Overexpression of long non-coding RNA ZXF2 promotes lung adenocarcinoma progression through c-Myc pathway

Cellular Physiology and Biochemistry

Volumn 35, Issue 6, 2015, Pages 2360-2370

  Yang, Ze Tian ^a   Li, Zhihong ^b   Wang, Xian Guo ^a   Tan, Tao ^c   Yi, Frank ^c   Zhu, Hua ^c   Zhao, Jin Ping ^a   Zhou, Xue Feng ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b CHENZHOU FIRST PEOPLE'S HOSPITAL   (China)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

c Myc; Cell proliferation; LncRNA ZXF2; Lung adenocarcinoma; Migration and invasion

Indexed keywords

LONG UNTRANSLATED RNA; SMALL INTERFERING RNA; MYC PROTEIN;

A549 CELL LINE; ADULT; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CELL CYCLE; CELL CYCLE ARREST; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CHROMOSOME 8Q; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ADENOCARCINOMA; LYMPH NODE METASTASIS; MALE; ONCOGENE C MYC; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SURVIVAL TIME; ADENOCARCINOMA; CELL MOTION; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; MIDDLE AGED; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE;

ADENOCARCINOMA; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-MYC; RNA, LONG NONCODING; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84928141071     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000374038     Document Type: Article

References (26)

1. Hellwig S, Bass BL: A starvation-induced noncoding RNA modulates expression of Dicer-regulated genes. Proc Natl Acad Sci U S A 2008;105:12897-12902.
2. Rinn JL, Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem 2012;81:145-166.
3. Ulitsky I, Bartel DP: lincRNAs: genomics, evolution, and mechanisms. Cell 2013;154:26-46.
4. Clark MB, Mattick JS: Long noncoding RNAs in cell biology. Semin Cell Dev Biol 2011;22:366-376.
5. Flockhart RJ, Webster DE, Qu K, Mascarenhas N, Kovalski J, Kretz M, Khavari PA: BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration. Genome Res 2012;22:1006-1014.
6. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, Wang Y, Brzoska P, Kong B, Li R, West RB, van de Vijver MJ, Sukumar S, Chang HY: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010;464:1071-1076.
7. Panzitt K, Tschernatsch MM, Guelly C, Moustafa T, Stradner M, Strohmaier HM, Buck CR, Denk H, Schroeder R, Trauner M, Zatloukal K: Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology 2007;132:330-342.
8. Zhang L, Zhou XF, Pan GF, Zhao JP: Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma. Biomed Pharmacother 2014;68:401-407.
9. Yu BL, Peng XH, Zhao FP, Liu X, Lu J, Wang L, Li G, Chen HH, Li XP: MicroRNA-378 functions as an onco-miR in nasopharyngeal carcinoma by repressing TOB2 expression. Int J Oncol 2014;44:1215-1222.
10. Yu L, Lu J, Zhang B, Liu X, Wang L, Li SY, Peng XH, Xu X, Tian WD, Li XP: miR-26a inhibits invasion and metastasis of nasopharyngeal cancer by targeting EZH2. Oncol Lett 2013;5:1223-1228.
11. Yang L, Zeng W, Li D, Zhou R: Inhibition of cell proliferation, migration and invasion by DNAzyme targeting MMP-9 in A549 cells. Oncol Rep 2009;22:121-126.
12. Nguyen VN, Mirejovsky P, Mirejovsky T, Melinova L, Mandys V: Expression of cyclin D1, Ki-67 and PCNA in non-small cell lung cancer: prognostic significance and comparison with p53 and bcl-2. Acta Histochem 2000;102:323-338.
13. He X, Tan X, Wang X, Jin H, Liu L, Ma L, Yu H, Fan Z: C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion. Tumour Biol 2014;10.1007/s13277-014-2526-4.
14. Mateen S, Raina K, Agarwal C, Chan D, Agarwal R: Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells. J Pharmacol Exp Ther 2013;345:206-214.
15. Yeager M, Orr N, Hayes RB, Jacobs KB, Kraft P, Wacholder S, Minichiello MJ, Fearnhead P, Yu K, Chatterjee N, Wang Z, Welch R, Staats BJ, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Gelmann EP, Tucker M, Gerhard DS, Fraumeni JF, Jr., Hoover R, Hunter DJ, Chanock SJ, Thomas G: Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet 2007;39:645-649.
16. Haiman CA, Le Marchand L, Yamamato J, Stram DO, Sheng X, Kolonel LN, Wu AH, Reich D, Henderson BE: A common genetic risk factor for colorectal and prostate cancer. Nat Genet 2007;39:954-956.
17. Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S, Penegar S, Chandler I, Gorman M, Wood W, Barclay E, Lubbe S, Martin L, Sellick G, Jaeger E, Hubner R, Wild R, Rowan A, Fielding S, Howarth K, Silver A, Atkin W, Muir K, Logan R, Kerr D, Johnstone E, Sieber O, Gray R, Thomas H, Peto J, Cazier JB, Houlston R: A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet 2007;39:984-988.
18. Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H: Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature 2008;451:202-206.
19. Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, Westermann F, Speleman F, Vandesompele J, Weinberg RA: miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010;12:247-256.
20. Robson SC, Ward L, Brown H, Turner H, Hunter E, Pelengaris S, Khan M: Deciphering c-MYC-regulated genes in two distinct tissues. BMC Genomics 2011;12:476.
21. Daksis JI, Lu RY, Facchini LM, Marhin WW, Penn LJ: Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle. Oncogene 1994;9:3635-3645.
22. Liao DJ, Thakur A, Wu J, Biliran H, Sarkar FH: Perspectives on c-Myc, Cyclin D1, and their interaction in cancer formation, progression, and response to chemotherapy. Crit Rev Oncog 2007;13:93-158.
23. Kim T, Cui R, Jeon YJ, Lee JH, Sim H, Park JK, Fadda P, Tili E, Nakanishi H, Huh MI, Kim SH, Cho JH, Sung BH, Peng Y, Lee TJ, Luo Z, Sun HL, Wei H, Alder H, Oh JS, Shim KS, Ko SB, Croce CM: Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5. Proc Natl Acad Sci U S A 2014;111:4173-4178.
24. Xiang JF, Yin QF, Chen T, Zhang Y, Zhang XO, Wu Z, Zhang S, Wang HB, Ge J, Lu X, Yang L, Chen LL: Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. Cell Res 2014;24:513-531.
25. Hung CL, Wang LY, Yu YL, Chen HW, Srivastava S, Petrovics G, Kung HJ: A long noncoding RNA connects c-Myc to tumor metabolism. Proc Natl Acad Sci U S A 2014;111:18697-18702.
26. Yang F, Xue X, Zheng L, Bi J, Zhou Y, Zhi K, Gu Y, Fang G: Long non-coding RNA GHET1 promotes gastric carcinoma cell proliferation by increasing c-Myc mRNA stability. FEBS J 2014;281:802-813.