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Volumn 34, Issue 4, 2016, Pages 1027-1039

Rankl Impairs Lactogenic Differentiation Through Inhibition of the Prolactin/Stat5 Pathway at Midgestation

Author keywords

Mammary alveoli; p Stat5; Progesterone; Prolactin; Rank; Rankl

Indexed keywords

MILK PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROLACTIN; STAT5 PROTEIN; STAT5A PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ELF5; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; ELF5 PROTEIN, MOUSE; JAK2 PROTEIN, MOUSE; JANUS KINASE 2; PROGESTERONE; TNFSF11 PROTEIN, MOUSE;

EID: 84954304973     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2271     Document Type: Article
Times cited : (25)

References (43)
  • 1
    • 0036370406 scopus 로고    scopus 로고
    • Hormonal control of alveolar development and its implications for breast carcinogenesis
    • Brisken C,. Hormonal control of alveolar development and its implications for breast carcinogenesis. J Mammary Gland Biol Neoplasia 2002; 7: 39-48.
    • (2002) J Mammary Gland Biol Neoplasia , vol.7 , pp. 39-48
    • Brisken, C.1
  • 3
    • 0032574830 scopus 로고    scopus 로고
    • A paracrine role for the epithelial progesterone receptor in mammary gland development
    • Brisken C, Park S, Vass T, et al., A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci USA 28 1998; 95: 5076-5081.
    • (1998) Proc Natl Acad Sci USA 28 , vol.95 , pp. 5076-5081
    • Brisken, C.1    Park, S.2    Vass, T.3
  • 4
    • 0042693019 scopus 로고    scopus 로고
    • Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform
    • Mulac-Jericevic B, Lydon JP, DeMayo FJ, et al., Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc Natl Acad Sci USA 19 2003; 100: 9744-9749.
    • (2003) Proc Natl Acad Sci USA 19 , vol.100 , pp. 9744-9749
    • Mulac-Jericevic, B.1    Lydon, J.P.2    DeMayo, F.J.3
  • 5
    • 0029115517 scopus 로고
    • Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities
    • Lydon JP, DeMayo FJ, Funk CR, et al., Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev 1995; 9: 2266-2278.
    • (1995) Genes Dev , vol.9 , pp. 2266-2278
    • Lydon, J.P.1    DeMayo, F.J.2    Funk, C.R.3
  • 6
    • 8544242334 scopus 로고    scopus 로고
    • Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse
    • Ormandy CJ, Camus A, Barra J, et al., Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev 1997; 11: 167-178.
    • (1997) Genes Dev , vol.11 , pp. 167-178
    • Ormandy, C.J.1    Camus, A.2    Barra, J.3
  • 7
    • 40249108932 scopus 로고    scopus 로고
    • The Ets transcription factor Elf5 specifies mammary alveolar cell fate
    • Oakes SR, Naylor MJ, Asselin-Labat ML, et al., The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes Dev 2008; 22: 581-586.
    • (2008) Genes Dev , vol.22 , pp. 581-586
    • Oakes, S.R.1    Naylor, M.J.2    Asselin-Labat, M.L.3
  • 8
    • 70350091566 scopus 로고    scopus 로고
    • Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A
    • Yamaji D, Na R, Feuermann Y, et al., Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A. Genes Dev 2009; 23: 2382-2387.
    • (2009) Genes Dev , vol.23 , pp. 2382-2387
    • Yamaji, D.1    Na, R.2    Feuermann, Y.3
  • 9
    • 0027993605 scopus 로고
    • Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription
    • Gouilleux F, Wakao H, Mundt M, et al., Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J 1994; 13: 4361-4369.
    • (1994) EMBO J , vol.13 , pp. 4361-4369
    • Gouilleux, F.1    Wakao, H.2    Mundt, M.3
  • 10
    • 0030670222 scopus 로고    scopus 로고
    • Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene
    • Horseman ND, Zhao W, Montecino-Rodriguez E, et al., Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. EMBO J 1997; 16: 6926-6935.
    • (1997) EMBO J , vol.16 , pp. 6926-6935
    • Horseman, N.D.1    Zhao, W.2    Montecino-Rodriguez, E.3
  • 11
    • 0000943469 scopus 로고    scopus 로고
    • Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
