S.1    Halama, E.D.2    Tilli, M.T.3
  • 38
    • 57349148680 scopus 로고    scopus 로고
    • A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability
    • Eirew P, Stingl J, Raouf A, et al. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med 2008; 14:1384-1389.
    • (2008) Nat Med , vol.14 , pp. 1384-1389
    • Eirew, P.1    Stingl, J.2    Raouf, A.3
  • 39
    • 16644364791 scopus 로고    scopus 로고
    • Enzymatic dissociation and culture of normal human mammary tissue to detect progenitor activity
    • Stingl J, Emerman JT, Eaves CJ. Enzymatic dissociation and culture of normal human mammary tissue to detect progenitor activity. Methods Mol Biol 2005; 290:249-263.
    • (2005) Methods Mol Biol , vol.290 , pp. 249-263
    • Stingl, J.1    Emerman, J.T.2    Eaves, C.J.3
  • 40
    • 84897541350 scopus 로고    scopus 로고
    • XBP1 promotes triple-negative breast cancer by controlling the HIF1alpha pathway
    • Chen X, Iliopoulos D, Zhang Q, et al. XBP1 promotes triple-negative breast cancer by controlling the HIF1alpha pathway. Nature 2014; 508:103-107.
    • (2014) Nature , vol.508 , pp. 103-107
    • Chen, X.1    Iliopoulos, D.2    Zhang, Q.3
  • 41
    • 80053152058 scopus 로고    scopus 로고
    • Aminoacyl-tRNA synthetases and tumorigenesis: More than housekeeping
    • Kim S, You S, Hwang D. Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping. Nat Rev Cancer 2011;11:708-718.
    • (2011) Nat Rev Cancer , vol.11 , pp. 708-718
    • Kim, S.1    You, S.2    Hwang, D.3
  • 42
    • 84937527027 scopus 로고    scopus 로고
    • RANK signaling amplifies WNT-responsive mammary progenitors through R-SPONDIN1
    • Joshi PA, Waterhouse PD, Kannan N, et al. RANK signaling amplifies WNT-responsive mammary progenitors through R-SPONDIN1. Stem Cell Reports 2015; 5:31-44.
    • (2015) Stem Cell Reports , vol.5 , pp. 31-44
    • Joshi, P.A.1    Waterhouse, P.D.2    Kannan, N.3
  • 43
    • 34548863946 scopus 로고    scopus 로고
    • Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    • Herschkowitz JI, Simin K, Weigman VJ, et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 2007; 8:R76.
    • (2007) Genome Biol , vol.8 , pp. R76
    • Herschkowitz, J.I.1    Simin, K.2    Weigman, V.J.3
  • 44
    • 84859098571 scopus 로고    scopus 로고
    • The sva package for removing batch effects and other unwanted variation in high-throughput experiments
    • Leek JT, Johnson WE, Parker HS, Jaffe AE, Storey JD. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 2012; 28:882-883.
    • (2012) Bioinformatics , vol.28 , pp. 882-883
    • Leek, J.T.1    Johnson, W.E.2    Parker, H.S.3    Jaffe, A.E.4    Storey, J.D.5
  • 45
    • 84864579879 scopus 로고    scopus 로고
    • TNBCtype: A subtyping tool for triple-negative breast cancer
    • Chen X, Li J, Gray WH, et al. TNBCtype: a subtyping tool for triple-negative breast cancer. Cancer Inform 2012; 11:147-156.
    • (2012) Cancer Inform , vol.11 , pp. 147-156
    • Chen, X.1    Li, J.2    Gray, W.H.3
  • 46
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann BD, Bauer JA, Chen X, et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011; 121:2750-2767.
    • (2011) J Clin Invest , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3


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