메뉴 건너뛰기




Volumn 7, Issue 12, 2016, Pages 14188-14198

DEPTOR suppresses the progression of esophageal squamous cell carcinoma and predicts poor prognosis

Author keywords

DEPTOR; Esophageal squamous cell carcinoma; mTOR; Proliferation

Indexed keywords

DEP DOMAIN CONTAINING MAMMALIAN TARGET OF RAPAMYCIN INTERACTING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; TUMOR MARKER; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; DEPTOR PROTEIN, HUMAN; MTOR PROTEIN, HUMAN; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE;

EID: 84971657513     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7420     Document Type: Article
Times cited : (26)

References (36)
  • 2
    • 84931054643 scopus 로고    scopus 로고
    • PI3K/AKT/mTOR pathway plays a major pathogenetic role in glycogen accumulation and tumor development in renal distal tubules of rats and men
    • Ribback S, Cigliano A, Kroeger N, Pilo MG, Terracciano L, Burchardt M, Bannasch P, Calvisi DF, Dombrowski F. PI3K/AKT/mTOR pathway plays a major pathogenetic role in glycogen accumulation and tumor development in renal distal tubules of rats and men. Oncotarget. 2015; 6:13036-13048. doi: 10.18632/oncotarget.3675.
    • (2015) Oncotarget. , vol.6 , pp. 13036-13048
    • Ribback, S.1    Cigliano, A.2    Kroeger, N.3    Pilo, M.G.4    Terracciano, L.5    Burchardt, M.6    Bannasch, P.7    Calvisi, D.F.8    Dombrowski, F.9
  • 3
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011; 12:21-35.
    • (2011) Nat Rev Mol Cell Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 4
    • 77950516104 scopus 로고    scopus 로고
    • mTOR signaling and drug development in cancer
    • Dancey J. mTOR signaling and drug development in cancer. Nat Rev Clin Oncol. 2010; 7:209-219.
    • (2010) Nat Rev Clin Oncol. , vol.7 , pp. 209-219
    • Dancey, J.1
  • 9
    • 80053203115 scopus 로고    scopus 로고
    • The mammalian target of rapamycin pathway as a therapeutic target in multiple myeloma
    • Gera J, Lichtenstein A. The mammalian target of rapamycin pathway as a therapeutic target in multiple myeloma. Leuk Lymphoma. 2011; 52:1857-1866.
    • (2011) Leuk Lymphoma. , vol.52 , pp. 1857-1866
    • Gera, J.1    Lichtenstein, A.2
  • 13
    • 84936768564 scopus 로고    scopus 로고
    • DEPTOR is linked to a TORC1-p21 survival proliferation pathway in multiple myeloma cells
    • Yang Y, Bardeleben C, Frost P, Hoang B, Shi Y, Finn R, Gera J, Lichtenstein A. DEPTOR is linked to a TORC1-p21 survival proliferation pathway in multiple myeloma cells. Genes Cancer. 2014; 5:407-419. doi: 10.18632/genesandcancer.44.
    • (2014) Genes Cancer. , vol.5 , pp. 407-419
    • Yang, Y.1    Bardeleben, C.2    Frost, P.3    Hoang, B.4    Shi, Y.5    Finn, R.6    Gera, J.7    Lichtenstein, A.8
  • 15
    • 79960411515 scopus 로고    scopus 로고
    • Overexpression of DEP domain containing mTOR-interacting protein correlates with poor prognosis in differentiated thyroid carcinoma
    • Pei L, Xie P, Zhou E, Yang Q, Luo Y, Tang Z. Overexpression of DEP domain containing mTOR-interacting protein correlates with poor prognosis in differentiated thyroid carcinoma. Mol Med Rep. 2011; 4:817-823.
    • (2011) Mol Med Rep. , vol.4 , pp. 817-823
    • Pei, L.1    Xie, P.2    Zhou, E.3    Yang, Q.4    Luo, Y.5    Tang, Z.6
  • 17
    • 81855228182 scopus 로고    scopus 로고
    • mTOR generates an auto-amplification loop by triggering the betaTrCP- and CK1alpha-dependent degradation of DEPTOR
    • Duan S, Skaar JR, Kuchay S, Toschi A, Kanarek N, Ben-Neriah Y, Pagano M. mTOR generates an auto-amplification loop by triggering the betaTrCP- and CK1alpha-dependent degradation of DEPTOR. Mol Cell. 2011; 44:317-324.
    • (2011) Mol Cell. , vol.44 , pp. 317-324
    • Duan, S.1    Skaar, J.R.2    Kuchay, S.3    Toschi, A.4    Kanarek, N.5    Ben-Neriah, Y.6    Pagano, M.7
  • 20
    • 49149112670 scopus 로고    scopus 로고
    • Boone J, Ten Kate FJ, Offerhaus GJ, van Diest PJ, Rinkes IH, van Hillegersberg R
    • Boone J, Ten Kate FJ, Offerhaus GJ, van Diest PJ, Rinkes IH, van Hillegersberg R. mTOR in squamous cell carcinoma of the oesophagus: a potential target for molecular therapy? J Clin Pathol. 2008; 61:909-913.