    • Teglund S, McKay C, Schuetz E, et al., Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 1998; 93: 841-850.
    • (1998) Cell , vol.93 , pp. 841-850
    • Teglund, S.1    McKay, C.2    Schuetz, E.3
  • 12
    • 2942587457 scopus 로고    scopus 로고
    • Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice
    • Wagner KU, Krempler A, Triplett AA, et al., Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice. Mol Cell Biol 2004; 24: 5510-5520.
    • (2004) Mol Cell Biol , vol.24 , pp. 5510-5520
    • Wagner, K.U.1    Krempler, A.2    Triplett, A.A.3
  • 13
    • 20044368235 scopus 로고    scopus 로고
    • Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation
    • Zhou J, Chehab R, Tkalcevic J, et al., Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. EMBO J 2005; 24: 635-644.
    • (2005) EMBO J , vol.24 , pp. 635-644
    • Zhou, J.1    Chehab, R.2    Tkalcevic, J.3
  • 14
    • 77953384898 scopus 로고    scopus 로고
    • Control of mammary stem cell function by steroid hormone signalling
    • Asselin-Labat ML, Vaillant F, Sheridan JM, et al., Control of mammary stem cell function by steroid hormone signalling. Nature 2010; 465: 798-802.
    • (2010) Nature , vol.465 , pp. 798-802
    • Asselin-Labat, M.L.1    Vaillant, F.2    Sheridan, J.M.3
  • 15
    • 77649259667 scopus 로고    scopus 로고
    • Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland
    • Beleut M, Rajaram RD, Caikovski M, et al., Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci USA 2010; 107: 2989-2994.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2989-2994
    • Beleut, M.1    Rajaram, R.D.2    Caikovski, M.3
  • 16
    • 77953388315 scopus 로고    scopus 로고
    • Progesterone induces adult mammary stem cell expansion
    • Joshi PA, Jackson HW, Beristain AG, et al., Progesterone induces adult mammary stem cell expansion. Nature 2010; 465: 803-807.
    • (2010) Nature , vol.465 , pp. 803-807
    • Joshi, P.A.1    Jackson, H.W.2    Beristain, A.G.3
  • 17
    • 0034730327 scopus 로고    scopus 로고
    • The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development
    • Fata JE, Kong YY, Li J, et al., The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell 2000; 103: 41-50.
    • (2000) Cell , vol.103 , pp. 41-50
    • Fata, J.E.1    Kong, Y.Y.2    Li, J.3
  • 18
    • 61349178831 scopus 로고    scopus 로고
    • The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse
    • Fernandez-Valdivia R, Mukherjee A, Ying Y, et al., The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. Dev Biol 2009; 328: 127-139.
    • (2009) Dev Biol , vol.328 , pp. 127-139
    • Fernandez-Valdivia, R.1    Mukherjee, A.2    Ying, Y.3
  • 19
    • 33846911452 scopus 로고    scopus 로고
    • RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini
    • Gonzalez-Suarez E, Branstetter D, Armstrong A, et al., RANK overexpression in transgenic mice with mouse mammary tumor virus promoter-controlled RANK increases proliferation and impairs alveolar differentiation in the mammary epithelia and disrupts lumen formation in cultured epithelial acini. Mol Cell Biol 2007; 27: 1442-1454.
    • (2007) Mol Cell Biol , vol.27 , pp. 1442-1454
    • Gonzalez-Suarez, E.1    Branstetter, D.2    Armstrong, A.3
  • 20
    • 84885095880 scopus 로고    scopus 로고
    • Constitutive activation of RANK disrupts mammary cell fate leading to tumorigenesis
    • Pellegrini P, Cordero A, Gallego MI, et al., Constitutive activation of RANK disrupts mammary cell fate leading to tumorigenesis. Stem Cells 2013; 31: 1954-1965.
    • (2013) Stem Cells , vol.31 , pp. 1954-1965
    • Pellegrini, P.1    Cordero, A.2    Gallego, M.I.3
  • 21
    • 0242495765 scopus 로고    scopus 로고
    • Receptor activator of NF-κB ligand induction via Jak2 and Stat5a in mammary epithelial cells
    • Srivastava S, Matsuda M, Hou Z, et al., Receptor activator of NF-κB ligand induction via Jak2 and Stat5a in mammary epithelial cells. J Biol Chem 2003; 278: 46171-46178.
