Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA)

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 22, 2011, Pages 6760-6766

  Matthews, Hayden ^a   Ranson, Marie ^a   Tyndall, Joel D A ^b   Kelso, Michael J ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Amiloride; Inhibitor; Structure activity relationships; uPA; Urokinase type plasminogen activator

Indexed keywords

5 (N ETHYL N ISOPROPYL)AMILORIDE; AMILORIDE DERIVATIVE; HEXAMETHYLENE AMILORIDE; UNCLASSIFIED DRUG; UROKINASE;

ARTICLE; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION;

AMILORIDE; ANTINEOPLASTIC AGENTS; DIURETICS; HUMANS; MODELS, MOLECULAR; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

ANIMALIA;

EID: 80054744515     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.044     Document Type: Article

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