PI3K/AKT/mTOR pathway plays a major pathogenetic role in glycogen accumulation and tumor development in renal distal tubules of rats and men

Oncotarget

Volumn 6, Issue 15, 2015, Pages 13036-13048

  Ribback, Silvia ^a   Cigliano, Antonio ^a   Kroeger, Nils ^a   Pilo, Maria G ^a   Terracciano, Luigi ^b   Burchardt, Martin ^a   Bannasch, Peter ^c   Calvisi, Diego F ^a   Dombrowski, Frank ^a  

^a UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

AKT mTOR; Clear cell tubules; Glycogen; Nephrocarcinogenesis

Indexed keywords

DACTOLISIB; GLYCOGEN; MAMMALIAN TARGET OF RAPAMYCIN; NITROSOMORPHOLINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STREPTOZOCIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CARCINOGENESIS; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; GLYCOGEN STORING CLEAR CELL TUBULE; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; KIDNEY CARCINOMA; KIDNEY DISTAL TUBULE; KIDNEY TUBULE EPITHELIUM; LIPOGENESIS; MALE; METABOLISM; MORPHOLOGY; NEPHRECTOMY; NONHUMAN; PATHOGENESIS; PRECANCER; RAT MODEL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; UPREGULATION; ANIMAL; CELL PROLIFERATION; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; IMMUNOHISTOCHEMISTRY; KIDNEY TUMOR; LEWIS RAT; PATHOLOGY; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; GLYCOGEN; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; MALE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED LEW; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84931054643     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3675     Document Type: Article

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