    • (2003) J Biol Chem , vol.278 , pp. 46171-46178
    • Srivastava, S.1    Matsuda, M.2    Hou, Z.3
  • 22
    • 84886419490 scopus 로고    scopus 로고
    • Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells
    • Obr AE, Grimm SL, Bishop KA, et al., Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells. Mol Endocrinol 2013; 27: 1808-1824.
    • (2013) Mol Endocrinol , vol.27 , pp. 1808-1824
    • Obr, A.E.1    Grimm, S.L.2    Bishop, K.A.3
  • 23
    • 78149284767 scopus 로고    scopus 로고
    • RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis
    • Gonzalez-Suarez E, Jacob AP, Jones J, et al., RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature 2010; 468: 103-107.
    • (2010) Nature , vol.468 , pp. 103-107
    • Gonzalez-Suarez, E.1    Jacob, A.P.2    Jones, J.3
  • 24
    • 77953011400 scopus 로고    scopus 로고
    • Isolation, culture and analysis of mouse mammary epithelial cells
    • Smalley MJ,. Isolation, culture and analysis of mouse mammary epithelial cells. Methods Mol Biol 2010; 633: 139-170.
    • (2010) Methods Mol Biol , vol.633 , pp. 139-170
    • Smalley, M.J.1
  • 25
    • 3342880916 scopus 로고    scopus 로고
    • Apoptosis and involution in the mammary gland are altered in mice lacking a novel receptor, beta1,4-Galactosyltransferase i
    • de la Cruz L, Steffgen K, Martin A, et al., Apoptosis and involution in the mammary gland are altered in mice lacking a novel receptor, beta1,4-Galactosyltransferase I. Dev Biol 2004; 272: 286-309.
    • (2004) Dev Biol , vol.272 , pp. 286-309
    • De La Cruz, L.1    Steffgen, K.2    Martin, A.3
  • 26
    • 34247864012 scopus 로고    scopus 로고
    • Three-dimensional culture models of normal and malignant breast epithelial cells
    • Lee GY, Kenny PA, Lee EH, et al., Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods 2007; 4: 359-365.
    • (2007) Nat Methods , vol.4 , pp. 359-365
    • Lee, G.Y.1    Kenny, P.A.2    Lee, E.H.3
  • 27
    • 30144432901 scopus 로고    scopus 로고
    • Purification and unique properties of mammary epithelial stem cells
    • Stingl J, Eirew P, Ricketson I, et al., Purification and unique properties of mammary epithelial stem cells. Nature 2006; 439: 993-997.
    • (2006) Nature , vol.439 , pp. 993-997
    • Stingl, J.1    Eirew, P.2    Ricketson, I.3
  • 28
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • Debnath J, Muthuswamy SK, Brugge JS,. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003; 30: 256-268.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 29
    • 34248226985 scopus 로고    scopus 로고
    • Key stages in mammary gland development. Secretory activation in the mammary gland: It's not just about milk protein synthesis!
    • Anderson SM, Rudolph MC, McManaman JL, et al., Key stages in mammary gland development. Secretory activation in the mammary gland: It's not just about milk protein synthesis! Breast Cancer Res 2007; 9: 204.
    • (2007) Breast Cancer Res , vol.9 , pp. 204
    • Anderson, S.M.1    Rudolph, M.C.2    McManaman, J.L.3
  • 30
    • 0024505367 scopus 로고
    • Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane
    • Barcellos-Hoff MH, Aggeler J, et al., Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Development 1989; 105: 223-235.
    • (1989) Development , vol.105 , pp. 223-235
    • Barcellos-Hoff, M.H.1    Aggeler, J.2
  • 31
    • 77955895963 scopus 로고    scopus 로고
    • Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
    • Lim E, Wu D, Pal B, et al., Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res 2010; 12: R21.
    • (2010) Breast Cancer Res , vol.12 , pp. R21
    • Lim, E.1    Wu, D.2    Pal, B.3
  • 32
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins JR,. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 1992; 258: 424-429.
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 33
    • 84888306068 scopus 로고    scopus 로고
    • STAT signaling in mammary gland differentiation, cell survival and tumorigenesis
