5′-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2A Receptor

Journal of Medicinal Chemistry

Volumn 59, Issue 10, 2016, Pages 4769-4777

  Massink, Arnault ^a   Louvel, Julien ^a   Adlere, Ilze ^b   Van Veen, Corine ^a   Huisman, Berend J H ^a   Dijksteel, Gabrielle S ^a   Guo, Dong ^a   Lenselink, Eelke B ^a   Buckley, Benjamin J ^c,d   Matthews, Hayden ^c   Ranson, Marie ^d   Kelso, Michael ^c   Ijzerman, Adriaan P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^c School of Chemistry   (United States)

^d UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; AMILORIDE;

ALLOSTERIC SITE; ALLOSTERISM; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADENOSINE A2 RECEPTOR ANTAGONISTS; ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMILORIDE; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; RECEPTOR, ADENOSINE A2A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84971622003     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00142     Document Type: Article

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