    • (2008) J Clin Pathol. , vol.61 , pp. 909-913
  • 21
    • 34347331090 scopus 로고    scopus 로고
    • An activated mTOR/p70S6K signaling pathway in esophageal squamous cell carcinoma cell lines and inhibition of the pathway by rapamycin and siRNA against mTOR
    • Hou G, Xue L, Lu Z, Fan T, Tian F, Xue Y. An activated mTOR/p70S6K signaling pathway in esophageal squamous cell carcinoma cell lines and inhibition of the pathway by rapamycin and siRNA against mTOR. Cancer Lett. 2007; 253:236-248.
    • (2007) Cancer Lett. , vol.253 , pp. 236-248
    • Hou, G.1    Xue, L.2    Lu, Z.3    Fan, T.4    Tian, F.5    Xue, Y.6
  • 22
    • 77649188319 scopus 로고    scopus 로고
    • mTOR inhibitor rapamycin alone or combined with cisplatin inhibits growth of esophageal squamous cell carcinoma in nude mice
    • Hou G, Zhang Q, Wang L, Liu M, Wang J, Xue L. mTOR inhibitor rapamycin alone or combined with cisplatin inhibits growth of esophageal squamous cell carcinoma in nude mice. Cancer Lett. 2010; 290:248-254.
    • (2010) Cancer Lett. , vol.290 , pp. 248-254
    • Hou, G.1    Zhang, Q.2    Wang, L.3    Liu, M.4    Wang, J.5    Xue, L.6
  • 24
    • 72849150434 scopus 로고    scopus 로고
    • Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy
    • Yuan R, Kay A, Berg WJ, Lebwohl D. Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy. J Hematol Oncol. 2009; 2:45.
    • (2009) J Hematol Oncol. , vol.2 , pp. 45
    • Yuan, R.1    Kay, A.2    Berg, W.J.3    Lebwohl, D.4
  • 25
    • 84883462981 scopus 로고    scopus 로고
    • A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin
    • Huang Y, Xi Q, Chen Y, Wang J, Peng P, Xia S, Yu S. A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin. Anti-cancer drugs. 2013; 24:889-898.
    • (2013) Anti-cancer drugs. , vol.24 , pp. 889-898
    • Huang, Y.1    Xi, Q.2    Chen, Y.3    Wang, J.4    Peng, P.5    Xia, S.6    Yu, S.7
  • 26
    • 84921789603 scopus 로고    scopus 로고
    • PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway
    • Xing X, Zhang L, Wen X, Wang X, Cheng X, Du H, Hu Y, Li L, Dong B, Li Z, Ji J. PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway. Anti-cancer drugs. 2014; 25:1129-1140.
    • (2014) Anti-cancer drugs. , vol.25 , pp. 1129-1140
    • Xing, X.1    Zhang, L.2    Wen, X.3    Wang, X.4    Cheng, X.5    Du, H.6    Hu, Y.7    Li, L.8    Dong, B.9    Li, Z.10    Ji, J.11
  • 30
    • 36549062090 scopus 로고    scopus 로고
    • Anchorage-independent culture maintains prostate stem cells
    • Shi X, Gipp J, Bushman W. Anchorage-independent culture maintains prostate stem cells. Developmental biology. 2007; 312:396-406.
    • (2007) Developmental biology. , vol.312 , pp. 396-406
    • Shi, X.1    Gipp, J.2    Bushman, W.3
  • 32
    • 81855167585 scopus 로고    scopus 로고
    • DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy
    • Zhao Y, Xiong X, Sun Y. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(betaTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Mol Cell. 2011; 44:304-316.
    • (2011) Mol Cell. , vol.44 , pp. 304-316
    • Zhao, Y.1    Xiong, X.2    Sun, Y.3
  • 33
    • 84874016733 scopus 로고    scopus 로고
    • Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer
    • Xie B, Zhou J, Shu G, Liu DC, Chen J, Yuan L. Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer. Cancer Cell Int. 2013; 13:18.
    • (2013) Cancer Cell Int. , vol.13 , pp. 18
    • Xie, B.1    Zhou, J.2    Shu, G.3    Liu, D.C.4    Chen, J.5    Yuan, L.6
  • 36
    • 84923275569 scopus 로고    scopus 로고
    • Galectin-1 is overexpressed in CD133+ human lung adenocarcinoma cells and promotes their growth and invasiveness
    • Zhou X, Li D, Wang X, Zhang B, Zhu H, Zhao1 J. Galectin-1 is overexpressed in CD133+ human lung adenocarcinoma cells and promotes their growth and invasiveness. Oncotarget. 2014; 6:3111-3122. doi: 10.18632/oncotarget.3076.
    • (2014) Oncotarget. , vol.6 , pp. 3111-3122
    • Zhou, X.1    Li, D.2    Wang, X.3    Zhang, B.4    Zhu, H.5    Zhaol, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.