    • Haricharan S, Li Y,. STAT signaling in mammary gland differentiation, cell survival and tumorigenesis. Mol Cell Endocrinol 2014; 382: 560-569.
    • (2014) Mol Cell Endocrinol , vol.382 , pp. 560-569
    • Haricharan, S.1    Li, Y.2
  • 34
    • 0034201442 scopus 로고    scopus 로고
    • Activation of NF-kappaB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated beta-casein gene expression
    • Geymayer S, Doppler W,. Activation of NF-kappaB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated beta-casein gene expression. FASEB J 2000; 14: 1159-1170.
    • (2000) FASEB J , vol.14 , pp. 1159-1170
    • Geymayer, S.1    Doppler, W.2
  • 35
    • 84875079780 scopus 로고    scopus 로고
    • Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells
    • Lee HJ, Gallego-Ortega D, Ledger A, et al., Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development 2013; 140: 1397-1401.
    • (2013) Development , vol.140 , pp. 1397-1401
    • Lee, H.J.1    Gallego-Ortega, D.2    Ledger, A.3
  • 36
    • 33846032306 scopus 로고    scopus 로고
    • Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells
    • Buser AC, Gass-Handel EK, Wyszomierski SL, et al., Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells. Mol Endocrinol 2007; 21: 106-125.
    • (2007) Mol Endocrinol , vol.21 , pp. 106-125
    • Buser, A.C.1    Gass-Handel, E.K.2    Wyszomierski, S.L.3
  • 37
    • 0028036423 scopus 로고
    • Progesterone and EGF inhibit mouse mammary gland prolactin receptor and beta-casein gene expression
    • Nishikawa S, Moore RC, Nonomura N, et al., Progesterone and EGF inhibit mouse mammary gland prolactin receptor and beta-casein gene expression. Am J Physiol 1994; 267: C1467-C1472.
    • (1994) Am J Physiol , vol.267 , pp. C1467-C1472
    • Nishikawa, S.1    Moore, R.C.2    Nonomura, N.3
  • 38
    • 0035861314 scopus 로고    scopus 로고
    • IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
    • Cao Y, Bonizzi G, Seagroves TN, et al., IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 2001; 107: 763-775.
    • (2001) Cell , vol.107 , pp. 763-775
    • Cao, Y.1    Bonizzi, G.2    Seagroves, T.N.3
  • 39
    • 0033523775 scopus 로고    scopus 로고
    • ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation
    • Jones FE, Welte T, Fu XY, et al., ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. J Cell Biol 1999; 147: 77-88.
    • (1999) J Cell Biol , vol.147 , pp. 77-88
    • Jones, F.E.1    Welte, T.2    Fu, X.Y.3
  • 40
    • 0038268166 scopus 로고    scopus 로고
    • Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b
    • Kabotyanski EB, Rosen JM,. Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b. J Biol Chem 2003; 278: 17218-17227.
    • (2003) J Biol Chem , vol.278 , pp. 17218-17227
    • Kabotyanski, E.B.1    Rosen, J.M.2
  • 41
    • 0242550638 scopus 로고    scopus 로고
    • Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5
    • Long W, Wagner KU, Lloyd KC, et al., Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development 2003; 130: 5257-5268.
    • (2003) Development , vol.130 , pp. 5257-5268
    • Long, W.1    Wagner, K.U.2    Lloyd, K.C.3
  • 42
    • 84861845629 scopus 로고    scopus 로고
    • Receptor activator of NF-κB ligand promotes proliferation of a putative mammary stem cell unique to the lactating epithelium
    • Thomas E, Lee-Pullen T, Rigby P, et al., Receptor activator of NF-κB ligand promotes proliferation of a putative mammary stem cell unique to the lactating epithelium. Stem Cells 2012; 30: 1255-1264.
    • (2012) Stem Cells , vol.30 , pp. 1255-1264
    • Thomas, E.1    Lee-Pullen, T.2    Rigby, P.3
  • 43
    • 84862881087 scopus 로고    scopus 로고
    • Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling
    • Chakrabarti R, Wei Y, Romano RA, et al., Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling. Stem Cells 2012; 30: 1496-1508.
    • (2012) Stem Cells , vol.30 , pp. 1496-1508
    • Chakrabarti, R.1    Wei, Y.2    Romano, R.A.3


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